The Cardiac Circadian Clock DOI Creative Commons
Martin E. Young

JACC Basic to Translational Science, Journal Year: 2023, Volume and Issue: 8(12), P. 1613 - 1628

Published: June 21, 2023

Virtually all aspects of physiology fluctuate with respect to the time day. This is beautifully exemplified by cardiovascular physiology, for which blood pressure and electrophysiology exhibit robust diurnal oscillations. At molecular/biochemical levels (eg, transcription, translation, signaling, metabolism), cardiovascular-relevant tissues (such as heart) are profoundly different during day vs night. Unfortunately, this in turn contributes toward 24-hour rhythms both risk adverse event onset arrhythmias, myocardial infarction) pathogenesis severity extent ischemic damage). Accumulating evidence indicates that cell-autonomous timekeeping mechanisms, termed circadian clocks, temporally govern biological processes known play critical roles function/dysfunction. In paper, a comprehensive review our current understanding cardiomyocyte clock health disease detailed. Unprecedented basic, translational, epidemiologic studies support need implement chronobiological considerations strategies designed prevention treatment disease.

Language: Английский

Exerkines in health, resilience and disease DOI Open Access
Lisa S. Chow, Robert E. Gerszten, Joan M. Taylor

et al.

Nature Reviews Endocrinology, Journal Year: 2022, Volume and Issue: 18(5), P. 273 - 289

Published: March 18, 2022

Language: Английский

Citations

516
Exercise metabolism and adaptation in skeletal muscle DOI
Jonathon A.B. Smith, Kevin A. Murach, Kenneth A. Dyar

et al.

Nature Reviews Molecular Cell Biology, Journal Year: 2023, Volume and Issue: 24(9), P. 607 - 632

Published: May 24, 2023

Language: Английский

Citations

111
Exercise benefits in cardiovascular diseases: from mechanisms to clinical implementation DOI
Pedro L. Valenzuela, Luís M. Ruilope, Alejandro Santos‐Lozano

et al.

European Heart Journal, Journal Year: 2023, Volume and Issue: 44(21), P. 1874 - 1889

Published: April 3, 2023

Abstract There is a pandemic of physical inactivity that appears to parallel the widespread prevalence cardiovascular disease (CVD). Yet, regular activity (PA) and exercise can play an important role not only in primary prevention but also secondary prevention. This review discusses some main effects PA/exercise mechanisms involved, including healthier metabolic milieu with attenuation systemic chronic inflammation, as well adaptations at vascular (antiatherogenic effects) heart tissue (myocardial regeneration cardioprotection) levels. The current evidence for safe implementation PA patients CVD summarized.

Language: Английский

Citations

104
Associations of timing of physical activity with all-cause and cause-specific mortality in a prospective cohort study DOI Creative Commons
Hongliang Feng, Lulu Yang, Yannis Yan Liang

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Feb. 18, 2023

There is a growing interest in the role of timing daily behaviors improving health. However, little known about optimal physical activity to maximize health benefits. We perform cohort study 92,139 UK Biobank participants with valid accelerometer data and all-cause cause-specific mortality outcomes, comprising over 7 years median follow-up (638,825 person-years). Moderate-to-vigorous intensity (MVPA) at any time day associated lower risks for all-cause, cardiovascular disease, cancer mortality. In addition, compared morning group (>50% MVPA during 05:00-11:00), midday-afternoon (11:00-17:00) mixed groups, but not evening (17:00-24:00), have disease These protective associations are more pronounced among elderly, males, less physically active participants, or those preexisting diseases. Here, we show that may potential improve public

Language: Английский

Citations

83
Temporal dynamics of the multi-omic response to endurance exercise training DOI Creative Commons
David Amar, Nicole R. Gay, Pierre M. Jean Beltran

et al.

Nature, Journal Year: 2024, Volume and Issue: 629(8010), P. 174 - 183

Published: May 1, 2024

Regular exercise promotes whole-body health and prevents disease, but the underlying molecular mechanisms are incompletely understood

Language: Английский

Citations

80
Organism-wide, cell-type-specific secretome mapping of exercise training in mice DOI Creative Commons
Wei Wei, Nicholas M. Riley,

Xuchao Lyu

et al.

Cell Metabolism, Journal Year: 2023, Volume and Issue: 35(7), P. 1261 - 1279.e11

Published: May 3, 2023

Language: Английский

Citations

46
Exercise induces tissue-specific adaptations to enhance cardiometabolic health DOI Creative Commons
Stephen P. Ashcroft, Ben Stocks, Brendan Egan

et al.

Cell Metabolism, Journal Year: 2024, Volume and Issue: 36(2), P. 278 - 300

Published: Jan. 5, 2024

The risk associated with multiple cancers, cardiovascular disease, diabetes, and all-cause mortality is decreased in individuals who meet the current recommendations for physical activity. Therefore, regular exercise remains a cornerstone prevention treatment of non-communicable diseases. An acute bout results coordinated interaction between tissues to increased energy demand exercise. Over time, metabolic stress each individual provides basis long-term adaptations across tissues, including system, skeletal muscle, adipose tissue, liver, pancreas, gut, brain. plethora benefits throughout whole body, improved cardiorespiratory fitness, function, glycemic control. Overall, we summarize exercise-induced that occur within how they converge ultimately improve cardiometabolic health.

Language: Английский

Citations

30
Circadian regulation of cancer stem cells and the tumor microenvironment during metastasis DOI
Yu Wang, Rajesh Narasimamurthy, Meng Qu

et al.

Nature Cancer, Journal Year: 2024, Volume and Issue: 5(4), P. 546 - 556

Published: April 23, 2024

Language: Английский

Citations

19
Exercise in adults with type 1 diabetes mellitus DOI
Michael C. Riddell, Anne L. Peters

Nature Reviews Endocrinology, Journal Year: 2022, Volume and Issue: 19(2), P. 98 - 111

Published: Oct. 31, 2022

Language: Английский

Citations

59
Timing of physical activity in relation to liver fat content and insulin resistance DOI Creative Commons
Jeroen H. P. M. van der Velde, Sebastiaan C. Boone, Esther Winters-van Eekelen

et al.

Diabetologia, Journal Year: 2022, Volume and Issue: 66(3), P. 461 - 471

Published: Nov. 1, 2022

Abstract Aims/hypothesis We hypothesised that the insulin-sensitising effect of physical activity depends on timing activity. Here, we examined cross-sectional associations breaks in sedentary time and with liver fat content insulin resistance a Dutch cohort. Methods In 775 participants Netherlands Epidemiology Obesity (NEO) study, assessed time, different intensities using sensors, by magnetic resonance spectroscopy ( n =256). Participants were categorised as being most active morning (06:00–12:00 hours), afternoon (12:00–18:00 hours) or evening (18:00–00:00 engaging moderate-to-vigorous-physical (MVPA) evenly distributed throughout day. Most certain block was defined spending majority (%) total daily MVPA block. between HOMA-IR linear regression analyses, adjusted for demographic lifestyle factors including body fat. Associations additionally MVPA. Results The (42% men) had mean (SD) age 56 (4) years BMI 26.2 (4.1) kg/m 2 . Total not associated resistance, whereas amount higher content. (−5%/h [95% CI −10%/h, 0%/h]) reduced but Compared who an even distribution day, similar (−3% −25%, 16%]) those morning, it (−18% −33%, −2%]) (−25% −49%, −4%]). Conclusions/interpretation number lower resistance. Moderate-to-vigorous reduction up to 25% Further studies should assess whether is also important occurrence type diabetes. Graphical abstract

Language: Английский

Citations

53