Hippocampus,
Journal Year:
2023,
Volume and Issue:
33(4), P. 373 - 390
Published: March 9, 2023
Abstract
Adult
hippocampal
neurogenesis
is
important
for
preserving
learning
and
memory‐related
cognitive
functions.
Physical
exercise,
especially
voluntary
running,
one
of
the
strongest
stimuli
to
promote
has
beneficial
effects
on
Voluntary
running
promotes
exit
neural
stem
cells
(NSCs)
from
quiescent
stage,
proliferation
NSCs
progenitors,
survival
newborn
cells,
morphological
development
immature
neuron,
integration
new
neurons
into
circuitry.
However,
detailed
mechanisms
driving
these
changes
remain
unclear.
In
this
review,
we
will
summarize
current
knowledge
with
respect
molecular
underlying
running‐induced
neurogenesis,
highlighting
recent
genome‐wide
gene
expression
analyses.
addition,
discuss
approaches
future
directions
dissecting
complex
cellular
change
in
adult‐born
response
physical
exercise.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: May 29, 2024
Despite
substantial
evidence
emphasizing
the
pleiotropic
benefits
of
exercise
for
prevention
and
treatment
various
diseases,
underlying
biological
mechanisms
have
not
been
fully
elucidated.
Several
attributed
to
signaling
molecules
that
are
released
in
response
by
different
tissues
such
as
skeletal
muscle,
cardiac
adipose,
liver
tissue.
These
molecules,
which
collectively
termed
exerkines,
form
a
heterogenous
group
bioactive
substances,
mediating
inter-organ
crosstalk
well
structural
functional
tissue
adaption.
Numerous
scientific
endeavors
focused
on
identifying
characterizing
new
mediators
with
properties.
Additionally,
some
investigations
molecular
targets
exerkines
cellular
cascades
trigger
adaption
processes.
A
detailed
understanding
tissue-specific
downstream
effects
is
crucial
harness
health-related
mediated
improve
targeted
programs
health
disease.
Herein,
we
review
current
vivo
exerkine-induced
signal
transduction
across
multiple
target
highlight
preventive
therapeutic
value
exerkine
diseases.
By
aspects
research,
provide
comprehensive
overview
(i)
underpinnings
secretion,
(ii)
receptor-dependent
receptor-independent
adaption,
(iii)
clinical
implications
these
disease
treatment.
Nanomaterials,
Journal Year:
2024,
Volume and Issue:
14(2), P. 160 - 160
Published: Jan. 11, 2024
Strokes
rank
as
the
second
most
common
cause
of
mortality
and
disability
in
human
population
across
world.
Currently,
available
methods
treating
or
preventing
strokes
have
significant
limitations,
primarily
need
to
use
high
doses
drugs
due
presence
blood-brain
barrier.
In
last
decade,
increasing
attention
has
been
paid
capabilities
nanotechnology.
However,
vast
majority
research
this
area
is
focused
on
mechanisms
anticancer
antiviral
effects
nanoparticles.
our
opinion,
not
enough
neuroprotective
nanomaterials.
review,
we
attempted
summarize
key
molecular
brain
cell
damage
during
ischemia.
We
discussed
current
literature
regarding
various
nanomaterials
for
treatment
strokes.
examined
features
all
known
nanomaterials,
possibility
which
are
currently
being
studied
regard,
positive
negative
properties
identified.
Particular
review
was
nanoselenium
since
selenium
a
vital
microelement
part
very
important
little-studied
proteins,
e.g.,
selenoproteins
selenium-containing
proteins.
An
analysis
modern
studies
cytoprotective
made
it
possible
establish
acute
chronic
protective
aimed
combine
information
action
nanoparticles
neurodegenerative
processes,
especially
cerebral
Neural Regeneration Research,
Journal Year:
2023,
Volume and Issue:
19(1), P. 6 - 15
Published: May 25, 2023
Adult
neurogenesis,
the
process
of
creating
new
neurons,
involves
coordinated
division,
migration,
and
differentiation
neural
stem
cells.
This
is
restricted
to
neurogenic
niches
located
in
two
distinct
areas
brain:
subgranular
zone
dentate
gyrus
hippocampus
subventricular
lateral
ventricle,
where
neurons
are
generated
then
migrate
olfactory
bulb.
Neurogenesis
has
been
thought
occur
only
during
embryonic
early
postnatal
stages
decline
with
age
due
a
continuous
depletion
Interestingly,
recent
years
have
seen
tremendous
progress
our
understanding
adult
brain
bridging
knowledge
gap
between
neurogenesis.
Here,
we
discuss
current
status
neurogenesis
light
what
know
about
In
this
notion,
talk
importance
intracellular
signaling
molecules
mobilizing
endogenous
cell
proliferation.
Based
on
understanding,
can
declare
that
these
play
role
targeting
mature
brain.
However,
achieve
goal,
need
avoid
undesired
proliferation
cells
by
controlling
necessary
checkpoints,
which
lead
tumorigenesis
prove
be
curse
instead
blessing
or
hope.
Abstract
Skeletal
muscle
can
undergo
detrimental
changes
in
various
diseases,
leading
to
dysfunction
and
atrophy,
thus
severely
affecting
people's
lives.
Along
with
exercise,
there
is
a
growing
interest
the
potential
of
nutritional
support
against
atrophy.
This
review
provides
brief
overview
molecular
mechanisms
driving
skeletal
atrophy
summarizes
recent
advances
interventions
for
preventing
treating
The
supplements
include
amino
acids
their
derivatives
(such
as
leucine,
β‐hydroxy,
β‐methylbutyrate,
creatine),
antioxidant
(like
Coenzyme
Q10
mitoquinone,
resveratrol,
curcumin,
quercetin,
Omega
3
fatty
acids),
minerals
magnesium
selenium),
vitamins
vitamin
B,
C,
D,
E),
well
probiotics
prebiotics
Lactobacillus,
Bifidobacterium,
1‐kestose).
Furthermore,
study
discusses
impact
combined
approach
involving
physical
therapy
prevent
suggests
appropriate
multi‐nutritional
multi‐modal
based
on
individual
conditions
optimize
treatment
outcomes,
enhances
recovery
function
patients.
By
understanding
behind
implementing
interventions,
it
possible
enhance
improve
patients'
quality
life.
