Nanomedicine,
Journal Year:
2023,
Volume and Issue:
18(27), P. 2021 - 2038
Published: Nov. 1, 2023
Aim:
To
study
the
biodistribution
and
toxicology
of
selenium
nanoparticles
(SeNPs)
versus
their
bulk
counterpart
in
young
adult
male
rats
a
28-day
study.
Methods:
SeNPs
were
synthesized
conjugated
with
indocyanine
green
to
assess
comparative
by
vivo
imaging
further
characterized
transmission
electron
microscopy,
Fourier
transform
infrared,
scanning
microscopy
/
energy
dispersive
x-ray
spectroscopy,
UV
ζ-analysis.
The
toxicity
was
evaluated
relative
its
nano
form
hematology
indices,
redox,
inflammatory
markers
histopathology.
Results:
Indocyanine
green-conjugated
showed
preferential
accumulation
liver,
followed
testis
kidney.
protective
effect
more
significantly
observed
livers
than
adults
compared
counterpart.
Conclusion:
Age-dependent
monitoring
diagnosis
may
need
different
biomarkers
also
provide
better
understanding
as
therapeutics.
Journal of Clinical Medicine,
Journal Year:
2024,
Volume and Issue:
13(8), P. 2381 - 2381
Published: April 19, 2024
Changes
in
trace
element
concentrations
are
being
wildly
considered
when
it
comes
to
neurodegenerative
disorders,
such
as
Alzheimer’s
disease
and
Parkinson’s
disease.
This
study
aims
present
the
role
that
elements
play
central
nervous
system.
Moreover,
we
reviewed
mechanisms
involved
their
neurotoxicity.
Low
zinc
concentrations,
well
high
levels
of
copper,
manganese,
iron,
activate
signalling
pathways
inflammatory,
oxidative
nitrosative
stress
response.
Neurodegeneration
occurs
due
association
between
metals
proteins,
which
is
then
followed
by
aggregate
formation,
mitochondrial
disorder,
and,
ultimately,
cell
death.
In
disease,
low
Zn
suppress
neurotoxicity
induced
β-amyloid
through
selective
precipitation
aggregation
intermediates.
High
iron
manganese
cause
intracellular
α-synuclein,
results
synaptic
dysfunction
axonal
transport
disruption.
caused
accumulation
Fe
midbrain
dopaminergic
nucleus,
pathogenesis
multiple
sclerosis
derives
from
deficiency,
leading
an
imbalance
T
functions.
Aluminium
disturbs
homeostasis
other
a
rise
production
oxygen
reactive
forms,
leads
cellular
Selenium,
with
plays
distinct
process
ferroptosis.
Outlining
influence
have
on
oxidoreduction
processes
crucial
recognising
pathophysiology
diseases
may
provide
possible
new
methods
for
both
avoidance
therapy.
Advances in Nutrition,
Journal Year:
2023,
Volume and Issue:
14(4), P. 819 - 839
Published: April 17, 2023
Alzheimer's
disease
(AD)
is
a
neurodegenerative
characterized
by
progressive
cognitive
impairment
and
neuroinflammation.
Recent
research
has
revealed
the
crucial
role
of
gut
microbiota
microbial
metabolites
in
modulating
AD.
However,
mechanisms
which
microbiome
affect
brain
function
remain
poorly
understood.
Here,
we
review
literature
on
changes
diversity
composition
patients
with
AD
animal
models
We
also
discuss
latest
progress
understanding
pathways
from
host
or
diet
regulate
By
effects
dietary
components
function,
composition,
metabolites,
examine
potential
for
manipulation
through
intervention
to
delay
progression
Although
it
challenging
translate
our
microbiome-based
approaches
guidelines
clinical
therapies,
these
findings
provide
an
attractive
target
promoting
function.
Neural Regeneration Research,
Journal Year:
2024,
Volume and Issue:
20(3), P. 613 - 631
Published: March 1, 2024
Alzheimer’s
disease
is
an
age-related
neurodegenerative
disorder
with
a
complex
and
incompletely
understood
pathogenesis.
Despite
extensive
research,
cure
for
has
not
yet
been
found.
Oxidative
stress
mediates
excessive
oxidative
responses,
its
involvement
in
pathogenesis
as
primary
or
secondary
pathological
event
widely
accepted.
As
member
of
the
selenium-containing
antioxidant
enzyme
family,
glutathione
peroxidase
4
reduces
esterified
phospholipid
hydroperoxides
to
maintain
cellular
redox
homeostasis.
With
discovery
ferroptosis,
central
role
anti-lipid
peroxidation
several
diseases,
including
disease,
received
widespread
attention.
Increasing
evidence
suggests
that
expression
inhibited
brain,
resulting
stress,
inflammation,
apoptosis,
which
are
closely
associated
damage
disease.
Several
therapeutic
approaches,
such
small
molecule
drugs,
natural
plant
products,
non-pharmacological
treatments,
ameliorate
cognitive
function
by
promoting
enhancing
activity.
Therefore,
upregulation
may
be
promising
strategy
treatment
This
review
provides
overview
gene
structure,
biological
functions,
regulatory
mechanisms
4,
discussion
on
important
events
related
summary
advances
small-molecule
therapies
targeting
Most
prior
studies
this
subject
used
animal
models,
relevant
clinical
lacking.
Future
trials
required
validate
effects
strategies
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
15
Published: Jan. 14, 2025
Premenstrual
dysphoric
disorder
(PMDD)
is
a
cyclical
mood
that
severely
affects
the
daily
life
of
women
reproductive
age.
Most
medications
being
used
clinically
have
limitations
such
as
low
efficacy,
side
effects,
and
high
cost,
so
there
an
urgent
need
to
discover
safer
more
effective
medications.
Rutin
natural
flavonol
glycoside
with
various
pharmacological
properties
including
antidepressant.
The
study
efficacy
mechanism
action
rutin
in
PMDD-depressed
subtype
model
rats
plays
important
role
discovery
new
drugs
for
treatment
PMDD.
Binding
gamma-aminobutyric
acid
type
A
receptors
(GABAA
receptors)
was
probed
using
molecular
docking,
microscale
thermophoresis,
radioactive
receptor
ligand
binding
assay
cell
membrane
clamp
experiment.
Behavioral
tests
mice
were
performed
screen
optimal
dose
rutin.
evaluate
effects
on
depressed
mood,
memory
impairment,
social
impairment
rats.
HE
staining
Golgi
observe
neuronal
damage
rat
hippocampus.
UHPLC-MS/MS
targeted
metabolomics
detect
changes
neurotransmitter
content
PCR
array
effect
mRNA
expression
GABAA
partial
subunits
docking
score
benzodiazepine
site
-11.442
gliding
-11.470.
Kd
(α1β2γ2)
1.17
±
0.89
μM.
competed
[H3]-flunitrazepam
inhibited
inward
flow
chloride
ions
(P
<
0.05).
In
rats,
alleviated
ameliorated
hippocampal
reduces
(GABA)
acetylcholine
(ACh)
levels
Moreover,
we
found
did
not
affect
relative
Overall,
which
may
be
related
sites,
inhibiting
flow,
ameliorating
reducing
GABA
ACh
levels.
results
this
provide
experimental
basis
scientific
evidence
development
Molecules,
Journal Year:
2023,
Volume and Issue:
29(1), P. 136 - 136
Published: Dec. 25, 2023
Selenium
(Se)
is
a
naturally
occurring
essential
micronutrient
that
required
for
human
health.
The
existing
form
of
Se
includes
inorganic
and
organic.
In
contrast
to
the
Se,
which
has
low
bioavailability
high
cytotoxicity,
organic
exhibits
higher
bioavailability,
lower
toxicity,
more
diverse
composition
structure.
This
review
presents
nutritional
benefits
by
listing
linking
selenoprotein
(SeP)
functions
evidence
health
benefits.
research
status
SeP
from
foods
in
recent
years
introduced
systematically,
particularly
sources,
biochemical
transformation
speciation,
bioactivities.
These
aspects
are
elaborated
with
references
further
utilization
compounds
field
Neurobiology of Disease,
Journal Year:
2025,
Volume and Issue:
207, P. 106816 - 106816
Published: Feb. 6, 2025
Spinocerebellar
ataxia
type
3
(SCA3),
a
neurodegenerative
disorder
caused
by
excess
CAG
repeats
in
the
ATXN3
gene,
leads
to
progressive
cerebellar
and
other
symptoms.
The
results
of
previous
studies
suggest
that
trace
element
dysregulation
contributes
onset.
Here,
we
investigated
relationships
with
repeat
length,
clinical
severity,
brain
structural
functional
connectivity
45
patients
SCA3
44
healthy
controls
(HCs).
Blood
levels
lithium
(Li),
selenium
(Se),
copper
(Cu)
were
significantly
lower
than
HCs;
Li
Se
negatively
correlated
especially
manifest
subgroup.
Diffusion
tensor
imaging
combined
resting-state
magnetic
resonance
revealed
fractional
anisotropy
white
matter
(WM)
bilateral
frontal
parietal
regions;
tractography
mapping
showed
Li-associated
region
nerve
fiber
pathways
SCA3.
Dynamic
causal
modeling
analyses
bidirectional
from
inferior
lobule(IPL)
cerebellum
was
blood
level
Time
series
correlation-based
analysis
intrinsic
connectivities
dorsal
premotor
cortex(PMd)
IPL
local
regions
weaker
HCs.
Our
dysregulation,
deficiency,
induces
alterations
manifestations
SCA3;
supplementation
may
be
beneficial
for
WM
or
astrocytes
this
patient
population.
