Adipose
tissue
undergoes
changes
with
aging,
leading
to
increased
adiposity,
inflammatory
cell
infiltration,
reduced
angiogenesis,
heightened
oxidative
stress,
and
alterations
in
its
metabolic
function.
Regular
exercise
has
been
recognized
as
a
powerful
intervention
that
can
positively
influence
adipose
health
mitigate
the
effects
of
aging.
However,
molecular
mechanisms
underlying
benefits
regular
on
aging
function
remain
poorly
understood.
Adipokines
released
through
play
potential
role
mitigating
enhancing
metabolism
glucose
lipids,
reducing
inflammation
fibrosis,
promoting
fat
browning
thermogenesis.
The
goal
this
review
is
offer
comprehensive
overview
addressing
age-related
decline
significance
disorders
associated
aged
will
be
discussed.
Journal of Agricultural and Food Chemistry,
Journal Year:
2024,
Volume and Issue:
72(24), P. 14044 - 14056
Published: June 7, 2024
Intramuscular
fat
(IMF)
contributed
positively
to
pork
quality,
whereas
subcutaneous
(SCF)
was
often
considered
be
a
detrimental
factor
impacting
growth
and
carcass
traits.
Reducing
SCF
while
maintaining
optimal
IMF
levels
requires
thorough
understanding
of
the
adipogenic
differences
between
these
two
adipose
depots.
Our
study
explored
in
adipogenesis
porcine
SCF,
results
showed
that
adipocytes
(SCAs)
demonstrate
greater
potential
for
differentiation,
both
vivo
vitro.
Lipidomic
transcriptomic
analyses
suggested
intramuscular
(IMAs)
are
more
inclined
biosynthesize
unsaturated
fatty
acids.
Furthermore,
single-cell
RNA
sequencing
(scRNA-seq)
employed
dissect
intrinsic
microenvironmental
discrepancies
SCF.
Comparative
analysis
indicated
enriched
with
preadipocytes,
exhibiting
an
enhanced
potential,
characterized
by
higher
abundance
stem
cells.
coculture
cells
myogenetic
niche
IMAs
inhibited
its
differentiation.
Cell
communication
identified
160
ligand–receptor
pairs
channels
IMF.
Collectively,
our
elucidated
novel
mechanisms
underpinning
divergence
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(4), P. 2013 - 2013
Published: Feb. 7, 2024
Understanding
the
intricate
molecular
mechanisms
governing
fate
of
human
adipose-derived
stem
cells
(hASCs)
is
essential
for
elucidating
delicate
balance
between
adipogenic
and
osteogenic
differentiation
in
both
healthy
pathological
conditions.
Long
non-coding
RNAs
(lncRNAs)
have
emerged
as
key
regulators
involved
lineage
commitment
cells,
operating
at
various
levels
gene
regulation,
including
transcriptional,
post-transcriptional,
post-translational
processes.
To
gain
deeper
insights
into
role
lncRNAs’
hASCs’
differentiation,
we
conducted
a
comprehensive
analysis
lncRNA
transcriptome
(RNA-seq)
translatome
(polysomal-RNA-seq)
during
24
h
period
adipogenesis
osteogenesis.
Our
findings
revealed
distinct
expression
patterns
processes,
highlighting
90
lncRNAs
that
are
exclusively
regulated
polysomal
fraction.
These
underscore
significance
investigating
associated
with
ribosomes,
considering
their
unique
potential
action,
such
translational
regulation
coding
capacity
microproteins.
Additionally,
identified
specific
programs
osteogenesis
early
stages
cell
differentiation.
By
shedding
light
on
functions
these
polysome-associated
lncRNAs,
aim
to
deepen
our
understanding
involvement
ultimately
paving
way
novel
therapeutic
strategies
regenerative
medicine.
Adipose
tissue
undergoes
changes
with
aging,
leading
to
increased
adiposity,
inflammatory
cell
infiltration,
reduced
angiogenesis,
heightened
oxidative
stress,
and
alterations
in
its
metabolic
function.
Regular
exercise
has
been
recognized
as
a
powerful
intervention
that
can
positively
influence
adipose
health
mitigate
the
effects
of
aging.
However,
molecular
mechanisms
underlying
benefits
regular
on
aging
function
remain
poorly
understood.
Adipokines
released
through
play
potential
role
mitigating
enhancing
metabolism
glucose
lipids,
reducing
inflammation
fibrosis,
promoting
fat
browning
thermogenesis.
The
goal
this
review
is
offer
comprehensive
overview
addressing
age-related
decline
significance
disorders
associated
aged
will
be
discussed.
