Physical Education Theory and Methodology,
Journal Year:
2024,
Volume and Issue:
24(4), P. 619 - 625
Published: Aug. 26, 2024
Objectives.
This
study
aimed
to
analyze
the
effect
of
a
four-week
moderate-intensity
exercise
regimen
on
increasing
growth
hormone
(GH)
levels
in
individuals
with
obesity.
Materials
and
methods.
A
total
25
female
aged
20-25
years,
body
mass
index
(BMI)
27.50-37.00
kg/m²,
were
involved
randomly
divided
into
two
groups,
namely
control
group
(CON;
n
=
12)
(MIE;
13).
The
(treadmill
for
30
minutes
at
60-70%
HRmax,
resistance
1RM)
was
conducted
3
times
per
week
period
4
weeks.
Blood
samples
from
participants
collected
pre-
post-exercise
sessions,
GH
analyzed
using
Enzyme-Linked
Immunosorbent
Assay
method.
Data
analysis
techniques
used
paired
sample
t-test
significance
level
5
%.
Results.
results
between
pre-exercise
sessions
CON
showed
change
(1291.79
±
383.76
1151.53
484.80
pg/mL;
p
0.694),
while
MIE
demonstrated
following
dynamics
—
(1161.79
133.72
2103.83
357.09
0.006).
Conclusions.
main
findings
this
revealed
that
after
implementing
intervention,
significant
increase
observed
obese
females.
Journal of Advanced Research,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Flavonoids
are
naturally
occurring
dietary
phytochemicals
with
significant
antioxidant
effects
aside
from
several
health
benefits.
People
often
consume
them
in
combination
other
food
components.
Compiling
data
establishes
a
link
between
bioactive
flavonoids
and
prevention
of
diseases
animal
models,
including
cardiovascular
diseases,
diabetes,
gut
dysbiosis,
metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD).
However,
numerous
clinical
studies
have
demonstrated
the
ineffectiveness
contradicting
rodent
thereby
challenging
validity
using
as
supplements.
This
review
provides
perspective
to
emphasize
effective
roles
well
summarize
their
specific
mechanisms
animals
briefly.
First,
this
offers
an
in-depth
elucidation
processes
within
human,
encompassing
small,
large
intestine,
liver.
Furthermore,
comprehensive
overview
various
functions
gastrointestinal
tract,
hindering
breakdown
assimilation
macronutrients,
such
polysaccharides
lipids,
regulating
hormone
secretion
inhibition
mineral
iron
absorption.
In
unabsorbed
major
portion
interact
flora
leading
biotransformation.
Once
absorbed
circulated
bloodstream,
or
metabolites
exert
beneficial
systemic
effects.
Lastly,
we
examine
protective
disorders,
endothelial
dysfunction,
MASLD,
disease,
obesity,
hyperlipidemia,
insulin
resistance.
conclusion,
outlines
safety
future
prospects
field
health,
especially
syndrome
(MetS).
Journal of Hepatology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 1, 2025
The
liver
acts
as
a
central
metabolic
hub,
integrating
signals
from
the
gastrointestinal
tract
and
adipose
tissue
to
regulate
carbohydrate,
lipid,
amino
acid
metabolism.
Gut-derived
metabolites,
such
acetate
ethanol
non-esterified
fatty
acids
white
(WAT),
influence
hepatic
processes,
which
rely
on
mitochondrial
function
maintain
systemic
energy
balance.
Metabolic
dysregulation
obesity,
insulin
resistance,
type
2
diabetes
disrupt
these
pathways,
leading
dysfunction-associated
steatotic
disease
(MASLD)
steatohepatitis
(MASH).
This
review
explores
fluxes
within
gut-adipose
tissue-liver
axis,
focusing
pivotal
role
of
de
novo
lipogenesis
(DNL),
dietary
substrates
like
glucose
fructose,
changes
in
during
MASLD
progression.
It
highlights
contributions
resistance
impaired
dynamics
lipid
accumulation.
Further
understanding
how
interplay
between
substrate
flux
gastro-intestinal
integrates
with
intersects
structural
functional
alterations
mitochondria
will
be
important
identify
novel
therapeutic
targets
advance
treatment
MASH.
Trends in Endocrinology and Metabolism,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 1, 2025
Prediabetes
is
a
highly
prevalent
and
increasingly
common
condition
affecting
significant
proportion
of
the
global
population.
The
heterogeneous
nature
prediabetes
presents
challenge
in
identifying
individuals
who
particularly
benefit
from
lifestyle
or
other
therapeutic
interventions
aiming
at
preventing
type
2
diabetes
(T2D)
associated
comorbidities.
phenotypic
characteristics
risk
for
are
with
both
specific
profiles
progression
differential
potential
to
facilitate
remission
reduce
future
T2D.
This
review
examines
current
definition
prevalence
evaluates
alarming
increase
burden
The Innovation Medicine,
Journal Year:
2024,
Volume and Issue:
2(3), P. 100090 - 100090
Published: Jan. 1, 2024
<p>Obesity,
a
growing
global
health
crisis,
is
driven
by
complex
interplay
of
genetic,
biological,
environmental,
behavioral,
socio-cultural,
and
economic
factors.
This
comprehensive
review
encapsulates
the
epidemiology,
pathophysiological
mechanism,
myriad
complications
it
triggers,
such
as
cardiovascular
diseases
(CVDs),
cancer,
neurological
disorders,
respiratory
ailments,
digestive
diseases,
mobility
impairments,
psychological
stress.
The
etiology
obesity
multifaceted,
involving
genetic
predispositions,
environmental
influences,
behavioral
tendencies,
socio-economic
elements.
underpinnings
encompass
multifaceted
aspects
energy
metabolism,
including
regulation
appetite,
glucose,
lipid,
amino
acid
metabolism.
also
addresses
seemingly
contradictory
roles
in
various
offering
insights
into
these
phenomena.
management
multi-pronged,
lifestyle
modifications,
pharmacological
interventions,
metabolic
surgeries.
Lifestyle
changes
are
foundational,
but
advancements
molecular
techniques,
digital
technology,
wearable
devices,
artificial
intelligence
opening
new
avenues
for
personalized
treatment
early
intervention.
Pharmacological
surgery
effective
should
be
judiciously
tailored
to
individual
patient
needs.
underscores
importance
approach
management,
aiming
curb
escalating
trend
enhance
future
interventions
treatments.
ultimate
goal
synthesize
current
evidence
innovative
strategies
combat
effectively.</p>
Cell Metabolism,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 1, 2024
Precision
medicine
is
still
not
considered
as
a
standard
of
care
in
obesity
treatment,
despite
large
heterogeneity
the
metabolic
phenotype
individuals
with
obesity.
One
strongest
factors
influencing
variability
disease
risk
adipose
tissue
(AT)
dysfunction;
however,
there
little
understanding
link
between
distinct
cell
populations,
cell-type-specific
transcriptional
programs,
and
severity.
Here,
we
generated
comprehensive
cellular
map
subcutaneous
visceral
AT
metabolically
healthy
unhealthy
By
combining
single-nucleus
RNA-sequencing
data
bulk
transcriptomics
clinical
parameters,
identified
that
mesothelial
cells,
adipocytes,
adipocyte-progenitor
cells
exhibit
correlation
disease.
Furthermore,
uncovered
cell-specific
such
transitioning
to
mesenchymal
phenotype,
are
involved
uncoupling
from
Together,
these
findings
provide
valuable
insights
by
revealing
biological
drivers
endpoints.
Cell Metabolism,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 1, 2024
Ferroptosis
is
characterized
as
an
iron-dependent
and
lipophilic
form
of
cell
death.
However,
it
remains
unclear
what
role
ferroptosis
has
in
adipose
tissue
function
activity.
Here,
we
find
a
lower
ferroptotic
signature
the
individuals
mice
with
obesity.
We
further
that
activation
signaling
by
non-lethal
dose
agonists
significantly
reduces
lipid
accumulation
primary
adipocytes
high-fat
diet
(HFD)-fed
mice.
Notably,
adipocyte-specific
overexpression
acyl-coenzyme
A
synthetase
long-chain
family
member
4
(Acsl4)
or
deletion
ferritin
heavy
chain
(Fth)
protects
from
HFD-induced
expansion
metabolic
disorders
via
signaling.
Mechanistically,
5,15-dihydroxyeicosatetraenoic
acid
(5,15-DiHETE)
activates
signaling,
resulting
degradation
hypoxia-inducible
factor-1α
(HIF1α),
thereby
derepressing
thermogenic
program
regulated
c-Myc-peroxisome
proliferator-activated
receptor
gamma
coactivator-1
beta
(Pgc1β)
pathway.
Our
findings
suggest
activating
tissues
might
help
to
prevent
treat
obesity
its
related
disorders.
