The hippocampus and related neocortical structures in memory transformation

Neuroscience Letters, Journal Year: 2018, Volume and Issue: 680, P. 39 - 53

Published: May 4, 2018

Language: Английский

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Representation of Real-World Event Schemas during Narrative Perception

Journal of Neuroscience, Journal Year: 2018, Volume and Issue: 38(45), P. 9689 - 9699

Published: Sept. 24, 2018

Understanding movies and stories requires maintaining a high-level situation model that abstracts away from perceptual details to describe the location, characters, actions, causal relationships of currently unfolding event. These models are built not only information present in current narrative, but also prior knowledge about schematic event scripts, which typical sequences encountered throughout lifetime. We analyzed fMRI data 44 human subjects (male female) presented with 16 three-minute stories, consisting four events drawn two different scripts (eating at restaurant or going through airport). Aside this shared script structure, varied widely terms their characters storylines, were highly dissimilar formats (audiovisual clips spoken narration). One group was an intact temporal sequence, while separate control same scrambled order. Regions including posterior medial cortex, prefrontal cortex (mPFC), superior frontal gyrus exhibited patterns generalized across subjects, modalities. Patterns mPFC sensitive overall temporally evoking weaker representations. Using Hidden Markov Model, these regions predicted (restaurant vs airport) unlabeled high accuracy used align multiple script. results extend work on perception controlled, artificial schemas animal experiments naturalistic complex narratives.SIGNIFICANCE STATEMENT In almost all situations we encounter our daily lives, able draw what typically happens world better perceive mentally represent ongoing experiences. contrast previous studies investigated cognition using simple, associations, measured brain activity watching listening depicting airport Our reveal network is structure situations. abstract particular each story, activating representation general type being perceived.

Language: Английский

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From Knowing to Remembering: The Semantic–Episodic Distinction

Trends in Cognitive Sciences, Journal Year: 2019, Volume and Issue: 23(12), P. 1041 - 1057

Published: Oct. 29, 2019

Language: Английский

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Multiple Scales of Representation along the Hippocampal Anteroposterior Axis in Humans

Current Biology, Journal Year: 2018, Volume and Issue: 28(13), P. 2129 - 2135.e6

Published: June 21, 2018

Language: Английский

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Deconstructing the Posterior Medial Episodic Network

Trends in Cognitive Sciences, Journal Year: 2020, Volume and Issue: 24(6), P. 451 - 465

Published: April 24, 2020

Language: Английский

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Transcending time in the brain: How event memories are constructed from experience

Hippocampus, Journal Year: 2019, Volume and Issue: 29(3), P. 162 - 183

Published: Feb. 7, 2019

Our daily lives unfold continuously, yet when we reflect on the past, remember those experiences as distinct and cohesive events. To understand this phenomenon, early investigations focused how individuals perceive natural breakpoints, or boundaries, in ongoing experience. More recent research has examined these boundaries modulate brain mechanisms that support long-term episodic memory. This work revealed a complex interplay between hippocampus prefrontal cortex promotes integration separation of sequential information to help organize our into mnemonic Here, discuss both temporal stability change one's thoughts, goals, surroundings may provide scaffolding for neural processes link separate memories across time. When learning novel familiar sequences information, dynamic hippocampal independently from concert with other regions bind representations together The formation storage discrete occur proactively an experience unfolds. They also retroactively, either during context shift reactivation bring past present allow integration. We describe conditions factors shape construction event different timescales. Together findings shed new light transcends time transform everyday meaningful memory representations.

Language: Английский

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No consolidation without representation: Correspondence between neural and psychological representations in recent and remote memory

Neuron, Journal Year: 2021, Volume and Issue: 109(14), P. 2239 - 2255

Published: May 19, 2021

Language: Английский

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Hippocampal ripples and their coordinated dialogue with the default mode network during recent and remote recollection

Neuron, Journal Year: 2021, Volume and Issue: 109(17), P. 2767 - 2780.e5

Published: July 22, 2021

Language: Английский

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Are episodic memories special? On the sameness of remembered and imagined event simulation

Journal of the Royal Society of New Zealand, Journal Year: 2018, Volume and Issue: 48(2-3), P. 64 - 88

Published: March 14, 2018

Over the past decade, episodic memory has been reconceptualised as future-oriented. In 2007, Schacter and I proposed 'constructive simulation hypothesis' to account for emerging findings that future thinking share overlapping cognitive neural substrates, arguing constructive nature of provides perfect neurocognitive architecture simulation. Here, update refine this theoretical position, that, fundamentally, memories are not special. shift emphasis from conceptualising basis imagination, instead proposing both instantiations same process. synthesise neuroscientific perspectives show how brain's default mode network underpins remembering, imagining perception event representations via a common process is iterative, involving interaction pre-existing knowledge reinstated perceptual content with incoming experiential information create online mental simulations experience.Donna Rose Addis.

Language: Английский

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Cortico-hippocampal network connections support the multidimensional quality of episodic memory

eLife, Journal Year: 2019, Volume and Issue: 8

Published: March 22, 2019

Episodic memories reflect a bound representation of multimodal features that can be reinstated with varying precision. Yet little is known about how brain networks involved in memory, including the hippocampus and posterior-medial (PM) anterior-temporal (AT) systems, interact to support quality content recollection. Participants learned color, spatial, emotion associations objects, later reconstructing visual using continuous color spectrum 360-degree panorama scenes. Behaviorally, dependencies memory were observed for gist but not precision event associations. Supporting this integration, hippocampus, AT, PM regions showed increased connectivity reduced modularity during retrieval compared encoding. These inter-network connections tracked multidimensional, objective measure quality. Moreover, distinct patterns item spatial findings demonstrate hippocampal-cortical reconfigure episodic retrieval, such dynamic interactions might flexibly multidimensional remembered events.

Language: Английский

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