Sleep benefits different stages of memory in Drosophila

Frontiers in Physiology, Journal Year: 2023, Volume and Issue: 14

Published: Jan. 19, 2023

Understanding the physiological mechanisms that modulate memory acquisition and consolidation remains among most ambitious questions in neuroscience. Massive efforts have been dedicated to deciphering how experience affects behavior, different sensory phenomena memory. Our ability encode, consolidate retrieve memories depends on internal drives, sleep stands out processes affect memory: one of relatable benefits is aiding occurs order both prepare brain learn new information, after a learning task, those memories. Drosophila lends itself study interactions between sleep. The fruit fly provides incomparable genetic resources, mapped connectome, an existing framework knowledge molecular, cellular, circuit sleep, making remarkable model decipher sophisticated regulation by quantity quality Research has stablished not only facilitates wild-type memory-impaired animals, but deprivation interferes with In addition, it well-accepted paramount processes. Finally, studies shown can promote drive. Nevertheless, molecular network underlying this intertwined relationship are still evasive. Recent work shed light neural substrates mediate sleep-dependent consolidation. similar way, mechanistic insights switch control sleep-independent strategies were recently described. This review will discuss , focusing recent advances field pointing awaiting be investigated.

Language: Английский

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Glia‐specific expression of neuropeptide receptor Lgr4 regulates development and adult physiology in Drosophila

Journal of Neuroscience Research, Journal Year: 2023, Volume and Issue: 102(1)

Published: Nov. 28, 2023

Abstract Similar to the human brain, Drosophila glia may well be divided into several subtypes that each carries out specific functions. Glial GPCRs play key roles in crosstalk between neurons and glia. Lgr4 (dLgr4) is a relaxin receptor homolog involved angiogenesis, cardiovascular regulation, collagen remodeling, wound healing. A recent study suggests ilp7 might ligand for regulates escape behavior of larvae. Here we demonstrate expression glial cells, not neurons, necessary early development, adult behavior, lifespan. Reducing level cells disrupts while knocking down other LGR family members has no impact. Adult‐specific knockdown but reduce locomotion, male reproductive success, animal longevity. The investigation how contributes this behavioral alteration will increase our understanding insulin signaling via selectively modulates neuronal activity behavior.

Language: Английский

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Adenosine signaling in glia modulates metabolic state-dependent behavior inDrosophila

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 8, 2024

Summary An animal’s metabolic state strongly influences its behavior. Hungry animals prioritize food seeking and feeding behaviors, while sated suppress these behaviors to engage in other activities. Additionally, neuronal activity synaptic transmission are among the most energy expensive processes. Yet neurons do not uptake nutrients from circulation. Instead, glia fulfill this highly evolutionary conserved function. Recent studies have shown that can modulate However, how different subtypes sense behavior is incompletely understood. Here, we unravel two types of glia-mediated modulation state-dependent In food-deprived flies, astrocyte-like perineurial promote foraging feeding, respectively, cortex behaviors. We further show adenosine receptor intracellular calcium levels subtypes, which ultimately controls This study reveals a new mechanism animal accordingly.

Language: Английский

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Evolution of Astrocyte-Neuron Interactions Across Species

Advances in neurobiology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 17

Published: Jan. 1, 2024

Language: Английский

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Male-specific sNPF peptidergic circuits control energy balance for mating duration through neuron-glia interactions.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 21, 2024

ABSTRACT This study reveals a sexually dimorphic sNPF-sNPF-R circuit in the Drosophila brain that regulates energy balance behavior, specifically shorter-mating-duration (SMD) response to sexual experience. sNPF is predominantly expressed neurons, while sNPF-R both neurons and glial cells, particularly astrocyte-like glia (ALG) subset of cells outside mushroom body (MB) termed "Rishi cells" (RS cells). Sexual experience induces global alterations calcium signaling synaptic plasticity within this circuit, with expressing RS playing critical role encoding experience-related information into behavior related mating duration. Neuronal glucose metabolism, Tret1l transporter, essential for maintaining high levels proper function near cells. novel intricate neuron-glia network acts as circuits processing interval timing behaviors, highlighting dynamic interplay between neural circuits, regulating balance.

Language: Английский

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Exploring the molecular makeup of support cells in insect camera eyes

BMC Genomics, Journal Year: 2023, Volume and Issue: 24(1)

Published: Nov. 22, 2023

Animals typically have either compound eyes, or camera-type both of which evolved repeatedly in the animal kingdom. Both eye types include two important kinds cells: photoreceptor cells, can be excited by light, and non-neuronal support cells (SupCs), provide essential to photoreceptors. At molecular level deeply conserved genes that relate differentiation fueled a discussion on whether not shared evolutionary origin might considered for this cell type. In contrast, only handful studies, primarily eyes Drosophila melanogaster, demonstrated similarities SupCs. D. melanogaster SupCs (Semper primary pigment cells) are specialized glia share several with certain vertebrate glia, including Müller glia. This led us question if there could signatures SupCs, even functionally different such as image-forming larval camera sunburst diving beetle Thermonectus marmoratus. To investigate possibility, we used an in-depth comparative whole-tissue transcriptomics approach. Specifically, dissected principal into SupC- retina-containing regions generated respective transcriptomes. Our analysis revealed common features enrichment glial function (e.g. gap junction proteins innexin 3), glycogen production (glycogenin), energy metabolism (glutamine synthetase 1 2). evaluate similarities, compared our transcriptomes those fly (Müller glia) well retinas. T. marmoratus were found distinct genetic overlap These results suggest form like photoreceptors, may conserved.

Language: Английский

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Exploring the molecular makeup of support cells in insect camera eyes

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: July 20, 2023

Animals generally have either compound eyes, which evolved repeatedly in different invertebrates, or camera many times across the animal kingdom. Both eye types include two important kinds of cells: photoreceptor cells, can be excited by light, and non-neuronal support cells (SupCs), provide essential to photoreceptors. Despite examples convergence evolution, similarities gross developmental plan molecular signatures been discovered, even between phylogenetically distant functionally types. For this reason, a shared evolutionary origin has considered for In contrast, only handful studies, primarily on eyes Drosophila melanogaster , demonstrated SupCs. D. SupCs (Semper primary pigment cells) are specialized glia that share several with certain vertebrate glia, including Müller glia. This led us speculate whether there conserved SupCs, such as image-forming larval sunburst diving beetle Thermonectus marmoratus . To investigate possibility, we used an in-depth comparative whole-tissue transcriptomics approach. Specifically, dissected principal into SupC- retina-containing regions generated respective transcriptomes. Our analysis revealed features enrichment genes glial function (e.g. gap junction proteins innexin 3), glycogen production (glycogenin), energy metabolism (glutamine synthetase 1 2). evaluate extent conservation, compared our transcriptomes those fly (Müller glia) well retinas. T. were found distinct genetic overlap both These results evidence deep conservation addition raising questions about eye-specific animals.

Language: Английский

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From the Perspective of a Neuron

SpringerBriefs in psychology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 28

Published: Jan. 1, 2024

Language: Английский

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Editorial overview: Insect neuroethology: More than behavior and neurons

Current Opinion in Insect Science, Journal Year: 2023, Volume and Issue: 57, P. 101037 - 101037

Published: April 19, 2023

Language: Английский

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Profiling neurotransmitter-evoked glial responses by RNA-sequencing analysis

Frontiers in Neural Circuits, Journal Year: 2023, Volume and Issue: 17

Published: Aug. 14, 2023

Fundamental properties of neurons and glia are distinctively different. Neurons excitable cells that transmit information, whereas have long been considered as passive bystanders. Recently, the concept tripartite synapse is proposed structurally functionally incorporated into synapse, basic unit information processing in brains. It has then become intriguing how actively communicate with presynaptic postsynaptic compartments to influence signal transmission. Here we present a thorough analysis at transcriptional level on respond different types neurotransmitters. Adult fly were purified from brains incubated neurotransmitters ex vivo . Subsequent RNA-sequencing analyses reveal distinct overlapping patterns for these transcriptomes. Whereas Acetylcholine (ACh) Glutamate (Glu) more vigorously activate glial gene expression, GABA retains its inhibitory effect. All fail trigger significant change expression their synthesis enzymes, yet Glu triggers increased neurotransmitter receptors including own nAChRs. Expressions transporters under diverse controls DA, GABA, Glu, suggesting evoked intracellular pathways by interconnected. Furthermore, changes genes involved calcium signaling also predict activity. Finally, general metabolic suppression except which upregulates number transporting nutrients amino acids. Our findings fundamentally dissect facing neuronal challenges; results provide insights crosstalk synaptic context underlie mechanism brain function behavior.

Language: Английский

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