Polymers,
Journal Year:
2022,
Volume and Issue:
14(5), P. 993 - 993
Published: Feb. 28, 2022
Over
recent
decades,
poly(lactic-co-glycolic
acid)
(PLGA)
based
nano-
and
micro-
drug
delivery
vehicles
have
been
rapidly
developed
since
PLGA
was
approved
by
the
Food
Drug
Administration
(FDA).
Common
factors
that
influence
particle
properties
extensively
studied
researchers,
such
as
size,
polydispersity
index
(PDI),
surface
morphology,
zeta
potential,
loading
efficiency.
These
all
found
to
be
key
for
determining
release
kinetics
of
particles.
For
applications
behavior
is
a
critical
property,
systems
are
still
plagued
with
issue
burst
when
large
portion
suddenly
released
from
rather
than
controlled
particles
designed
for.
Other
can
play
role
in
behavior,
glass
transition
temperature
(Tg).
The
Tg,
however,
an
underreported
property
current
systems.
This
review
summarizes
basic
knowledge
particles,
effect
Tg
on
presents
awareness
applications.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(4), P. 2034 - 2034
Published: Feb. 12, 2022
Polymeric
materials
have
been
extensively
explored
in
the
field
of
nanomedicine;
within
them,
poly
lactic-co-glycolic
acid
(PLGA)
holds
a
prominent
position
micro-
and
nanotechnology
due
to
its
biocompatibility
controllable
biodegradability.
In
this
review
we
focus
on
combination
PLGA
with
different
inorganic
nanomaterials
form
nanocomposites
overcome
polymer’s
limitations
extend
applications.
We
discuss
their
physicochemical
properties
variety
well-established
synthesis
methods
for
preparation
PLGA-based
materials.
Recent
progress
design
biomedical
applications
are
thoroughly
discussed
provide
framework
future
research.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2020,
Volume and Issue:
8
Published: Feb. 11, 2020
Polymeric
biomaterials
have
found
widespread
applications
in
nanomedicine,
and
PLGA
particular
has
been
successfully
implemented
numerous
drug
delivery
formulations
due
to
its
synthetic
malleability
biocompatibility.
However,
the
need
for
preconception
these
is
increasing,
this
can
be
achieved
by
selection
elimination
of
design
variables
order
systems
tailored
their
specific
applications.
The
starting
materials
preparation
methods
shown
influence
various
parameters
PLGA-based
nanocarriers
implementation
systems,
while
computational
simulations
as
a
component
formulation
studies
provide
valuable
information
on
characteristics.
This
review
provides
critical
summary
synthesis
bio-medicine
outlines
experimental
considerations
systems.
Pharmaceutics,
Journal Year:
2019,
Volume and Issue:
11(1), P. 22 - 22
Published: Jan. 8, 2019
Theranostics
has
emerged
in
recent
years
to
provide
an
efficient
and
safer
alternative
cancer
management.
This
review
presents
updated
description
of
nanotheranostic
formulations
under
development
for
skin
(including
melanoma),
head
neck,
thyroid,
breast,
gynecologic,
prostate,
colon
cancers,
brain-related
cancer,
hepatocellular
carcinoma.
With
this
focus,
we
appraised
the
clinical
advantages
drawbacks
metallic,
polymeric,
lipid-based
nanosystems,
such
as
low
invasiveness,
toxicity
surrounding
healthy
tissues,
high
precision,
deeper
tissue
penetration,
dosage
adjustment
a
real-time
setting.
Particularly
recognizing
increased
complexity
multimodality
area,
multifunctional
hybrid
nanoparticles,
comprising
different
nanomaterials
functionalized
with
targeting
moieties
and/or
anticancer
drugs,
present
best
characteristics
theranostics.
Several
examples,
focusing
on
their
design,
composition,
imaging
treatment
modalities,
vitro
vivo
characterization,
are
detailed
herein.
Briefly,
all
studies
followed
common
trend
design
these
theranostics
use
materials
drugs
that
share
both
inherent
(e.g.,
contrast
agents)
therapeutic
properties
heating
or
production
reactive
oxygen
species).
rationale
allows
one
apparently
overcome
heterogeneity,
complexity,
harsh
conditions
tumor
microenvironments,
leading
successful
targeted
therapies.
ACS Applied Materials & Interfaces,
Journal Year:
2019,
Volume and Issue:
12(3), P. 3279 - 3300
Published: Dec. 24, 2019
Among
the
different
synthetic
polymers
developed
for
biomedical
applications,
poly(lactic-co-glycolic
acid)
(PLGA)
has
attracted
considerable
attention
because
of
its
excellent
biocompatibility
and
biodegradability.
Nanocomposites
based
on
PLGA
metal-based
nanostructures
(MNSs)
have
been
employed
extensively
as
an
efficient
strategy
to
improve
structural
functional
properties
polymer.
The
MNSs
used
impart
new
PLGA,
such
antimicrobial
labeling.
In
present
review,
strategies
available
fabrication
MNS/PLGA
nanocomposites
their
applications
in
field
will
be
discussed,
beginning
with
a
description
preparation
routes,
activity,
cytotoxicity
concerns
nanocomposites.
these
nanocomposites,
carriers
scaffolds
tissue
regeneration
other
therapies
are
subsequently
reviewed.
addition,
potential
advantages
using
treatment
illnesses
analyzed
vitro
vivo
studies,
support
future
research
field.
Journal of Advanced Research,
Journal Year:
2021,
Volume and Issue:
36, P. 223 - 247
Published: June 16, 2021
Skin
cancer
has
been
the
leading
type
of
worldwide.
Melanoma
and
non-melanoma
skin
cancers
are
now
most
common
types
that
have
reached
to
epidemic
proportion.
Based
on
rapid
prevalence
cancers,
lack
efficient
drug
delivery
systems,
it
is
essential
surge
possible
ways
prevent
or
cure
disease.Although
surgical
modalities
therapies
made
great
progress
in
recent
years,
however,
there
still
an
urgent
need
alleviate
its
increased
burden.
Hence,
understanding
precise
pathophysiological
signaling
mechanisms
all
other
factors
such
insults
will
be
beneficial
for
development
more
therapies.In
this
review,
we
explained
new
understandings
about
onset
described
management
via
polymeric
micro/nano
carriers-based
therapies,
highlighting
current
key
bottlenecks
future
prospective
field.
In
therapeutic
drug/gene
approaches,
system
promising
strategy.
This
review
discusses
how
polymers
successfully
exploited
micro/nanosized
systems
anticancer
genes
drugs
overcoming
barriers
limitations
associated
with
available
conventional
therapies.
addition
delivery,
intelligent
nanocarriers
platforms
also
established
combination
including
photodynamic
photothermal,
theranostic
applications.
portfolio
latest
approaches
could
promote
blooming
growth
research
their
clinical
availability.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(11)
Published: Feb. 1, 2023
Owing
to
the
increase
in
multidrug-resistant
bacterial
isolates
hospitals
globally
and
lack
of
truly
effective
antimicrobial
agents,
antibiotic
resistant
infections
have
increased
substantially.
There
is
thus
an
urgent
need
develop
new
drugs
their
related
formulations.
In
recent
years,
natural
peptides
(AMPs),
AMP
optimization,
self-assembled
AMPs,
hydrogels,
biomaterial-assisted
delivery
AMPs
shown
great
potential
treatment
infections.
this
review,
it
focused
on
development
prospects
shortcomings
various
AMP-based
biomaterials
for
treating
animal
model
infections,
such
as
abdominal,
skin,
eye
It
hoped
that
review
will
inspire
further
innovations
design
accelerate
commercialization.
Pharmaceuticals,
Journal Year:
2023,
Volume and Issue:
16(3), P. 454 - 454
Published: March 17, 2023
In
recent
years,
biodegradable
polymers
have
gained
the
attention
of
many
researchers
for
their
promising
applications,
especially
in
drug
delivery,
due
to
good
biocompatibility
and
designable
degradation
time.
Poly
(lactic-co-glycolic
acid)
(PLGA)
is
a
functional
polymer
made
from
polymerization
lactic
acid
(LA)
glycolic
(GA)
widely
used
pharmaceuticals
medical
engineering
materials
because
its
biocompatibility,
non-toxicity,
plasticity.
The
aim
this
review
illustrate
progress
research
on
PLGA
biomedical
as
well
shortcomings,
provide
some
assistance
future
development.
