Tough, Injectable Calcium Phosphate Cement Based Composite Hydrogels to Promote Osteogenesis

Gels, Journal Year: 2023, Volume and Issue: 9(4), P. 302 - 302

Published: April 3, 2023

Osteoporosis is one of the most disabling consequences aging, and osteoporotic fractures a higher risk subsequent lead to substantial disability deaths, indicating that both local fracture healing early anti-osteoporosis therapy are great significance. However, combining simple clinically approved materials achieve good injection molding provide mechanical support remains challenge. To meet this challenge, bioinspired by natural bone components, we develop appropriate interactions between inorganic biological scaffolds organic osteogenic molecules, achieving tough hydrogel firmly loaded with calcium phosphate cement (CPC) injectable. Here, component CPC composed biomimetic composition precursor, incorporating gelatin methacryloyl (GelMA) N-Hydroxyethyl acrylamide (HEAA), endow system fast polymerization crosslinking through ultraviolet (UV) photo-initiation. The GelMA-poly (N-Hydroxyethyl acrylamide) (GelMA-PHEAA) chemical physical network formed in situ enhances performances maintains bioactive characteristics CPC. This combined new promising candidate for commercial clinical material help patients survive fracture.

Language: Английский

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Spatiotemporal self-strengthening hydrogels for oral tissue regeneration

Composites Part B Engineering, Journal Year: 2022, Volume and Issue: 243, P. 110119 - 110119

Published: July 8, 2022

Language: Английский

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Natural vs Synthetic Polymers: How Do They Communicate with Cells for Skin Regeneration—A Review

Journal of Composites Science, Journal Year: 2023, Volume and Issue: 7(9), P. 385 - 385

Published: Sept. 13, 2023

Modern research has evolved several approaches toward skin regeneration and one of the novel concerns is use polymer-based systems due to their excellent beneficial properties skin. Several polymers, such as cellulose, hyaluronan, alginate, chitosan, collagen, fibrin fibroin, have been tested proven benefits for regeneration, most them are derived from either polysaccharide- or protein-based materials. In order understand mode action, researchers investigated cell–matrix interaction possible signaling mechanism in regeneration. Not only but also cell communication determines application polymers practice. Based on above significance, this review disclosed recent findings compile a method between cells polysaccharide-based (such agar, xanthan gum) gelatin, fibrin, silk fibroin) materials along with other poly(vinyl alcohol), polyglycolide poly(glycolic acid), poly(lactic acid) Accordingly, addresses fundamental concept communication, which helps us basis polymer’s functions biomedical field.

Language: Английский

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Tough, adhesive biomimetic hyaluronic acid methacryloyl hydrogels for effective wound healing

Frontiers in Bioengineering and Biotechnology, Journal Year: 2023, Volume and Issue: 11

Published: July 19, 2023

The development of cost-effective, biocompatible soft wound dressings is highly desirable; however, conventional are only designed for flat wounds, which creates difficulty with promising healing efficiency in complex practical conditions. Herein, we developed a tough, adhesive biomimetic hyaluronic acid methacryloyl hydrogels composed chemically crosslinked (HAMA) network and poly(N-hydroxyethyl acrylamide) (PHEAA) rich multiple hydrogen bonding. Due to the chemical crosslinking sites (acrylamide groups) HAMA; bulk HEMA/PHEAA presented significant enhancements mechanical properties (∼0.45 MPa) than common (<0.1 MPa). abundant bonding also endowed resultant extremely high adhesiveness on many nonporous substrates, including glass biological tissues (e.g., heart, liver, lung, kidney, stomach, muscle), considerable interfacial toughness ∼1432 J m-2. Accordingly, since both natural derivative polymers hydrophilic PHEAA networks biocompatible, hydrogel matrix possesses good blood compatibility (<5% hemolysis ratio) satisfies general dressing requirements (>99% cell viability). Based these physicochemical features, have demonstrated that this hydrogel, administered form patch, could be applied tissue by promoting epithelialization, angiogenesis, collagen deposition. We believe our proposed design holds great potential repair HAMA/PHEAA next-generation healings emergency situations.

Language: Английский

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Thermosensitive-based synergistic antibacterial effects of novel LL37@ZPF-2 loaded poloxamer hydrogel for infected skin wound healing

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125210 - 125210

Published: Jan. 1, 2025

Language: Английский

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