Advancing osteoarthritis therapy with GMOCS hydrogel-loaded BMSCs-exos DOI Creative Commons

Renyi Zhou,

Jiarong Guo, Zhe Jin

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Aug. 19, 2024

This study investigated the mechanism of extracellular matrix-mimicking hydrogel-mediated TGFB1/Nrf2 signaling pathway in osteoarthritis using bone marrow mesenchymal stem cell-derived exosomes (BMSCs-Exos). A GMOCS-Exos hydrogel was synthesized and evaluated for its impact on chondrocyte viability neutrophil traps (NETs) formation. In an OA rat model, promoted cartilage regeneration inhibited NETs Transcriptome sequencing identified TGFB1 as a key gene, with activating Nrf2 through TGFB1. Depletion hindered cartilage-protective effect GMOCS-Exos. sheds light promising therapeutic strategy GMOCS-Exos-mediated modulation.

Language: Английский

Harnessing the potential of hyaluronic acid methacrylate (HAMA) hydrogel for clinical applications in orthopaedic diseases DOI Creative Commons
Junliang Lu, Zongzhan Gao, Wei He

et al.

Journal of Orthopaedic Translation, Journal Year: 2025, Volume and Issue: 50, P. 111 - 128

Published: Jan. 1, 2025

The treatment of orthopaedic diseases, such as fractures and osteoarthritis, remains a significant challenge due to the complex requirements for mechanical strength tissue repair. Hydrogels based on hyaluronic acid methacrylate (HAMA) show promise engineering materials these conditions. Hyaluronic (HA) is natural component extracellular matrix, known its good compatibility. HAMA-based hydrogels can be adjusted through crosslinking by combining them with other materials. This review provides an overview recent research applications in diseases. First, we summarize techniques preparation characterization HAMA hydrogels. Next, offer detailed use treating conditions cartilage injuries, bone defects, meniscus injuries. Additionally, discuss diseases related orthopaedics. Finally, point out challenges propose future directions clinical translation strong translational potential orthopaedics their biocompatibility, adjustable properties, regenerative capabilities. With ongoing research, are well-positioned applications, particularly repair, osteoarthritis treatment.

Language: Английский

Citations

3

Biomimetic Materials for Skin Tissue Regeneration and Electronic Skin DOI Creative Commons

Sol Youn,

Mi‐Ran Ki, Mohamed Abdel‐Hamid

et al.

Biomimetics, Journal Year: 2024, Volume and Issue: 9(5), P. 278 - 278

Published: May 7, 2024

Biomimetic materials have become a promising alternative in the field of tissue engineering and regenerative medicine to address critical challenges wound healing skin regeneration. Skin-mimetic enormous potential improve outcomes enable innovative diagnostic sensor applications. Human skin, with its complex structure diverse functions, serves as an excellent model for designing biomaterials. Creating effective coverings requires mimicking unique extracellular matrix composition, mechanical properties, biochemical cues. Additionally, integrating electronic functionality into these presents exciting possibilities real-time monitoring, diagnostics, personalized healthcare. This review examines biomimetic their role healing, well integration technologies. It discusses recent advances, challenges, future directions this rapidly evolving field.

Language: Английский

Citations

14

Progress of polysaccharide-based tissue adhesives DOI
Gi‐Yeon Han, H. S. Kwack, Yohan Kim

et al.

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 327, P. 121634 - 121634

Published: Nov. 28, 2023

Language: Английский

Citations

15

Microneedles based on hyaluronic acid-polyvinyl alcohol with antibacterial, anti-inflammatory, and antioxidant effects promote diabetic wound healing DOI
Xuemei Li, Xi Xiao, Yiheng Zhang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 137185 - 137185

Published: Nov. 1, 2024

Language: Английский

Citations

5

Photocrosslinkable Biomaterials for 3D Bioprinting: Mechanisms, Recent Advances, and Future Prospects DOI Open Access

Yushang Lai,

Xiong Xiao, Ziwei Huang

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12567 - 12567

Published: Nov. 22, 2024

Constructing scaffolds with the desired structures and functions is one of main goals tissue engineering. Three-dimensional (3D) bioprinting a promising technology that enables personalized fabrication devices regulated biological mechanical characteristics similar to natural tissues/organs. To date, 3D has been widely explored for biomedical applications like engineering, drug delivery, screening, in vitro disease model construction. Among different bioinks, photocrosslinkable bioinks have emerged as powerful choice advanced devices, fast crosslinking speed, high resolution, great print fidelity. The biomaterials used light-based printing play pivotal role functional constructs. Herein, this review outlines general approaches related biomaterials, including extrusion-based printing, inkjet stereolithography laser-assisted printing. Further, mechanisms, advantages, limitations photopolymerization photoinitiators are discussed. Next, recent advances synthetic highlighted. Finally, challenges future perspectives envisaged.

Language: Английский

Citations

4

Mg2+-containing composite scaffolds mediate macrophage polarization to enhance meniscus regeneration DOI
Li Zong,

Weili Shi,

Ming Tian

et al.

Bio-Design and Manufacturing, Journal Year: 2025, Volume and Issue: 8(3), P. 344 - 358

Published: May 1, 2025

Language: Английский

Citations

0

Morphological and biological assessment of films based on Hyaluronic acid doped with cerium oxide and aluminum oxide for wound healing applications DOI
Amani Saleh Almuslem, A.M. Alshehri, A.A. Menazea

et al.

Materials Chemistry and Physics, Journal Year: 2024, Volume and Issue: 320, P. 129450 - 129450

Published: May 10, 2024

Language: Английский

Citations

3

The biological applications of IPN hydrogels DOI Creative Commons
María I. León‐Campos, Juan J. Mendoza, Hilda Aguayo‐Morales

et al.

ADMET & DMPK, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 14, 2024

Background and purpose: Interpenetrating polymer network (IPN) hydrogels are an adaptable category of materials, exhibiting remarkable promise for various biological applications due to their distinctive structural functional attributes. This review delves into the synthesis IPN through both physical chemical methodologies, elucidating how these techniques allow precise tailoring mechanical pro­perties, swelling behaviour, biocompatibility. Experimental approach: We conducted extensive literature by searching well-established online research databases articles published since 2009 gather comprehensive data on hydrogels. Key results: Our highlights several critical appli­cations in biomedical field; i) Tissue engineering: evaluated capacity emulate extracellular matrix, making them excellent scaffolds tissue engineering; ii) Con­trolled drug release: The ability modulate release rates protect bioactive molecules is explored. Their structure enables sustained targeted delivery therapeutic agents, enhancing treatment efficacy; iii) 3D bioprinting: use as bioinks bioprinting assessed, demonstrating capability construct intricate, biomimetic structures with high precision; iv) Regenerative medicine: development regenerative medicine, emphasizing potential closely replicate natural environments, thereby promoting effective repair regeneration. Conclusion: emerge a versatile multifaceted platform significant implications advancing science clinical therapies. diverse highlight revolutionize current practices contribute innovative solutions.

Language: Английский

Citations

3

Nature-Inspired Healing: Biomimetic Nanomaterials for Advanced Wound Management DOI

Elnaz Sarrami-Foroushani,

Maryam Yavari, Atefeh Zarepour

et al.

Materials Today Sustainability, Journal Year: 2024, Volume and Issue: 28, P. 100975 - 100975

Published: Sept. 6, 2024

Language: Английский

Citations

3

New Formulation of Platelet-Rich Plasma Enriched in Platelet and Extraplatelet Biomolecules Using Hydrogels DOI Open Access

Jon Mercader Ruiz,

Maider Beitia, Diego Delgado

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(18), P. 13811 - 13811

Published: Sept. 7, 2023

Platelet-rich plasma (PRP) is an autologous biologic product used in several fields of medicine for tissue repair due to the regenerative capacity biomolecules its formulation. PRP consists a with platelet concentration higher than basal levels but any present out platelets. Plasma contains extraplatelet known enhance properties. Therefore, containing not only platelets also that could have stronger performance standard PRP. Considering this, aim this work develop new method obtain enriched both and molecules. The based on absorption water using hydroxyethyl acrylamide (HEAA)-based hydrogels. A fraction obtained from blood, proteins, was placed contact HEAA hydrogel powder absorb half volume water. resulting characterized, bioactivity analyzed vitro. novel (nPRP) showed derived growth factor (PDGF) similar (sPRP), factors IGF-1 (p < 0.0001) HGF 0.001) were significantly increased. Additionally, cells exposed nPRP increased cell viability those sPRP human dermal fibroblasts primary chondrocytes 0.01). In conclusion, absorption-based produces characteristics compared PRPs, promising vitro results potentially trigger improved regeneration capacity.

Language: Английский

Citations

6