Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Aug. 19, 2024
This
study
investigated
the
mechanism
of
extracellular
matrix-mimicking
hydrogel-mediated
TGFB1/Nrf2
signaling
pathway
in
osteoarthritis
using
bone
marrow
mesenchymal
stem
cell-derived
exosomes
(BMSCs-Exos).
A
GMOCS-Exos
hydrogel
was
synthesized
and
evaluated
for
its
impact
on
chondrocyte
viability
neutrophil
traps
(NETs)
formation.
In
an
OA
rat
model,
promoted
cartilage
regeneration
inhibited
NETs
Transcriptome
sequencing
identified
TGFB1
as
a
key
gene,
with
activating
Nrf2
through
TGFB1.
Depletion
hindered
cartilage-protective
effect
GMOCS-Exos.
sheds
light
promising
therapeutic
strategy
GMOCS-Exos-mediated
modulation.
Journal of Orthopaedic Translation,
Journal Year:
2025,
Volume and Issue:
50, P. 111 - 128
Published: Jan. 1, 2025
The
treatment
of
orthopaedic
diseases,
such
as
fractures
and
osteoarthritis,
remains
a
significant
challenge
due
to
the
complex
requirements
for
mechanical
strength
tissue
repair.
Hydrogels
based
on
hyaluronic
acid
methacrylate
(HAMA)
show
promise
engineering
materials
these
conditions.
Hyaluronic
(HA)
is
natural
component
extracellular
matrix,
known
its
good
compatibility.
HAMA-based
hydrogels
can
be
adjusted
through
crosslinking
by
combining
them
with
other
materials.
This
review
provides
an
overview
recent
research
applications
in
diseases.
First,
we
summarize
techniques
preparation
characterization
HAMA
hydrogels.
Next,
offer
detailed
use
treating
conditions
cartilage
injuries,
bone
defects,
meniscus
injuries.
Additionally,
discuss
diseases
related
orthopaedics.
Finally,
point
out
challenges
propose
future
directions
clinical
translation
strong
translational
potential
orthopaedics
their
biocompatibility,
adjustable
properties,
regenerative
capabilities.
With
ongoing
research,
are
well-positioned
applications,
particularly
repair,
osteoarthritis
treatment.
Biomimetics,
Journal Year:
2024,
Volume and Issue:
9(5), P. 278 - 278
Published: May 7, 2024
Biomimetic
materials
have
become
a
promising
alternative
in
the
field
of
tissue
engineering
and
regenerative
medicine
to
address
critical
challenges
wound
healing
skin
regeneration.
Skin-mimetic
enormous
potential
improve
outcomes
enable
innovative
diagnostic
sensor
applications.
Human
skin,
with
its
complex
structure
diverse
functions,
serves
as
an
excellent
model
for
designing
biomaterials.
Creating
effective
coverings
requires
mimicking
unique
extracellular
matrix
composition,
mechanical
properties,
biochemical
cues.
Additionally,
integrating
electronic
functionality
into
these
presents
exciting
possibilities
real-time
monitoring,
diagnostics,
personalized
healthcare.
This
review
examines
biomimetic
their
role
healing,
well
integration
technologies.
It
discusses
recent
advances,
challenges,
future
directions
this
rapidly
evolving
field.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(23), P. 12567 - 12567
Published: Nov. 22, 2024
Constructing
scaffolds
with
the
desired
structures
and
functions
is
one
of
main
goals
tissue
engineering.
Three-dimensional
(3D)
bioprinting
a
promising
technology
that
enables
personalized
fabrication
devices
regulated
biological
mechanical
characteristics
similar
to
natural
tissues/organs.
To
date,
3D
has
been
widely
explored
for
biomedical
applications
like
engineering,
drug
delivery,
screening,
in
vitro
disease
model
construction.
Among
different
bioinks,
photocrosslinkable
bioinks
have
emerged
as
powerful
choice
advanced
devices,
fast
crosslinking
speed,
high
resolution,
great
print
fidelity.
The
biomaterials
used
light-based
printing
play
pivotal
role
functional
constructs.
Herein,
this
review
outlines
general
approaches
related
biomaterials,
including
extrusion-based
printing,
inkjet
stereolithography
laser-assisted
printing.
Further,
mechanisms,
advantages,
limitations
photopolymerization
photoinitiators
are
discussed.
Next,
recent
advances
synthetic
highlighted.
Finally,
challenges
future
perspectives
envisaged.
ADMET & DMPK,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 14, 2024
Background
and
purpose:
Interpenetrating
polymer
network
(IPN)
hydrogels
are
an
adaptable
category
of
materials,
exhibiting
remarkable
promise
for
various
biological
applications
due
to
their
distinctive
structural
functional
attributes.
This
review
delves
into
the
synthesis
IPN
through
both
physical
chemical
methodologies,
elucidating
how
these
techniques
allow
precise
tailoring
mechanical
properties,
swelling
behaviour,
biocompatibility.
Experimental
approach:
We
conducted
extensive
literature
by
searching
well-established
online
research
databases
articles
published
since
2009
gather
comprehensive
data
on
hydrogels.
Key
results:
Our
highlights
several
critical
applications
in
biomedical
field;
i)
Tissue
engineering:
evaluated
capacity
emulate
extracellular
matrix,
making
them
excellent
scaffolds
tissue
engineering;
ii)
Controlled
drug
release:
The
ability
modulate
release
rates
protect
bioactive
molecules
is
explored.
Their
structure
enables
sustained
targeted
delivery
therapeutic
agents,
enhancing
treatment
efficacy;
iii)
3D
bioprinting:
use
as
bioinks
bioprinting
assessed,
demonstrating
capability
construct
intricate,
biomimetic
structures
with
high
precision;
iv)
Regenerative
medicine:
development
regenerative
medicine,
emphasizing
potential
closely
replicate
natural
environments,
thereby
promoting
effective
repair
regeneration.
Conclusion:
emerge
a
versatile
multifaceted
platform
significant
implications
advancing
science
clinical
therapies.
diverse
highlight
revolutionize
current
practices
contribute
innovative
solutions.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(18), P. 13811 - 13811
Published: Sept. 7, 2023
Platelet-rich
plasma
(PRP)
is
an
autologous
biologic
product
used
in
several
fields
of
medicine
for
tissue
repair
due
to
the
regenerative
capacity
biomolecules
its
formulation.
PRP
consists
a
with
platelet
concentration
higher
than
basal
levels
but
any
present
out
platelets.
Plasma
contains
extraplatelet
known
enhance
properties.
Therefore,
containing
not
only
platelets
also
that
could
have
stronger
performance
standard
PRP.
Considering
this,
aim
this
work
develop
new
method
obtain
enriched
both
and
molecules.
The
based
on
absorption
water
using
hydroxyethyl
acrylamide
(HEAA)-based
hydrogels.
A
fraction
obtained
from
blood,
proteins,
was
placed
contact
HEAA
hydrogel
powder
absorb
half
volume
water.
resulting
characterized,
bioactivity
analyzed
vitro.
novel
(nPRP)
showed
derived
growth
factor
(PDGF)
similar
(sPRP),
factors
IGF-1
(p
<
0.0001)
HGF
0.001)
were
significantly
increased.
Additionally,
cells
exposed
nPRP
increased
cell
viability
those
sPRP
human
dermal
fibroblasts
primary
chondrocytes
0.01).
In
conclusion,
absorption-based
produces
characteristics
compared
PRPs,
promising
vitro
results
potentially
trigger
improved
regeneration
capacity.
