Network analysis of internet addiction and depression among Chinese college students during the COVID-19 pandemic: A longitudinal study

Computers in Human Behavior, Journal Year: 2022, Volume and Issue: 138, P. 107424 - 107424

Published: Aug. 5, 2022

Language: Английский

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Pharmacological activities and pharmacokinetics of liquiritin: A review

Journal of Ethnopharmacology, Journal Year: 2022, Volume and Issue: 293, P. 115257 - 115257

Published: April 5, 2022

Language: Английский

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Network analysis links adolescent depression with childhood, peer, and family risk environment factors

Journal of Affective Disorders, Journal Year: 2023, Volume and Issue: 330, P. 165 - 172

Published: Feb. 23, 2023

Language: Английский

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A network model of depressive and anxiety symptoms: a statistical evaluation

Molecular Psychiatry, Journal Year: 2024, Volume and Issue: 29(3), P. 767 - 781

Published: Jan. 18, 2024

Language: Английский

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Non-invasive vagus nerve stimulation conditions increased invigoration and wanting in depression

Comprehensive Psychiatry, Journal Year: 2024, Volume and Issue: 132, P. 152488 - 152488

Published: April 16, 2024

Major depressive disorder (MDD) is often marked by impaired motivation and reward processing, known as anhedonia. Many patients do not respond to first-line treatments, improvements in can be slow, creating an urgent need for rapid interventions. Recently, we demonstrated that transcutaneous auricular vagus nerve stimulation (taVNS) acutely boosts effort invigoration healthy participants, but its effects on depression remain unclear.

Language: Английский

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Prodromal Symptoms in Depression: A Systematic Review

Psychotherapy and Psychosomatics, Journal Year: 2021, Volume and Issue: 90(6), P. 365 - 372

Published: Jan. 1, 2021

Introduction: Appraisal of prodromal symptoms unipolar depression may complement the traditional cross-sectional approach and provide a longitudinal perspective, according to staging model illness. Objective: To an updated systematic review clinical studies concerned with depression, PRISMA guidelines. Methods: Keyword searches were conducted in PubMed, Scopus, Web Science. Longitudinal on signs adult patients primarily diagnosed selected. Findings examined separately study design (i.e., retrospective or prospective). Results: Twenty-five met criteria for inclusion this review. indicate that distinct symptomatology – commonly characterized by anxiety, tension, irritability, somatic complaints exists before onset depression. The duration phase was highly variable across studies, ranging from less than month several years. Prodromal profile consistent within individuals depressive episodes. There close relationship between residual same episode. Conclusions: present addresses important, yet relatively neglected, issue deserves further investigation be immediate practical value. findings challenging insights into pathogenesis course which result more timely effective treatment recurrences. definition would benefit joint use symptom identification, biomarkers, neuroimaging.

Language: Английский

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Emotional blunting in patients with depression. Part I: clinical characteristics

Annals of General Psychiatry, Journal Year: 2022, Volume and Issue: 21(1)

Published: April 4, 2022

Emotional blunting-inability to feel positive or negative emotions, detachment, reduced emotional responsiveness-is common in people with depression. However, there is a paucity of studies comprehensively investigating this symptom and its functional impact. This study investigated the experience blunting, impact on overall functioning quality life, acute remission phases depression from perspective patients healthcare providers. paper presents data clinical presentation blunting patient perspective.Cross-sectional, observational conducted Brazil, Canada, Spain between April 15 May 18, 2021. Data were collected via self-completed online survey. Respondents adults (acute phase), who currently using prescribed antidepressant, reported during past 6 weeks. was assessed Oxford Depression Questionnaire (ODQ; total score range 26-130, higher scores indicate greater blunting).In all, 752 completed survey (62% female; mean age, 45 years). Overall, 44% rated their as extremely severe phase [n = 300], 72%; 452], 25%; difference, p < 0.01). In 56% considered be caused by phase, 62%; 52%). Mean ODQ 94.8 for 85.7 those (difference, 'antidepressant cause' domain (maximum possible score, 30) 18.0 17.6 remission. 45% believed that antidepressant medication emotions 39% considering stopping had already stopped because perceived emotion-related side effects.Almost three-quarters one-quarter blunting. Approximately depression, while negatively affecting emotions. Just over one-third result.

Language: Английский

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Association between thyroid dysfunction, metabolic disturbances, and clinical symptoms in first-episode, untreated Chinese patients with major depressive disorder: Undirected and Bayesian network analyses

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 28, 2023

Aims Thyroid dysfunction and metabolic disturbances are common in major depressive disorder (MDD) patients. We aimed to assess the relationship between thyroid dysfunction, disturbances, clinical symptoms Chinese first-episode, drug-naïve (FEDN) MDD patients using undirected Bayesian network methods. Methods 1718 FEDN were recruited. Serum levels of free triiodothyronine (FT3), thyroxine (FT4), stimulating hormone (TSH), anti-thyroglobulin (TgAb), peroxidases antibody (TPOAb), total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL-C), low-density (LDL-C), glucose assessed. Blood pressure body mass index measured. Hamilton Rating Scale for Depression (HAMD), Anxiety, positive subscale Positive And Negative Syndrome Scales used detect symptoms. An with EBICglasso default a directed acyclic graph (DAG) approach was conducted. Results The prevalence rates symptoms, as follows: anxiety (n=894, 52%), psychotic (171, 10%), subclinical hypothyroidism (SCH, n=1041, 61%), abnormal TgAb (n=297, 17%), TPOAb (n=438, 25%), hyperthyroidism (n=5, 0.3%), (n=3, 0.2%), hyperglycemia (n=241, 14%), hypertriglyceridemia (n=668, 39%), low HDL-C (n=429, hypercholesterolemia (421, TC (357, 21%), LDL-C (185, 11%). overweight or obesity (n=1026, 60%), hypertension (n=92, 5.4%). Both networks demonstrated serum TSH severity depression played an important role pathophysiology MDD. Conclusions may have early stage. Targeting hypercholesterolemia, SCH hold promise reducing dysfunction.

Language: Английский

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Childhood trauma and depressive symptoms in bipolar disorder: A network analysis

Acta Psychiatrica Scandinavica, Journal Year: 2023, Volume and Issue: 147(3), P. 286 - 300

Published: Jan. 16, 2023

Abstract Background Childhood trauma is related to an increased number of depressive episodes and more severe symptoms in bipolar disorder. The evaluation the networks symptoms—or patterns relationships between individual symptoms—among people with disorder without a history childhood may assist further clarifying this complex relationship. Methods Data from over 500 participants Heinz C. Prechter Longitudinal Study Bipolar Disorder were used construct series regularised Gaussian Graphical Models. symptoms—self‐reported (Patient Health Questionnaire—9; n = 543) clinician‐rated (Hamilton Depression Rating Scale—17; 529)—among (Childhood Trauma Questionnaire) characterised compared. Results Across sets networks, depressed mood consistently emerged as central symptom (as indicated by strength centrality expected influence); regardless participants' trauma. Additionally, feelings worthlessness key network self‐reported among with—but not without—a Conclusion present analyses—although exploratory—provide nuanced insights into impact on presentation disorder, which have potential aid detection inform targeted intervention development.

Language: Английский

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At-home, telehealth-supported ketamine treatment for depression: Findings from longitudinal, machine learning and symptom network analysis of real-world data

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 361, P. 198 - 208

Published: May 27, 2024

Improving safe and effective access to ketamine therapy is of high priority given the growing burden mental illness. Telehealth-supported administration sublingual being explored toward this goal. In longitudinal study, moderately-to-severely depressed patients received four doses at home over weeks within a supportive digital health context. Treatment was structured resemble methods therapeutic psychedelic trials. Patients receiving second course treatment were also examined. Symptoms assessed using Patient Health Questionnaire (PHQ-9) for depression. We conducted preregistered machine learning symptom network analyses investigate outcomes (osf.io/v2rpx). A sample 11,441 analyzed, demonstrating modal antidepressant response from both non-severe (n = 6384, 55.8 %) severe 2070, 18.1 baseline depression levels. Adverse events detected in 3.0–4.8 % participants predominantly neurologic or psychiatric nature. helped extend improvements who responded favorably initial treatment. Improvement most strongly predicted by lower scores age baseline. Depressed mood Anhedonia sustained despite ongoing This study limited absence comparison control groups lack fixed-dose procedure administration. At-home, telehealth-supported largely safe, well-tolerated, associated with improvement Strategies combining psychedelic-oriented therapies rigorous telehealth models, as here, may uniquely address barriers

Language: Английский

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