Deciphering the Puzzle: Literature Insights on Chlamydia trachomatis-Mediated Tumorigenesis, Paving the Way for Future Research DOI Creative Commons
Rafaela Rodrigues, Carlos Sousa, Nuno Vale

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(6), P. 1126 - 1126

Published: May 31, 2024

Some infectious agents have the potential to cause specific modifications in cellular microenvironment that could be propitious carcinogenesis process. Currently, there are viruses and bacteria, such as human papillomavirus (HPV) Helicobacter pylori, well established risk factors for neoplasia. Chlamydia trachomatis (CT) infections one of most common bacterial sexually transmitted worldwide, recent European data confirmed a continuous rise across Europe. The infection is often asymptomatic both sexes, requiring screening program early detection. Notwithstanding, not all countries Europe it. can chronic persistent infections, resulting inflammation, plausible biological mechanisms link genital with tumorigenesis. Herein, we aimed understand epidemiological plausibility CT causing endometrial, ovarian, cervical tumors. Also, covered some best suitable vitro techniques used study this association. In addition, defend point view personalized medicine strategy treat those patients through discovery biomarkers allow This review supports need development further fundamental studies area, order investigate establish role chlamydial oncogenesis.

Language: Английский

The Promising Biological Role of Postbiotics in Treating Human Infertility DOI
Nader Khani, Amir Hesam Shakeri, Sousan Houshmandi

et al.

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

Language: Английский

Citations

0
Microbiota transplantation and administration of live biotherapeutic products for the treatment of dysbiosis-associated diseases DOI
Samantha Flores-Treviño, Paola Bocanegra‐Ibarias, Daniel Salas‐Treviño

et al.

Expert Opinion on Biological Therapy, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

The microbiota composition in humans varies according to the anatomical site and is crucial for maintaining homeostasis an overall healthy state. Several gastrointestinal, vaginal, respiratory, skin diseases are associated with dysbiosis. Alternative therapies such as transplantation can help restore normal be implemented treat clinically relevant diseases. Current conducted clinical trials were included this review (after searching on MEDLINE database from years 2017 2025) fecal (FMT) against recurrent Clostridiodes difficile infection (rCDI) vaginal (VMT) bacterial vaginosis. Washed (WMT) live biotherapeutic products (LBPs) also reviewed. In microbiota-based therapy, selecting optimal donors a limitation. A stool or bank should overcome time-consuming expensive process of donor recruitment. Microbiota-based LBPs promising treatment alternatives rCDI other dysbiosis-associated Specific could engineered out fluids-derived strains achieve selection specific beneficial microorganisms Personalized treatments solutions diseases, which remains important necessity practice.

Language: Английский

Citations

0
Reproductive Effects of S. boulardii on Sub-Chronic Acetamiprid and Imidacloprid Toxicity in Male Rats DOI Creative Commons
Çiğdem Sevim, Erol Akpınar, Emrah Hicazi Aksu

et al.

Toxics, Journal Year: 2023, Volume and Issue: 11(2), P. 170 - 170

Published: Feb. 12, 2023

The potential health-promoting effects of probiotics against intoxication by pesticides is a topic increasing commercial interest with limited scientific evidence. In this study, we aimed to investigate the positive probiotic Saccharomyces boulardii on male reproductive system under low dose neonicotinoid pesticide exposure conditions. We observed that acetamiprid and imidacloprid caused degeneration necrosis spermatocytes in tubular wall, severe edema intertubular region hyperemia. This was concomittant increased levels 8-hydroxy-2′-deoxyguanosine reflecting oxidative stress, an increase caspase 3 expression, apoptosis. According our results, supplementation mitigates these toxic effects. Further vivo clinical studies are needed clarify molecular mechanisms protection. Altogether, study reinforces burden evidence from emerging linking composition gut microbiome function system.

Language: Английский

Citations

10
Management of dog sperm parameters and gut microbiota composition with Lactobacillus rhamnosus supplementation DOI
Feriel Yasmine Mahiddine, Inhwan You,

Heekee Park

et al.

Veterinary Research Communications, Journal Year: 2023, Volume and Issue: 47(3), P. 1629 - 1640

Published: March 28, 2023

Language: Английский

Citations

9
Polycystic ovary syndrome: Insights into its prevalence, diagnosis, and management with special reference to gut microbial dysbiosis DOI
Nisha H. Khobragade, Devang Sheth, Chirag Patel

et al.

Steroids, Journal Year: 2024, Volume and Issue: 208, P. 109455 - 109455

Published: June 13, 2024

Language: Английский

Citations

3
Oral probiotics increased the proportion of Treg, Tfr, and Breg cells to inhibit the inflammatory response and impede gestational diabetes mellitus DOI Creative Commons
Weijie Liang, Yuanyi Feng, Dongmei Yang

et al.

Molecular Medicine, Journal Year: 2023, Volume and Issue: 29(1)

Published: Sept. 8, 2023

Children of mothers with gestational diabetes mellitus (GDM) are more prone to acquire type 2 and obesity as adults. Due this link, early intervention strategies that alter the gut microbiome may benefit mother kid long-term. This work uses metagenomic transcriptome sequencing investigate how probiotics affect microbiota dysbiosis inflammation in GDM.GDM control data were obtained from SRA database. helped us understand abundance function. KEGG detected extracted functional pathway genes. Transcriptome evaluated GDM-related gene expression. Finally, GDM animal models given orally evaluate inflammatory response, regulatory immune cell fractions, leptin protein levels.GDM patients had Fusobacteria Firmicutes, while healthy people Bacteroidetes. Gut composition by altering L-aspartate L-asparagine super pathways. Mannan degradation synthesis enhanced mice overexpression. Oral prevent lowering leptin. increased Treg, Tfr, Breg cells, which decreased TNF-α IL-6 TGF-β IL-10, preventing preserving mouse pregnancy.Dysbiosis increase expression cause GDM. enhance limit response assist sustaining normal pregnancy. Thus, oral GDM, enabling targeted modulation maternal fetal health.

Language: Английский

Citations

9
Anti-inflammatory-antioxidant modifications and synbiotics improved health-related conditions in patients with progressive forms of multiple sclerosis: A single-center, randomized clinical trial DOI
Amir Reza Moravejolahkami, Ahmad Chitsaz, Akbar Hassanzadeh

et al.

Complementary Therapies in Clinical Practice, Journal Year: 2023, Volume and Issue: 53, P. 101794 - 101794

Published: Aug. 17, 2023

Language: Английский

Citations

8
Crosstalk between Mycotoxins and Intestinal Microbiota and the Alleviation Approach via Microorganisms DOI Creative Commons
Daiyang Xia,

Qianyuan Mo,

Lin Yang

et al.

Toxins, Journal Year: 2022, Volume and Issue: 14(12), P. 859 - 859

Published: Dec. 6, 2022

Mycotoxins are secondary metabolites produced by fungus. Due to their widespread distribution, difficulty in removal, and complicated subsequent harmful by-products, mycotoxins pose a threat the health of humans animals worldwide. Increasing studies recent years have highlighted impact on gut microbiota. Numerous researchers sought illustrate novel toxicological mechanisms examining alterations microbiota caused mycotoxins. However, few efficient techniques been found ameliorate toxicity via microbial pathways terms animal husbandry, human management, prognosis mycotoxin poisoning. This review seeks examine crosstalk between five typical microbes, summarize functions mycotoxins-induced microbes processes investigate application prospects prevention therapy from variety perspectives. The work is intended provide support for future research interaction advance technology preventing controlling

Language: Английский

Citations

12
The supplementation of female dogs with live yeast Saccharomyces cerevisiae var. boulardii CNCM I-1079 acts as gut stabilizer at whelping and modulates immunometabolic phenotype of the puppies DOI Creative Commons

Quentin Garrigues,

Amélie Mugnier, Sylvie Chastant‐Maillard

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: April 12, 2024

Time around parturition is a stressful period for both bitches and their puppies. The use of probiotics has been proposed, e.g., in pigs, to improve health status sows, reproductive performances turn, the performance progeny. objective present study was evaluate impact, on dams puppies, supplementation with live yeast Saccharomyces cerevisiae var. boulardii CNCM I-1079 (SB-1079) during second part gestation lactation period. A total 36 medium large-sized breeds were enrolled. They divided into two groups, one which received 1.3 × 10 9 colony forming units per day. At dam’s level, SB-1079 shaped different microbiota structure between groups just after whelping, impacted alpha diversity some plasma metabolites related energy metabolism. Regarding performances, improved gross colostrum (1.4 vs. 1.2 kcal ME/g) as well concentration protein milk at Day 7 (10.4 7.6%). also reduced odds having low birth weight litter. puppy’s modulation immunometabolic phenotype suggested by observation increased growth rates early pediatric (i.e., 21 56 days life, 225 190%) decrease IL-8:IL-10 ratio vaccination against rabies (4.2 16.9). Our findings suggest that potential enhance turn puppies through maternal programming.

Language: Английский

Citations

2
Microbiome in Female Reproductive Health: Implications for Fertility and Assisted Reproductive Technologies DOI Creative Commons
Liwen Xiao, Zhenqiang Zuo, Fangqing Zhao

et al.

Genomics Proteomics & Bioinformatics, Journal Year: 2023, Volume and Issue: 22(1)

Published: Dec. 13, 2023

Abstract The microbiome plays a critical role in the process of conception and outcomes pregnancy. Disruptions homeostasis women reproductive age can lead to various pregnancy complications, which significantly impact maternal fetal health. Recent studies have associated female tract (FRT) with assisted technology (ART) outcomes, restoring balance has been shown improve fertility infertile couples. This review provides an overview health, including its implications for ARTs. Additionally, recent advances use microbial biomarkers as indicators disorders are summarized. A comprehensive understanding characteristics before during on health will greatly promote Such knowledge also contribute development ARTs microbiome-based interventions.

Language: Английский

Citations

6