Recent advances in neuropeptide signaling in Drosophila, from genes to physiology and behavior

Progress in Neurobiology, Journal Year: 2019, Volume and Issue: 179, P. 101607 - 101607

Published: March 22, 2019

Language: Английский

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Commensal bacteria and essential amino acids control food choice behavior and reproduction

PLoS Biology, Journal Year: 2017, Volume and Issue: 15(4), P. e2000862 - e2000862

Published: April 25, 2017

Choosing the right nutrients to consume is essential health and wellbeing across species. However, factors that influence these decisions are poorly understood. This particularly true for dietary proteins, which important determinants of lifespan reproduction. We show in Drosophila melanogaster, amino acids (eAAs) concerted action commensal bacteria Acetobacter pomorum Lactobacilli critical modulators food choice. Using a chemically defined diet, we absence any single eAA from diet sufficient elicit specific appetites acid (AA)-rich food. Furthermore, buffer animal lack eAAs: both increased yeast appetite decreased reproduction induced by deprivation rescued presence commensals. Surprisingly, effects do not seem be due changes AA titers, suggesting gut act through different mechanism change behavior Thus, eAAs potent feeding reproductive output. demonstrates how interaction with microbiome can shape behavioral life history traits.

Language: Английский

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Matching Dietary Amino Acid Balance to the In Silico-Translated Exome Optimizes Growth and Reproduction without Cost to Lifespan

Cell Metabolism, Journal Year: 2017, Volume and Issue: 25(3), P. 610 - 621

Published: March 1, 2017

Language: Английский

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Sexual circuitry in Drosophila

Current Opinion in Neurobiology, Journal Year: 2016, Volume and Issue: 38, P. 18 - 26

Published: March 3, 2016

Language: Английский

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A complex peripheral code for salt taste in Drosophila

eLife, Journal Year: 2018, Volume and Issue: 7

Published: Oct. 11, 2018

Each taste modality is generally encoded by a single, molecularly defined, population of sensory cells. However, salt stimulates multiple pathways in mammals and insects, suggesting more complex code for taste. Here, we examine coding Drosophila. After creating comprehensive molecular map comprised five discrete neuron classes across the fly labellum, find that four are activated salt: two exhibiting characteristics ‘low salt’ cells, ‘high classes. Behaviorally, low attraction depends primarily on ‘sweet’ neurons, with additional input from neurons expressing ionotropic receptor IR94e. High avoidance mediated ‘bitter’ glutamatergic Ppk23. Interestingly, impact these prior consumption. These results support model flies combinatorially integrates inputs cell types to afford robust flexible behaviors.

Language: Английский

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Internal states drive nutrient homeostasis by modulating exploration-exploitation trade-off

eLife, Journal Year: 2016, Volume and Issue: 5

Published: Oct. 22, 2016

Internal states can profoundly alter the behavior of animals. A quantitative understanding behavioral changes upon metabolic challenges is key to a mechanistic dissection how animals maintain nutritional homeostasis. We used an automated video tracking setup characterize amino acid and reproductive interact shape exploitation exploration decisions taken by adult Drosophila melanogaster. find that these two have specific effects on stop at leave proteinaceous food patches. Furthermore, internal nutrient state defines exploration-exploitation trade-off: nutrient-deprived flies focus patches while satiated explore more globally. Finally, we show olfaction mediates efficient recognition yeast as appropriate protein source in mated females octopamine specifically required mediate homeostatic postmating responses without affecting sensing. therefore modulate aspects change selection.

Language: Английский

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Branch-specific plasticity of a bifunctional dopamine circuit encodes protein hunger

Science, Journal Year: 2017, Volume and Issue: 356(6337), P. 534 - 539

Published: May 4, 2017

The drive to eat protein is mediated by plastic changes in a dedicated neuronal circuit Drosophila .

Language: Английский

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Recent advances in the genetic basis of taste detection in Drosophila

Cellular and Molecular Life Sciences, Journal Year: 2019, Volume and Issue: 77(6), P. 1087 - 1101

Published: Oct. 9, 2019

Language: Английский

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Internal amino acid state modulates yeast taste neurons to support protein homeostasis in Drosophila

eLife, Journal Year: 2018, Volume and Issue: 7

Published: Feb. 2, 2018

To optimize fitness, animals must dynamically match food choices to their current needs. For drosophilids, yeast fulfills most dietary protein and micronutrient requirements. While several metabolites activate known gustatory receptor neurons (GRNs) in Drosophila melanogaster, the chemosensory channels mediating feeding remain unknown. Here we identify a class of proboscis GRNs required for intake. Within this class, taste peg are specifically sustain feeding. Sensillar GRNs, however, mediate initiation. Furthermore, response but not sweet is enhanced following deprivation from amino acids, providing potential basis protein-specific appetite. Although nutritional reproductive states synergistically increase appetite, state acts independently state, modulating processing downstream GRNs. Together, these results suggest that different internal act at distinct levels dedicated circuit elicit nutrient-specific appetites towards complex, ecologically relevant source.

Language: Английский

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Neuropeptides Modulate Female Chemosensory Processing upon Mating in Drosophila

PLoS Biology, Journal Year: 2016, Volume and Issue: 14(5), P. e1002455 - e1002455

Published: May 4, 2016

A female's reproductive state influences her perception of odors and tastes along with changed behavioral physiological needs. The mechanism that modulates chemosensory processing, however, remains largely elusive. Using Drosophila, we have identified a behavioral, neuronal, genetic adapts the senses smell taste, major modalities for food quality perception, to needs gravid female. Pungent smelling polyamines, such as putrescine spermidine, are essential cell proliferation, reproduction, embryonic development in all animals. polyamine-rich diet increases success many species, including flies. combination analysis vivo physiology, show polyamine attraction is modulated females through G-protein coupled receptor, sex peptide receptor (SPR), its neuropeptide ligands, MIPs (myoinhibitory peptides), which act directly polyamine-detecting olfactory taste neurons. This modulation triggered by an increase SPR expression neurons, sufficient convert virgin mated female choice behavior. Together, our data neuropeptide-mediated peripheral neurons preference important nutrients, thereby ensuring optimal conditions growing progeny.

Language: Английский

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