iScience, Journal Year: 2024, Volume and Issue: 27(6), P. 110087 - 110087
Published: May 23, 2024
Taste organs contain distinct gustatory receptors that help organisms differentiate between nourishing and potentially harmful foods. The detection of high pH levels plays a crucial role in food selection, but the specific responsible for perceiving elevated foods have remained unknown. By using
Language: Английский
eLife, Journal Year: 2022, Volume and Issue: 11
Published: April 20, 2022
olfactory neurons have long been thought to express only one chemosensory receptor gene family. There are two main families in
Language: Английский
Citations
101
Cell, Journal Year: 2023, Volume and Issue: 186(12), P. 2556 - 2573.e22
Published: May 25, 2023
In Drosophila, a dedicated olfactory channel senses male pheromone, cis-vaccenyl acetate (cVA), promoting female courtship while repelling males. Here, we show that separate cVA-processing streams extract qualitative and positional information. cVA sensory neurons respond to concentration differences in 5-mm range around male. Second-order projection encode the angular position of by detecting inter-antennal concentration, which are amplified through contralateral inhibition. At third circuit layer, identify 47 cell types with diverse input-output connectivity. One population responds tonically flies, second is tuned looming, integrates taste coincidentally promote mating. The separation features resembles mammalian what where visual streams; together multisensory integration, this enables behavioral responses appropriate specific ethological contexts.
Language: Английский
Citations
43
Nature, Journal Year: 2024, Volume and Issue: 634(8032), P. 210 - 219
Published: Oct. 2, 2024
Language: Английский
Citations
19
Cellular and Molecular Life Sciences, Journal Year: 2019, Volume and Issue: 77(6), P. 1087 - 1101
Published: Oct. 9, 2019
Language: Английский
Citations
110
Genetics, Journal Year: 2021, Volume and Issue: 217(1), P. 1 - 34
Published: Jan. 1, 2021
Genetic approaches in the fruit fly, Drosophila melanogaster, have led to a major triumph field of sensory biology-the discovery multiple large families receptors and channels. Some these families, such as transient receptor potential channels, are conserved from animals ranging worms humans, while others, "gustatory receptors," "olfactory "ionotropic restricted invertebrates. Prior identification flies, it was widely assumed that proteins function just one modality vision, smell, taste, hearing, somatosensation, which includes thermosensation, light, noxious mechanical touch. By employing vast combination genetic, behavioral, electrophysiological, other concept emerge is many multitaskers. The earliest example this idea individual channels senses. It now clear multitasking exhibited by including gustatory receptors, ionotropic epithelial Na+ (also referred Pickpockets), even opsins, were formerly thought exclusively light sensors. characterizations neurons express them also reveal mechanisms through flies can accurately differentiate between different stimuli when they activate same receptor, well adaptation, amplification, integration. insights gleaned studies been highly influential directing investigations animal models.
Language: Английский
Citations
101
eLife, Journal Year: 2019, Volume and Issue: 8
Published: May 21, 2019
Female Aedes aegypti mosquitoes are deadly vectors of arboviral pathogens and breed in containers freshwater associated with human habitation. Because high salinity is lethal to offspring, correctly evaluating water purity a crucial parenting decision. We found that the DEG/ENaC channel ppk301 sensory neurons expressing control egg-laying initiation choice Ae. aegypti. Using calcium imaging, we ppk301-expressing cells show ppk301-dependent responses but, unexpectedly, also respond salt ppk301-independent fashion. This suggests instructive for at low-salt concentrations, but pathway responsible inhibiting high-salt concentrations. Water key resource insect survival understanding how interact different behaviors an opportunity study evolution chemosensory systems.
Language: Английский
Citations
100
Cell Reports, Journal Year: 2019, Volume and Issue: 26(6), P. 1432 - 1442.e4
Published: Feb. 1, 2019
The decision to consume or reject a food based on the degree of acidity is critical for animal survival. However, gustatory receptors that detect sour compounds and influence feeding behavior have been elusive. Here, using fly, Drosophila melanogaster, we reveal member ionotropic receptor family, IR7a, essential rejecting foods laced with high levels acetic acid. IR7a dispensable repulsion other acidic compounds, indicating sensation acids occurs through repertoire rather than single receptor. fly’s main taste organ, labellum, decorated bristles house dendrites neurons (GRNs). expressed in subset bitter GRNs dedicated taste. Our findings indicate flies receptors, enabling them discriminate basis acid composition just pH.
Language: Английский
Citations
86
Proceedings of the National Academy of Sciences, Journal Year: 2019, Volume and Issue: 116(43), P. 21828 - 21833
Published: Oct. 7, 2019
Finding a suitable oviposition site is challenging task for gravid female moth. At the same time, it of paramount importance considering limited capability most caterpillars to relocate alternative host plants. The hawkmoth, Manduca sexta (Sphingidae), oviposits on solanaceous Larvae hatching plant that already attacked by conspecific can face food competition, as well an increased exposure predators and induced defenses. Here, we show feces from are sufficient deter M. ovipositing this deterrence based feces-emitted carboxylic acids 3-methylpentanoic acid hexanoic acid. Using combination genome editing (CRISPR-Cas9), electrophysiological recordings, calcium imaging, behavioral analyses, demonstrate ionotropic receptor 8a (IR8a) essential acid-mediated avoidance in hawkmoths.
Language: Английский
Citations
80
Frontiers in Molecular Neuroscience, Journal Year: 2021, Volume and Issue: 13
Published: Feb. 1, 2021
Ionotropic receptors (IRs) are a highly divergent subfamily of ionotropic glutamate (iGluR) and conserved across Protostomia, major branch the animal kingdom that encompasses both Ecdysozoa Lophothrochozoa. They broadly expressed in peripheral sensory systems, concentrated dendrites, function chemosensation, thermosensation, hygrosensation. As iGluRs, four IR subunits form functional ion channel to detect environmental stimuli. Most comprise individual stimulus-specific tuning one or two coreceptors. This review summarizes discoveries structure complexes expression each IR, as well discusses future direction for studies.
Language: Английский
Citations
61
Current Biology, Journal Year: 2022, Volume and Issue: 32(8), P. 1776 - 1787.e4
Published: March 15, 2022
Language: Английский
Citations
54