Evolution of the human pathogenic lifestyle in fungi

Nature Microbiology, Journal Year: 2022, Volume and Issue: 7(5), P. 607 - 619

Published: May 4, 2022

Fungal pathogens cause more than a billion human infections every year, resulting in 1.6 million deaths annually. Understanding the natural history and evolutionary ecology of fungi is helping us understand how disease-relevant traits have repeatedly evolved. Different types mechanisms genetic variation contributed to evolution fungal pathogenicity specific differences distinguish from non-pathogens. Insights into traits, elements, ecological that contribute are crucial for developing strategies both predict emergence develop drugs combat them.

Language: Английский

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EukProt: A database of genome-scale predicted proteins across the diversity of eukaryotes

Peer Community Journal, Journal Year: 2022, Volume and Issue: 2

Published: Sept. 20, 2022

EukProt is a database of published and publicly available predicted protein sets selected to represent the breadth eukaryotic diversity, currently including 993 species from all major supergroups as well orphan taxa. The goal provide single, convenient resource for gene-based research across spectrum life, such phylogenomics gene family evolution. Each placed within UniEuk taxonomic framework in order facilitate downstream analyses, each data set associated with unique, persistent identifier comparison replication among analyses. regularly updated, versions will be permanently stored made via FigShare. current version has number updates, notably 'The Comparative Set' (TCS), reduced high estimated completeness while maintaining substantial phylogenetic breadth, which comprises 196 proteomes. A BLAST web server graphical displays are at http://evocellbio.com/eukprot/. We invite community suggestions new annotation features included subsequent versions, building collaborative that promote understand diversity diversification.

Language: Английский

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Evolutionary biology of lichen symbioses

New Phytologist, Journal Year: 2022, Volume and Issue: 234(5), P. 1566 - 1582

Published: March 18, 2022

Lichens are the symbiotic outcomes of open, interspecies relationships, central to which a fungus and phototroph, typically an alga and/or cyanobacterium. The evolutionary processes that led global success lichens poorly understood. In this review, we explore goods services exchange between phototroph how propelled both symbiont symbiosis. Lichen fungal symbionts count among only filamentous fungi expose most their mycelium aerial environment. Phototrophs export carbohydrates fungus, converts them specific polyols. Experimental evidence suggests polyols not growth respiratory substrates but also play role in anhydrobiosis, capacity survive desiccation. We propose dual functionality is pivotal evolution symbionts, enabling persistence environments otherwise hostile while simultaneously imposing costs on growth. Phototrophs, turn, benefit from protection herbivory light stress, appearing exert leverage over sex morphogenesis. Combined with recently recognized habit occur multiple symbioses, creates conditions for multiplayer marketplace rewards penalties could drive selection lichen diversification.

Language: Английский

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Incongruence in the phylogenomics era

Nature Reviews Genetics, Journal Year: 2023, Volume and Issue: 24(12), P. 834 - 850

Published: June 27, 2023

Language: Английский

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Pushing the Frontiers of Biodiversity Research: Unveiling the Global Diversity, Distribution, and Conservation of Fungi

Annual Review of Environment and Resources, Journal Year: 2023, Volume and Issue: 48(1), P. 149 - 176

Published: Sept. 18, 2023

Fungi comprise approximately 20% of all eukaryotic species and are connected to virtually life forms on Earth. Yet, their diversity remains contentious, distribution elusive, conservation neglected. We aim flip this situation by synthesizing current knowledge. present a revised estimate 2–3 million fungal with “best estimate” at 2.5 million. To name the unknown >90% these end century, we propose recognition known only from DNA data call for large-scale sampling campaigns. an updated global map richness, highlighting tropical temperate ecoregions high diversity. further Red List assessments enhanced management guidelines aid conservation. Given that fungi play inseparable role in our lives ecosystems, considering fascinating questions remaining be answered, argue constitute next frontier biodiversity research.

Language: Английский

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A genome-informed higher rank classification of the biotechnologically important fungal subphylum Saccharomycotina

Studies in Mycology, Journal Year: 2023, Volume and Issue: 105(1), P. 1 - 22

Published: May 26, 2023

Language: Английский

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Genomic factors shape carbon and nitrogen metabolic niche breadth across Saccharomycotina yeasts

Science, Journal Year: 2024, Volume and Issue: 384(6694)

Published: April 25, 2024

Organisms exhibit extensive variation in ecological niche breadth, from very narrow (specialists) to broad (generalists). Two general paradigms have been proposed explain this variation: (i) trade-offs between performance efficiency and breadth (ii) the joint influence of extrinsic (environmental) intrinsic (genomic) factors. We assembled genomic, metabolic, data nearly all known species ancient fungal subphylum Saccharomycotina (1154 yeast strains 1051 species), grown 24 different environmental conditions, examine evolution. found that large differences carbon utilization traits yeasts stem genes encoding specific metabolic pathways, but we limited evidence for trade-offs. These comprehensive argue factors shape microbes.

Language: Английский

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Current trends, limitations and future research in the fungi?

Fungal Diversity, Journal Year: 2024, Volume and Issue: 125(1), P. 1 - 71

Published: March 20, 2024

Abstract The field of mycology has grown from an underappreciated subset botany, to a valuable, modern scientific discipline. As this study grown, there have been significant contributions science, technology, and industry, highlighting the value fungi in era. This paper looks at current research, along with existing limitations, suggests future areas where scientists can focus their efforts, mycology. We show how become important emerging diseases medical discuss trends potential drug novel compound discovery. explore phylogenomics, its potential, outcomes address question phylogenomics be applied fungal ecology. In addition, functional genomics studies are discussed importance unravelling intricate mechanisms underlying behaviour, interactions, adaptations, paving way for comprehensive understanding biology. look research building materials, they used as carbon sinks, biocircular economies. numbers always great interest often written about estimates varied greatly. Thus, we needs order obtain more reliable estimates. aspects machine learning (AI) it mycological research. Plant pathogens affecting food production systems on global scale, such, needed area, particularly disease detection. latest data High Throughput Sequencing if still gaining new knowledge same rate before. A review nanotechnology is provided addressed. Arbuscular Mycorrhizal Fungi addressed acknowledged. Fungal databases becoming important, therefore provide major databases. Edible medicinal huge medicines, especially Asia prospects discussed. Lifestyle changes (e.g., endophytes, pathogens, and/or saprobes) also extremely trend special issue Diversity.

Language: Английский

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Phylogenomics, divergence times and notes of orders in Basidiomycota

Fungal Diversity, Journal Year: 2024, Volume and Issue: 126(1), P. 127 - 406

Published: July 9, 2024

Language: Английский

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What are the 100 most cited fungal genera?

Studies in Mycology, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

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