Cell Discovery,
Journal Year:
2023,
Volume and Issue:
9(1)
Published: Nov. 7, 2023
Phase
separation,
a
biophysical
segregation
of
subcellular
milieus
referred
as
condensates,
is
known
to
regulate
transcription,
but
its
impacts
on
physiological
processes
are
less
clear.
Here,
we
demonstrate
the
formation
liquid-like
nuclear
condensates
by
SGF29,
component
SAGA
transcriptional
coactivator
complex,
during
cellular
senescence
in
human
mesenchymal
progenitor
cells
(hMPCs)
and
fibroblasts.
The
Arg
207
within
intrinsically
disordered
region
identified
key
amino
acid
residue
for
SGF29
form
phase
separation.
Through
epigenomic
transcriptomic
analysis,
our
data
indicated
that
both
condensate
H3K4me3
binding
essential
establishing
precise
chromatin
location,
recruiting
factors
co-activators
target
specific
genomic
loci,
initiating
expression
genes
associated
with
senescence,
such
CDKN1A.
alone,
however,
may
not
be
sufficient
drive
or
achieve
transactivation
functions.
Our
study
establishes
link
between
separation
aging
regulation,
highlighting
functional
unit
facilitate
shaping
landscapes
aging.
Cell Reports,
Journal Year:
2022,
Volume and Issue:
41(3), P. 111451 - 111451
Published: Oct. 1, 2022
Stem
cells
play
central
roles
in
tissue
development,
homeostasis,
and
regeneration.
Decades
of
scientific
research
have
uncovered
processes
stem
cell
decline
organismal
aging,
more
recently,
pioneering
technologies
permit
the
dissection
its
underlying
mechanisms
inform
therapeutic
development
for
aging
aging-associated
disorders.
In
this
review,
we
elucidate
aging-related
features
across
different
somatic
types,
with
a
specific
focus
on
epigenetic
changes,
loss
protein
systemic
influencing
factors,
including
chronic
inflammation,
circadian
rhythm
dysregulation,
metabolic
disorder.
Our
survey
summarizes
biological
implications,
points
to
potential
biomarkers
discusses
cell-based
strategies
promoting
healthy
combating
age-related
diseases.
Annual Review of Biomedical Data Science,
Journal Year:
2023,
Volume and Issue:
6(1), P. 129 - 152
Published: April 26, 2023
Organismal
aging
exhibits
wide-ranging
hallmarks
in
divergent
cell
types
across
tissues,
organs,
and
systems.
The
advancement
of
single-cell
technologies
generation
rich
datasets
have
afforded
the
scientific
community
opportunity
to
decode
these
at
an
unprecedented
scope
resolution.
In
this
review,
we
describe
technological
advancements
bioinformatic
methodologies
enabling
data
interpretation
cellular
level.
Then,
outline
application
such
for
decoding
potential
intervention
targets
summarize
common
themes
context-specific
molecular
features
representative
organ
systems
body.
Finally,
provide
a
brief
summary
available
databases
relevant
research
present
outlook
on
opportunities
emerging
field.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: June 17, 2024
Cancer
incidence
escalates
exponentially
with
advancing
age;
however,
the
underlying
mechanism
remains
unclear.
In
this
study,
we
build
a
chronological
molecular
clock
at
single-cell
transcription
level
mammary
stem
cell-enriched
population
to
depict
physiological
aging
dynamics
in
female
mice.
We
find
that
process
is
asynchronous
and
progressive,
initiated
by
an
early
senescence
program,
succeeded
entropic
late
program
elevated
cancer
associated
pathways,
vulnerable
predisposition.
The
transition
towards
governed
cell
factor
Bcl11b,
loss
of
which
accelerates
ageing
enhanced
DMBA-induced
tumor
formation.
have
identified
drug
TPCA-1
can
rejuvenate
cells
significantly
reduce
aging-related
incidence.
Our
findings
establish
portrait
progressive
elucidate
transcriptional
regulatory
network
bridging
predisposition,
has
potential
implications
for
management
prevalence
aged.
