Multiple early factors anticipate post-acute COVID-19 sequelae

Cell, Journal Year: 2022, Volume and Issue: 185(5), P. 881 - 895.e20

Published: Jan. 25, 2022

Post-acute sequelae of COVID-19 (PASC) represent an emerging global crisis. However, quantifiable risk factors for PASC and their biological associations are poorly resolved. We executed a deep multi-omic, longitudinal investigation 309 patients from initial diagnosis to convalescence (2-3 months later), integrated with clinical data patient-reported symptoms. resolved four PASC-anticipating at the time diagnosis: type 2 diabetes, SARS-CoV-2 RNAemia, Epstein-Barr virus viremia, specific auto-antibodies. In gastrointestinal PASC, SARS-CoV-2-specific CMV-specific CD8+ T cells exhibited unique dynamics during recovery COVID-19. Analysis symptom-associated immunological signatures revealed coordinated immunity polarization into endotypes, exhibiting divergent acute severity PASC. find that between diminish over time, leading distinct convalescent immune states. Detectability most emphasizes importance early disease measurements understanding emergent chronic conditions suggests treatment strategies.

Language: Английский

The prevalence and long-term health effects of Long Covid among hospitalised and non-hospitalised populations: a systematic review and meta-analysis

EClinicalMedicine, Journal Year: 2022, Volume and Issue: 55, P. 101762 - 101762

Published: Dec. 1, 2022

Language: Английский

The Lancet Commission on lessons for the future from the COVID-19 pandemic

The Lancet, Journal Year: 2022, Volume and Issue: 400(10359), P. 1224 - 1280

Published: Sept. 14, 2022

Language: Английский

SARS-CoV-2-Specific Immune Response and the Pathogenesis of COVID-19

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(3), P. 1716 - 1716

Published: Feb. 2, 2022

The review aims to consolidate research findings on the molecular mechanisms and virulence pathogenicity characteristics of coronavirus disease (COVID-19) causative agent, severe acute respiratory syndrome 2 (SARS-CoV-2), their relevance four typical stages in development viral infection. These are invasion; primary blockade antiviral innate immunity; engagement virus’s protection against factors adaptive acute, long-term complications COVID-19. invasion stage entails recognition spike protein (S) SARS-CoV-2 target cell receptors, namely, main receptor (angiotensin-converting enzyme 2, ACE2), its coreceptors, potential alternative receptors. presence a diverse repertoire receptors allows infect various types cells, including those not expressing ACE2. During second stage, majority polyfunctional structural, non-structural, extra proteins synthesizes infected cells involved blockage immunity. A high degree redundancy systemic action characterizing these pathogenic overcome at initial invasion. third includes passive active virus from immunity, overcoming barrier function focus inflammation, generalization body. fourth is associated with deployment variants SARS-CoV-2’s ability induce autoimmune autoinflammatory pathways tissue both immunosuppressive hyperergic inflammation critical this

Language: Английский

Effect of COVID-19 Vaccines on Reducing the Risk of Long COVID in the Real World: A Systematic Review and Meta-Analysis

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(19), P. 12422 - 12422

Published: Sept. 29, 2022

The coronavirus disease 2019 (COVID-19) is still in a global pandemic state. Some studies have reported that COVID-19 vaccines had protective effect against long COVID. However, the conclusions of on COVID were not consistent. This study aimed to systematically review relevant real world, and performed meta-analysis explore relationship between vaccination We searched PubMed, Embase, Web science, ScienceDirect from inception 19 September 2022. PICO (P: patients; I: intervention; C: comparison; O: outcome) was as follows: patients diagnosed with (P); (I); divided into vaccinated unvaccinated groups (C); outcomes occurrence COVID, well various symptoms (O). A fixed-effect model random-effects chosen based heterogeneity order pool value. results showed group 29% lower risk developing compared (RR = 0.71, 95% CI: 0.58-0.87,

Language: Английский

Long COVID: pathophysiological factors and abnormalities of coagulation

Trends in Endocrinology and Metabolism, Journal Year: 2023, Volume and Issue: 34(6), P. 321 - 344

Published: April 19, 2023

Acute COVID-19 infection is followed by prolonged symptoms in approximately one ten cases: known as Long COVID. The disease affects ~65 million individuals worldwide. Many pathophysiological processes appear to underlie COVID, including viral factors (persistence, reactivation, and bacteriophagic action of SARS CoV-2); host (chronic inflammation, metabolic endocrine dysregulation, immune autoimmunity); downstream impacts (tissue damage from the initial infection, tissue hypoxia, dysbiosis, autonomic nervous system dysfunction). These mechanisms culminate long-term persistence disorder characterized a thrombotic endothelialitis, endothelial hyperactivated platelets, fibrinaloid microclots. abnormalities blood vessels coagulation affect every organ represent unifying pathway for various

Language: Английский

Long-COVID post-viral chronic fatigue and affective symptoms are associated with oxidative damage, lowered antioxidant defenses and inflammation: a proof of concept and mechanism study

Molecular Psychiatry, Journal Year: 2022, Volume and Issue: 28(2), P. 564 - 578

Published: Oct. 24, 2022

Language: Английский

Post COVID-19 Syndrome (“Long COVID”) and Diabetes: Challenges in Diagnosis and Management

Diabetes & Metabolic Syndrome Clinical Research & Reviews, Journal Year: 2021, Volume and Issue: 15(5), P. 102235 - 102235

Published: July 28, 2021

Language: Английский

Post‐COVID syndrome: A single‐center questionnaire study on 1007 participants recovered from COVID‐19

Journal of Medical Virology, Journal Year: 2021, Volume and Issue: 93(12), P. 6566 - 6574

Published: July 13, 2021

Post recovery manifestations have become another concern in patients who recovered from coronavirus disease 2019 (COVID-19). Numerous reports shown that COVID-19 has a variety of long-term effects on almost all systems including respiratory, cardiovascular, gastrointestinal, neurological, psychiatric, and dermatological systems. We aimed to investigate the prevalence characteristics post-COVID syndrome among survivors determine factors associated with persistent symptoms. This prospective study enrolled followed hospital or outpatient clinics Ankara City Hospital. performed special questionnaire inquire about presence symptoms beyond 12 weeks first diagnosis. Demographic data, comorbid diseases, acute COVID-19, by systems, knowledge clinic visits after were assessed. Of total 1007 participants, 39.0% had at least one comorbidity, 47.5% Fatigue/easy fatigability, myalgia, loss weight most frequent (overall 29.3%) respiratory (25.4%). A 235 participants visited due several reasons during post-COVID-19 period, 17 them hospitalized. Severe hospitalization, comorbidity independent for development Fully understanding spectrum is essential appropriate management its effects. Our once again underlined fact higher than expected concerns many multidisciplinary follow-up should be provided post period.

Language: Английский

Generalisable long COVID subtypes: findings from the NIH N3C and RECOVER programmes

EBioMedicine, Journal Year: 2022, Volume and Issue: 87, P. 104413 - 104413

Published: Dec. 21, 2022

Stratification of patients with post-acute sequelae SARS-CoV-2 infection (PASC, or long COVID) would allow precision clinical management strategies. However, COVID is incompletely understood and characterised by a wide range manifestations that are difficult to analyse computationally. Additionally, the generalisability machine learning classification COVID-19 outcomes has rarely been tested.

Language: Английский