Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2023, Volume and Issue: 292, P. 122410 - 122410
Published: Jan. 26, 2023
Language: Английский
ACS Sensors, Journal Year: 2022, Volume and Issue: 7(9), P. 2521 - 2536
Published: Sept. 1, 2022
Fluorescence sensing can not only identify a target substrate qualitatively but also achieve the purpose of quantitative detection through change fluorescence signal. It has advantages immense sensitivity, rapid response, and excellent selectivity. The proposed aggregation-induced emission (AIE) concept solves problem traditional fluorescent molecules becoming weak or quenched in high concentration aggregated state conditions. Schiff base probes have simple synthesis, low toxicity, easy design. They are often used for various substances. In this review we cover late developments compounds with AIE characteristics working as sensors.
Language: Английский
Citations
89
Chemical Reviews, Journal Year: 2022, Volume and Issue: 123(7), P. 3944 - 3975
Published: Sept. 15, 2022
Micro-/nanorobots (MNRs) can be autonomously propelled on demand in complex biological environments and thus may bring revolutionary changes to biomedicines. Fluorescence has been widely used real-time imaging, chemo-/biosensing, photo-(chemo-) therapy. The integration of MNRs with fluorescence generates fluorescent unique advantages optical trackability, on-the-fly environmental sensitivity, targeting chemo-/photon-induced cytotoxicity. This review provides an up-to-date overview MNRs. After the highlighted elucidation about various propulsion mechanisms introductory information emphasis materials, we systematically illustrate design preparation strategies integrate substances their biomedical applications imaging-guided drug delivery, intelligent sensing In end, summarize main challenges provide outlook future directions work is expected attract inspire researchers from different communities advance creation practical application a broad horizon.
Language: Английский
Citations
84
Microchemical Journal, Journal Year: 2025, Volume and Issue: 210, P. 112968 - 112968
Published: Feb. 4, 2025
Language: Английский
Citations
3
Coordination Chemistry Reviews, Journal Year: 2020, Volume and Issue: 429, P. 213638 - 213638
Published: Nov. 1, 2020
Language: Английский
Citations
107
Chemical Science, Journal Year: 2020, Volume and Issue: 12(4), P. 1220 - 1226
Published: Dec. 15, 2020
The chronological evolution of small organic molecular fluorescent probes for thiols: from separation dependency analysis to cellular specific analysis, what's next?
Language: Английский
Citations
106
Accounts of Chemical Research, Journal Year: 2020, Volume and Issue: 53(10), P. 2273 - 2285
Published: Sept. 15, 2020
ConspectusCarbon monoxide (CO) is a gaseous signaling molecule produced in humans via the breakdown of heme an O2-dependent reaction catalyzed by oxygenase enzymes. A long-lived species relative to other molecules (e.g., NO, H2S), CO exerts its physiological effects binding low-valent transition metal centers proteins and Studies involving administration low doses have shown potential as therapeutic agent produce vasodilation, anti-inflammatory, antiapoptotic, anticancer effects. In pursuit developing tools define better role CO, carbon releasing (CORMs) were developed. To date, vast majority reported CORMs been carbonyl complexes, with most well-known being Ru2Cl4(CO)6 (CORM-2), Ru(CO)3Cl(glycinate) (CORM-3), Mn(CO)4(S2CNMe(CH2CO2H)) (CORM-401). These complexes used probe hundreds cell- animal-based experiments. However, through recent investigations, it has become evident that these reagents exhibit complicated reactivity biological environments. The interpretation some obscured protein binding, such their formulation not clear, leakage redox activity. An additional weakness regard CORM-2 CORM-3 compounds cannot be tracked fluorescence. Therefore, unclear where or when release occurs, which confounds experiments using molecules. address weaknesses, our research team pioneered development metal-free based on structurally tunable extended flavonol quinolone scaffolds. addition highly controlled, only occurring upon triggering visible light (photoCORMs), donors are trackable fluorescence prior cellular environments can targeted specific locations.In Account, we highlight application series related photoCORMs (1) sense characteristics release; (2) enable evaluation influence cytosolic versus mitochondrial-localized bioenergetics; (3) cytotoxicity anti-inflammatory intracellular extracellular delivery; (4) demonstrate albumin delivery photoCORM enables potent key advantage triggered investigations ability examine molecular vehicle absence presence localized release, thus providing insight into independent contributions CO. Overall, flavonol-based offer opportunities for triggerable, trackable, targetable unprecedented terms previously and, thus, significant applications systems.
Language: Английский
Citations
103
Biosensors and Bioelectronics, Journal Year: 2021, Volume and Issue: 196, P. 113724 - 113724
Published: Oct. 22, 2021
Language: Английский
Citations
67
Topics in Current Chemistry, Journal Year: 2022, Volume and Issue: 380(4)
Published: April 12, 2022
Language: Английский
Citations
63
Chinese Chemical Letters, Journal Year: 2023, Volume and Issue: 35(2), P. 108658 - 108658
Published: June 7, 2023
Language: Английский
Citations
30
TrAC Trends in Analytical Chemistry, Journal Year: 2023, Volume and Issue: 169, P. 117377 - 117377
Published: Oct. 19, 2023
Language: Английский
Citations
29