Metal-Based Nanoparticles for Cancer Metalloimmunotherapy DOI Creative Commons
I. Suliman, K. H. Kim, Weihsuan Chen

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(7), P. 2003 - 2003

Published: July 21, 2023

Although the promise of cancer immunotherapy has been partially fulfilled with unprecedented clinical success several immunotherapeutic interventions, some issues, such as limited response rate and immunotoxicity, still remain. Metalloimmunotherapy offers a new form that utilizes inherent immunomodulatory features metal ions to enhance anticancer immune responses. Their versatile functionalities for multitude direct indirect activities together their biocompatibility suggest can help overcome current issues associated immunotherapy. However, exhibit poor drug-like properties due intrinsic physicochemical profiles impede in vivo pharmacological performance, thus necessitating an effective pharmaceutical formulation strategy improve behavior. Metal-based nanoparticles provide promising platform technology reshaping into more formulations nano-enabled engineering approaches. This review provides general overview immunotherapy, system how it works against cells, role host modulation, well impact on process via regulation cells. The preclinical studies have demonstrated potential metal-based metalloimmunotherapy are presented representative constructed manganese, zinc, iron, copper, calcium, sodium ions. Lastly, perspectives future directions discussed, particularly respect applications.

Language: Английский

Tumor cell metabolic reprogramming and hypoxic immunosuppression: driving carcinogenesis to metastatic colonization DOI Creative Commons
Theodora Katopodi, Savvas Petanidis, Doxakis Anestakis

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 16, 2024

A significant factor in the antitumor immune response is increased metabolic reprogramming of immunological and malignant cells. Increasing data points to fact that cancer metabolism affects not just signaling, which essential for maintaining carcinogenesis survival, but also expression cells immune-related factors such as lactate, PGE2, arginine, IDO, regulate signaling mechanism. In reality, this energetic interaction between system tumor results competition ecosystem, limiting amount nutrients available causing microenvironmental acidosis, impairs ability operate. More intriguingly, different types use keep body self a state homeostasis. The process cell proliferation, differentiation, performance effector functions, crucial response, are currently being linked reprogramming. Here, we cover regulation by well potential strategies pathway targeting context anticancer immunotherapy. We discuss prospective immunotherapy-metabolic intervention combinations might be utilized maximize effectiveness current immunotherapy regimes.

Language: Английский

Citations

8
Recent Findings on Therapeutic Cancer Vaccines: An Updated Review DOI Creative Commons
Sara Sheikhlary, David Humberto Lopez,

Sophia Moghimi

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(4), P. 503 - 503

Published: April 21, 2024

Cancer remains one of the global leading causes death and various vaccines have been developed over years against it, including cell-based, nucleic acid-based, viral-based cancer vaccines. Although many effective in vivo clinical studies some FDA-approved, there are major limitations to overcome: (1) developing universal vaccine for a specific is difficult, as tumors with different antigens individuals, (2) tumor may be similar body’s own antigens, (3) possibility recurrence. Therefore, personalized ability distinguish between indispensable. This paper provides comprehensive review types highlights important factors necessary efficient Moreover, application other technologies therapy discussed. Finally, several insights conclusions presented, such using cold plasma stem cells future vaccines, tackle developmental process.

Language: Английский

Citations

7
Advances in Nanomaterials for Immunotherapeutic Improvement of Cancer Chemotherapy DOI Creative Commons
Jie Liu, Bei Li, Li Li

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: May 21, 2024

Immuno-stimulative effect of chemotherapy (ISECT) is recognized as a potential alternative to conventional immunotherapies, however, the clinical application constrained by its inefficiency. Metronomic chemotherapy, though designed overcome these limitations, offers inconsistent results, with effectiveness varying based on cancer types, stages, and patient-specific factors. In parallel, wealth preclinical nanomaterials holds considerable promise for ISECT improvement modulating cancer-immunity cycle. area biomedical nanomaterials, current literature reviews mainly concentrate specific category nanotechnological perspectives, while two essential issues are still lacking, i.e., comprehensive analysis addressing causes inefficiency thorough summary elaborating improvement. This review thus aims fill gaps catalyze further development in this field. For first time, comprehensively discusses It then meticulously categorizes six types improving ISECT. Subsequently, practical strategies proposed inefficient ISECT, along detailed discussion exemplary nanomedicines. Finally, provides insights into challenges perspectives chemo-immunotherapy innovations nanomaterials.

Language: Английский

Citations

7
Vax-Innate: improving therapeutic cancer vaccines by modulating T cells and the tumour microenvironment DOI
Faezzah Baharom, Dalton Hermans, Lélia Delamarre

et al.

Nature reviews. Immunology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 21, 2024

Language: Английский

Citations

7
Single-cell atlases link macrophages and CD8+ T-cell subpopulations to disease progression and immunotherapy response in urothelial carcinoma DOI Creative Commons
Yuan Liang, Yezhen Tan, Bao Guan

et al.

Theranostics, Journal Year: 2022, Volume and Issue: 12(18), P. 7745 - 7759

Published: Jan. 1, 2022

Immune checkpoint inhibitors (ICIs) have revolutionized the management of locally advanced or metastatic urothelial carcinoma. Strikingly, compared to carcinoma bladder (UCB), upper tract (UTUC) has a higher response rate ICIs. The stratification patients most likely benefit from ICI therapy remains major clinical challenge.

Language: Английский

Citations

28
Recent advances in curcumin-loaded biomimetic nanomedicines for targeted therapies DOI

Fenting Lei,

Pei Li, Tangting Chen

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 80, P. 104200 - 104200

Published: Jan. 23, 2023

Language: Английский

Citations

15
M2pep-Modified Cyclodextrin-siRNA Nanoparticles Modulate the Immunosuppressive Tumor Microenvironment for Prostate Cancer Therapy DOI Creative Commons
Yao Sun,

Michael F. Cronin,

Monique Culturato Padilha Mendonça

et al.

Molecular Pharmaceutics, Journal Year: 2023, Volume and Issue: 20(11), P. 5921 - 5936

Published: Oct. 24, 2023

Prostate cancer (PCa) is the most prevalent cause of deaths in men. Conventional strategies, such as surgery, radiation, or chemotherapy, face challenges including poor prognosis and resistance. Therefore, development new improved strategies vital to enhance patient outcomes. Recently, immunotherapy has shown potential treatment a range cancers, PCa. Tumor-associated macrophages (TAMs) play an important role tumor microenvironment (TME) reprogramming TAMs associated with remodeling TME. The colony-stimulating factor-1/colony stimulating factor-1 receptor (CSF-1/CSF-1R) signaling pathway closely related polarization TAMs. downregulation CSF-1R, using small interfering RNA (siRNA), been achieve TAMs, from immunosuppressive M2 phenotype immunostimulatory M1 one. To maximize specific cellular delivery macrophage-targeting peptide, M2pep, was formulated amphiphilic cationic β-Cyclodextrin (CD) incorporating CSF-1R siRNA. resulting nanoparticles (NPs) increased macrophage targeting both vitro vivo, promoting release factors simultaneously downregulating levels through TAM reprogramming. subsequent TME resulted reduction growth subcutaneous PCa mouse model mainly mediated recruitment cytotoxic T cells. In summary, this M2pep-targeted CD-based system demonstrated significant antitumor efficacy, thus presenting alternative immunotherapeutic strategy for treatment.

Language: Английский

Citations

14
CRISPR-Cas gene knockouts to optimize engineered T cells for cancer immunotherapy DOI
Valentine De Castro, Jeanne Galaine, Romain Loyon

et al.

Cancer Gene Therapy, Journal Year: 2024, Volume and Issue: 31(8), P. 1124 - 1134

Published: April 12, 2024

Language: Английский

Citations

6
Overcoming the challenges of primary resistance and relapse after CAR-T cell therapy DOI
Alexandra Dreyzin, Alexander W. Rankin,

Katia Luciani

et al.

Expert Review of Clinical Immunology, Journal Year: 2024, Volume and Issue: 20(7), P. 745 - 763

Published: May 13, 2024

Introduction While CAR T-cell therapy has led to remarkable responses in relapsed B-cell hematologic malignancies, only 50% of patients ultimately have a complete, sustained response. Understanding the mechanisms resistance and relapse after is crucial future development improving outcomes.

Language: Английский

Citations

6
Multimodal stimulation screens reveal unique and shared genes limiting T cell fitness DOI Creative Commons
Chun‐Pu Lin, Pierre Lévy,

Astrid Alflen

et al.

Cancer Cell, Journal Year: 2024, Volume and Issue: 42(4), P. 623 - 645.e10

Published: March 14, 2024

Genes limiting T cell antitumor activity may serve as therapeutic targets. It has not been systematically studied whether there are regulators that uniquely or broadly contribute to fitness. We perform genome-scale CRISPR-Cas9 knockout screens in primary CD8 cells uncover genes negatively impacting fitness upon three modes of stimulation: (1) intense, triggering activation-induced death (AICD); (2) acute, expansion; (3) chronic, causing dysfunction. Besides established regulators, we controlling either specifically commonly differential stimulation. Dap5 ablation, ranking highly all screens, increases translation while enhancing tumor killing. Loss Icam1-mediated homotypic clustering amplifies expansion and effector functions after both acute intense Lastly, Ctbp1 inactivation induces functional persistence exclusively chronic Our results functionally annotate based on their unique shared contribution traits activity.

Language: Английский

Citations

5