Recent progress in biomimetic nanomedicines based on versatile targeting strategy for atherosclerosis therapy DOI Open Access

Yiping Deng,

Zuojin Ao,

Jun Tang

et al.

Authorea (Authorea), Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 23, 2023

Atherosclerosis (AS) is considered to be one of the major causes cardiovascular disease. Its pathological microenvironment characterized by increased production reactive oxygen species, lipid oxides, and excessive inflammatory factors, which accumulate at monolayer endothelial cells in vascular wall form AS plaques. Therefore, intervention would beneficial delaying AS. Researchers have designed biomimetic nanomedicine (nanomedicine) with excellent biocompatibility ability avoid being cleared immune system through different therapeutic strategies achieve better effects for characteristics Biomimetic can further enhance delivery efficiency improve treatment efficacy due their good evade clearance system. based on such as neutralizing ROS scavengers, integration diagnosis are versatile approaches effective The review firstly summarizes targeting strategy recent 5 years. using cell membranes, proteins, extracellular vesicles carriers been developed

Language: Английский

Oral hydrogel nanoemulsion co-delivery system treats inflammatory bowel disease via anti-inflammatory and promoting intestinal mucosa repair DOI Creative Commons

Fenting Lei,

Fancai Zeng, Xin Yu

et al.

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Aug. 18, 2023

Due to oral nano-delivery systems for the treatment of inflammatory bowel disease (IBD) are often failed accumulated colonic site and could not achieve controlled drug release, it's urgent develop a microenvironment responsive delivery improve therapy efficacy. Inflammation at IBD is mainly mediated by macrophages, which key effector cells. Excessive inflammation leads oxidative stress intestinal mucosal damage. The use curcumin (CUR) emodin (EMO) together promising due their respective anti-inflammatory repair effects. In view pH gradient environment gastrointestinal tract, here we prepared pH-responsive sodium alginate (SA) hydrogel-coated nanoemulsions co-deliver CUR EMO (CUR/EMO NE@SA) release specifically target macrophages colon.In this study, CUR/EMO NE@SA was successfully developed, in NE loaded chitosan further crosslinked with alginate. had property colon. preparation significantly alleviate colon decreasing TNF-α IL-6 expression, increasing IL-10 scavenging reactive oxygen species ameliorating restoration tight junction protein expression. Furthermore, revealed molecular mechanism treatment, might synergic inhibition NF-κB pro-inflammatory microenvironment. Our study provides new strategy via synergically inhibiting inflammatory, repairing clearing ROS pH-sensitive hydrogel-encapsulated nanoemulsion system, be developed other chronic treatment.It's suggested that nanoemulsion-based codelivery combinatorial platform IBD.

Language: Английский

Citations

34
Surface saturation of drug-loaded hollow manganese dioxide nanoparticles with human serum albumin for treating rheumatoid arthritis DOI Creative Commons

Ming Jia,

Wei Ren,

Minrui Wang

et al.

Drug Delivery, Journal Year: 2024, Volume and Issue: 31(1)

Published: July 23, 2024

Rheumatoid arthritis (RA) is a chronic inflammatory joint disease accompanied by energy depletion and accumulation of reactive oxygen species (ROS). Inorganic nanoparticles (NPs) offer great promise for the treatment RA because they mostly have functions beyond being drug carriers. However, conventional nanomaterials become coated with protein corona (PC) or lose their cargo prematurely in vivo, reducing therapeutic efficacy. To avoid these problems, we loaded methotrexate (MTX) into hollow structured manganese dioxide (H-MnO2 NPs), then them 'pseudo-corona' human serum albumin (HSA) at physiological concentrations to obtain HSA-MnO2@MTX NPs. Efficacy MTX, MnO2@MTX, NPs was compared vitro vivo. Compared HSA-coated were taken up better lipopolysaccharide-activated RAW264.7 more effective lowering levels pro-inflammatory cytokines preventing ROS accumulation. also efficient blocking proliferation migration fibroblast-like synoviocytes from rats collagen-induced arthritis. In this rat model, showed biodistribution than other treatments, specifically targeting ankle joint. Furthermore, reduced swelling paw, regulated cytokine production, limited cartilage degradation signs inflammation. These results establish potential against RA.

Language: Английский

Citations

4
Chitosan/Virgin Coconut Oil-Based Emulsions Doped with Photosensitive Curcumin Loaded Capsules: A Functional Carrier to Topical Treatment DOI Open Access
Luísa C. Rodrigues, Adriana P. Ribeiro, Simone S. Silva

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(5), P. 641 - 641

Published: Feb. 27, 2024

In recent years, there has been a growing interest in developing smart drug delivery systems based on natural resources combined with stimulus-sensitive elements. This trend aims to formulate innovative and sustainable platforms tailored for topical applications. work proposed the use of layer-by-layer (LbL) methodology fabricate biocompatible photo-responsive multilayer systems. These are composed polyoxometalate inorganic salt (POM) ([NaP5W30O110]14−) origin polymer, chitosan (CHT). Curcumin (CUR), bioactive compound, was incorporated enhance functionality these during formation hollow capsules. The capsules produced, sizes between 2–5µm (SEM), were further dispersed into CHT/VCO (virgin coconut oil) emulsion solutions that casted molds dried at 37 °C 48 h. system presented higher water uptake PBS than acidic conditions, still significantly lower earlier reported other CHT/VCO-based release profile is not influenced by medium pH reaching maximum 37% ± 1% after antioxidant performance designed structures studied, suggesting synergistic beneficial effect resulting from CUR, POM, VCO individual bioactivities. increased amount those excipients released media over time promoted an increase activity system, 38.1% 0.1% represents promising step towards advanced,

Language: Английский

Citations

2
Nanoparticles Based on Chondroitin Sulfate from Tuna Heads and Chitooligosaccharides for Enhanced Water Solubility and Sustained Release of Curcumin DOI Open Access
Yaowapha Waiprib, Pattarachat Ingrungruengluet,

Wanchai Worawattanamateekul

et al.

Polymers, Journal Year: 2023, Volume and Issue: 15(4), P. 834 - 834

Published: Feb. 8, 2023

This study aimed to separate chondroitin sulfate (CS) from the heads of skipjack tuna (Katsuwonus pelamis) and yellowfin (Thunnus albacares), by-products derived canned processing, via a biological process. The use 1% w/w papain an incubation time 48 h resulted in degree hydrolysis 93.75 ± 2.94% CS content 59.53 1.77 mg/100 g. FTIR spectra extracted products exhibited identical functional groups found commercially available CS. molecular weights were 11.0 kDa 7.7 kDa, respectively. Subsequently, CH:CS ratio 3:2 for chitooligosaccharides (CH) was chosen as optimal preparation spherical nanoparticles, with %EE, mean particle size, PDI, zeta potential values 50.89 0.66%, 128.90 3.29 nm, 0.27 0.04, −12.47 2.06, CU enhanced 127.21 1.66 μg/mL. release this particular nanosystem involved mainly drug diffusion mechanism, burst first 3 followed by sustained over 24 h. DPPH ABTS scavenging activity results confirmed efficient encapsulation into CHCS nanoparticles. will provide theoretical basis head cartilages be used component specific properties food biomedical applications.

Language: Английский

Citations

5
The Homoleptic Curcumin–Copper Single Crystal (ML2): A Long Awaited Breakthrough in the Field of Curcumin Metal Complexes DOI Creative Commons
Antonino Arenaza‐Corona, Marco A. Obregón‐Mendoza, William Meza-Morales

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(16), P. 6033 - 6033

Published: Aug. 12, 2023

The first single crystal structure of the homoleptic copper (II) ML2 complex (M=Cu (II), L = curcumin) was obtained and its elucidated by X-ray diffraction showing a square planar geometry, also confirmed EPR. supramolecular arrangement is supported C-H···O interactions solvent (MeOH) plays an important role in stabilizing packing Crystallinity additionally assessed XRD patterns. log P value (2.3 ± 0.15) determined improvement water solubility. cytotoxic activity against six cancer cell lines substantially surpasses that curcumin itself, it particularly selective leukemia (K562) human glioblastoma (U251) lines, with similar antioxidant to BHT. This constitutes pristine complexed metal ion.

Language: Английский

Citations

5
The Homoleptic Curcumin-Copper Single Crystal (ML2): A Long Awaited Cherry on the Cake in the Field of Curcumin Metal Complexes DOI Open Access

Antonino Arenaza Corona,

Marco A. Obregón‐Mendoza,

William Meza Morales

et al.

Published: June 29, 2023

The first single crystal structure of the homoleptic copper (II) ML2 complex (M=Cu (II), L=curcumin) was obtained and its elucidated by X-ray diffraction showing a square planar geometry. supramolecular arrangement is supported C-H···O interactions solvent (MeOH) plays an important role in stabilizing packing. cytotoxic activity against six cancer cell lines substantially surpasses that curcumin itself, it particularly selective leukemia (K562) human glioblastoma (U251) with similar antioxidant to BHT. This constitutes pristine complexed metal ion.

Language: Английский

Citations

4
Preparation and evaluation of water-soluble chondroitin sulfate-curcumin conjugate DOI
L. H. Long, Zhiqiang Yang,

Kaicheng Zeng

et al.

Materials Letters, Journal Year: 2023, Volume and Issue: 351, P. 135035 - 135035

Published: Aug. 9, 2023

Language: Английский

Citations

4
Recent progress in biomimetic nanomedicines based on versatile targeting strategy for atherosclerosis therapy DOI
Lijuan Liang,

Yiping Deng,

Zuojin Ao

et al.

Journal of drug targeting, Journal Year: 2024, Volume and Issue: 32(6), P. 606 - 623

Published: April 24, 2024

Atherosclerosis (AS) is considered to be one of the major causes cardiovascular disease. Its pathological microenvironment characterised by increased production reactive oxygen species, lipid oxides, and excessive inflammatory factors, which accumulate at monolayer endothelial cells in vascular wall form AS plaques. Therefore, intervention would beneficial delaying AS. Researchers have designed biomimetic nanomedicines with excellent biocompatibility ability avoid being cleared immune system through different therapeutic strategies achieve better effects for characteristics Biomimetic can further enhance delivery efficiency improve treatment efficacy due their good evade clearance system. based on such as neutralising ROS scavengers, integration diagnosis are versatile approaches effective The review firstly summarises targeting strategy nanomedicine recent 5 years. using cell membranes, proteins, extracellular vesicles carriers been developed

Language: Английский

Citations

1
Magneto-Plasmonic Nanoparticles in Biomedicine: A Comprehensive Exploration of Iron Oxide and Gold Nanoparticle Applications DOI
Álvaro de Jesús Ruíz-Baltazar

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 103, P. 106429 - 106429

Published: Nov. 22, 2024

Language: Английский

Citations

1
Lipid nanocarriers encapsulating herbal drugs for brain diseases therapy DOI Creative Commons

Sara Gad,

Riham I. El-Gogary, Ahmed S. Geneidi

et al.

Archives of Pharmaceutical Sciences Ain Shams University, Journal Year: 2023, Volume and Issue: 7(1), P. 60 - 86

Published: June 1, 2023

The blood-brain barrier (BBB) is an essential component in safeguarding the brain and preserving its equilibrium.The BBB represents a challenge for various types of drug delivery systems, particularly context treating numerous neuropathological disorders wherein therapeutic agents cannot cross BBB.Nonetheless, existing neurotherapeutics have drawbacks such as toxicity lack specificity.Advances nano lipid-based nanocarriers, aim to deliver active therapeutics across improve neurological conditions Alzheimer's, Parkinson's, tumors, offering novel treatment strategy with enhanced delivery, increased target specificity, efficacy, more significantly, minimized biomimetic manner.In this context, review sheds light on use lipid nanocarriers loaded drugs natural origin ferulic acid, resveratrol, curcumin, rosmarinic acid their better bioavailability exceptional improvement potential treat major future clinics.

Language: Английский

Citations

2