COVID-19 vaccine hesitancy in the UK: a longitudinal household cross-sectional study

BMC Public Health, Journal Year: 2022, Volume and Issue: 22(1)

Published: Jan. 15, 2022

Abstract Background The approved COVID-19 vaccines have shown great promise in reducing disease transmission and severity of outcomes. However, the success vaccine rollout is dependent on public acceptance willingness to be vaccinated. In this study, we aim examine how attitude towards sector officials government impact willingness. secondary understand ethnicity vaccine-willingness after explicitly account for trust institutions. Methods This cross-sectional study used data from a UK population based longitudinal household survey (Understanding Society Understanding Society: Household Longitudinal Study) between April 2020-January 2021. Data 22,421 participants Waves 6 7 were included excluding missing data. Demographic details addition previous responses relating sector/governmental as covariates main analysis. A logit model was produced describe association mistrust vaccination with interaction terms ethnicity/socio-economic status. Results support existing literature, identified those BAME groups more likely unwilling take vaccine. We found that positive opinions (OR 2.680: 95% CI 1.888 – 3.805) 3.400; 2.454—4.712) led substantive increase Most notably effect vary across socio-economic status South Asian background 4.513; 1.012—20.123) possessing negative being most Conclusions These findings suggests play key factor low rates particularly seen at-risk groups. Given additional morbidity/mortality risk posed by lower or ethnic minority backgrounds, there needs urgent health action review tailor promotion advice given these methods improve government.

Language: Английский

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Effectiveness of COVID-19 vaccines against SARS-CoV-2 variants of concern in real-world: a literature review and meta-analysis

Emerging Microbes & Infections, Journal Year: 2022, Volume and Issue: 11(1), P. 2383 - 2392

Published: Sept. 7, 2022

Knowing vaccine effectiveness (VE) against variants of concern (VOCs) in the real-world setting is essential for public health decision-making. A systematic landscape VE a series clinical outcomes caused by VOCs needed. We systematically searched studies that evaluated and collected individual data. identified 113 meeting eligibility criteria. found full vaccination provided strong protection each outcome with summary ranging from 86.8% to 96.0% Alpha, moderate infection Beta, Gamma Delta 70.9% 72.8%, severe disease 84.9% 90.3%, limited 23.5% (95% CI, 17.0-29.5) 56.5% 82.4% diseases Omicron. Booster can provide substantial improvement Omicron, but not as much Delta. The meta-regression analysis showed Omicron wanned over time, hospitalization declined relatively slowly, compared infection. Those findings supported need measures, increasing booster coverage response current new infectious waves driven developing broadly protective vaccines confront virus evolution.

Language: Английский

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Factors associated with COVID-19 vaccine intentions during the COVID-19 pandemic; a systematic review and meta-analysis of cross-sectional studies

BMC Public Health, Journal Year: 2022, Volume and Issue: 22(1)

Published: Sept. 2, 2022

Abstract Background A high COVID-19 vaccine uptake is essential to achieve herd immunity combat the current strain of and potential future variants. This review aimed identify factors associated with public intention receive vaccines until February 2021 provide accessible data policymakers inform framing targeting messages designed optimise uptake. Methods Medline, Embase, CINAHL, PsycINFO, PsycARTICLES, Sociological Abstracts Applied Social Sciences Index were searched for cross-sectional studies reporting regarding intentions, published between 01/01/2020 12/02/2021. Title/abstract full-text screening performed independently by two authors. The Appraisal Tool Cross-sectional Studies (AXIS) was used assess bias quality. Both random-effects meta-analysis narrative synthesis describe intentions factors. subgroup analysis assessing impact sex, sampling method time survey on performed. Results Searches identified 4739 studies, 23 deemed eligible review; 22 online surveys one a mixed-methods study design. Eighteen conducted in first half 2020 five latter 2020. Fifteen countries represented, most common being United States ( n = 4) Kingdom 41,403 participants across all surveys. Most employed convenience 11 non-responder rates raised concerns over non-response bias. From 18 included meta-analysis, pooled proportion willing 73.3% 18, 95% Confidence Interval 64.2 81.5%, I 2 99.7%). Factors higher acceptance greater perceived risk COVID-19, lower level harm, educational attainment household income, older age, White ethnicity male sex. Conclusions There willingness which influenced sociodemographic perceptions. findings suggest research should explore reasoning behind different groups allow targeted communication strategies be formulated health agencies. Registration PROSPERO Number: CRD42021239134.

Language: Английский

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COVID-19 Vaccine Refusal among Nurses Worldwide: Review of Trends and Predictors

Vaccines, Journal Year: 2022, Volume and Issue: 10(2), P. 230 - 230

Published: Feb. 2, 2022

COVID-19 vaccination hesitancy has become a major concern around the world. Recent reports have also highlighted in healthcare workers. Despite media and scientific publications, little is known about extent predictors of refusal among nurses. Thus, purpose this study was to assess vaccine rates nurses globally explore reasons for factors associated with uptake vaccines. A scoping review published literature conducted, final pool 51 studies (n = 41,098 nurses) from 36 countries included review. The overall pooled prevalence rate worldwide 20.7% (95% CI 16.5-27%). were higher March 2020-December 2020 compared January 2021-May 2021. concerns safety, side effects, efficacy; misinformation lack knowledge; mistrust experts, authorities, or pharmaceutical companies. acceptance vaccines were: male sex, older age, flu history. Evidence-based strategies should be implemented systems increase ensure their safety patients community members.

Language: Английский

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Assessing public knowledge, attitudes and determinants of third COVID-19 vaccine booster dose acceptance: current scenario and future perspectives

Journal of Pharmaceutical Policy and Practice, Journal Year: 2022, Volume and Issue: 15(1)

Published: March 28, 2022

People with weakened immune systems may not develop adequate protection after taking two doses of the mRNA-combined COVID-19 vaccine. The additional dose improve level against Covid-19.Current study aimed to evaluate knowledge, attitude and determents third vaccine booster acceptance among population in UAE.This is online descriptive cross-sectional community-based conducted students faculty Ajman University from 25 August 20 October 2021. questionnaire, which was English language, encompassed sections containing 22 items. Section one gathered demographic details respondents, while used 13 questions respondents' knowledge dose.614 respondents participated this study. average score 44.6% a 95% confidence interval (CI) [41%, 49%]. Better scores were observed postgraduates (OR 4.29; CI 2.28-8.11), employees healthcare sector 1.62; 1.05-2.51), participants who had relatives infected Covid-19 1.46; 1.05-2.02), 2.21; 1.43-3.43) received first 2.08; 1.40-3.11). 70.2% [69.2%, 71.2%].Necessary steps should be taken by government public health authorities, line local culture, increase vaccination foster positive attitudes towards A suitable approach would an educational framework that could demonstrate risks avoidance or delay general population. Moreover, authorities pay more attention false information being disseminated across internet, especially social media. Also, workers trained vaccinology virology make sure they are able understand important developments these fields convey findings their patients.

Language: Английский

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Determinants of the Hesitancy toward COVID-19 Vaccination in Eastern European Countries and the Relationship with Health and Vaccine Literacy: A Literature Review

Vaccines, Journal Year: 2022, Volume and Issue: 10(5), P. 672 - 672

Published: April 23, 2022

Herd immunity is necessary to control the coronavirus disease 2019 (COVID-19) pandemic. However, a low proportion of vaccinated people and levels vaccine acceptance have been noted in Eastern Europe. Our paper aimed review central attitudes associated with hesitancy toward COVID-19 vaccination specific European countries. The main determinants identified from included studies are: public confidence vaccines' safety efficacy, literacy, trust government medical system. Each these discussed along possible improvement measures. Variables Europe that predict willingness vaccinate also highlighted. their context as by our should be incorporated into local health programs, ultimate goal reducing viral spreading, mutation emergence, morbidity mortality both within borders beyond.

Language: Английский

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COVID-19 vaccination hesitancy in Italian healthcare workers: a systematic review and meta-analysis

Expert Review of Vaccines, Journal Year: 2022, Volume and Issue: 21(9), P. 1289 - 1300

Published: June 27, 2022

As for other vaccines, vaccination hesitancy may be a determining factor in the success (or otherwise) of COVID-19 immunization campaign healthcare workers (HCWs).To estimate proportion HCWs Italy who expressed vaccine hesitancy, we conducted systematic review relevant literature and meta-analysis. Determinants compliance options suggested by these studies to address among were also analyzed. Seventeen included meta-analysis review, selected from scientific articles available MEDLINE/PubMed, Google Scholar Scopus databases between 1 January 2020 25 2022. The rate was 13.1% (95%CI: 6.9-20.9%). investigated before during 18.2% (95%CI = 12.8-24.2%) 8.9% 3.4-16.6%), respectively. That main reasons hesitation lack information about vaccination, opinion that is unsafe, fear adverse events.Despite strategies achieve greater willingness immunize this category, mandatory appears one most important measures can guarantee protection patients they care for.

Language: Английский

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COVID-19 and Seasonal Influenza Vaccination: Cross-Protection, Co-Administration, Combination Vaccines, and Hesitancy

Pharmaceuticals, Journal Year: 2022, Volume and Issue: 15(3), P. 322 - 322

Published: March 8, 2022

SARS-CoV-2 and influenza are the main respiratory viruses for which effective vaccines currently available. Strategies in COVID-19 administered simultaneously or combined into a single preparation advantageous may increase vaccination uptake. Here, we comprehensively review available evidence on COVID-19/influenza vaccine co-administration combination candidates from standpoints of safety, immunogenicity, efficacy, policy public acceptance. While several observational studies have shown that trained immunity induced by can protect against some COVID-19-related endpoints, it is not yet understood whether exert additive effects relevant outcomes. In randomized controlled trials, has proved safe, with reactogenicity profile similar to either alone. From immunogenicity standpoint, immune response towards four strains spike protein groups generally non-inferior seen receiving Several health authorities advocated co-administration. Different (pre)-clinical development. The hesitancy multifaceted phenomenon be higher than acceptance separately. Public implications discussed.

Language: Английский

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COVID-19 Vaccine Hesitancy: The Role of Information Sources and Beliefs in Dutch Adults

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(6), P. 3205 - 3205

Published: March 9, 2022

COVID-19 vaccine hesitancy may be regarded as a new pandemic hindering the elimination of or coping with COVID-19. This study assessed reasons for using I-Change Model (ICM) by considering role informational and psychosocial factors. A cross-sectional online survey convenience sample was conducted among Dutch adults (

Language: Английский

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Vaccine hesitancy educational tools for healthcare providers and trainees: A scoping review

Vaccine, Journal Year: 2022, Volume and Issue: 41(1), P. 23 - 35

Published: Nov. 25, 2022

In the era of vaccine hesitancy, highlighted by current SARS-CoV2 pandemic, there is an acute need to develop approach reduce and address apprehension towards vaccinations. We sought map present overview existing educational interventions for healthcare providers (HCPs) on strategies engage in effective discussion. applied Joanna Briggs Institute methodology framework this scoping review. searched five relevant databases (MEDLINE, CINAHL, EMBASE, PsycInfo, SCOPUS) grey literature through Google search engine using keywords subject headings that were systematically identified. identified 3384 citations peer-reviewed 41 literature. After screening our inclusion criteria, we included 28 from peer reviewed 16 analysis. a total unique education interventions. Interventions available multiple disciplines, training levels, clinical settings, diseases/vaccines. predominantly centered around two foci: knowledge sharing communication training. Most facilitated with modes delivery. more topical generally self-directed. several gaps knowledge. Firstly, accessibility generalizability was limited. Secondly, distribution did not adequately nursing pharmacy cover breadth medical specialties whom discussions apply. Thirdly, no addressed self monitoring clinicians' recognition management emotions during difficult conversations. There gap provide available, credible comprehensive will support hesitant patients.

Language: Английский

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