Sub-lethal Toxicity Effects of Iron Oxide Nanoparticles (IONPs) on the biochemical, oxidative biomarkers, and metabolic profile in Caridina fossarum

Journal of Trace Elements in Medicine and Biology, Journal Year: 2025, Volume and Issue: 88, P. 127613 - 127613

Published: Feb. 2, 2025

Language: Английский

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Transgenerational effects of extracts containing Microcystin-LR exposure on reproductive toxicity and offspring growth inhibition in a model organism zebrafish

Aquatic Toxicology, Journal Year: 2024, Volume and Issue: 268, P. 106860 - 106860

Published: Feb. 5, 2024

Language: Английский

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Microcystins Exposure Associated with Blood Lipid Profiles and Dyslipidemia: A Cross-Sectional Study in Hunan Province, China

Toxins, Journal Year: 2023, Volume and Issue: 15(4), P. 293 - 293

Published: April 18, 2023

Increasing evidence from experimental research suggests that exposure to microcystins (MCs) may induce lipid metabolism disorder. However, population-based epidemiological studies of the association between MCs and risk dyslipidemia are lacking. Therefore, we conducted a cross-sectional study involving 720 participants in Hunan Province, China, evaluated effects on blood lipids. After adjusting related metals, used binary logistic regression multiple linear models examine associations among serum concentration, lipids (triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL-C) low-density (LDL-C)). Moreover, additive model was explore interaction metals. Compared lowest quartile exposure, [odds ratios (OR) = 2.27, 95% confidence interval (CI): 1.46, 3.53] hyperTG (OR 3.01, CI: 1.79, 5.05) highest significantly increased, showed dose-response relationships. were positively associated with TG level (percent change, 9.43%; 3.53%, 15.67%) negatively HDL-C -3.53%; -5.70%, -2.10%). In addition, an antagonistic effect Zn also reported [relative excess due (RERI) -1.81 (95% -3.56, -0.05)], attributable proportion reduced antagonism these two exposures 83% -1.66, -0.005). Our first indicated is independent factor for manner.

Language: Английский

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Integration of Multi-Omics, Histological, and Biochemical Analysis Reveals the Toxic Responses of Nile Tilapia Liver to Chronic Microcystin-LR Exposure

Toxins, Journal Year: 2024, Volume and Issue: 16(3), P. 149 - 149

Published: March 14, 2024

Microcystin-LR (MC-LR) is a cyanobacterial metabolite produced during blooms and toxic to aquatic animals, the liver main targeted organ of MC-LR. To comprehensively understand toxicity mechanism chronic exposure environmental levels MC-LR on fish, juvenile Nile tilapia were exposed 0 μg/L (control), 1 (M1), 3 (M3), 10 (M10), 30 (M30) for 60 days. Then, hepatotoxicity induced by was systematically evaluated via histological biochemical determinations, underlying mechanisms explored through combining analysis parameters, multi-omics (transcriptome metabolome), gene expression. The results exhibited that caused slight minor structural damage lipid accumulation in M10 group, while resulting serious M30 indicating obvious hepatotoxicity, which confirmed increased indexes (i.e., AST, ALT, AKP). Transcriptomic metabolomic revealed extensive changes expression metabolites six typical pathways, including oxidative stress, apoptosis, autophagy, amino acid metabolism, primary bile biosynthesis, metabolism. Taken together, inhibited fatty deposition tilapia.

Language: Английский

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Transcriptome analysis provides preliminary insights into the response of Sepia esculenta to high salinity stress

Agriculture Communications, Journal Year: 2024, Volume and Issue: unknown, P. 100064 - 100064

Published: Nov. 1, 2024

Language: Английский

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Transcriptomics-based analysis of neurotoxic and reproductive effects in turbot (Scophthalmus maximus) after exposure to tris (2-chloroethyl) phosphate (TCEP)

BMC Genomics, Journal Year: 2025, Volume and Issue: 26(1)

Published: Jan. 15, 2025

Tris (2-chloroethyl) phosphate (TCEP), a widely used flame retardant, is widespread in the environment and potentially harmful to organisms. However, specific mechanisms of TCEP-induced neurological reproductive toxicity fish are largely unknown. Turbot (Scophthalmus maximus) cultivated on large scale, emergence pollutants with endocrine disrupting effects seriously affects its economic benefits. This study aimed investigate toxic TCEP turbot by integrating physio-biochemical transcriptomic analyses. exposure induced severe neuroendocrine turbot. Firstly, hormone levels luteinizing (LH), follicle-stimulating (FSH), estradiol (E2), 11-ketotestosterone (11-KT) were significantly decreased under prolonged stress, which may have negative impact normal function. We identified summarized representative differentially expressed genes (DEGs) their functions, such as system oxidative stress. Pathway enrichment showed that toxicological characteristics regulation disorders, including phosphorylation, apoptosis, steroid biosynthesis, GnRH signaling pathway so on. Weighted gene co-expression network analysis (WGCNA) also revealed key involved these pathways. Among genes, those encoding components electron transport chain presented an initial increase expression followed decrease, indicating stress might affect mitochondrial function lead cell damage. finding was supported upregulation apoptosis-related expression. Moreover, acute regulated MAPK-mediated transduction signaling, thereby altering hypothalamic-pituitary-gonadal (HPG) axis-related genes. These findings biomarkers related toxicity, providing early warning for monitoring healthy aquaculture.

Language: Английский

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Microcystin-LR induces histopathological injury and cell apoptosis in the hepatopancreas of white shrimp, Litopenaeus vannamei

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 285, P. 117059 - 117059

Published: Sept. 19, 2024

Language: Английский

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Transcriptomic analysis revealed the dynamic response mechanism to acute ammonia exposure in the ivory shell, Babylonia areolata

Fish & Shellfish Immunology, Journal Year: 2023, Volume and Issue: 143, P. 109198 - 109198

Published: Nov. 4, 2023

Language: Английский

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Integrating regular and transcriptomic analyses reveal resistance mechanisms in Corbicula fluminea (Müller, 1774) in response to toxic Microcystis aeruginosa exposure

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 251, P. 114553 - 114553

Published: Jan. 19, 2023

The frequent occurrence of cyanobacterial blooms (CYBs) caused by toxic Microcystis aeruginosa poses a great threat to aquatic organisms. Although freshwater benthic bivalves have proven be capable uptake high levels microcystins (MCs) due their filter-feeding habits, there is paucity information concerning systemic resistance mechanisms MCs. In this study, the in Corbicula fluminea (O. F. Müller, 1774) response exposure M. were explored through transcriptional analysis combined with histopathological and biochemical phenotypic analysis. Toxic dose-dependent histological damage hepatopancreas. conjugation reaction catalyzed glutathione S-transferases was vulnerable being activated concentrations (10 ×105 cells mL-1). Additionally, reactive oxygen species scavenging processes mediated superoxide dismutase catalase active initial stage exposure. results integrated biomarker index suggested that biotransformation antioxidant defense system C. could continuously after acute concentration aeruginosa. eggNOG GO differentially expressed genes (DEGs) indicated DEGs significantly enriched transporter activity, oxidant detoxification oxidative stress categories, which consistent alterations indices. Besides, annotated few KEGG pathways involved (oxidation, cooxidation conjugation) immunoreaction (lysosome phagosome responses), responsible for tolerance These findings improve our understanding potential

Language: Английский

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Microcystin-LR-induced autophagy via miR-282–5p/PIK3R1 pathway in Eriocheir sinensis hepatopancreas

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 267, P. 115661 - 115661

Published: Nov. 1, 2023

With the intensifying climate warming, blue-green algae blooms have become more frequent and severe, releasing environmental hazards such as microcystin that pose potential threats to human animal health. Autophagy has been shown play a crucial role in regulating immune responses induced by hazards, enabling cells adapt stress protect against damage. Although microcystin-LR (MC-LR) identified affect autophagy mammalian, its impact on aquatic animals poorly studied. To investigate toxicological effects of MC-LR ecosystems, we constructed microRNA profile acute hepatopancreas Chinese mitten crab. Interestingly, found exposure activated based following evidence. Specifically, mRNA expression level ATG7, Beclin1 Gabarap was significantly up-regulated, regulatory pathways were enriched, numerous autolysosomes autophagosomes observed. Additionally, miR-282-5p target gene PIK3R1 played important roles vivo vitro experiments. Overexpression mimicked MC-LR-induced inhibiting expression, while silencing inhibited promoting expression. Altogether, our findings suggest increases miR-282-5p, which then targets inhibition stimulate autophagy. This study focused response mechanisms juvenile crabs toxic pollutants water, offering for alleviating toxicity MC-LR. These lay foundation reducing organisms.

Language: Английский

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