New insights into the anticancer therapeutic potential of icaritin and its synthetic derivatives DOI
Octavio D. Reyes‐Hernández, Gabriela Figueroa‐González, Laura Itzel Quintas‐Granados

et al.

Drug Development Research, Journal Year: 2024, Volume and Issue: 85(2)

Published: April 1, 2024

Abstract Icaritin is a natural prenylated flavonoid derived from the Chinese herb Epimedium. The compound has shown antitumor effects in various cancers, especially hepatocellular carcinoma (HCC). exerts its anticancer activity by modulating multiple signaling pathways, such as IL‐6/JAK/STAT3, ER‐α36, and NF‐κB, affecting tumor microenvironment immune system. Several clinical trials have evaluated safety efficacy of icaritin advanced HCC patients with poor prognoses, who are unsuitable for conventional therapies. results demonstrated that can improve survival, delay progression, produce benefits these patients, favorable profile minimal adverse events. Moreover, enhance response regulating function phenotype cells, CD8+ T MDSCs, neutrophils, macrophages. These findings suggest promising candidate immunotherapy other cancers. However, further studies needed to elucidate molecular mechanisms optimal dosing regimens potential synergistic agents. Therefore, this comprehensive review scientific literature aims summarize advances knowledge preclinical well pharmacokinetic, metabolism, toxicity, action recognize main challenge, gaps, opportunities develop medication cancer use. Thus, our objective was clarify current state use an drug.

Language: Английский

Therapeutic Effects of Natural Products on Liver Cancer and Their Potential Mechanisms DOI Open Access
Jinhong Guo, Wenjie Yan,

Hao Duan

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(11), P. 1642 - 1642

Published: May 27, 2024

Liver cancer ranks third globally among causes of cancer-related deaths, posing a significant public health challenge. However, current treatments are inadequate, prompting growing demand for novel, safe, and effective therapies. Natural products (NPs) have emerged as promising candidates in drug development due to their diverse biological activities, low toxicity, minimal side effects. This paper begins by reviewing existing treatment methods drugs liver cancer. It then summarizes the therapeutic effects NPs sourced from various origins on Finally, we analyze potential mechanisms treating cancer, including inhibition angiogenesis, migration, invasion; regulation cell cycle; induction apoptosis, autophagy, pyroptosis, ferroptosis; influence tumor metabolism; immune regulation; intestinal function; key signaling pathways. systematic review aims provide comprehensive overview research treatment, offering foundation further application pharmaceuticals functional foods.

Language: Английский

Citations

10
Preparation and Evaluation of Chitosan Coated PLGA Nanoparticles Encapsulating Ivosidenib with Enhanced Cytotoxicity Against Human Liver Cancer Cells DOI Creative Commons
Bader B. Alsulays, Alhussain Aodah,

Mohammad Ahmed

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 3461 - 3473

Published: April 1, 2024

Purpose: Ivosidenib (IVO), an isocitrate dehydrogenase-1 (IDH1) used for treatment of acute myeloid leukemia (AML) and cholangiocarcinoma.However, poor solubility, low bioavailability, high dose side effects limit clinical application IVO.Methods: Ivosidenib-loaded PLGA nanoparticles (IVO-PLGA-NPs) chitosan coated (IVO-CS-PLGA-NPs) were prepared using emulsification solvent evaporation method the liver cancer. Results:The developed IVO-PLGA-NPs evaluated their particle size (171.7±4.9 nm), PDI (0.333), ZP (-23.0±5.8 mV), EE (96.3±4.3%), DL (9.66±1.1%);similarly, IVO-CS-PLGA-NPs (177.3±5.2 (0.311), +25.9±5.7 mV, (90.8±5.7%), (9.42±0.7%).The coating was evidenced by increase in mean positive value.Because coating, showed a more stable prolonged release IVO than IVO-PLGA-NPs.In comparison to pure-IVO, found be effective against HepG2 cells, with IC 50 values MTT assay being approximately half those pure-IVO.In expressions caspase-3, caspase-9, p53 significantly (p < 0.05) elevated.Conclusion: Overall, these findings suggest that improves delivery efficacy ivosidenib cancer treatment.

Language: Английский

Citations

9
Antitumor effects of BPCO on liver cancer cells DOI

Shan-Bin Li,

Tong-Shi-Yao Zhao,

Zhen Ye

et al.

Journal of Asian Natural Products Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13

Published: Feb. 22, 2025

Esculetin is a coumarin compound with anticancer, antioxidant, and anti-inflammatory activities. In this study, we synthesized an esculetin derivative, 6,7-bis(Pentyloxy)-2H-Chromen-2-One (BPCO), through etherification. BPCO inhibited the proliferation of HepG2 cells in dose- time-dependent manner. It also cell migration, promoted apoptosis, caused cycle arrest at G1 phase. Additionally, downregulated expression levels Bcl-2 Bcl-XL upregulated Bax Bak. This study shows that inhibits hepatocellular carcinoma induces providing basis for further as antitumor agent.

Language: Английский

Citations

1
Anticancer Potential of Natural Chalcones: In Vitro and In Vivo Evidence DOI Open Access
Radka Michalková, Ladislav Mirossay, Martin Kello

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(12), P. 10354 - 10354

Published: June 19, 2023

There is no doubt that significant progress has been made in tumor therapy the past decades. However, discovery of new molecules with potential antitumor properties still remains one most challenges field anticancer therapy. Nature, especially plants, a rich source phytochemicals pleiotropic biological activities. Among plethora phytochemicals, chalcones, bioprecursors flavonoid and isoflavonoids synthesis higher have attracted attention due to broad spectrum activities clinical applications. Regarding antiproliferative effects multiple mechanisms action including cell cycle arrest, induction different forms death modulation various signaling pathways documented. This review summarizes current knowledge related natural chalcones types malignancies breast cancers, cancers gastrointestinal tract, lung renal bladder melanoma.

Language: Английский

Citations

21
Immunotherapies for advanced hepatocellular carcinoma DOI Creative Commons
Li‐Yang Sun,

Kang-Jun Zhang,

Ya-Ming Xie

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: March 21, 2023

Primary liver cancer is the second leading cause of tumor-related deaths in China, with hepatocellular carcinoma (HCC) accounting for 80%–90% these. Since there a lack symptoms early stages HCC, large proportion patients were identified unresectable HCC when diagnosed. Due to severe resistance chemotherapy, advanced traditionally treated systematic therapy past decades, and tyrosine kinase inhibitor (TKI) sorafenib has remained only treatment option since 2008. Immunotherapies, particularly immune checkpoint inhibitors (ICIs), have shown strong anti-tumor effect been supported by several guidelines recently. ICIs, example programmed cell death-1 (PD-1) such as nivolumab pembrolizumab, death ligand 1 (PD-L1) atezolizumab, cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) ipilimumab, ICI-based combination TKIs, VEGF-neutralizing antibody or local therapies, are being further studied clinical trials. However, immune-related adverse events (irAEs) including cutaneous toxicity, gastrointestinal hepatotoxicity may lead termination ICI even threaten patients’ lives. This review aims summarize currently available immunotherapies introduce irAEs their managements order provide references application research.

Language: Английский

Citations

18
Cepharanthine, a regulator of keap1-Nrf2, inhibits gastric cancer growth through oxidative stress and energy metabolism pathway DOI Creative Commons
Yangyang Lu,

Chunyang Zhu,

Yixin Ding

et al.

Cell Death Discovery, Journal Year: 2023, Volume and Issue: 9(1)

Published: Dec. 12, 2023

Cepharanthine (CEP), a bioactive compound derived from Stephania Cephalantha Hayata, is cytotoxic to various malignancies. However, the underlying mechanism of gastric cancer unknown. CEP inhibited cellular activity AGS, HGC27 and MFC cell lines in this study. CEP-induced apoptosis reduced Bcl-2 expression increased cleaved caspase 3, 9, Bax, Bad expression. caused G2 cycle arrest cyclin D1 cyclin-dependent kinases 2 (CDK2) Meanwhile, it oxidative stress, decreased mitochondrial membrane potential, enhanced reactive oxygen species (ROS) accumulation lines. Mechanistically, Kelch-like ECH-associated protein (Keap1) while activating NF-E2 related factor (Nrf2) nuclear translocations, increasing transcription Nrf2 target genes quinone oxidoreductase 1 (NQO1), heme oxygenase (HMOX1), glutamate-cysteine ligase modifier subunit (GCLM). Furthermore, combined analysis targeted energy metabolism RNA sequencing revealed that could alter levels metabolic substances such as D (+) - Glucose, D-Fructose 6-phosphate, citric acid, succinic pyruvic thereby altering AGS cells. In addition, significantly tumor growth BALB/c nude mice vivo, consistent with vitro findings. Overall, can induce stress by regulating Nrf2/Keap1 metabolism, resulting anti-gastric effects. Our findings suggest potential application treatment.

Language: Английский

Citations

17
The pharmacological properties of Gypsophila eriocalyx: The endemic medicinal plant of northern central Turkey DOI
Merve İnanır, Esra Uçar, Burak Tüzün

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 266, P. 130943 - 130943

Published: March 22, 2024

Language: Английский

Citations

8
Pathogenic Th17 cell-mediated liver fibrosis contributes to resistance to PD-L1 antibody immunotherapy in hepatocellular carcinoma DOI

Meiying Song,

Luoyang Wang,

Suli Jiang

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 129, P. 111601 - 111601

Published: Feb. 13, 2024

Language: Английский

Citations

7
A comprehensive review of phytoconstituents in liver cancer prevention and treatment: targeting insights into molecular signaling pathways DOI
Md. Rezaul Islam, Abdur Rauf,

Shopnil Alash

et al.

Medical Oncology, Journal Year: 2024, Volume and Issue: 41(6)

Published: May 4, 2024

Language: Английский

Citations

7
Recent Progress in Understanding the Action of Natural Compounds at Novel Therapeutic Drug Targets for the Treatment of Liver Cancer DOI Creative Commons

Yannan Zheng,

Wenhui Zhang, Lin Xu

et al.

Frontiers in Oncology, Journal Year: 2022, Volume and Issue: 11

Published: Jan. 26, 2022

Liver cancer is the third most common cause of cancer-related death following lung and stomach cancers. As a highly lethal disease, liver diagnosed frequently in less developed countries. Natural compounds extracted from herbs, animals natural materials have been adopted by traditional Chinese medicine (TCM) practices reported to be effective development new medications for treatment diseases. It important focus on mechanisms action against hepatocellular carcinoma (HCC), particularly terms cell cycle regulation, apoptosis induction, autophagy mediation migration invasion. In this review, we characterize novel representative according their pharmacologic effects based recently published studies. The aim review summarize explore therapeutic drug targets compounds, which could accelerate discovery anticancer drugs.

Language: Английский

Citations

28