Nanomaterials for Nanotheranostics: Tuning Their Properties According to Disease Needs DOI
Xin Yi Wong, Amadeo Sena‐Torralba, Ruslán Álvarez-Diduk

et al.

ACS Nano, Journal Year: 2020, Volume and Issue: 14(3), P. 2585 - 2627

Published: Feb. 7, 2020

Nanotheranostics is one of the biggest scientific breakthroughs in nanomedicine. Most currently available diagnosis and therapies are invasive, time-consuming, associated with severe toxic side effects. Nanotheranostics, on other hand, has potential to bridge this gap by harnessing capabilities nanotechnology nanomaterials for combined therapeutics diagnostics markedly enhanced efficacy. However, nanomaterial applications nanotheranostics still its infancy. This due fact that each disease a particular microenvironment well-defined characteristics, which promotes deeper selection criteria meet needs. In review, we have outlined how designed tailored cancer diseases such as neurodegenerative, autoimmune (particularly rheumatoid arthritis), cardiovascular diseases. The penetrability retention biological system, therapeutic strategy used, imaging mode selected some aspects discussed disease. specific properties terms feasibility, physicochemical challenges, progress clinical trials, toxicity, their future application translational medicine addressed. Our review meticulously critically examines various nanomaterials, including graphene, across several diseases, offering broader perspective emerging field.

Language: Английский

Clinical development and potential of photothermal and photodynamic therapies for cancer DOI
Xingshu Li, Jonathan F. Lovell, Juyoung Yoon

et al.

Nature Reviews Clinical Oncology, Journal Year: 2020, Volume and Issue: 17(11), P. 657 - 674

Published: July 22, 2020

Language: Английский

Citations

2548

Versatile Polydopamine Platforms: Synthesis and Promising Applications for Surface Modification and Advanced Nanomedicine DOI
Wei Cheng, Xiaowei Zeng, Hongzhong Chen

et al.

ACS Nano, Journal Year: 2019, Volume and Issue: 13(8), P. 8537 - 8565

Published: Aug. 1, 2019

As a mussel-inspired material, polydopamine (PDA), possesses many properties, such as simple preparation process, good biocompatibility, strong adhesive property, easy functionalization, outstanding photothermal conversion efficiency, and quenching effect. PDA has attracted increasingly considerable attention because it provides versatile approach to functionalize material surfaces for obtaining variety of multifunctional nanomaterials. In this review, recent significant research developments including its synthesis polymerization mechanism, physicochemical different nano/microstructures, diverse applications are summarized discussed. For the sections in surface modification biomedicine, we mainly highlight achievements past few years (2016–2019). The remaining challenges future perspectives PDA-based nanoplatforms discussed rationally at end. This timely overall review should be desirable wide range scientists facilitate further development coating methods production materials.

Language: Английский

Citations

849

Advanced Fluorescence Imaging Technology in the Near-Infrared-II Window for Biomedical Applications DOI
Chunyan Li, Guangcun Chen, Yejun Zhang

et al.

Journal of the American Chemical Society, Journal Year: 2020, Volume and Issue: 142(35), P. 14789 - 14804

Published: Aug. 7, 2020

Fluorescence imaging has become a fundamental tool for biomedical applications; nevertheless, its intravital capacity in the conventional wavelength range (400–950 nm) been restricted by extremely limited tissue penetration. To tackle this challenge, novel approach using fluorescence second near-infrared window (NIR-II, 1000–1700 developed past decade to achieve deep penetration and high-fidelity imaging, thus significant applications have begun emerge. In Perspective, we first examine recent discoveries challenges development of NIR-II fluorophores compatible apparatuses. Subsequently, advances bioimaging, biosensing, therapy such cutting-edge technique are highlighted. Finally, based on achievement representative studies, elucidate main concerns regarding give some advice prospects future applications.

Language: Английский

Citations

778

Photothermal Nanomaterials: A Powerful Light-to-Heat Converter DOI Creative Commons
Ximin Cui, Qifeng Ruan, Xiaolu Zhuo

et al.

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(11), P. 6891 - 6952

Published: May 3, 2023

All forms of energy follow the law conservation energy, by which they can be neither created nor destroyed. Light-to-heat conversion as a traditional yet constantly evolving means converting light into thermal has been enduring appeal to researchers and public. With continuous development advanced nanotechnologies, variety photothermal nanomaterials have endowed with excellent harvesting capabilities for exploring fascinating prospective applications. Herein we review latest progresses on nanomaterials, focus their underlying mechanisms powerful light-to-heat converters. We present an extensive catalogue nanostructured materials, including metallic/semiconductor structures, carbon organic polymers, two-dimensional materials. The proper material selection rational structural design improving performance are then discussed. also provide representative overview techniques probing photothermally generated heat at nanoscale. finally recent significant developments applications give brief outlook current challenges future directions nanomaterials.

Language: Английский

Citations

772

Second near-infrared photothermal materials for combinational nanotheranostics DOI
Cheng Xu, Kanyi Pu

Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 50(2), P. 1111 - 1137

Published: Nov. 27, 2020

This review summarizes the recent development of second near-infrared photothermal combinational nanotheranostics for cancer, infectious diseases and regenerative medicine.

Language: Английский

Citations

724

Design of superior phototheranostic agents guided by Jablonski diagrams DOI
Guangxue Feng, Guoqiang Zhang, Dan Ding

et al.

Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 49(22), P. 8179 - 8234

Published: Jan. 1, 2020

Phototheranostics represents a promising direction for modern precision medicine, which has recently attracted great research interest from multidisciplinary areas. Organic optical agents including small molecular fluorophores, semiconducting/conjugated polymers, aggregation-induced emission luminogens, etc. with tuneable photophysical properties, high biosafety and biocompatibility, facile processability ease of functionalization have delivered encouraging performance in disease phototheranostics. This review summarizes the recent progress organic phototheranostic an emphasis on main strategies to manipulate three excitation energy dissipation pathways, namely, radiative decay, thermal deactivation, intersystem crossing, assistance Jablonski diagram, particularly showcases how diagram been guiding design molecule aggregate levels promote outcomes. Molecular nanoengineering modulate processes convert absorbed photons into fluorescent/phosphorescent/photoacoustic signals and/or photodynamic/photothermal curing effects improved phototheranostics are elaborated. Noteworthily, adaptive activatable transformable functions demand, regulation such as chemiexcitation efficacies also included. A brief summary discussion current challenges future perspectives this field is further presented.

Language: Английский

Citations

584

Insights into the Photothermal Conversion of 2D MXene Nanomaterials: Synthesis, Mechanism, and Applications DOI

Dingxin Xu,

Zhidong Li, Laisheng Li

et al.

Advanced Functional Materials, Journal Year: 2020, Volume and Issue: 30(47)

Published: April 22, 2020

Abstract Since their discovery in 2011, 2D transition metal carbide/nitride (MXene) materials have received extensive interest due to unique planar structure, chemical diversity, and superior physiochemical features. Very recently, MXenes demonstrated outstanding photothermal conversion by virtue of excellent electromagnetic wave absorption capacity a localized surface plasmon resonance effect. Photothermal is an efficient way utilize solar energy that allows the transformation illumination into thermal energy, thus enabling be applied various fields, such as steam generation biomedicals. However, light‐to‐heat capability has been paid much less attention until now. Recent progress reviewed provide comprehensive understanding mechanism applications. First, synthetic strategies nanocomposites will briefly summarized, discussion and, most importantly, current advances applications follow. It highly anticipated MXenes, through elaborate material design interdisciplinary approach, become one mainstream application fields also expanded near future.

Language: Английский

Citations

580

Molecular Motion in Aggregates: Manipulating TICT for Boosting Photothermal Theranostics DOI

Shunjie Liu,

Xin Zhou, Haoke Zhang

et al.

Journal of the American Chemical Society, Journal Year: 2019, Volume and Issue: 141(13), P. 5359 - 5368

Published: March 13, 2019

Planar donor and acceptor (D–A) conjugated structures are generally believed to be the standard for architecting highly efficient photothermal theranostic agents, in order restrict intramolecular motions aggregates (nanoparticles). However, other channels of extra nonradiative decay may blocked. Now this challenge is addressed by proposing an "abnormal" strategy based on molecular motion aggregates. Molecular rotors bulky alkyl chains grafted central D–A core lower intermolecular interaction. The enhanced favors formation a dark twisted charge transfer state, whose enhances properties. Result shows that small-molecule NIRb14 with long branched at second carbon exhibits properties compared NIRb6, short chains, much higher than NIR6, linear commercial gold nanorods. Both vitro vivo experiments demonstrate nanoparticles can used as nanoagents photoacoustic imaging-guided therapy. Moreover, reversal poly(β-amino ester) makes specifically accumulate tumor sites. This study thus provides excited approach toward phototheranostic agents.

Language: Английский

Citations

570

Biomedicine Meets Fenton Chemistry DOI
Zhongmin Tang, Peiran Zhao, Han Wang

et al.

Chemical Reviews, Journal Year: 2021, Volume and Issue: 121(4), P. 1981 - 2019

Published: Jan. 25, 2021

Since the first connection between Fenton chemistry and biomedicine, numerous studies have been presented in this field. Comprehensive presentation of guidance from a summary its representative applications cancer therapy would help us understand promote further development This comprehensive review supplies basic information regarding chemistry, including reactions Fenton-like reactions. Subsequently, current progress is discussed, with some corresponding examples presented. Furthermore, strategies for optimizing performance chemodynamic guided by are highlighted. Most importantly, future perspectives on combination biomedicine or wider range catalytic approaches We hope that will attract positive attention materials science, fields tighten their connections.

Language: Английский

Citations

563

NIR Light‐Driving Barrier‐Free Group Rotation in Nanoparticles with an 88.3% Photothermal Conversion Efficiency for Photothermal Therapy DOI
Dongmei Xi, Ming Xiao, Jianfang Cao

et al.

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(11)

Published: Feb. 5, 2020

Abstract Traditional photothermal therapy requires high‐intensity laser excitation for cancer treatments due to the low conversion efficiency (PCE) of agents (PTAs). PTAs with ultra‐high PCEs can decrease required excited light intensity, which allows safe and efficient in deep tissues. In this work, a PTA is synthesized high PCE 88.3% based on BODIPY scaffold, by introducing CF 3 “barrier‐free” rotor meso ‐position (tfm‐BDP). both ground state, moiety tfm‐BDP has no energy barrier rotation, allowing it efficiently dissipate absorbed (NIR) photons as heat. Importantly, barrier‐free rotation be maintained after encapsulating into polymeric nanoparticles (NPs). Thus, irradiation intensity (0.3 W cm −2 , 808 nm) lead complete tumor ablation tumor‐bearing mice intravenous injection NPs. This strategy “barrier‐free rotation” provides new platform future design PTT clinical treatment.

Language: Английский

Citations

553