ACS Nano,
Journal Year:
2020,
Volume and Issue:
14(3), P. 2585 - 2627
Published: Feb. 7, 2020
Nanotheranostics
is
one
of
the
biggest
scientific
breakthroughs
in
nanomedicine.
Most
currently
available
diagnosis
and
therapies
are
invasive,
time-consuming,
associated
with
severe
toxic
side
effects.
Nanotheranostics,
on
other
hand,
has
potential
to
bridge
this
gap
by
harnessing
capabilities
nanotechnology
nanomaterials
for
combined
therapeutics
diagnostics
markedly
enhanced
efficacy.
However,
nanomaterial
applications
nanotheranostics
still
its
infancy.
This
due
fact
that
each
disease
a
particular
microenvironment
well-defined
characteristics,
which
promotes
deeper
selection
criteria
meet
needs.
In
review,
we
have
outlined
how
designed
tailored
cancer
diseases
such
as
neurodegenerative,
autoimmune
(particularly
rheumatoid
arthritis),
cardiovascular
diseases.
The
penetrability
retention
biological
system,
therapeutic
strategy
used,
imaging
mode
selected
some
aspects
discussed
disease.
specific
properties
terms
feasibility,
physicochemical
challenges,
progress
clinical
trials,
toxicity,
their
future
application
translational
medicine
addressed.
Our
review
meticulously
critically
examines
various
nanomaterials,
including
graphene,
across
several
diseases,
offering
broader
perspective
emerging
field.
ACS Nano,
Journal Year:
2019,
Volume and Issue:
13(8), P. 8537 - 8565
Published: Aug. 1, 2019
As
a
mussel-inspired
material,
polydopamine
(PDA),
possesses
many
properties,
such
as
simple
preparation
process,
good
biocompatibility,
strong
adhesive
property,
easy
functionalization,
outstanding
photothermal
conversion
efficiency,
and
quenching
effect.
PDA
has
attracted
increasingly
considerable
attention
because
it
provides
versatile
approach
to
functionalize
material
surfaces
for
obtaining
variety
of
multifunctional
nanomaterials.
In
this
review,
recent
significant
research
developments
including
its
synthesis
polymerization
mechanism,
physicochemical
different
nano/microstructures,
diverse
applications
are
summarized
discussed.
For
the
sections
in
surface
modification
biomedicine,
we
mainly
highlight
achievements
past
few
years
(2016–2019).
The
remaining
challenges
future
perspectives
PDA-based
nanoplatforms
discussed
rationally
at
end.
This
timely
overall
review
should
be
desirable
wide
range
scientists
facilitate
further
development
coating
methods
production
materials.
Journal of the American Chemical Society,
Journal Year:
2020,
Volume and Issue:
142(35), P. 14789 - 14804
Published: Aug. 7, 2020
Fluorescence
imaging
has
become
a
fundamental
tool
for
biomedical
applications;
nevertheless,
its
intravital
capacity
in
the
conventional
wavelength
range
(400–950
nm)
been
restricted
by
extremely
limited
tissue
penetration.
To
tackle
this
challenge,
novel
approach
using
fluorescence
second
near-infrared
window
(NIR-II,
1000–1700
developed
past
decade
to
achieve
deep
penetration
and
high-fidelity
imaging,
thus
significant
applications
have
begun
emerge.
In
Perspective,
we
first
examine
recent
discoveries
challenges
development
of
NIR-II
fluorophores
compatible
apparatuses.
Subsequently,
advances
bioimaging,
biosensing,
therapy
such
cutting-edge
technique
are
highlighted.
Finally,
based
on
achievement
representative
studies,
elucidate
main
concerns
regarding
give
some
advice
prospects
future
applications.
Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
123(11), P. 6891 - 6952
Published: May 3, 2023
All
forms
of
energy
follow
the
law
conservation
energy,
by
which
they
can
be
neither
created
nor
destroyed.
Light-to-heat
conversion
as
a
traditional
yet
constantly
evolving
means
converting
light
into
thermal
has
been
enduring
appeal
to
researchers
and
public.
With
continuous
development
advanced
nanotechnologies,
variety
photothermal
nanomaterials
have
endowed
with
excellent
harvesting
capabilities
for
exploring
fascinating
prospective
applications.
Herein
we
review
latest
progresses
on
nanomaterials,
focus
their
underlying
mechanisms
powerful
light-to-heat
converters.
We
present
an
extensive
catalogue
nanostructured
materials,
including
metallic/semiconductor
structures,
carbon
organic
polymers,
two-dimensional
materials.
The
proper
material
selection
rational
structural
design
improving
performance
are
then
discussed.
also
provide
representative
overview
techniques
probing
photothermally
generated
heat
at
nanoscale.
finally
recent
significant
developments
applications
give
brief
outlook
current
challenges
future
directions
nanomaterials.
Chemical Society Reviews,
Journal Year:
2020,
Volume and Issue:
50(2), P. 1111 - 1137
Published: Nov. 27, 2020
This
review
summarizes
the
recent
development
of
second
near-infrared
photothermal
combinational
nanotheranostics
for
cancer,
infectious
diseases
and
regenerative
medicine.
Chemical Society Reviews,
Journal Year:
2020,
Volume and Issue:
49(22), P. 8179 - 8234
Published: Jan. 1, 2020
Phototheranostics
represents
a
promising
direction
for
modern
precision
medicine,
which
has
recently
attracted
great
research
interest
from
multidisciplinary
areas.
Organic
optical
agents
including
small
molecular
fluorophores,
semiconducting/conjugated
polymers,
aggregation-induced
emission
luminogens,
etc.
with
tuneable
photophysical
properties,
high
biosafety
and
biocompatibility,
facile
processability
ease
of
functionalization
have
delivered
encouraging
performance
in
disease
phototheranostics.
This
review
summarizes
the
recent
progress
organic
phototheranostic
an
emphasis
on
main
strategies
to
manipulate
three
excitation
energy
dissipation
pathways,
namely,
radiative
decay,
thermal
deactivation,
intersystem
crossing,
assistance
Jablonski
diagram,
particularly
showcases
how
diagram
been
guiding
design
molecule
aggregate
levels
promote
outcomes.
Molecular
nanoengineering
modulate
processes
convert
absorbed
photons
into
fluorescent/phosphorescent/photoacoustic
signals
and/or
photodynamic/photothermal
curing
effects
improved
phototheranostics
are
elaborated.
Noteworthily,
adaptive
activatable
transformable
functions
demand,
regulation
such
as
chemiexcitation
efficacies
also
included.
A
brief
summary
discussion
current
challenges
future
perspectives
this
field
is
further
presented.
Advanced Functional Materials,
Journal Year:
2020,
Volume and Issue:
30(47)
Published: April 22, 2020
Abstract
Since
their
discovery
in
2011,
2D
transition
metal
carbide/nitride
(MXene)
materials
have
received
extensive
interest
due
to
unique
planar
structure,
chemical
diversity,
and
superior
physiochemical
features.
Very
recently,
MXenes
demonstrated
outstanding
photothermal
conversion
by
virtue
of
excellent
electromagnetic
wave
absorption
capacity
a
localized
surface
plasmon
resonance
effect.
Photothermal
is
an
efficient
way
utilize
solar
energy
that
allows
the
transformation
illumination
into
thermal
energy,
thus
enabling
be
applied
various
fields,
such
as
steam
generation
biomedicals.
However,
light‐to‐heat
capability
has
been
paid
much
less
attention
until
now.
Recent
progress
reviewed
provide
comprehensive
understanding
mechanism
applications.
First,
synthetic
strategies
nanocomposites
will
briefly
summarized,
discussion
and,
most
importantly,
current
advances
applications
follow.
It
highly
anticipated
MXenes,
through
elaborate
material
design
interdisciplinary
approach,
become
one
mainstream
application
fields
also
expanded
near
future.
Journal of the American Chemical Society,
Journal Year:
2019,
Volume and Issue:
141(13), P. 5359 - 5368
Published: March 13, 2019
Planar
donor
and
acceptor
(D–A)
conjugated
structures
are
generally
believed
to
be
the
standard
for
architecting
highly
efficient
photothermal
theranostic
agents,
in
order
restrict
intramolecular
motions
aggregates
(nanoparticles).
However,
other
channels
of
extra
nonradiative
decay
may
blocked.
Now
this
challenge
is
addressed
by
proposing
an
"abnormal"
strategy
based
on
molecular
motion
aggregates.
Molecular
rotors
bulky
alkyl
chains
grafted
central
D–A
core
lower
intermolecular
interaction.
The
enhanced
favors
formation
a
dark
twisted
charge
transfer
state,
whose
enhances
properties.
Result
shows
that
small-molecule
NIRb14
with
long
branched
at
second
carbon
exhibits
properties
compared
NIRb6,
short
chains,
much
higher
than
NIR6,
linear
commercial
gold
nanorods.
Both
vitro
vivo
experiments
demonstrate
nanoparticles
can
used
as
nanoagents
photoacoustic
imaging-guided
therapy.
Moreover,
reversal
poly(β-amino
ester)
makes
specifically
accumulate
tumor
sites.
This
study
thus
provides
excited
approach
toward
phototheranostic
agents.
Chemical Reviews,
Journal Year:
2021,
Volume and Issue:
121(4), P. 1981 - 2019
Published: Jan. 25, 2021
Since
the
first
connection
between
Fenton
chemistry
and
biomedicine,
numerous
studies
have
been
presented
in
this
field.
Comprehensive
presentation
of
guidance
from
a
summary
its
representative
applications
cancer
therapy
would
help
us
understand
promote
further
development
This
comprehensive
review
supplies
basic
information
regarding
chemistry,
including
reactions
Fenton-like
reactions.
Subsequently,
current
progress
is
discussed,
with
some
corresponding
examples
presented.
Furthermore,
strategies
for
optimizing
performance
chemodynamic
guided
by
are
highlighted.
Most
importantly,
future
perspectives
on
combination
biomedicine
or
wider
range
catalytic
approaches
We
hope
that
will
attract
positive
attention
materials
science,
fields
tighten
their
connections.
Advanced Materials,
Journal Year:
2020,
Volume and Issue:
32(11)
Published: Feb. 5, 2020
Abstract
Traditional
photothermal
therapy
requires
high‐intensity
laser
excitation
for
cancer
treatments
due
to
the
low
conversion
efficiency
(PCE)
of
agents
(PTAs).
PTAs
with
ultra‐high
PCEs
can
decrease
required
excited
light
intensity,
which
allows
safe
and
efficient
in
deep
tissues.
In
this
work,
a
PTA
is
synthesized
high
PCE
88.3%
based
on
BODIPY
scaffold,
by
introducing
CF
3
“barrier‐free”
rotor
meso
‐position
(tfm‐BDP).
both
ground
state,
moiety
tfm‐BDP
has
no
energy
barrier
rotation,
allowing
it
efficiently
dissipate
absorbed
(NIR)
photons
as
heat.
Importantly,
barrier‐free
rotation
be
maintained
after
encapsulating
into
polymeric
nanoparticles
(NPs).
Thus,
irradiation
intensity
(0.3
W
cm
−2
,
808
nm)
lead
complete
tumor
ablation
tumor‐bearing
mice
intravenous
injection
NPs.
This
strategy
“barrier‐free
rotation”
provides
new
platform
future
design
PTT
clinical
treatment.