Recent progress in development of siRNA delivery vehicles for cancer therapy

Advanced Drug Delivery Reviews, Journal Year: 2016, Volume and Issue: 104, P. 61 - 77

Published: June 26, 2016

Language: Английский

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Smart chemistry-based nanosized drug delivery systems for systemic applications: A comprehensive review

Journal of Controlled Release, Journal Year: 2017, Volume and Issue: 258, P. 226 - 253

Published: May 2, 2017

Language: Английский

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Advances in drug delivery systems, challenges and future directions

Heliyon, Journal Year: 2023, Volume and Issue: 9(6), P. e17488 - e17488

Published: June 1, 2023

Advances in molecular pharmacology and an improved understanding of the mechanism most diseases have created need to specifically target cells involved initiation progression diseases. This is especially true for life-threatening requiring therapeutic agents which numerous side effects, thus accurate tissue targeting minimize systemic exposure. Recent drug delivery systems (DDS) are formulated using advanced technology accelerate specific site, maximizing efficacy minimizing off-target accumulation body. As a result, they play important role disease management treatment. DDS offer greater advantages when compared conventional due their enhanced performance, automation, precision, efficacy. They made nanomaterials or miniaturized devices with multifunctional components that biocompatible, biodegradable, high viscoelasticity extended circulating half-life. review, therefore, provides comprehensive insight into history technological advancement systems. It updates recent systems, applications, challenges associated use, future directions performance use.

Language: Английский

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Asymmetric organocatalysis: an enabling technology for medicinal chemistry

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(3), P. 1522 - 1586

Published: Jan. 1, 2021

This review provides a comprehensive overview of the recent applications organocatalytic strategies in pharmaceutical synthesis, with focus on preparation antiviral, anticancer, neuroprotective, cardiovascular, antibacterial and antiparasitic agents.

Language: Английский

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Advances in Nanomaterial-Mediated Photothermal Cancer Therapies: Toward Clinical Applications

Biomedicines, Journal Year: 2021, Volume and Issue: 9(3), P. 305 - 305

Published: March 16, 2021

Photothermal therapy (PTT) has attracted extensive research attention as a noninvasive and selective treatment strategy for numerous cancers. PTT functions via photothermal effects induced by converting light energy into heat on near-infrared laser irradiation. Despite the great advances in cancer treatment, therapeutics using devise only or non-specific small molecule agents been limited because of its low conversion efficiency, concerns about biosafety agents, their tumor accumulation, resistance specific types cancer. Using nanomaterials themselves, delivery offers improved therapeutic outcomes with fewer side through enhanced accumulation agent tissue, and, extension, combination other therapies. Herein, we review PTT’s current clinical progress present future outlooks applications. To better understand applications, describe nanomaterial-mediated mechanism action microenvironment. This also summarizes recent studies alone Overall, innovative strategically designed platforms are promising next-generation treatments to move closer toward

Language: Английский

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Nanocarriers for drug delivery applications

Environmental Chemistry Letters, Journal Year: 2018, Volume and Issue: 17(2), P. 849 - 865

Published: Nov. 21, 2018

Language: Английский

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Noble Metal Nanomaterials for NIR‐Triggered Photothermal Therapy in Cancer

Advanced Healthcare Materials, Journal Year: 2021, Volume and Issue: 10(6)

Published: Jan. 20, 2021

Abstract It is of great significance to develop anticancer therapeutic agents or technologies with high degree specificity and patient compliance, while low toxicity. The emerging photothermal therapy (PTT) has become a new powerful technology due its noninvasiveness, specificity, side effects normal tissues strong efficacy. Noble metal nanomaterials possess surface plasmon resonance (SPR) effect synthetic tunability, which make them facile effective PTT superior optical characteristics, such as absorption cross‐section, incomparable optical‐thermal conversion efficiency in the near infrared (NIR) region, well potential bioimaging. By incorporating various functional reagents antibodies, peptides, biocompatible polymers, chemo‐drug immune factors, noble have presented multifunctional cancer therapy. Herein, recent development regarding application for NIR‐triggered treatment summarized. A variety studies good against from impressive efficacy are concluded. Intelligent nanoplatforms through ingenious fabrication showing PTT, combined chemo‐therapy, immunotherapy, photodynamic (PDT), simultaneous imaging modality also demonstrated.

Language: Английский

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Polymerization Reactions and Modifications of Polymers by Ionizing Radiation

Polymers, Journal Year: 2020, Volume and Issue: 12(12), P. 2877 - 2877

Published: Nov. 30, 2020

Ionizing radiation has become the most effective way to modify natural and synthetic polymers through crosslinking, degradation, graft polymerization. This review will include an in-depth analysis of chemistry mechanisms kinetics radiation-induced C-centered free radical, anion, cation polymerization, grafting. It also presents sections on modifications polymers. For decades, low linear energy transfer (LLET) ionizing radiation, such as gamma rays, X-rays, up 10 MeV electron beams, been primary tool produce many products polymerization reactions. Photons electrons interaction with display various mechanisms. While interactions ray X-ray photons are mainly photoelectric effect, Compton scattering, pair-production, high-energy take place coulombic interactions. Despite type used materials, or high electrons, in both cases ions produced. The between monomers takes within less than a nanosecond. Depending dose rate (dose is defined absorbed per unit mass), kinetic chain length propagation can be controlled, hence allowing for some control over degree When submitted bulk, contrasting behaviors observed dominant effect cross-linking scission, depending chemical nature physical characteristics material. Polymers solution subject indirect effects resulting from radiolysis medium. Likewise, rate, radicals generated polymer chains undergo reactions, inter/intramolecular combination disproportionation, b-scission. These reactions lead structural functional modifications. In presence oxygen, playing irradiation dose-rates, one favor crosslinking promotes degradations oxidations. competition their oxygen described fundamental mechanism formalisms. fundamentals herein presented meet industrial needs materials produced degraded by irradiation. Notably, medical applications endless thus it vital investigate sterilization copolymers different molecular structures morphologies. absence groups, crystallinity, temperature, etc. all greatly affect irradiated Over past decade, grafting new functionalities solid (also called RIG Radiation-Induced Grafting) widely exploited develop innovative coherence actual societal expectations. novel respond not only health emergencies but carbon-free (e.g., hydrogen fuel cells, piezoelectricity, etc.) environmental concerns development numerous specific adsorbents hazards pollutants. modification durable covalently bonds monomers. As penetration depths varied, this technique surface bulk. parameters influencing that yield process discussed review. monomer reactivity, dose, solvent, inhibitor homopolymerization, Today, general knowledge applied any may predict, extent, location. A special focus how sources (ion UVs) chosen mixed combine nanostructuration RIG. LLET extensively synthesize hydrogel nanogel drug delivery systems other advanced applications. particular, nanogels either simultaneous hydrophilic “nanocompartments”, i.e., aqueous phase inverse micelles, intramolecular suitable water-soluble radiolytically oxidizing species water, •OH radicals, easily abstract H-atoms backbone dissolved (or add unsaturated bonds) leading formation radicals. two main competitive reactions; intermolecular crosslinking. beam irradiation, higher temperatures, rates pulse, pulse repetition favour enabling better particle size distribution. biopolymers polysaccharides, proteins, DNA RNA, abstraction H atoms addition unsaturation direct scission backbone, double, single strand breaks these

Language: Английский

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Nanotechnology for Cancer Therapy Based on Chemotherapy

Molecules, Journal Year: 2018, Volume and Issue: 23(4), P. 826 - 826

Published: April 4, 2018

Chemotherapy has been widely applied in clinics. However, the therapeutic potential of chemotherapy against cancer is seriously dissatisfactory due to nonspecific drug distribution, multidrug resistance (MDR) and heterogeneity cancer. Therefore, combinational therapy based on mediated by nanotechnology, trend clinical research at present, which can result a remarkably increased efficiency with few side effects normal tissues. Moreover, achieve accurate pre-diagnosis real-time monitoring for tumor, nano-theranostics, integrates diagnosis treatment process, promising field treatment. In this review, recent studies will be systematically discussed. Furthermore, as current treatment, advance theranostic nanoparticles exemplified briefly. Finally, present challenges improvement tips presented combination nano-theranostics.

Language: Английский

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Nanotherapeutics: An insight into healthcare and multi-dimensional applications in medical sector of the modern world

Biomedicine & Pharmacotherapy, Journal Year: 2017, Volume and Issue: 97, P. 1521 - 1537

Published: Nov. 21, 2017

Language: Английский

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