Clinical development and potential of photothermal and photodynamic therapies for cancer

Nature Reviews Clinical Oncology, Journal Year: 2020, Volume and Issue: 17(11), P. 657 - 674

Published: July 22, 2020

Language: Английский

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Nanomaterials for cancer therapy: current progress and perspectives

Journal of Hematology & Oncology, Journal Year: 2021, Volume and Issue: 14(1)

Published: May 31, 2021

Abstract Cancer is a disease with complex pathological process. Current chemotherapy faces problems such as lack of specificity, cytotoxicity, induction multi-drug resistance and stem-like cells growth. Nanomaterials are materials in the nanorange 1–100 nm which possess unique optical, magnetic, electrical properties. used cancer therapy can be classified into several main categories. Targeting cells, tumor microenvironment, immune system, these nanomaterials have been modified for wide range therapies to overcome toxicity enhance drug capacity well bioavailability. Although number studies has increasing, approved nano-drugs not increased much over years. To better improve clinical translation, further research needed targeted delivery by nano-carriers reduce toxicity, permeability retention effects, minimize shielding effect protein corona. This review summarizes novel fabricated use, discusses current limitations obstacles that hinder translation from provides suggestions more efficient adoption therapy.

Language: Английский

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Nanoparticle Surface Functionalization: How to Improve Biocompatibility and Cellular Internalization

Frontiers in Molecular Biosciences, Journal Year: 2020, Volume and Issue: 7

Published: Nov. 26, 2020

The use of nanoparticles (NP) in diagnosis and treatment many human diseases, including cancer, is increasing interest. However, cytotoxic effects NPs on cells the uptake efficiency significantly limit their clinical practice. physico-chemical properties surface composition, superficial charge, size shape are considered key factors that affect biocompatibility these nanoplatforms. Thanks to possibility modifying NPs, it possible improve through functionalization NP surface. In this review, we summarize some most recent studies which modification enhances uptake. Furthermore, used techniques assess also reported.

Language: Английский

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Progressing nanotechnology to improve targeted cancer treatment: overcoming hurdles in its clinical implementation

Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)

Published: Oct. 9, 2023

Abstract The use of nanotechnology has the potential to revolutionize detection and treatment cancer. Developments in protein engineering materials science have led emergence new nanoscale targeting techniques, which offer renewed hope for cancer patients. While several nanocarriers medicinal purposes been approved human trials, only a few authorized clinical cells. In this review, we analyze some formulations discuss challenges translating findings from lab clinic. This study highlights various compounds that can be used selective tumor inherent difficulties therapy. Nanotechnology provides promising platform improving future, but further research is needed overcome current limitations translation. Graphical

Language: Английский

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Photodynamic Therapy for the Treatment and Diagnosis of Cancer–A Review of the Current Clinical Status

Frontiers in Chemistry, Journal Year: 2021, Volume and Issue: 9

Published: Aug. 2, 2021

Photodynamic therapy (PDT) has been used as an anti-tumor treatment method for a long time and photosensitizers (PS) can be in various types of tumors. Originally, light is effective tool that the diseases ages. The effects combination specific dyes with illumination was demonstrated at beginning 20th century novel PDT approaches have developed ever since. Main strategies current studies are to reduce off-target improve pharmacokinetic properties. Given high interest vast literature about topic, approval first drug/device by FDA should come no surprise. consists two stages treatment, combining energy PS order destruct tumor cells after activation light. In general, fewer side toxicity than chemotherapy and/or radiotherapy. addition purpose several PSs diagnostic purposes Such called photodynamic diagnosis (PDD). this Review, we provide general overview clinical applications cancer, including therapeutic approaches. Assessment efficacy clinic will discussed, since identifying predictors determine response crucial. addition, examples tumors discussed. Furthermore, other modalities such chemotherapy, radiotherapy, surgery immunotherapy emphasized, seem promising terms enhancing effectiveness against tumor. treatments may yield better results single treatments. Moreover, utilization lower doses setting cause less therapy. A understanding well optimization complex multimodal expand PDT.

Language: Английский

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Smart Nanomaterials in Cancer Theranostics: Challenges and Opportunities

ACS Omega, Journal Year: 2023, Volume and Issue: 8(16), P. 14290 - 14320

Published: April 10, 2023

Cancer is ranked as the second leading cause of death globally. Traditional cancer therapies including chemotherapy are flawed, with off-target and on-target toxicities on normal cells, requiring newer strategies to improve cell selective targeting. The application nanomaterial has been extensively studied explored chemical biology tools in theranostics. It shows greater applications toward stability, biocompatibility, increased permeability, resulting precise targeting, mitigating shortcomings traditional therapies. nanoplatform offers an exciting opportunity gain targeting multifunctionality. advent nanotechnology, particular development smart nanomaterials, transformed diagnosis treatment. large surface area nanoparticles enough encapsulate many molecules ability functionalize various biosubstrates such DNA, RNA, aptamers, antibodies, which helps theranostic action. Comparatively, biologically derived nanomaterials perceive advantages over produced by conventional methods terms economy, ease production, reduced toxicity. present review summarizes techniques theranostics emphasizes (such organic (NPs), inorganic NPs, carbon-based NPs). We also critically discussed challenges impeding their translation treatment diagnostic applications. This concludes that use could significantly will facilitate new dimensions for tumor detection therapy.

Language: Английский

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Lipid and Polymer-Based Nanoparticle siRNA Delivery Systems for Cancer Therapy

Molecules, Journal Year: 2020, Volume and Issue: 25(11), P. 2692 - 2692

Published: June 10, 2020

RNA interference (RNAi) uses small interfering RNAs (siRNAs) to mediate gene-silencing in cells and represents an emerging strategy for cancer therapy. Successful RNAi-mediated gene silencing requires overcoming multiple physiological barriers achieve efficient delivery of siRNAs into vivo, including tumor and/or host the micro-environment (TME). Consequently, lipid polymer-based nanoparticle siRNA systems have been developed surmount these barriers. In this article, we review strategies that facilitate survival circulatory system, movement from blood tissues TME, targeted or specific cell types, cellular uptake, escape endosomal degradation. We also discuss use various types carriers therapy, a section on anti-tumor nanovaccines enhanced by siRNAs. Finally, current recent clinical trials using NPs loaded with The therapeutics field is rapidly evolving, it conceivable precision therapy could, relatively near future, benefit combined therapies, example immune checkpoint blockade together gene-targeting siRNAs, personalized enhancing fine-tuning patient’s therapeutic response.

Language: Английский

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Gold nanoparticles (GNPs) in biomedical and clinical applications: A review

Nano Select, Journal Year: 2021, Volume and Issue: 3(4), P. 792 - 828

Published: Oct. 13, 2021

Abstract Gold nanoparticles (GNPs) have been extensively used in various applications ranging from environmental detection to biomedical applications. Due their unique characteristics such as tunable surface properties well plasmon resonance (SPR), GNPs garnered attention exclusively therapy and diagnostics. Their ease of synthesis compatibility with functionalizing ligands has made them efficient a robust platform. flexibility functionalization, profoundly cancer treatment as, antiviral, antibacterial agents. In addition, owing possessing optical properties, utilized molecular imaging contrast agent. This article discusses highlights special that exploited recent years improve research field nuclear medicine, agent, vaccine development, medical implant, diagnostics, biosensing, lab‐on‐chip Moreover, size dependent biocompatibility, biodistribution, excreation was discussed details for vivo At the forefront modern theraputic technology, based antiviral agents great potential which is also highlighted briefly this article. current state ongoing clinical trials challenges associated regulatory approval are explored. Lastly, sheds light on findings toxicity prospects future direct research.

Language: Английский

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Anticancer Activity of Natural and Synthetic Chalcones

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(21), P. 11306 - 11306

Published: Oct. 20, 2021

Cancer is a condition caused by many mechanisms (genetic, immune, oxidation, and inflammatory). Anticancer therapy aims to destroy or stop the growth of cancer cells. Resistance treatment theleading cause inefficiency current standard therapies. Targeted therapies are most effective due low number side effects resistance. Among small molecule natural compounds, flavonoids particular interest for theidentification new anticancer agents. Chalcones precursors all have biological activities. The activity chalcones ability these compounds act on targets. Natural chalcones, such as licochalcones, xanthohumol (XN), panduretin (PA), loncocarpine, been extensively studied modulated. Modification basic structure in order obtain with superior cytotoxic properties has performed modulating aromatic residues, replacing residues heterocycles, obtaining hybrid molecules. A huge chalcone derivatives diaryl ether, sulfonamide, amine obtained, their presence being favorable activity. amino group aminochalconesis always antitumor This why molecules different nitrogen hetercycles obtained. From these, azoles (imidazole, oxazoles, tetrazoles, thiazoles, 1,2,3-triazoles, 1,2,4-triazoles) importance identification

Language: Английский

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Recent Advances in Functionalized Nanoparticles in Cancer Theranostics

Nanomaterials, Journal Year: 2022, Volume and Issue: 12(16), P. 2826 - 2826

Published: Aug. 17, 2022

Cancer theranostics is the combination of diagnosis and therapeutic approaches for cancer, which essential in personalized cancer treatment. The aims application nanoparticles detection therapy are to reduce delays treatment hence improve patient care. Recently, it has been found that functionalization can efficiency, performance, specificity sensitivity structure, increase stability body acidic environment. Moreover, functionalized have possess a remarkable theranostic ability revolutionized Each modality, such as MRI-guided gene therapy, thermal magnetic hyperthermia treatment, chemotherapy, immunotherapy, photothermal photodynamic its strengths weaknesses, combining modalities allows better platform improved control. This why investigated thoroughly recent years enabled by nanoparticles. In this topical review, we look at advances using Through understanding updating development nanoparticle-based theranostics, find out future challenges perspectives novel type

Language: Английский

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