Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy

Journal of Hematology & Oncology, Journal Year: 2024, Volume and Issue: 17(1)

Published: April 2, 2024

Abstract Cancer immunotherapy and vaccine development have significantly improved the fight against cancers. Despite these advancements, challenges remain, particularly in clinical delivery of immunomodulatory compounds. The tumor microenvironment (TME), comprising macrophages, fibroblasts, immune cells, plays a crucial role response modulation. Nanoparticles, engineered to reshape TME, shown promising results enhancing by facilitating targeted These nanoparticles can suppress fibroblast activation, promote M1 macrophage polarization, aid dendritic cell maturation, encourage T infiltration. Biomimetic further enhance increasing internalization agents cells such as cells. Moreover, exosomes, whether naturally secreted body or bioengineered, been explored regulate TME immune-related affect cancer immunotherapy. Stimuli-responsive nanocarriers, activated pH, redox, light conditions, exhibit potential accelerate co-application with checkpoint inhibitors is an emerging strategy boost anti-tumor immunity. With their ability induce long-term immunity, nanoarchitectures are structures development. This review underscores critical overcoming current driving advancement modification.

Language: Английский

---

The CAR macrophage cells, a novel generation of chimeric antigen-based approach against solid tumors

Biomarker Research, Journal Year: 2023, Volume and Issue: 11(1)

Published: Nov. 28, 2023

Abstract Today, adoptive cell therapy has many successes in cancer therapy, and this subject is brilliant using chimeric antigen receptor T cells. The CAR with its FDA-approved drugs, could treat several types of hematological malignancies thus be very attractive for treating solid cancer. Unfortunately, the cannot functional cancers due to unique features. This treatment method harmful adverse effects that limit their applications, so novel treatments must use new cells like NK cells, NKT macrophage Among these innate features, are more tumor seem a better candidate prior methods. have vital roles microenvironment and, direct effect, can eliminate efficiently. In addition, being part immune system, attended sites. With high infiltration, modulations effective. review investigates last achievements CAR-macrophage future immunotherapy method.

Language: Английский

---

Molecular panorama of therapy resistance in prostate cancer: a pre-clinical and bioinformatics analysis for clinical translation

Cancer and Metastasis Reviews, Journal Year: 2024, Volume and Issue: 43(1), P. 229 - 260

Published: Feb. 19, 2024

Language: Английский

---

Tissue macrophages: origin, heterogenity, biological functions, diseases and therapeutic targets

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: March 7, 2025

Abstract Macrophages are immune cells belonging to the mononuclear phagocyte system. They play crucial roles in defense, surveillance, and homeostasis. This review systematically discusses types of hematopoietic progenitors that give rise macrophages, including primitive progenitors, erythro-myeloid stem cells. These have distinct genetic backgrounds developmental processes. Accordingly, macrophages exhibit complex diverse functions body, phagocytosis clearance cellular debris, antigen presentation, response, regulation inflammation cytokine production, tissue remodeling repair, multi-level regulatory signaling pathways/crosstalk involved homeostasis physiology. Besides, tumor-associated a key component TME, exhibiting both anti-tumor pro-tumor properties. Furthermore, functional status is closely linked development various diseases, cancer, autoimmune disorders, cardiovascular disease, neurodegenerative metabolic conditions, trauma. Targeting has emerged as promising therapeutic strategy these contexts. Clinical trials macrophage-based targeted drugs, immunotherapies, nanoparticle-based therapy were comprehensively summarized. Potential challenges future directions targeting also been discussed. Overall, our highlights significance this versatile cell human health which expected inform research clinical practice.

Language: Английский

---

The Role of Macrophages in Various Types of Tumors and the Possibility of Their Use as Targets for Antitumor Therapy

Cancers, Journal Year: 2025, Volume and Issue: 17(3), P. 342 - 342

Published: Jan. 21, 2025

In solid tumors, tumor-associated macrophages (TAMs) are one of the most numerous populations and play an important role in processes tumor cell invasion, metastasis, angiogenesis. Therefore, TAMs considered promising diagnostic prognostic biomarkers many attempts have been made to influence these cells as part antitumor therapy. There several key principles action on ТАМs: inhibition monocyte/macrophage transition; destruction macrophages; reprogramming macrophage phenotypes (polarization M2 M1); stimulation phagocytic activity CAR-M Despite large number studies this area, date, there no adequate approaches using therapy based alterations TAM functioning that would show high efficacy when administered a mono-regimen for treatment malignant neoplasms. Studies devoted evaluation drugs acting characterized by small sample heterogeneity patient groups; addition, such studies, chemotherapy or immunotherapy is used, which significantly complicates effectiveness agent TAMs. review, we attempted systematize evidence malignancies lung cancer, breast colorectal cervical prostate gastric head neck squamous soft tissue sarcomas.

Language: Английский

---

Functional Polarization of Liver Macrophages by Glyco Gold Nanoparticles

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Abstract Macrophages are crucial drivers of innate immunity. Reprogramming macrophages to a restorative phenotype in cancer or autoimmune diseases can stop their cancer‐promoting activity trigger anti‐inflammatory Glycans have emerged as key components for immunity they involved many pathophysiological disorders. Previous studies demonstrated that supraphysiological amounts mannose (Man) sialic acid (Sia) inhibit tumor growth and stimulate differentiation regulatory T cells. Man is known affect glucose metabolism glycolysis by competing the same intracellular transporters affecting macrophage polarization, whereas Sia alters via signaling through Siglec‐1. Herein, this work describes targeting platform using gold nanoparticles (GNPs) functionalized with monosaccharides which exhibit high liver tropism. A single dose glyco‐GNPs convert two completely different immune environments. promotes tumor‐associated toward an antitumorigenic MC38 colorectal model secretion TNF‐α, IL ‐1β, ‐6 microenvironment. However, proinflammatory environment, observed mouse disease, primary biliary cholangitis, impairs production IL‐1β, Arg1, IL‐6 cytokines. The results probe dual role repolarization response system. This study proof‐of‐concept demonstrates nanomedicine specific glycans designed target other cells such myeloid cells, promising strategy not only against but also pathologies diseases.

Language: Английский

---

Enhancing cancer immunotherapy: Nanotechnology-mediated immunotherapy overcoming immunosuppression

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(9), P. 3834 - 3854

Published: June 3, 2024

Immunotherapy is an important cancer treatment method that offers hope for curing patients. While immunotherapy has achieved initial success, a major obstacle to its widespread adoption the inability benefit majority of The success or failure closely linked tumor's immune microenvironment. Recently, there been significant attention on strategies regulate tumor microenvironment in order stimulate anti-tumor responses immunotherapy. distinctive physical properties and design flexibility nanomedicines have extensively utilized target cells (including tumor-associated macrophages (TAMs), T cells, myeloid-derived suppressor (MDSCs), fibroblasts (TAFs)), offering promising advancements In this article, we reviewed aimed at targeting various focus models are based nanomedicines, with goal inducing enhancing improve It worth noting combining other treatments, such as chemotherapy, radiotherapy, photodynamic therapy, can maximize therapeutic effects. Finally, identified challenges nanotechnology-mediated needs overcome more effective nanosystems.

Language: Английский

---

Anti-stromal nanotherapeutics for hepatocellular carcinoma

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 367, P. 500 - 514

Published: Feb. 3, 2024

Language: Английский

---

Macrophage colony-stimulating factor and its role in the tumor microenvironment: novel therapeutic avenues and mechanistic insights

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: April 4, 2024

The tumor microenvironment is a complex ecosystem where various cellular and molecular interactions shape the course of cancer progression. Macrophage colony-stimulating factor (M-CSF) plays pivotal role in this context. This study delves into biological properties functions M-CSF regulating tumor-associated macrophages (TAMs) its modulating host immune responses. Through specific binding to receptor 1 (CSF-1R), orchestrates cascade downstream signaling pathways modulate macrophage activation, polarization, proliferation. Furthermore, extends influence other cell populations, including dendritic cells. Notably, heightened expression within often associated with dismal patient prognoses. Therefore, comprehensive investigation roles growth advances our comprehension development mechanisms unveils promising novel strategies approaches for treatment.

Language: Английский

---

Tumor-associated macrophages in nanomaterial-based anti-tumor therapy: as target spots or delivery platforms

Frontiers in Bioengineering and Biotechnology, Journal Year: 2023, Volume and Issue: 11

Published: Aug. 16, 2023

Targeting tumor-associated macrophages (TAMs) has emerged as a promising approach in cancer therapy. This article provides comprehensive review of recent advancements the field nanomedicines targeting TAMs. According to crucial role TAMs tumor progression, strategies inhibit macrophage recruitment, suppress TAM survival, and transform phenotypes are discussed potential therapeutic avenues. To enhance capacity nanomedicines, various approaches such use ligands, immunoglobulins, short peptides explored. The utilization live programmed macrophages, cell membrane-coated nanoparticles macrophage-derived extracellular vesicles drug delivery platforms is also highlighted, offering improved biocompatibility prolonged circulation time. However, challenges remain achieving precise controlled release. heterogeneity variability surface markers pose hurdles specific recognition. Furthermore, safety clinical applicability these requires further investigation. In conclusion, hold great promise therapy, enhanced specificity reduced side effects. Addressing existing limitations expanding our understanding biology will pave way for successful translation nano-therapies into practice.

Language: Английский

---