Materials Futures,
Journal Year:
2023,
Volume and Issue:
2(3), P. 032001 - 032001
Published: June 16, 2023
Abstract
Ultrasound
(US)
is
a
kind
of
acoustic
wave
with
frequency
higher
than
20
kHz.
Learning
from
the
echo
detection
ability
bats
and
dolphins,
scientists
applied
US
for
clinical
imaging
by
sending
out
waves
detecting
echoes
shifted
intensities
frequencies
human
tissue.
has
long
played
critical
role
in
noninvasive,
real-time,
low-cost
portable
diagnostic
imaging.
With
in-depth
study
multidisciplinary
fields,
US-responsive
materials
have
shown
practical
value
not
only
disease
diagnosis,
but
also
treatment.
In
this
review,
we
introduce
recently
proposed
representative
biomedical
applications,
including
therapeutic
applications.
We
focused
on
US-mediated
physicochemical
therapies,
such
as
sonodynamic
therapy,
high-intensity
ablation,
sonothermal
thrombolysis,
etc,
US-controlled
delivery
chemotherapeutics,
gases,
genes,
proteins
bacteria.
conclude
current
challenges
facing
translation
smart
prospects
future
development
medicine.
ACS Applied Materials & Interfaces,
Journal Year:
2023,
Volume and Issue:
15(44), P. 50721 - 50741
Published: March 29, 2023
Successful
regeneration
of
critical-size
defects
remains
one
the
significant
challenges
in
regenerative
engineering.
These
large-scale
bone
are
difficult
to
regenerate
and
often
reconstructed
with
matrices
that
do
not
provide
adequate
oxygen
levels
stem
cells
involved
process.
Hypoxia-induced
necrosis
predominantly
occurs
center
large
since
host
tissue's
local
vasculature
fails
sufficient
nutrients
oxygen.
Indeed,
utilizing
oxygen-generating
materials
can
overcome
central
hypoxic
region,
induce
tissue
in-growth,
increase
quality
life
for
patients
extensive
damage.
This
article
reviews
recent
advances
biomaterials
translational
We
discussed
different
oxygen-releasing
delivery
methods,
fabrication
methods
matrices,
biology,
oxygen's
role
regeneration,
emerging
new
could
potentially
be
used
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
33(34)
Published: May 5, 2023
Abstract
Stem‐cell‐based
therapeutic
strategies
are
promising
in
the
clinical
treatment
of
intrauterine
adhesions
(IUAs),
while
endometrial
regeneration
still
hardly
restores
structure
and
function
endometrium
because
inadequate
microenvironment
for
grafted
stem
cells
subsequent
limited
efficiency.
Herein,
an
injectable
porous
hydrogel
scaffold
(PH
scaffold)
with
customizable
shapes
is
presented
by
using
a
microfluidic‐based
3D
printing
technique
adipose‐derived
(ADSCs)
delivery
to
enhance
regeneration.
These
scaffolds
display
controllable
interconnected
structure,
which
not
only
facilitates
encapsulation
ADSCs
within
but
also
supports
recovery
their
original
after
injection.
Furthermore,
cell
viability
laden
well‐maintained
post‐injection,
exhibiting
promotive
effects
on
migration,
proliferation,
tube
formation.
Based
these
features,
ADSCs‐laden
PH
hollow
endometrium‐mimicking
morphology
designed
situ
injected
into
damaged
rats
IUAs.
results
show
that
can
functional
suppressing
inflammatory
response,
promoting
improving
vascularization.
Thus,
it
believed
such
unique
3D‐printed
candidates
delivery,
provides
minimally‐invasive
effective
strategy
SusMat,
Journal Year:
2024,
Volume and Issue:
4(3)
Published: May 27, 2024
Abstract
Spider
silk,
possessing
exceptional
combination
properties,
is
classified
as
a
bio‐gel
fiber.
Thereby,
it
serves
valuable
origin
of
inspiration
for
the
advancement
various
artificial
gel
fiber
materials
with
distinct
functionalities.
Gel
fibers
exhibit
promising
potential
utilization
in
diverse
fields,
including
smart
textiles,
muscle,
tissue
engineering,
and
strain
sensing.
However,
there
are
still
numerous
challenges
improving
performance
functionalizing
applications
spider
silk‐inspired
fibers.
Thus,
to
gain
penetrating
insight
into
bioinspired
fibers,
this
review
provided
comprehensive
overview
encompassing
three
key
aspects:
fundamental
design
concepts
implementing
strategies
properties
strengthening
functionalities
application
prospects
In
particular,
multiple
toughening
mechanisms
were
introduced
at
micro,
nano,
molecular‐level
structures
Additionally,
existing
summarized.
This
aims
offer
significant
guidance
development
inspire
further
research
field
high‐performance
Regenerative Biomaterials,
Journal Year:
2024,
Volume and Issue:
11
Published: Jan. 1, 2024
Tendinopathy
is
a
common
disorder
that
causes
local
dysfunction
and
reduces
quality
of
life.
Recent
research
has
indicated
alterations
in
the
inflammatory
microenvironment
play
vital
role
pathogenesis
tendinopathy.
Herein,
injectable
methacrylate
gelatin
(GelMA)
microspheres
(GM)
were
fabricated
loaded
with
heparin-dopamine
conjugate
(HDC)
hepatocyte
growth
factor
(HGF).
GM@HDC@HGF
designed
to
balance
by
inhibiting
oxidative
stress
inflammation,
thereby
regulating
extracellular
matrix
(ECM)
metabolism
halting
tendon
degeneration.
Combining
factors
heparin
was
expected
improve
encapsulation
rate
maintain
long-term
efficacy
HGF.
In
addition,
catechol
groups
on
dopamine
have
adhesion
antioxidant
properties,
allowing
potential
attachment
at
injured
site,
better
function
synergized
injected
ACS Applied Polymer Materials,
Journal Year:
2023,
Volume and Issue:
5(2), P. 1180 - 1190
Published: Jan. 20, 2023
Hydrogels
are
commonly
used
materials
in
tissue
engineering
and
organ-on-chip
devices.
This
study
investigated
the
nanomechanical
properties
of
monolithic
multilayered
poly(ethylene
glycol)
diacrylate
(PEGDA)
hydrogels
manufactured
using
bulk
polymerization
layer-by-layer
projection
lithography
processes,
respectively.
An
increase
number
layers
(or
reduction
layer
thickness)
from
1
to
8
further
60
results
a
elastic
modulus
5.53
1.69
0.67
MPa,
It
was
found
that
decrease
induces
lower
creep
index
(CIT)
three-dimensional
(3D)
printed
PEGDA
hydrogels.
is
attributed
mesoscale
imperfections
appear
as
pockets
voids
at
interfaces
localized
regions
unreacted
prepolymers,
resulting
variations
defect
density
samples
examined.
degree
cross-linking
introduced
by
higher
dosage
ultraviolet
(UV)
exposure
leads
modulus.
implies
behavior
governed
influenced
interfaces.
These
findings
can
guide
an
optimal
manufacturing
pathway
obtain
desirable
3D
hydrogels,
critical
for
performance
living
cells
tissues,
which
be
engineered
through
control
fabrication
parameters.
Engineered Regeneration,
Journal Year:
2022,
Volume and Issue:
3(3), P. 310 - 322
Published: July 27, 2022
Primary
liver
cancer
is
the
fifth
most
common
malignancy
and
third
leading
cause
of
death
worldwide.
Although
current
advances
in
treatment
cancer,
prognosis
this
remains
unfavorable.
Appropriate
model
vitro
an
important
way
to
study
pathogenesis
drug
screening
cancer.
This
review
provides
a
comprehensive
summary
discussion
on
construction
application
models
vitro,
particular
hepatocellular
carcinoma
(HCC).
Specifically,
after
introducing
methods
or
techniques
for
preparing
3D
models,
summarizes
relevant
applications
these
e.g.
screening,
personalized
medicine,
other
applications.
In
end,
discusses
advantages
disadvantages
proposes
future
prospects
research
directions.
