Fertility treatment-induced oxidative stress and reproductive disorders

Journal of Integrated Science and Technology, Journal Year: 2024, Volume and Issue: 12(3)

Published: Jan. 3, 2024

Rising global infertility rates have amplified the dependence on assisted reproductive technologies (ARTs) for conception. This necessitates a thorough examination of fertility drug effects health. review explores impact drugs, such as antioxidants, antibiotics, and anti-inflammatory agents, oxidative stress (OS), irregularities, treatment outcomes. While antioxidants can potentially improve outcomes by modulating OS, excessive consumption lead to 'antioxidant paradox' — delicate balance between external antioxidant intake, OS reduction, its fertility. Moreover, some antibiotics drugs intensify possibly exacerbating issues. The article emphasizes complex relationship ovarian stimulation, highlighting need personalized treatments careful weighing advantages drawbacks interventions. intricate among semen quality, advocating plans assessment benefits comprehensive insights obtained from this extensive aims aid clinical protocols support informed decisions in medicine. URN:NBN:sciencein.jist.2024.v12.756

Language: Английский

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Association of exposure to ambient air pollution with ovarian reserve among women in Shanxi province of north China

Environmental Pollution, Journal Year: 2021, Volume and Issue: 278, P. 116868 - 116868

Published: March 3, 2021

Language: Английский

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Thermal tolerance of early development predicts the realized thermal niche in marine ectotherms

Functional Ecology, Journal Year: 2021, Volume and Issue: 35(8), P. 1679 - 1692

Published: June 4, 2021

Abstract Predictions of ectotherms' responses to global warming depend on the relationship between environmental temperature and organismal performance. To date, most predictions thermal are generated from experimentally derived measures tolerances adults or estimates niches geographic distributions adults. It is unknown how these different approaches compare, or, as performance ectotherms varies through ontogeny, they compare across life stages. understand efficacy temperature–performance early developmental stages predictors range, we empirically documented upper lower tolerance limits embryos eight species with complex cycles. We compared embryonic each that (documented in a previous study), well an estimate niche adult distributions. Our results show all limit estimated significantly than The for similar, but survival lower. Warming tolerances, calculated difference average ambient during warmest month, also smaller (~1°C) (~5°C). These stages, which often easier obtain large sample sizes over array temperatures adults, powerful, potentially more accurate tool predicting future climate change. A free Plain Language Summary can be found within Supporting Information this article.

Language: Английский

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Whole-genome resequencing of Chinese pangolins reveals a population structure and provides insights into their conservation

Communications Biology, Journal Year: 2022, Volume and Issue: 5(1)

Published: Aug. 25, 2022

Poaching and trafficking have a substantial negative impact on the population growth range expansion of Chinese pangolin (Manis pentadactyla). However, recently reported activities pangolins in several sites Guangdong province China indicate promising sign for recovery this threatened species. Here, we re-sequence genomes 15 individuals perform comprehensive genomics analyses with previously published 22 individuals. These are found to be divided into three distinct populations. Multiple lines evidence existence newly discovered (CPA) comprises entirely from province. The other two populations (CPB CPC) been documented. genetic differentiation CPA CPC is extremely large (F

Language: Английский

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Associations between exposure to pesticides mixture and semen quality among the non-occupationally exposed males: Four statistical models

Environmental Research, Journal Year: 2024, Volume and Issue: 257, P. 119400 - 119400

Published: June 10, 2024

Language: Английский

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Assisted Reproduction Technologies (ART): Impact of Mitochondrial (Dys)function and Antioxidant Therapy

Animals, Journal Year: 2025, Volume and Issue: 15(3), P. 289 - 289

Published: Jan. 21, 2025

In the last decades, major changes in ecosystems related to industrial development and environmental modifications have had a direct impact on mammalian fertility, as well biodiversity. It is widely demonstrated that all these impair reproductive function. Several studies connected increase of reactive oxygen species (ROS) generated mitochondria recently identified decline fertility due various factors, including heat stress. The study antioxidants, especially targeted has been focused identifying more efficient less toxic therapies could circumvent problems. These antioxidants can be derived from natural compounds diet delivered effective forms, providing much therapy. use mitochondriotropic diet-based assisted technologies (ART) may an important way overcome low allowing conservation animal biodiversity productivity. This paper provides concise review current state art this topic, with particular focus mitoquinone, AntiOxBEN2, AntiOxCIN4, urolithin A piperine, their effects bovine other species.

Language: Английский

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Climate change: on the pathway of heat-induced reproductive disaster?

Veterinaria México OA, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 30, 2025

Human-driven climate change generates extreme weather events, a well-known consequence of global warming. This leads to increased exposure most living beings higher temperatures, resulting in longer, more frequent, and intense heat stress (HS) periods. jeopardizes the welfare survival animals, negatively affecting process that connects generations ensures subsistence natural selection: reproduction. letter aims draw attention impact increasing HS on animal reproductive capacity potential alternatives address this phenomenon. With rising temperatures regions worldwide, will increase many including humans. occur even if we achieve goal limiting temperature rise no than 1.5 °C by year 2100, relative pre-industrial levels, as set 2015 Paris Agreement(1). Roth(2) indicates HS, upon inducing cellular stress, triggers both indirect (e.g., systemic physiological alterations) direct perturbation gametes, embryos, tissues) negative effects In context, fertility insects,(3) aquatic organisms;(1, 3, 4) amphibians,(5) reptiles,(6) birds,(7) mammalian pets,(8) cattle,(2, 9, 10) wild mammals,(11) laboratory mammals,(12) non-human primates,(13) humans(4) is threatened elevated temperatures. Consequently, given unavoidable trend continues, potentially all groups are at risk experiencing least partial declines worldwide. scenario endanger production food goods from sources, affect welfare, threaten populations, To mitigate widespread failures due excessive heating, or prevent them, alongside coordinated environment-oriented efforts governments, private industry, scientists, general public reduce warming, modifications management their gametes necessary. For instance, Hansen(9) suggests following reproduction farm animals: diet pattern changes; active passive cooling systems; genetic selection transgenesis greater thermotolerance; vivo supplementation compounds orally, intramuscular/intravenous administration); vitro gametes/embryos (for use biotechnologies) decrease stress. These strategies aim heat-induced alterations, systemically directly structures. Given serious warming poses physiology, urgently need studies overall context under HS. addition, require specific focus processes, considering factors such regions, systems, species, breeds/strains, backgrounds. Therefore, whether heating planet Earth experiences lead disastrous controlled, perhaps partially reversible, capacity, could be influenced measures plan now. include society, veterinary professionals. Time running out: situation calls for immediate action.

Language: Английский

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Mechanisms of Hormonal, Genetic, and Temperature Regulation of Germ Cell Proliferation, Differentiation, and Death During Spermatogenesis

Biomolecules, Journal Year: 2025, Volume and Issue: 15(4), P. 500 - 500

Published: March 29, 2025

Spermatogenesis is a complex and highly regulated process involving the proliferation, differentiation, apoptosis of germ cells. This controlled by various hormonal, genetic, environmental factors, including temperature. In hormonal regulation, follicle-stimulating hormone (FSH), luteinizing (LH), testosterone (T) are essential for correct spermatogenesis development from early stages spermatogonia proliferation to cell maturation. Other hormones, like inhibin activin, finely participate tuning spermatogenesis. Genetic regulation involves transcription such as SOX9, SRY, DMRT1, which crucial maintenance testis MicroRNAs (miRNAs) play significant role regulating gene expression post-transcriptionally. Epigenetic modifications, DNA methylation, histone chromatin remodelling, also vital. Temperature another critical aspect, with testicular temperature maintained around 2-4 °C below body temperature, efficient Heat shock proteins (HSPs) protect cells heat-induced damage acting molecular chaperones, ensuring proper protein folding preventing aggregation misfolded during thermal stress. Elevated can impair spermatogenesis, increasing inducing oxidative stress, damage, disruption blood-testis barrier, leading death impaired differentiation. The cellular mechanisms include mitotic divisions maintain pool produce spermatocytes. Spermatocytes undergo meiosis haploid spermatids, then differentiate into mature spermatozoa. Apoptosis, or programmed death, ensures removal defective regulates population. Hormonal imbalance, genetic defects, stress trigger Understanding these addressing male infertility developing therapeutic interventions. Advances in biology genetics continue uncover intricate details how at multiple levels, providing new insights potential targets treatment.

Language: Английский

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Reactivation of retrotransposable elements is associated with environmental stress and ageing

Nature Reviews Genetics, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Language: Английский

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Automated Detection and Recognition of Oocyte Toxicity by Fusion of Latent and Observable Features

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 138411 - 138411

Published: April 1, 2025

Language: Английский

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