Triphenyl phosphate interferes with the synthesis of steroid hormones through the PPARγ/CD36 pathway in human trophoblast JEG‐3 cells DOI
Yuting Chen, Qian Liu, Yao Wang

et al.

Environmental Toxicology, Journal Year: 2024, Volume and Issue: 39(6), P. 3400 - 3409

Published: March 7, 2024

Abstract Triphenyl phosphate (TPhP), a chemical commonly found in human placenta and breast milk, has been shown to disturb the endocrine system. Our previous study confirmed that TPhP could accumulate interference with placental lipid metabolism steroid hormone synthesis, as well induce endoplasmic reticulum (ER) stress through PPARγ trophoblast JEG‐3 cells. However, molecular mechanism underlying this disruption remains unknown. aimed identify role of PPARγ/CD36 pathway TPhP‐induced disruption. We increased accumulation, total cholesterol, low‐ high‐density protein progesterone, estradiol, glucocorticoid, aldosterone levels, genes related hormones including 3βHSD1 , 17βHSD1 CYP11A CYP19 CYP21 . These effects were largely blocked by co‐exposure either antagonist GW9662 or knockdown CD36 using siRNA (siCD36). Furthermore, an ER inhibitor 4‐PBA attenuated effect on progesterone glucocorticoid siCD36 reduced stress‐related levels induced TPhP, BiP, PERK, CHOP. findings suggest may also play synthesis TPhP. As our shed light pathway's involvement disturbance biosynthesis cells, further investigations potential impacts function following birth outcome are warranted.

Language: Английский

Astaxanthin activates the Nrf2/Keap1/HO-1 pathway to inhibit oxidative stress and ferroptosis, reducing triphenyl phosphate (TPhP)-induced neurodevelopmental toxicity DOI Creative Commons
Qiong Zhang,

Congying Luo,

Zhikang Li

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 271, P. 115960 - 115960

Published: Jan. 16, 2024

Triphenyl phosphate (TPhP) serves as a major organophosphorus flame retardant, and its induced neurodevelopmental toxicity has attracted widespread attention, but the mechanism remains unclear. In this study, we involved zebrafish to explore new of TPhP inducing oxidative stress ferroptosis promote toxicity. The results suggested that affected embryonic development, reduced number neurons, led abnormal neural behavior in larvae. also ROS accumulation, activated antioxidant defense signal Nrf2 Keap1, significantly changed activities Acetylcholinesterase (AChE), Adenosine triphosphatase (ATPase) glutathione S-transferase (GST). addition, zebrafish, which was reflected increase Fe2+ content, expression GPX4 protein genes related iron metabolism (gpx4a, slc7a11, acsl4b, tfa, slc40a1, fth1b, tfr2, tfr1a, tfr1b ncoa4). Astaxanthin intervention specifically inhibited levels, reversed SLC7A11 levels thus alleviating by TPhP. partially activity AChE, GST neurodevelopmental-related (gap43, gfap, neurog1 syn2a), so rescue developmental abnormalities motor disorders More interestingly, mitochondrial apoptosis-related BAX, anti-apoptotic BCL-2, Caspase3 Caspase9 altered exposed group, could be intervention. summary, our exposure can induce ferroptosis, thereby causing neurodevelopment while reverse reduce larvae activating Nrf2/Keap1/HO-1 signaling pathway.

Language: Английский

Citations

17
Neurotoxicity of an emerging organophosphorus flame retardant, resorcinol bis(diphenyl phosphate), in zebrafish larvae DOI

Qipeng Shi,

Huaran Yang,

Ya-Nan Zheng

et al.

Chemosphere, Journal Year: 2023, Volume and Issue: 334, P. 138944 - 138944

Published: May 19, 2023

Language: Английский

Citations

23
Thallium’s Threat to Aquatic Life: Stage-Specific Toxicity in Zebrafish Embryos and Larvae DOI Creative Commons
Jian Liu, Guizhen Yan,

Zihui Huo

et al.

Environment & Health, Journal Year: 2024, Volume and Issue: 2(3), P. 114 - 125

Published: Feb. 7, 2024

The escalating frequency of thallium (Tl) contamination incidents amplifies its environmental risk. However, the potential risk Tl to aquatic organisms, especially across varying developmental stages, remains poorly understood. In this study, we employed zebrafish as a representative model organism and exposed embryos larvae at distinct periods (specifically, 6 h postfertilization (hpf) 72 hpf) low concentrations Tl(I) (0.25 0.50 mg/L). exposure was performed for short duration 24 h, followed by 96 depuration period. Our results revealed that exerted disparate biological effects on different stages. Embryos exhibited negligible uptake Tl(I), whereas showed significant accumulation struggled with rapid elimination. Notably, able permeate blood-brain barrier, thereby posing nervous system. Transcriptomic analysis indicated triggered toxicological pathways in larvae. It mainly interfered metabolic processes embryos, while larvae, it disrupted intracellular ion homeostasis, both consequently provoking neurotoxicity. This emphasizes multifaceted nature toxicity depends stages organism. study clearly shows bioeffects are intricately related stage zebrafish, offering valuable perspective pollutant assessment.

Language: Английский

Citations

13
Neurotoxic effects of 2-ethylhexyl diphenyl phosphate exposure on zebrafish larvae: Insight into inflammation-driven changes in early motor behavior DOI

Anyu Ni,

Fang Lü,

M Xi

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 915, P. 170131 - 170131

Published: Jan. 20, 2024

Language: Английский

Citations

9
Cellular and physiological mechanisms of halogenated and organophosphorus flame retardant toxicity DOI Creative Commons
Leila Khani, Leonardo Martín, Łukasz Pułaski

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 897, P. 165272 - 165272

Published: July 3, 2023

Flame retardants (FRs) are chemical substances used to inhibit the spread of fire in numerous industrial applications, and their abundance modern manufactured products indoor outdoor environment leads extensive direct food chain exposure humans. Although once considered relatively non-toxic, FRs demonstrated by recent literature have disruptive effects on many biological processes, including signaling pathways, genome stability, reproduction, immune system function. This review provides a summary research investigating impact major groups FRs, halogenated organophosphorus animals humans vitro and/or vivo. We put focus those studies that explained or referenced modes FR action at level cells, tissues organs. Since highly hydrophobic chemicals, biophysical biochemical usually involve lipophilic interactions, e.g. with membranes elements pathways. present selected toxicological information about these molecular actions show how they can lead damaging membrane integrity, DNA compromising its repair, changing gene expression, cell cycle as well accelerating death. Moreover, we indicate this translates deleterious bioactivity physiological level, disruption hormonal action, dysregulation metabolism, adverse male female reproduction alteration normal pattern immunity. Concentrating subjects, make clear both advances knowledge years remaining gaps our understanding, especially mechanistic level.

Language: Английский

Citations

21
A comprehensive and quantitative comparison of organophosphate esters: Characteristics, applications, environmental occurrence, toxicity, and health risks DOI
Mengyan Huang,

Lingjun Zeng,

Chen Wang

et al.

Critical Reviews in Environmental Science and Technology, Journal Year: 2024, Volume and Issue: 55(5), P. 310 - 333

Published: Sept. 28, 2024

Language: Английский

Citations

7
The effects of plastic additives on swimming activity and startle response in marine amphipod Echinogammarus marinus DOI
Bidemi Green-Ojo, Hung Tan, Marina Tenório Botelho

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 918, P. 170793 - 170793

Published: Feb. 7, 2024

Language: Английский

Citations

6
Triphenyl phosphate induces cardiotoxicity through myocardial fibrosis mediated by apoptosis and mitophagy of cardiomyocyte in mice DOI
Feibo Xu,

Yu He,

Aili Xu

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 346, P. 123651 - 123651

Published: Feb. 24, 2024

Language: Английский

Citations

6
Environmental pollution of paraben needs attention: A study of methylparaben and butylparaben co-exposure trigger neurobehavioral toxicity in zebrafish DOI
Jing Xiang,

B. Lv,

Yajun Shi

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 356, P. 124370 - 124370

Published: June 12, 2024

Language: Английский

Citations

4
Neurotoxicity and Mechanism in Zebrafish Embryo Induced by Tetrabromobisphenol A bis (2-Hydroxyethyl) Ether (TBBPA-DHEE) Exposure DOI Creative Commons
Xinyu Zhang,

Liguo Guo,

Yiwen Luo

et al.

Toxics, Journal Year: 2025, Volume and Issue: 13(2), P. 76 - 76

Published: Jan. 22, 2025

Tetrabromobisphenol A bis (2-hydroxyethyl) ether (TBBPA-DHEE), a derivative of TBBPA, has been frequently detected in the environment. In this study, median lethal concentration (LC50) TBBPA-DHEE at 96 h post-fertilization (hpf) was 1.573 mg/L. Based on reported environmental concentrations, we investigated effects nervous system zebrafish embryos following exposure to varying concentrations (0, 20, 100, and 500 μg/L) for 4 144 hpf. Our results indicated that 100 μg/L hpf led behavioral abnormalities zebrafish. Furthermore, inhibited development central motor neurons Real-time polymerase chain reaction (PCR) analysis revealed significantly downregulated expression levels neurodevelopmental genes (shha, syn2a, elavl3, gfap, gap43). Additionally, increased oxidative stress Transcriptomic demonstrated affected signaling pathways involved neurodevelopment. Overall, study may disrupt early system, leading abnormal behavior larvae, provided novel insights into potential mechanisms neurotoxicity.

Language: Английский

Citations

0