Building towards an adolescent neural urbanome: Expanding environmental measures using linked external data (LED) in the ABCD study

Developmental Cognitive Neuroscience, Journal Year: 2024, Volume and Issue: 65, P. 101338 - 101338

Published: Jan. 4, 2024

Many recent studies have demonstrated that environmental contexts, both social and physical, an important impact on child adolescent neural behavioral development. The adoption of geospatial methods, such as in the Adolescent Brain Cognitive Development (ABCD) Study, has facilitated exploration many contexts surrounding participants' residential locations without creating additional burdens for research participants (i.e., youth families) neuroscience studies. However, number linked databases increases, developing a framework considers various domains related to environments external their home becomes crucial. Such needs identify structural contextual factors may yield inequalities children's built natural environments; these differences may, turn, result downstream negative effects children from historically minoritized groups. In this paper, we develop – which describe "adolescent urbanome" use it categorize newly geocoded information incorporated into ABCD Study by Linked External Data (LED) Environment & Policy Working Group. We also highlight relationships between measures possible applications Neural Urbanome. Finally, provide recommendations considerations regarding responsible communication data, highlighting potential harm groups through misuse.

Language: Английский

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Environmental pollution

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 47 - 64

Published: Jan. 1, 2024

Language: Английский

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Outdoor air pollution and brain development in childhood and adolescence

Trends in Neurosciences, Journal Year: 2024, Volume and Issue: 47(8), P. 593 - 607

Published: July 24, 2024

Language: Английский

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Sex, gender diversity, and brain structure in early adolescence

Human Brain Mapping, Journal Year: 2024, Volume and Issue: 45(5)

Published: April 1, 2024

Abstract There remains little consensus about the relationship between sex and brain structure, particularly in early adolescence. Moreover, few pediatric neuroimaging studies have analyzed both gender as variables of interest—many which included small sample sizes relied on binary definitions gender. The current study examined diversity with a continuous felt‐gender score categorized based X Y allele frequency large children ages 9–11 years old ( N = 7195). Then, statistical model‐building approach was employed to determine whether independently or jointly relate morphology, including subcortical volume, cortical thickness, gyrification, white matter microstructure. Additional sensitivity analyses found that male versus female differences gyrification were largely accounted for by total rather than per se. model sex, but not diversity, best‐fitting 60.1% gray regions 61.9% after adjusting volume. proportion variance negligible all cases. While models explained greater amount regions, alone significant predictor its own any examined. Overall, these findings demonstrate at old, accounts while is directly associated neurostructural diversity.

Language: Английский

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Exposure to multiple ambient air pollutants changes white matter microstructure during early adolescence with sex-specific differences

Communications Medicine, Journal Year: 2024, Volume and Issue: 4(1)

Published: Aug. 1, 2024

Air pollution is ubiquitous, yet questions remain regarding its impact on the developing brain. Large changes occur in white matter microstructure across adolescence, with notable differences by sex. We investigate sex-stratified effects of annual exposure to fine particulate (PM2.5), nitrogen dioxide (NO2), and ozone (O3) at ages 9–10 years longitudinal patterns over a 2-year period. Diffusion-weighted imaging was collected 3T MRI scanners for 8182 participants (1–2 scans per subject; 45% two scans) from Adolescent Brain Cognitive Development (ABCD) Study®. Restriction spectrum performed quantify intracellular isotropic (RNI) directional (RND) diffusion. Ensemble-based air concentrations were assigned each child's primary residential address. Multi-pollutant, linear mixed-effect models assessed associations between pollutants RNI/RND age time, adjusting sociodemographic factors. Here we show higher PM2.5 associated RND 9 both sexes, no significant change time. Higher NO2 RNI as well attenuating time females. O3 9, sexes. Criteria influence maturation 9–13 old, some sex-specific magnitude anatomical locations affected tracts. This occurs that are below current U.S. standards, suggesting low-level during adolescence may have long-term consequences. known affect health, but it unclear whether affects growing human investigated there development connections, which allow faster communication different brain regions, children aged 9-13 living areas relatively low or high USA. In large group teens, find polluted linked 9-10 old next years. cases, males females showed part showing amount change. Our study suggests levels deemed acceptable under regulations USA could how grows. Further studies needed better understand these changes. Cotter et al. ambient pollutant microstructural transition childhood adolescence. There associations, primarily affecting sexes

Language: Английский

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Exposure to residential air pollution and the development of functional connectivity of brain networks throughout adolescence

Environment International, Journal Year: 2025, Volume and Issue: unknown, P. 109245 - 109245

Published: Jan. 1, 2025

A few studies linked air pollution to differences in functional connectivity of resting-state brain networks children, but how exposure affects the development remains poorly understood. Therefore, we studied association from birth 3 years and one year before first imaging assessment with across adolescence. We utilized data 3,626 children Generation R Study (The Netherlands). estimated residential PM10, PM2.5, PM2.5 absorbance, NOX, NO2 land-use regression models. Between- within-network was calculated for 13 cortical networks, amygdala, hippocampus, caudate nucleus at two assessments (8.6-12.0 12.6-17.1 years), resulting 4,628 scans (2,511 1 2,117 2) individuals. investigated between linear mixed models adjusted life-style socioeconomic variables, corrected multiple testing. Higher associated persistently lower over time amygdala ventral attention, somatomotor hand, auditory throughout adolescence (e.g. -0.027 [95 % CI -0.040; -0.013] - attention network per 5 μg/m3higher PM2.5). PM10 salience medial-parietal Air not a faster or slower change age. early life persistent alterations involved somatomotor, function. Concurrent related higher cognitive functions (i.e. networks).

Language: Английский

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A Systematic Review of Air Pollution Exposure and Brain Structure and Function during Development

Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 121368 - 121368

Published: March 1, 2025

Language: Английский

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Prenatal and childhood air pollution exposure, cellular immune biomarkers, and brain connectivity in early adolescents

Brain Behavior & Immunity - Health, Journal Year: 2024, Volume and Issue: 38, P. 100799 - 100799

Published: May 31, 2024

Ambient air pollution is a neurotoxicant with hypothesized immune-related mechanisms. Adolescent brain structural and functional connectivity may be especially vulnerable to ambient due the refinement of large-scale networks during this period, which vary by sex have important implications for cognitive, behavioral, emotional functioning. In current study we explored associations between pollutants, immune markers, in early adolescence leveraging cross-sectional sex-stratified data from Brain Cognitive Development℠ Study®. Pollutant concentrations fine particulate matter, nitrogen dioxide, ozone were assigned each child's primary residential address prenatal period childhood (9-10 years-old) using an ensemble-based modeling approach. Data collected at 11-13 years-old included resting-state default mode, frontoparietal, saliency limbic regions interest, intracellular directional isotropic diffusion available white matter tracts, markers cellular activation. Using partial least squares correlation, multivariate data-driven method that identifies variables within latent dimensions, investigated 1) pollutants connectivity, 2) 3) separately. Air exposure was related ages years, but direction varied sex. There no years. Childhood dioxide negatively correlated blood cell count males. Immune biomarkers positively females both Lastly, there reliable negative correlation lymphocyte-to-monocyte ratio mode network females, as well compromised marker profile associated lower salience left hippocampus post-hoc exploratory analyses, found PLSC identified tracts rsFC processing speed cognitive control performance NIH Toolbox. We novel links activation males, sexes. Future research should explore potentially mediating role activity how affect neurological outcomes potential consequences patterns service improved health all.

Language: Английский

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Racial and ethnic socioenvironmental inequity and neuroimaging in psychiatry: a brief review of the past and recommendations for the future

Neuropsychopharmacology, Journal Year: 2024, Volume and Issue: 50(1), P. 3 - 15

Published: June 20, 2024

Language: Английский

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Air pollution and age-dependent changes in emotional behavior across early adolescence in the U.S.

Environmental Research, Journal Year: 2023, Volume and Issue: 240, P. 117390 - 117390

Published: Oct. 21, 2023

Language: Английский

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