The benefits of removing toxic chemicals from plastics DOI Creative Commons
Maureen Cropper, Sarah A. Dunlop,

H. Corwin Hinshaw

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(52)

Published: Dec. 16, 2024

More than 16,000 chemicals are incorporated into plastics to impart properties such as color, flexibility, and durability. These may leach from plastics, resulting in widespread human exposure during everyday use. Two plastic-associated chemicals—bisphenol A (BPA) di(2-ethylhexyl) phthalate (DEHP)—and a class of chemicals—brominated flame retardants [polybrominated diphenyl ethers (PBDEs)]—are credibly linked adverse health cognitive impacts. BPA exposures associated with ischemic heart disease (IHD) stroke, DEHP increased all-cause mortality among persons 55 64 y old, prenatal PBDE mothers IQ losses their children. We estimate BPA, DEHP, 38 countries containing one-third the world’s population. find that 2015, 5.4 million cases IHD 346,000 stroke were exposure; approximately 164,000 deaths 55-to-64 olds; 11.7 points lost due maternal exposure. costs these impacts be $1.5 trillion 2015 purchasing power parity dollars. If United States had been at levels since 2003, 515,000 fewer would have attributed between 2003 2015. 2005, over 42 saved 2005

Language: Английский

The triple exposure nexus of microplastic particles, plastic-associated chemicals, and environmental pollutants from a human health perspective DOI Creative Commons
Andi Alijagić, Damir Suljević, Muhamed Fočak

et al.

Environment International, Journal Year: 2024, Volume and Issue: 188, P. 108736 - 108736

Published: May 10, 2024

The presence of microplastics (MPs) is increasing at a dramatic rate globally, posing risks for exposure and subsequent potential adverse effects on human health. Apart from being physical objects, MP particles contain thousands plastic-associated chemicals (i.e., monomers, chemical additives, non-intentionally added substances) captured within the polymer matrix. These are often migrating MPs can be found in various environmental matrices food chains; health effects. In addition to attributes MPs, plastic surfaces effectively bind exogenous chemicals, including pollutants (e.g., heavy metals, persistent organic pollutants). Therefore, act as vectors pollution across air, drinking water, food, further amplifying posed by exposure. Critically, fragmentation plastics environment increases risk interactions with cells, available leach adsorb transfer pollutants. This review proposes so-called triple nexus approach comprehensively map existing knowledge interconnected particles, Based data, there large gap regard cumulative nexus. Each component known induce genotoxicity, inflammation, endocrine disruption, but about long-term inter-individual lacking. Furthermore, not readily excreted organisms after ingestion they have been accumulated blood, cardiac tissue, placenta, etc. Even though number studies MPs-associated impacts rapidly, this underscores that pressing necessity achieve an integrated assessment MPs' order address future gaps.

Language: Английский

Citations

35
Pathways to reduce global plastic waste mismanagement and greenhouse gas emissions by 2050 DOI Open Access
A S Pottinger, Roland Geyer, Nivedita Biyani

et al.

Science, Journal Year: 2024, Volume and Issue: 386(6726), P. 1168 - 1173

Published: Nov. 14, 2024

Plastic production and plastic pollution have a negative effect on our environment, environmental justice, climate change. Using detailed global regional plastics datasets coupled with socioeconomic data, we employ machine learning to predict that, without intervention, annual mismanaged waste will nearly double 121 million metric tonnes (Mt) [100 139 Mt 95% confidence interval] by 2050. Annual greenhouse gas emissions from the system are projected grow 37% 3.35 billion CO 2 equivalent (3.09 3.54) over same period. The United Nations treaty presents an opportunity reshape these outcomes. We simulate eight candidate policies find that just four could together reduce 91% (86 98%) gross plastic–related one-third.

Language: Английский

Citations

21
Mind over Microplastics: Exploring Microplastic-Induced Gut Disruption and Gut-Brain-Axis Consequences DOI Creative Commons
Charlotte E. Sofield, Ryan S. Anderton, Anastazja M. Gorecki

et al.

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(5), P. 4186 - 4202

Published: April 30, 2024

As environmental plastic waste degrades, it creates an abundance of diverse microplastic particles. Consequently, microplastics contaminate drinking water and many staple food products, meaning the oral ingestion is important exposure route for human population. Microplastics have long been considered inert, however their ability to promote microbial dysbiosis as well gut inflammation dysfunction suggests they are more noxious than first thought. More alarmingly, there evidence permeating from throughout body, with adverse effects on immune nervous systems. Coupled now-accepted role gut-brain axis in neurodegeneration, these findings support hypothesis that this ubiquitous pollutant contributing rising incidence neurodegenerative diseases, like Alzheimer’s disease Parkinson’s disease. This comprehensive narrative review explores consequences gut-brain-axis by considering current gastrointestinal uptake disruption, activation, translocation neurological effects. now a permanent feature global environment, understanding gut, brain, whole body will facilitate critical further research inform policy changes aimed at reducing any consequences.

Language: Английский

Citations

14
An Umbrella Review of Meta-Analyses Evaluating Associations between Human Health and Exposure to Major Classes of Plastic-Associated Chemicals DOI Creative Commons
Christos Symeonides, Edoardo Aromataris Aromataris, Yannick Mulders

et al.

Annals of Global Health, Journal Year: 2024, Volume and Issue: 90(1), P. 52 - 52

Published: Aug. 13, 2024

Epidemiological research investigating the impact of exposure to plastics, and plastic-associated chemicals, on human health is critical, especially given exponentially increasing plastic production. In parallel with production, academic has also increased both in terms primary literature ensuing systematic reviews meta-analysis. However, there are few overviews that capture a broad range chemical classes present state play regarding impacts health.

Language: Английский

Citations

13
TNF/TNFR1 Signaling Mediates DEHP-Induced Hepatocyte Pyroptosis via the GSDMD–mtROS Axis DOI
Hao Zhang,

Jia-Gen Cui,

Ming‐Shan Chen

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Di(2-ethylhexyl) phthalate (DEHP), which is widely used in agricultural plastics, accumulates humans and animals through the food chain over time, resulting liver toxicity. Recent studies have reported that pyroptosis mitochondrial damage are closely related to a variety of diseases, but specific mechanism still unclear. To address this issue, vitro vivo hepatotoxicity models were established. The results demonstrated exposure DEHP caused buildup MEHP livers, altered metabolite composition, pyroptosis-like changes hepatocytes. After treatment, REDOX homeostasis was unbalanced, reactive oxygen species (mtROS) overproduced. activates mediated by TNF/TNFR1 signaling upregulates perforating protein GSDMD-N destroy membrane Above all, study elucidates potential involvement signaling-mediated confirms regulation helpful maintaining normal function.

Language: Английский

Citations

1
Adjustable chromatographic performance of silica-based mixed-mode stationary phase through the control of co-grafting amounts of imidazole and C18 chain DOI
Yali Yang, Jia Chen, Xiaojing Liang

et al.

Journal of Chromatography A, Journal Year: 2024, Volume and Issue: 1722, P. 464889 - 464889

Published: April 9, 2024

Language: Английский

Citations

8
Ecosystem risk-based prioritization of micropollutants in wastewater treatment plant effluents across China DOI
Jianchao Liu,

Tian Ouyang,

Guanghua Lu

et al.

Water Research, Journal Year: 2024, Volume and Issue: 263, P. 122168 - 122168

Published: July 28, 2024

Language: Английский

Citations

7
Impacts associated with the plastic polymers polycarbonate, polystyrene, polyvinyl chloride, and polybutadiene across their life cycle: A review DOI Creative Commons
Bhedita J. Seewoo, Enoch V.S. Wong, Yannick Mulders

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(12), P. e32912 - e32912

Published: June 1, 2024

Polymers are the main building blocks of plastic, with annual global production volume fossil carbon-based polymers reaching over 457 million metric tons in 2019 and this figure is anticipated to triple by 2060. There potential for environmental harm adverse human health impacts associated its constituent chemicals therein, at all stages plastic life cycle, from extraction raw materials, manufacturing, consumption, through ultimate disposal waste management. While there have been considerable research policy efforts identifying mitigating problematic products such as single-use plastics hazardous plastics, national and/or international regulations phase out their use, often overlooked. In review, polymer dimension current knowledge on release, exposure discussed across including used additives commonly achieve properties needed applications which generally used. This review focuses polycarbonate, polystyrene, polyvinyl chloride, polybutadiene, four common made monomers, bisphenol, styrene, vinyl chloride 1,3-butadiene, respectively. Potential alternative polymers, chemicals, considered. Our findings emphasise need a whole system approach be undertaken effective regulation whereby assessed respect entire cycle.

Language: Английский

Citations

6
How do plastics, including microplastics and plastic-associated chemicals, affect human health? DOI
Bhedita J. Seewoo, Louise M. Goodes, Kevin V. Thomas

et al.

Nature Medicine, Journal Year: 2024, Volume and Issue: 30(11), P. 3036 - 3037

Published: Oct. 8, 2024

Language: Английский

Citations

6
Effects of Microplastic Exposure on Human Digestive, Reproductive, and Respiratory Health: A Rapid Systematic Review DOI Creative Commons
Nicholas Chartres, Courtney Cooper, Garret D. Bland

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 18, 2024

Microplastics are ubiquitous environmental contaminants for which there documented human exposures, but is a paucity of research evaluating their impacts on health. We conducted rapid systematic review using the "Navigation Guide" method. searched four databases in July 2022 and April 2024 with no restriction date. included studies predefined eligibility criteria that quantitatively examined association microplastic exposure any health outcomes. amended after screening prioritized digestive, reproductive, respiratory outcomes further evaluation. three observational examining reproductive (

Language: Английский

Citations

6