Multi-Omics Analysis Reveals Toxicity and Gut-Liver Axis Disruption Induced by Polychlorinated Biphenyls Exposure in Yellowfin Seabream (Acanthopagrus latus)

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 487, P. 137296 - 137296

Published: Jan. 19, 2025

Language: Английский

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Gut microbiota and their metabolites in the immune response of rheumatoid arthritis: Therapeutic potential and future directions

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 147, P. 114034 - 114034

Published: Jan. 12, 2025

Language: Английский

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Kidney function mediates the association of per- and poly-fluoroalkyl substances (PFAS) and heavy metals with hepatic fibrosis risk

Environmental Research, Journal Year: 2024, Volume and Issue: unknown, P. 120092 - 120092

Published: Sept. 1, 2024

Language: Английский

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Unraveling the Role of the Human Gut Microbiome in Health and Diseases

Microorganisms, Journal Year: 2024, Volume and Issue: 12(11), P. 2333 - 2333

Published: Nov. 15, 2024

The human gut is a complex ecosystem that supports billions of living species, including bacteria, viruses, archaea, phages, fungi, and unicellular eukaryotes. Bacteria give genes enzymes for microbial host-produced compounds, establishing symbiotic link between the external environment host at both systemic levels. microbiome, which primarily made up commensal critical maintaining healthy host's immune system, aiding digestion, synthesizing essential nutrients, protecting against pathogenic as well influencing endocrine, neural, humoral, immunological functions metabolic pathways. Qualitative, quantitative, and/or topographic shifts can alter resulting in dysbiosis dysfunction, contribute to variety noncommunicable illnesses, hypertension, cardiovascular disease, obesity, diabetes, inflammatory bowel cancer, irritable syndrome. While most evidence date observational does not establish direct causation, ongoing clinical trials advanced genomic techniques are steadily enhancing our understanding these intricate interactions. This review will explore key aspects relationship microbiota, eubiosis, health highlighting emerging strategies microbiome engineering potential therapeutic approaches various conditions.

Language: Английский

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Urinary Metabolomics of Plastic Manufacturing Workers: A Pilot Study

Journal of Xenobiotics, Journal Year: 2025, Volume and Issue: 15(2), P. 39 - 39

Published: March 4, 2025

The plastic manufacturing industry has a crucial role in the global economy with significant impact wide range of fields. chemical risk to which workers are potentially exposed is difficult characterize and strictly related both products processes adopted. Among chemicals used, we can cite styrene, phenol, butadiene phthalates, but nano- microplastic particles also be released work environment. In this pilot study, present for first time an NMR-based metabolomic approach assessing urinary profiles employed company. Urine samples from twelve thirteen healthy volunteers were collected analyzed by NMR spectroscopy. Forty-six metabolites belonging different classes univocally identified quantified. dataset so obtained was then subjected multivariate statistical analysis each profile highlight any differences. An alteration some involved several pathways, such as amino acid metabolism NAD metabolism, found, strong on gut microflora speculated. Ultimately, our objective adding tile knowledge biological effects possibly occupational exposure even if it below threshold limit values.

Language: Английский

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The Western Diet and Atopic Dermatitis: The Potential Role of Nutrients, Contaminants, and Additives in Dysbiosis and Epithelial Barrier Dysfunction

Antioxidants, Journal Year: 2025, Volume and Issue: 14(4), P. 386 - 386

Published: March 25, 2025

Atopic dermatitis (AD) is a chronic inflammatory skin disorder influenced by both genetic and environmental factors, collectively termed the exposome. Among these determinants, diet emerges as pivotal component, with diverse nutrients, contaminants, additives shaping immune responses, microbiota composition, systemic status. This literature review aimed to elucidate interplay between dietary factors dysbiosis in AD, providing insights into how interactions may impact disease susceptibility progression. A comprehensive search of PubMed Scopus was conducted using relevant keywords medical subject headings (MeSH). Studies published English within past 25 years were included, encompassing vitro, vivo, ex vivo research, well reviews. Priority given frequently cited articles, reflecting significant contributions current understanding. Findings suggest that habits influence AD modulating gut microbiota, pathways, processes. These underscore importance considering broader exposome framework, paving way for targeted interventions improve management. Further research needed clarify mechanisms optimize nutritional strategies, potentially informing preventive therapeutic approaches AD.

Language: Английский

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Swimming Into View: Zebrafish Uncover Targets, Mechanisms, and Therapies for Cadmium Toxicity

Current Environmental Health Reports, Journal Year: 2025, Volume and Issue: 12(1)

Published: April 22, 2025

Language: Английский

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Prenatal PFAS exposure and outcomes related to maternal gut microbiome composition in later pregnancy

Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 121709 - 121709

Published: April 1, 2025

Language: Английский

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Organophosphate Insecticide Malathion Induces Alzheimer’s Disease-Like Cognitive Impairment in Mice: Evidence of the Microbiota-Gut-Brain Axis

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 15, 2024

Evidence suggests that exposure to organophosphate pesticides increases the risk of neurodegenerative diseases, but mechanisms remain unclear. This study investigated effects malathion on Alzheimer's disease (AD)-like symptoms at environmentally relevant concentrations using wild-type (WT) and APP/PS1 transgenic mouse models. Results showed induced AD-like cognitive impairment, amyloid-β (Aβ) accumulation, neuroinflammation in WT mice, with worsened mice. Mechanistic studies revealed gut microbiota dysbiosis (reduced Lactobacillus Akkermansia, increased Dubosiella), causing barrier impairment tryptophan metabolism disruptions. resulted a significant increase indole derivatives activation colonic aryl hydrocarbon receptor (AhR), promoting kynurenine (KYN) pathway while inhibiting serotonin (5-HT) pathway. Increased neurotoxic KYN metabolites (3-hydroxykynurenine quinolinic acid) triggered systemic inflammation, upregulating hippocampal IL-6 IL-1β mRNA levels thereby neuroinflammation. Gut disruptions caused neurotransmitter imbalances, reducing 5-HT its derivatives. These promoted AD progression both highlights crucial role microbiota-gut-brain axis by exposure, providing insights into risks posed pesticides.

Language: Английский

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Early-life exposure to PCBs and PFAS exerts negative effects on the developing Central Nervous System

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 485, P. 136832 - 136832

Published: Dec. 10, 2024

Persistent organic pollutants (POPs) are ubiquitous in the environment and display capacity to bioaccumulate living organisms, constituting a hazard both wildlife humans. Although restrictions have been applied prohibit production of several POPs since 1960s, high levels these compounds can still be detected many environmental biological matrices, due their chemical properties significantly long half-lives. Some passed from mother fetus gain entry central nervous system (CNS), by crossing blood-brain barrier (BBB), resulting significant deleterious effects, including neurocognitive psychiatric abnormalities, which may lead long-term socio-economic burdens. A growing body evidence obtained clinical experimental studies has increasingly indicated that influence neurodevelopment through cellular molecular mechanisms. However, assessing mechanisms action incipient, requiring further research. Polychlorinated biphenyls (PCBs) per- polyfluoroalkyl substances (PFAS) two main classes associated with disturbances different human systems, mainly endocrine systems. This narrative review discusses PCB PFAS effects on CNS, focusing neuroinflammation oxidative stress consequences for neural development BBB integrity. Moreover, we propose could involved POP-induced neurodevelopmental defects. In this sense, highlight potential pathways affect explored preventive therapies formulate public health policies.

Language: Английский

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