Ecotoxicology and Environmental Safety,
Journal Year:
2024,
Volume and Issue:
282, P. 116689 - 116689
Published: July 15, 2024
The
recent
acceleration
of
industrialization
and
urbanization
has
brought
significant
attention
to
N-(1,3-Dimethylbutyl)-N'-phenyl-p-phenylenediamine
quinone
(6-PPDQ),
an
emerging
environmental
pollutant
from
tire
wear,
due
its
long-term
effects
on
the
environment
organisms.
Recent
studies
suggest
that
6-PPDQ
can
disrupt
neurotransmitter
synthesis
release,
impact
receptor
function,
alter
signaling
pathways,
potentially
causing
oxidative
stress,
inflammation,
apoptosis.
This
review
investigates
potential
neurotoxic
prolonged
exposure,
mechanisms
underlying
cytotoxicity,
associated
health
risks.
We
emphasize
need
for
future
research,
including
precise
exposure
assessments,
identification
individual
differences,
development
risk
assessments
intervention
strategies.
article
provides
a
comprehensive
overview
6-PPDQ's
behavior,
impact,
neurotoxicity
in
environment,
highlighting
key
areas
challenges
research.
Ecotoxicology and Environmental Safety,
Journal Year:
2024,
Volume and Issue:
272, P. 116056 - 116056
Published: Feb. 1, 2024
Using
Caenorhabditis
elegans
as
animal
model,
we
investigated
the
effect
of
exposure
to
polystyrene
nanoparticles
(PS-NPs)
in
range
μg/L
on
high
glucose
toxicity
induction.
With
lifespan
and
locomotion
behavior
endpoints,
observed
that
PS-NP
(10
100
μg/L)
enhanced
50
mM
treated
animals.
In
insulin
signaling
pathway,
expressions
genes
encoding
receptor
(daf-2),
kinases
(age-1
akt-1/2),
peptides
(ins-9,
ins-6,
daf-28)
were
increased,
daf-16
its
target
sod-3
decreased
nematodes
followed
by
exposure.
Toxicity
enhancement
was
inhibited
RNAi
daf-2,
age-1,
akt-2,
akt-1,
3
genes,
but
increased
sod-3.
The
resistance
animals
with
daf-2
could
be
suppressed
daf-16.
Moreover,
exposure,
expression
ins-9,
daf-28.
Our
data
demonstrated
risk
enhancing
toxicity.
More
importantly,
alteration
pathway
associated
Environment International,
Journal Year:
2024,
Volume and Issue:
187, P. 108677 - 108677
Published: April 21, 2024
N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine
(6PPD)
is
commonly
used
in
rubber
compounds
as
antioxidants
to
protect
against
degradation
from
heat,
oxygen,
and
ozone
exposure.
This
practice
extends
the
lifespan
of
products,
including
tires,
by
preventing
cracking,
aging,
deterioration.
However,
environmental
consequences
waste
generated
during
product
use,
particularly
formation
6PPD-quinone
(6PPD-Q)
through
reaction
6PPD
with
ozone,
have
raised
significant
concerns
due
their
detrimental
effects
on
ecosystems.
Extensive
research
has
revealed
widespread
occurrence
its
derivate
6PPD-Q
various
compartments,
air,
water,
soil.
The
emerging
substance
been
shown
pose
acute
mortality
long-term
hazards
aquatic
terrestrial
organisms
at
concentrations
below
environmentally
relevant
levels.
Studies
demonstrated
toxic
a
range
organisms,
zebrafish,
nematodes,
mammals.
These
include
neurobehavioral
changes,
reproductive
dysfunction,
digestive
damage
exposure
pathways.
Mechanistic
insights
suggest
that
mitochondrial
stress,
DNA
adduct
formation,
disruption
lipid
metabolism
contribute
toxicity
induced
6PPD-Q.
Recent
findings
human
samples,
such
blood,
urine,
cerebrospinal
fluid,
underscore
importance
further
public
health
toxicological
implications
these
compounds.
distribution,
fate,
biological
effects,
underlying
mechanisms
environment
highlight
urgent
need
for
additional
understand
address
impacts
