The invisible Threat: Assessing the reproductive and transgenerational impacts of micro- and nanoplastics on fish

Environment International, Journal Year: 2024, Volume and Issue: 183, P. 108432 - 108432

Published: Jan. 1, 2024

Micro- and nanoplastics (MNPs), emerging as pervasive environmental pollutants, present multifaceted threats to diverse ecosystems. This review critically examines the ability of MNPs traverse biological barriers in fish, leading their accumulation gonadal tissues subsequent reproductive toxicity. A focal concern is potential transgenerational harm, where offspring not directly exposed exhibit toxic effects. Characterized by extensive specific surface areas marked hydrophobicity, readily adsorb concentrate other contaminants, potentially intensifying comprehensive analysis aims provide profound insights into repercussions on fish health progeny, highlighting intricate interplay between pollutants. We delve mechanisms MNPs-induced toxicity, including histopathologic alterations, oxidative stress, disruptions hypothalamic-pituitary-gonadal axis. The also underscores urgency for future research explore size-specific dynamics long-term implications chronic exposure. Understanding these aspects crucial assessing ecological risks posed formulating strategies safeguard aquatic life.

Language: Английский

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Predicting the impacts of chemical pollutants on animal groups

Trends in Ecology & Evolution, Journal Year: 2022, Volume and Issue: 37(9), P. 789 - 802

Published: June 16, 2022

Wildlife are exposed to an increasing number and diversity of chemical pollutants.Chemical pollutants can elicit a range sublethal effects on individual organisms, but research how these contaminants affect social interactions animal groups is severely lacking.It imperative that perspectives from behavioural ecology ecotoxicology integrated, increase our understanding contaminant individuals might cascade group-level processes.We present conceptual framework for researchers practitioners guide the study emergence, organisation, function groups. Chemical pollution among fastest-growing agents global change. Synthetic chemicals with diverse modes-of-action being detected in tissues wildlife pervade entire food webs. Although such lacking. Here we synthesise two related, largely segregated fields – examine pathways by which could disrupt processes govern self-organisation, collective Our review provides roadmap prioritising within context sociality highlights important methodological advancements future research. Pollution arising production consumption synthetic now outpaces other environmental megatrends (e.g., rising CO2 emissions [1.Bernhardt E.S. et al.Synthetic as change.Front. Ecol. Environ. 2017; 15: 84-90Crossref Scopus (377) Google Scholar]). Increasing human reliance, coupled world population growth insufficient regulation, has driven exponential rise products marketed globally (>350 000 [2.Wang Z. al.Toward pollution: first comprehensive analysis national regional inventories.Environ. Sci. Technol. 2020; 54: 2575-2584Crossref PubMed (332) Scholar]), corresponding surge infiltrating environment [3.Landrigan P.J. al.Pollution health agenda prevention.Environ. Health Perspect. 2018; 126084501Crossref (52) Scholar]. Ecosystems worldwide staggering array compounds agrochemicals [4.Tang F.H.M. al.Risk pesticide at scale.Nat. Geosci. 2021; 14: 206-210Crossref (293) Scholar] metals [5.Briffa J. al.Heavy metal their toxicological humans.Heliyon. 6e04691Abstract Full Text PDF (1161) Scholar], pharmaceuticals [6.Wilkinson J.L. al.Pharmaceutical world's rivers.Proc. Natl. Acad. U. S. A. 2022; 119e2113947119Crossref (328) personal care [7.Dey al.1 - Pharmaceuticals product (PPCP) contamination—a discharge inventory.in: Prasad M.N.V. Personal Care Products: Waste Management Treatment Technology. Butterworth-Heinemann, 2019: 1-26Crossref (84) Many degrade slowly remain highly persistent environment, while others released near-constant rate thus considered be 'pseudo-persistent'. Consequently, have been wide [8.Li Y. al.Neonicotinoids decline bird biodiversity United States.Nat. Sustain. 3: 1027-1035Crossref (70) Scholar,9.Garcia-Cegarra A.M. al.Persistence, bioaccumulation vertical transfer long-finned pilot whales stranded Chilean Patagonia.Sci. Total 770145259Crossref (8) pervading webs [10.Richmond E.K. al.A suite contaminates stream riparian webs.Nat. Commun. 9: 1-9Crossref (165) Scholar,11.Yamamuro M. aquatic decrease fishery yields.Science. 2019; 366: 620-623Crossref (145) A wealth dating back Rachel Carson's seminal 1962 publication Silent Spring [12.Carson R. Spring. Fawcett Publications, 1962Google documented adverse impacts wildlife. Besides causing mortality acutely lethal levels, animals, even minute concentrations including disrupting behaviour. Such may hidden drivers declines ecological instability [13.Saaristo al.Direct indirect behaviour, evolution wildlife.Proc. Soc. B Biol. 28520181297PubMed fuelling calls better integration indicators into risk assessment [14.Ford A.T. al.The role behavioral protection.Environ. 55: 5620-5628Crossref (83) However, nearly all (see Glossary) focused behaviours little consideration emergent group functions. This critical oversight because many animals engage over lifetime live structured societies or form loosely (Figure 1). These coordinate conspecifics provide protection against predation, gain reproductive opportunities, find food, reduce energy expenditure [15.Krause al.Living Groups. Oxford University Press, 2002Google Collective behaviour directly affects both fitness. Here, novel outlines instrumental emergence self-organisation We formulate predictions disruptions ultimately outcomes, detail themselves exacerbate buffer contamination, species Importantly, presents timely opportunity integrate key step towards improving threat posed influence impacting units compose (i.e., individuals) and/or those sociality). manifest across local spatial scales change formation 2, Key figure ). integrates mechanisms underlie different types systems, dynamic fission–fusion relatively stable To predict groups, need understand they environmentally realistic exposure levels. Documented severe physiological physical impairment, subtler not stress escape response. focus examples cascading implications level (Box 1).Box 1Can make generalised certain classes will impact groups?Chemical unique challenge due sheer classes, existence numerous between classes. The species-specific, contingent several factors, degree homology non-target intended target species. Further, do primary mode-of-action conventionally associated disruption antibiotics, antihistamines), specifically designed metals, surfactants), yet still so. makes generating difficult. biological targets, disruption, general valuable directing studies sociality. In Table I, outline series individual-level induced expected consequences, identify predicted induce effects.Table IGeneral consequencesIndividual-level effectsChemical classesaFor each class, use example subgroup narrow specific targets. class 1–8.Group formationGroup dynamicsRefsAntisocial behaviour1,2,3,4,5Reduced tendency accept Higher rejection potential members.Increased conflict amongst members weaker networks. Altered structure.[33.Whitlock S.E. al.Environmentally relevant antidepressant alters courtship songbird.Chemosphere. 211: 17-24Crossref (18) Scholar,34.Hubená P. al.Prescribed aggression fishes: modify concentrations.Ecotoxicol. Saf. 227112944Crossref Scholar,92.Santos M.E.S. al.Traces tramadol water native European fish.Ecotoxicol. 212111999Crossref (9) Scholar, 93.Brodin T. al.Dilute psychiatric drug alter behavior fish natural populations.Science. 2013; 339: 814-815Crossref (602) 94.Fenske L. al.17-α-Ethinylestradiol modulates endocrine responses zebrafish.Environ. Pollut. Res. Int. 27: 29341-29351Crossref (14) Scholar]Reduced anxiety perception1,2,6Decrease propensity join (particularly if grouping primarily antipredator strategy).Slow response times actions. Less coordination cohesion. risk-taking poorer predator evasion.[30.Cerveny D. al.Bioconcentration four benzodiazepines mixture wild fish.Sci. 702134780Crossref (20) Scholar,57.Martin J.M. psychoactive pollutant fluoxetine compromises fish.Environ. 222: 592-599Crossref (90) Scholar,93.Brodin Scholar]Hyperactivity3,4Higher interaction rates, lower capacity adjust formation.Faster movement, altering cohesion polarisation. Hyperactive rejected unimpaired groups.[95.Horký al.Methamphetamine elicits addiction fish.J. Exp. 224jeb242145Crossref (23) Scholar,96.De Serrano A.R. al.Paternal common pharmaceutical (Ritalin) transgenerational Trinidadian guppies.Sci. Rep. 11: 3985Crossref (6) Scholar]Lower activity/compromised locomotion1,5,6,7,8Inability impaired join, move between, groups.Slower Impaired likely groups.[42.Eng M.L. al.Imidacloprid chlorpyrifos insecticides impair migratory ability seed-eating songbird.Sci. 7: 15176Crossref (105) Scholar,97.Ložek F. al.Behaviour cardiac signal crayfish tramadol.Aquat. Toxicol. 213105217Crossref (17) 98.Almeida C.H.S. al.Sublethal agrochemical exposures honey bees' neotropical stingless color preferences, respiration locomotory responses.Sci. 779146432Crossref 99.Bachour R.-L. al.Behavioral citalopram, tramadol, binary zebrafish (Danio rerio) larvae.Chemosphere. 238124587Crossref (39) 100.Matus G.N. al.Behavior histopathology biomarkers evaluation paracetamol propranolol Phalloceros harpagos.Environ. 25: 28601-28618Crossref Scholar]Altered cognition4,7,8Reduced process information cues formation.Reduced competence inappropriate partners. Poorer decision-making coordination.[16.Bókony V. al.Effects little-studied early development anurans.Environ. 260114078Crossref (15) Scholar,95.Horký Scholar,101.Siviter H. al.Quantifying pesticides learning memory bees.J. Appl. 2812-2821Crossref (94) Scholar]Sensory disruption3,8Inability attract discriminate members. Reduced assortment.Poor communication Uncoordinated increased failure actions.[20.Besson al.Anthropogenic stressors sensory survival via thyroid disruption.Nat. 1-10Crossref (26) Scholar,23.Ankley G.T. androgenic promoter 17-β-trenbolone fecundity endocrinology fathead minnow.Environ. Chem. 2003; 22: 1350-1360Crossref Scholar,60.Tomkins al.An endocrine-disrupting agricultural sequential female mate choice 237: 103-110Crossref (28) Scholar]1-Antidepressants selective serotonin reuptake inhibitors)2- Anxiolytics benzodiazepines)3-Steroids androgens)4- Psychostimulants central nervous system stimulants)5- Analgesics opioids)6- Beta-blockers nonselective blockers)7- Anticonvulsants dibenzazepines)8- Insecticides neonicotinoids)a For 1–8. Open table new tab 1-Antidepressants inhibitors) 2- benzodiazepines) 3-Steroids androgens) 4- stimulants) 5- opioids) 6- blockers) 7- dibenzazepines) 8- neonicotinoids) Exposure lead dramatic morphological alterations, changes body size [16.Bókony colouration [17.Chatelain al.Do trace visual signals? Effects iridescent melanic feather feral pigeon.Oikos. 126: 1542-1553Crossref sex [18.Kidd K.A. al.Collapse after estrogen.Proc. 2007; 104: 8897-8901Crossref (1577) Perhaps most fundamental interfere anatomy involved visual, auditory, olfactory, tactile senses). Various surfactants pesticides, herbicides damage chemoreceptors olfactory [19.Razmara al.Mechanism copper nanoparticle toxicity rainbow trout mucosa.Environ. 284117141Crossref (13) Scholar,20.Besson amphibians [21.Sievers al.Contaminant mixtures interact predator-avoidance larval amphibian.Ecotoxicol. 161: 482-488Crossref (44) insects [22.Williamson S.M. Wright G.A. multiple cholinergic impairs honeybees.J. 216: 1799-1807PubMed greatly reducing detect cues. extreme cases, anatomy. instance, minnows, Pimephales promelas, 17β-trenbolone developed nuptial tubercles, structures typically only found males [23.Ankley Beyond abnormalities, often causes physiological, neurological, hormonal leading phenotypic expression [24.Goodchild C.G. al.Male zebra finches (Pb) during reduced volume song nuclei, altered sexual traits, received less attention females adults.Ecotoxicol. 210111850Crossref 25.Yamindago al.Fluoxetine neurotransmission systems animals.Ecotoxicol. 227112931Crossref (10) 26.Straub al.Negative neonicotinoids male honeybee survival, physiology field.J. 58: 2515-2528Crossref individual's metabolic state, foraging activity [27.Tan al.Chronic pervasive erodes among-individual variation 263114450Crossref Changes neurological cognitive occur when mimic block actions neurotransmitters, neurohormones, steroid hormones modulate [28.Vaudin al.When drugs become pollutants: neural underlying mechanisms.Environ. 205112495PubMed also receptors signalling molecules, functionality enzymes, modulation transmission de- hyperpolarisation [29.Richardson J.R. al.Neurotoxicity pesticides.Acta Neuropathol. 138: 343-362Crossref (211) Pollutants stemming medications, behaviours, [30.Cerveny Scholar,31.Buřič citalopram invertebrate.Aquat. 200: 226-232Crossref (50) Scholar,32.Chabenat al.Alteration predatory gro

Language: Английский

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The plastic health map: A systematic evidence map of human health studies on plastic-associated chemicals

Environment International, Journal Year: 2023, Volume and Issue: 181, P. 108225 - 108225

Published: Oct. 10, 2023

The global production and use of plastic materials has increased dramatically since the 1960s there is increasing evidence human health impacts related to exposure plastic-associated chemicals. There is, however, no comprehensive, regulatory, post-market monitoring for effects chemicals or particles it unclear how many these have been investigated in humans, therefore what knowledge gaps are.To create a systematic map peer-reviewed studies investigating potential particles/chemicals on identify research provide recommendations future regulation policy.Medline Embase databases were used primary published English from Jan 1960 - 2022 that relationships between exposures included measured detected bio-samples outcomes. Plastic-associated are: micro nanoplastics, due their widespread occurrence exposure; polymers, main building blocks plastic; plasticizers flame retardants, two most common types additives with highest concentration ranges materials; bisphenols per- polyfluoroalkyl substances, chemical classes known concern are plastics. We extracted metadata population study characteristics (country, intergenerational, sex, age, general/special risk status, design), (plastic-associated particle/chemical, multiple exposures), outcome measures (biochemical, physiological, and/or clinical), which we produced interactive database 'Plastic Health Map' narrative summary.We identified 100,949 unique articles, 3,587 met our inclusion criteria map. Plastic Map freely available at https://osf.io/fhw7d/ summary tables, plots overall observations this report.We present first compiling wide range several different classes, order stakeholders, including researchers, regulators, concerned individuals, an efficient way access literature matter determine gaps. also examples data clusters facilitate reviews help direct efforts. Extensive breadth populations, outcomes addressed No nanoplastics found, found 26/1,202 search hazard confirmed be active production. Few recent "substitution" restricted such as organophosphate phthalate substitutes, bisphenol analogues. call paradigm shift whereby new rigorously tested safety before being introduced consumer products, ongoing post-introduction biomonitoring levels humans throughout individuals' life span, old age across generations.

Language: Английский

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Multi- and Transgenerational Developmental Impairments Are Induced by Decabromodiphenyl Ethane (DBDPE) in Zebrafish Larvae

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(7), P. 2887 - 2897

Published: Feb. 13, 2023

A novel brominated flame retardant decabromodiphenyl ethane (DBDPE) has become a ubiquitous emerging pollutant; hence, the knowledge of its long-term toxic effects and underlying mechanism would be critical for further health risk assessment. In present study, multi- transgenerational toxicity DBDPE was investigated in zebrafish upon life cycle exposure at environmentally relevant concentrations. The significantly increased malformation rate declined survival specifically occurred unexposed F2 larvae suggested development by DBDPE. changing profiles revealed transcriptome DNA methylome confirmed an susceptibility figured out potential disruptions glycolipid metabolism, mitochondrial energy neurodevelopment. changes biochemical indicators such as ATP production disturbance whereas alterations neurotransmitter contents light–dark stimulated behavior provided evidence neurotoxicity zebrafish. Our findings also highlighted necessity considering impacts when evaluating wild animals well human beings pollutants.

Language: Английский

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Chronic Paternal/Maternal Exposure to Environmental Concentrations of Imidacloprid and Thiamethoxam Causes Intergenerational Toxicity in Zebrafish Offspring

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(36), P. 13384 - 13396

Published: Aug. 31, 2023

Imidacloprid (IMI) and thiamethoxam (THM) are ubiquitous in aquatic ecosystems. Their negative effects on parental fish investigated while intergenerational at environmentally relevant concentrations remain unclear. In this study, F0 zebrafish exposed to IMI THM (0, 50, 500 ng L-1) for 144 days post-fertilization (dpf) was allowed spawn with two modes (internal mating cross-mating), resulting four types of F1 generations investigate the effects. affected fecundity, gonadal development, sex hormone VTG levels, accumulations found muscles ovaries. generation, paternal or maternal exposure also influenced hormones levels elevated heart rate spontaneous movement rate. LncRNA-mRNA network analysis revealed that cell cycle oocyte meiosis-related pathways groups steroid biosynthesis related were significantly enriched offspring. Similar transcriptional alterations dmrt1, insl3, cdc20, ccnb1, dnd1, ddx4, cox4i1l, cox5b2 observed gonads generations. The findings indicated prolonged could severely cause toxicity, developmental toxicity endocrine-disrupting

Language: Английский

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Paternal exposures to endocrine-disrupting chemicals induce intergenerational epigenetic influences on offspring: A review

Environment International, Journal Year: 2024, Volume and Issue: 187, P. 108689 - 108689

Published: April 24, 2024

Endocrine-disrupting chemicals (EDCs) are ubiquitous in ecological environments and have become a great issue of public health concern since the 1990 s. There is deep scientific understanding toxicity EDCs. However, recent studies found that abnormal physiological functions parents caused by EDCs could be transmitted to their unexposed offspring, leading intergenerational toxicity. We questioned whether sustained epigenetic changes occur through male germline. In this review, we (1) systematically searched available research on impacts aquatic mammal organisms, including 42 articles, (2) summarized genetic effects, such as decreased offspring survival, reproductive dysfunction, metabolic disorders, behavioral abnormalities, (3) mechanisms paternal interactions, (4) propose suggestions future directions develop deeper risk

Language: Английский

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Fish models to explore epigenetic determinants of hypoxia-tolerance

Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology, Journal Year: 2025, Volume and Issue: 302, P. 111811 - 111811

Published: Jan. 6, 2025

Language: Английский

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MOFs and their derivatives: Functionalization strategy and applications as sensitive electrode materials for environmental EDCs analysis

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 531, P. 216504 - 216504

Published: Feb. 12, 2025

Language: Английский

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Disruption by stealth - Interference of endocrine disrupting chemicals on hormonal crosstalk with thyroid axis function in humans and other animals

Environmental Research, Journal Year: 2021, Volume and Issue: 203, P. 111906 - 111906

Published: Aug. 18, 2021

Thyroid hormones (THs) are important regulators of growth, development, and homeostasis all vertebrates. There many environmental contaminants that known to disrupt TH action, yet their mechanisms only partially understood. While the effects Endocrine Disrupting Chemicals (EDCs) mostly studied as "hormone system silos", present critical review highlights complexity EDCs interfering with function through interactions other hormonal axes involved in reproduction, stress, energy metabolism. The impact on components shared between hormone signaling pathways or intersect can thus extend beyond molecular ramifications cellular, physiological, behavioral, whole-body consequences for exposed organisms. comparatively more extensive studies conducted mammalian models provides encouraging support expanded investigation highlight paucity data generated non-mammalian vertebrate classes. As greater genomics-based resources become available across classes, better identification delineation EDC effects, modes effective biomarkers suitable HPT disruption is possible. EDC-derived likely cascade into a plurality physiological far complex than few variables tested within any research studies. field should move towards understanding systems' rather maintaining silos.

Language: Английский

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Molecular consequences of the exposure to toxic substances for the endocrine system of females

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 155, P. 113730 - 113730

Published: Sept. 21, 2022

Endocrine-disrupting chemicals (EDCs) are common in the environment and everyday products such as cosmetics, plastic food packaging, medicines. These substances toxic small doses (even order of micrograms) enter body through skin, digestive or respiratory system. Numerous studies confirm negative impact EDCs on living organisms. They disrupt endocrine functions, contributing to development neoplastic neurological diseases, well problems with circulatory system reproduction. affect humans animals by modulating epigenetic processes that can lead disturbances gene expression failure even death. also steroid hormones binding their receptors interfering synthesis secretion hormones. Prenatal exposure may be related offspring, resulting effects these ovaries leading reduction fertility function steroidogenesis gametogenesis. Current literature indicates need continue research female reproductive The aim this review was identify endocrine-disrupting genetic based recent literature.

Language: Английский

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