Developmental dyslexia genes are selectively targeted by diverse environmental pollutants DOI Creative Commons
Yangyang Yang, Tingting Zheng,

Qidi Tang

et al.

BMC Psychiatry, Journal Year: 2024, Volume and Issue: 24(1)

Published: July 17, 2024

Abstract Background Developmental dyslexia, a complex neurodevelopmental disorder, not only affects children’s academic performance but is also associated with increased healthcare costs, lower employment rates, and reduced productivity. The pathogenesis of dyslexia remains unclear it generally considered to be caused by the overlap genetic environmental factors. Systematically exploring close relationship between exposure compounds susceptibility genes in development currently lacking high necessary. Methods In this study, we systematically compiled 131 publicly reported for sourced from DisGeNET, OMIM, GeneCards databases. Comparative Toxicogenomics Database database was used explore 95 compounds, including metals, persistent organic pollutants, polycyclic aromatic hydrocarbons, pesticides. Chemical bias towards risk taken into account observation/expectation ratios > 1 corresponding P value obtained hypergeometric probability test. Results Our study found that number targeted each chemical varied 109. A total 35 chemicals were involved reactions dyslexia-associated genes, significant enrichment values (observed/expected genes) ranging 1.147 (Atrazine) 66.901 (Dibenzo(a, h)pyrene). Conclusion results indicated implicated certain reactions. However, these findings are exploratory, further research involving animal or cellular experiments needed.

Language: Английский

Pesticides at brain borders: Impact on the blood-brain barrier, neuroinflammation, and neurological risk trajectories DOI
Noémie Cresto,

Isabel Forner-Piquer,

Asma Baig

et al.

Chemosphere, Journal Year: 2023, Volume and Issue: 324, P. 138251 - 138251

Published: March 4, 2023

Language: Английский

Citations

35
Degradation strategies of pesticide residue: From chemicals to synthetic biology DOI Creative Commons
Bi Ruomeng,

Ou Meihao,

Zhou Siru

et al.

Synthetic and Systems Biotechnology, Journal Year: 2023, Volume and Issue: 8(2), P. 302 - 313

Published: March 23, 2023

The past 50 years have witnessed a massive expansion in the demand and application of pesticides. However, pesticides are difficult to be completely degraded without intervention hence pesticide residue could pose persistent threat non-target organisms many aspects. To aim at problem abuse products excessive residues environment, chemical biological degradation methods widely developed but scaled insufficient solve such pollution. In recent years, bio-degradative tools instructed by synthetic principles been further studied paved way for degradation. Combining customized design strategy standardized assembly mode, engineering bacteria multi-dimensional has become an effective tool This review introduces mechanisms hazards different pesticides, summarizes applied residues, discusses advantages, applications, prospects biology degrading residues.

Language: Английский

Citations

33
Glyphosate and environmental toxicity with “One Health” approach, a review DOI
Margherita Ferrante, Paola Rapisarda,

Alfina Grasso

et al.

Environmental Research, Journal Year: 2023, Volume and Issue: 235, P. 116678 - 116678

Published: July 15, 2023

Language: Английский

Citations

29
Recent advances in removing glyphosate herbicide and its aminomethylphosphonic acid metabolite in water DOI
Jordana Georgin, Dison S.P. Franco, Claudete Gindri Ramos

et al.

Journal of Molecular Liquids, Journal Year: 2024, Volume and Issue: 402, P. 124786 - 124786

Published: April 21, 2024

Language: Английский

Citations

16
Oxidative stress induced by combined glyphosate and TBBPA exposure promotes gill autophagy and inflammation via the PI3K/AKT/mTOR pathway DOI

Mingyue Li,

Shuang Lou,

Kai Chen

et al.

Fish & Shellfish Immunology, Journal Year: 2025, Volume and Issue: unknown, P. 110190 - 110190

Published: Feb. 1, 2025

Language: Английский

Citations

1
Pesticides and the Microbiome-Gut-Brain Axis: Convergent Pathways in the Pathogenesis of Parkinson’s Disease DOI Creative Commons
Kristína Kulcsarová, Corinna Bang, Daniela Berg

et al.

Journal of Parkinson s Disease, Journal Year: 2023, Volume and Issue: 13(7), P. 1079 - 1106

Published: Oct. 31, 2023

The increasing global burden of Parkinson’s disease (PD), termed the PD pandemic, is exceeding expectations related purely to population aging and likely driven in part by lifestyle changes environmental factors. Pesticides are well recognized risk factors for PD, supported both epidemiological experimental evidence, with multiple detrimental effects beyond dopaminergic neuron damage alone. microbiome-gut-brain axis has gained much attention recent years considered be a significant contributor driver pathogenesis. In this narrative review, we first focus on how pesticides microbiome may influence initiation progression independently, describing pesticide-related central peripheral neurotoxicity microbiome-related local systemic due dysbiosis microbial metabolites. We then depict bidirectional interplay between context synthesizing current knowledge about pesticide-induced dysbiosis, microbiome-mediated alterations pesticide availability, metabolism toxicity, complex pesticide-microbiome-host interactions inflammatory metabolic pathways, insulin resistance other mechanisms. An overview unknowns follows, role pesticide-microbiome proposed body-/brain-first phenotypes complexity exposures gene-environment discussed. final deals possible further steps translation, consisting recommendations future use research as an outline promising preventive/therapeutic approaches targeted strengthening or restoring healthy gut microbiome, closing summary gaps perspectives field.

Language: Английский

Citations

20
Association between glyphosate exposure and cognitive function, depression, and neurological diseases in a representative sample of US adults: NHANES 2013–2014 analysis DOI
Ching-Chung Hsiao, An-Ming Yang, Chikang Wang

et al.

Environmental Research, Journal Year: 2023, Volume and Issue: 237, P. 116860 - 116860

Published: Aug. 9, 2023

Language: Английский

Citations

19
In situ preparation of controllable hierarchical pores Zr-PDCs metal–organic frameworks for adsorption of glyphosate DOI
Wenyu Li, Zhen Chen, Li Yang

et al.

Chemical Engineering Science, Journal Year: 2024, Volume and Issue: 288, P. 119797 - 119797

Published: Jan. 23, 2024

Language: Английский

Citations

8
Glyphosate detection via a nanomaterial-enhanced electrochemical molecularly imprinted polymer sensor DOI Creative Commons

Youssra Aghoutane,

Hakan Burhan, Fatih Şen

et al.

Journal of Analytical Science & Technology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Feb. 2, 2024

Abstract Glyphosate (GLY) is a widely used herbicide with an important role in agriculture. It effectively controls weeds, enhancing agricultural yield and product quality. However, its use raises significant concerns such as potential risks to non-target ecosystems human health. In response these concerns, we develop electrochemical sensor molecularly imprinted polymer (MIP) gold nanoparticles for GLY detection. The includes screen-printed carbon electrode (SPCE) functionalized self-assembled polyvinyl carboxylic acid chloride (PVC-COOH) layer. compounds interact groups are encapsulated by of methacrylic (MAA) cross-linked ethylene glycol dimethacrylate (EGDMA). Electrochemical performance was assessed using differential pulse voltammetry (DPV), cyclic (CV), impedance spectroscopy (EIS). Morphological characterization performed scanning electron microscopy (SEM), Fourier transform infrared (FTIR), atomic force (AFM). exhibits impressive selectivity, detecting within range 273–1200 pg/mL minimal interference from other pesticides. boasts low detection limit 0.8 (signal-to-noise ratio S / N = 3) DPV 0.001 EIS. sensor’s versatility extends various sample types, including surface water, wastewater, soil, cucumber, demonstrating high recovery rates (> 96.05%) relative standard deviation (RSD) (< 5.7%). developed MIP proven be valuable tool rapid highly sensitive diverse environmental agri-food samples.

Language: Английский

Citations

5
Impact of pesticides exposure during neurodevelopmental period on autism spectrum disorders – A focus on gut microbiota DOI Creative Commons

Yongyong Yang,

Shun Zhou, Ying Xing

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 260, P. 115079 - 115079

Published: May 30, 2023

Accumulating evidence indicates exposure to pesticides during the crucial neurodevelopmental period increases susceptibility many diseases, including disorder known as autism spectrum (ASD). In last few years, it has been hypothesized that gut microbiota dysbiosis is strongly implicated in aetiopathogenesis of ASD. Recently, new studies have suggested may be involved neurological and behavioural defects caused by pesticides, ASD symptoms. This review highlights available from recent animal human on relationship between potential disturb intestinal homeostasis, The mechanisms through which trigger ASD-like behaviours induced via altered production bacterial metabolites (short chain fatty acids, lipids, retinol, amino acid) are also described. According research, a major contributor symptoms associated with exposure. However, determine detailed mechanism action pesticide-induced behaviours, actual population scenarios epidemiological should used basis for appropriate pattern dosage studies.

Language: Английский

Citations

12