Kidney function decline mediates the adverse effects of per- and poly-fluoroalkyl substances (PFAS) on uric acid levels and hyperuricemia risk

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 471, P. 134312 - 134312

Published: April 16, 2024

Language: Английский

---

Association between exposure to per- and polyfluoroalkyl substances (PFAS) and chronic cough in American adults: Results from NHANES 2003–2012

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 291, P. 117901 - 117901

Published: Feb. 1, 2025

Chronic cough, which affects approximately 10 % of the global population, is recognized as a significant health issue, especially among females. Recent research suggests that chronic cough may be an independent disease rather than merely symptom other conditions. This study focuses on potential role exposure to perfluoroalkyl and polyfluoroalkyl substances (PFAS) in development noting PFAS has been linked various adverse outcomes. We aimed explore association between risk U.S. analyzing data from National Health Nutrition Examination Survey (NHANES) 2003 2012 examining sex-based differences. Our findings reveal several factors independently associated with increased incidence including elevated levels serum perfluorobutane sulfonic acid (PFBS) perfluoroheptanoic (PFHP). The multi-pollutant models consistently demonstrated positive correlation higher adult males, PFBS PFHP primary contributors. However, due cross-sectional design NHANES study, further necessary elucidate precise mechanisms by contribute cough.

Language: Английский

---

Associations of per- and polyfluoroalkyl substances (PFAS) and their mixture with risk of rheumatoid arthritis in the U.S. adult population

Environmental Health, Journal Year: 2024, Volume and Issue: 23(1)

Published: April 13, 2024

Abstract Background Per- and polyfluoroalkyl substances (PFAS) are known environmental contaminants with immunosuppressive properties. Their connection to rheumatoid arthritis (RA), a condition influenced by the immune system, is not well studied. This research explores association between PFAS exposure RA prevalence. Methods utilized data from NHANES, encompassing sample of 10,496 adults 2003–2018 cycles, focusing on serum levels several PFAS. The presence was determined based self-reports. study used multivariable logistic regression assess relationship individual risk, adjusting for covariates calculate odds ratios (ORs). combined effects mixtures were evaluated using BKMR, WQS regression, quantile g-computation. Additionally, sex-specific associations explored through stratified analysis. Results Higher PFOA (OR = 0.88, 95% CI: 0.79, 0.98), PFHxS 0.91, 0.83, 1.00), PFNA 0.87, 0.77, PFDA 0.89, 0.81, 0.99) concentration related lower RA. Sex-specific analysis in single chemical models indicated significant inverse only evident females. BKMR did show an obvious pattern estimates across mixture. outcomes sex-stratified g-computation demonstrated that increase mixture associated decreased females (OR: 0.76, 0.62, 0.92). We identified interaction term WQS*sex 100 repeated hold out Notably, higher significantly reduced (mean OR 0.93, 0.98). Conclusions indicates potential various their observed relationships statistically but males. These findings contribute growing body evidence indicating may have effects.

Language: Английский

---

Utilization of Artificial Intelligence Coupled with a High-Throughput, High-Content Platform in the Exploration of Neurodevelopmental Toxicity of Individual and Combined PFAS

Journal of Xenobiotics, Journal Year: 2025, Volume and Issue: 15(1), P. 24 - 24

Published: Feb. 2, 2025

Per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals used in various products, such as firefighting foams non-stick cookware, due to their resistance heat degradation. However, these same properties make them persistent the environment human body, raising public health concerns. This study selected eleven PFAS commonly found drinking water exposed Caenorhabditis elegans concentrations ranging from 0.1 200 µM assess neurodevelopmental toxicity using a high-throughput, high-content screening (HTS) platform coupled with artificial intelligence for image analysis. Our findings showed that 6:2 FTS, HFPO-DA, PFBA, PFBS, PFHxA, PFOS inhibited dopaminergic neuron activity, fluorescence intensity reductions observed across 100 µM. PFBS also disrupted synaptic transmission, causing reduced motility increased paralysis aldicarb-induced assays, most pronounced effects at higher concentrations. These impairments both activity function led behavioral deficits. Notably, was one of toxic PFAS, affecting multiple endpoints. results emphasize developmental risks exposure, highlighting impact individual compounds mixtures on neurodevelopment. knowledge is essential assessing PFAS-related informing mitigation strategies.

Language: Английский

---

Associations of body mass index, waist circumference and the weight‐adjusted waist index with daily living ability impairment in older Chinese people: A cross‐sectional study of the Chinese Longitudinal Healthy Longevity Survey

Diabetes Obesity and Metabolism, Journal Year: 2024, Volume and Issue: 26(9), P. 4069 - 4077

Published: July 4, 2024

Abstract Aim To investigate the associations of body mass index (BMI), waist circumference (WC) and weight‐adjusted (WWI) with impairment activities daily living (ADL) in older Chinese people. Methods A total 13 260 participants aged 65 years from 2018 Longitudinal Healthy Longevity Survey were included this cross‐sectional study. BMI, WC WWI calculated measurements height, weight WC. Binary logistic regression was used to estimate odds ratios (ORs) 95% confidence intervals (95% CIs). Non‐linear correlations investigated using restricted cubic spline curves. Results In multivariate fully adjusted for confounding variables, our analyses revealed significant between ADL impairment, ORs CI) 1.01 (1.00, 1.01) 1.08 (1.03, 1.12), respectively. Meanwhile, a high had higher risk compared those low WWI, an OR 1.12 (1.02, 1.23). Subgroup showed that only association did not differ any different populations. addition, we found non‐linearly associated impairment. Conclusions There are The findings show ability serve as comprehensive effective indicator obesity people emphasize importance assessing screening preventing

Language: Английский

---

Exploring the Potential Link between PFAS Exposure and Endometrial Cancer: A Review of Environmental and Sociodemographic Factors

Cancers, Journal Year: 2024, Volume and Issue: 16(5), P. 983 - 983

Published: Feb. 28, 2024

This exploratory narrative review paper delves into the intricate interplay between per- and polyfluoroalkyl substances (PFAS) exposure, sociodemographic factors, influence of stressors in context endometrial cancer. PFAS, ubiquitous environmental contaminants notorious for their persistence ecosystem, have garnered attention potential to disrupt endocrine systems provoke immune responses. We comprehensively examine various sources PFAS encompassing household items, water, air, soil, thus shedding light on multifaceted routes through which individuals encounter these compounds. Furthermore, we explore such as income, education, occupation, ethnicity/race, geographical location relationship cancer risk. also investigated role stress exposure The results revealed a significant impact factors both levels Stress emerged notable contributing factor influencing development cancer, further emphasizing importance management practices overall well-being. By synthesizing evidence from diverse fields, this underscores need interdisciplinary research targeted interventions address complex stressors,

Language: Английский

---

Associations of life’s essential 8 with MAFLD and liver fibrosis among US adults: a nationwide cross-section study

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: June 12, 2024

Background Life’s essential’ 8 (LE8) is a newly updated cardiovascular health (CVH) metrics from the American Heart Association, with close relevance to metabolism. Our objective explore association between LE8 scores and incidence of metabolic dysfunction-associated fatty liver disease (MAFLD) advanced fibrosis in adults. Methods This population-based cross-sectional study utilized data National Health Nutrition Examination Survey (NHANES) conducted 2005 2018, encompassing adults aged 20 years or older. Validated non-invasive scoring systems were employed define steatosis fibrosis. Multivariable logistic regression smooth curve fitting techniques applied evaluate associations. All analyses adjusted for survey’ complex design parameters accounted sample weights. Results A total 11,820 participants included. higher score was found be inversely associated MAFLD fibrosis, odds ratios (OR) 0.64 (95% CI: 0.57–0.71) 0.75 0.61–0.92) per 1 standard deviation (SD) increase score. Similar patterns relationship behaviors/factors In subgroup analyses, interaction test showed that age, education level, marital status, CVD, hypertension diabetes had significant impact on (all P < 0.05). Among male, elderly, wealthy, other race, depression participants, correlation not statistically ( > Younger exhibited more pronounced negative CVH metric both life Conclusion its subscales presence non-linear patterns. Optimal may significantly reduce risk

Language: Английский

---

Serum lipids mediate the association of per- and polyfluoroalkyl substances exposure and age-related macular degeneration

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(1), P. e0317678 - e0317678

Published: Jan. 31, 2025

This study aims to investigate the connection between serum lipids, per- and polyfluoroalkyl substances (PFAS), age-related macular degeneration (AMD) risk assess whether lipids mediate association PFAS AMD. 1605 participants were enrolled from NHANES 2005-2008. Four levels with high detective rates, including perfluorononanoic acid (PFNA), perfluorooctanoic (PFOA), perfluorooctane sulfonic (PFOS), perfluorohexane (PFHxS) examined. Restricted cubic spline analysis (RCS) weighted quantile sum (WQS) employed detect nonlinear mixed exposure effects. PFOS level was associated any AMD (OR, 1.54; 95% CI, 1.12 2.11; P = 0.011), early 1.43; 1.06 1.95; 0.024), late 3.35; 1.55 7.23; 0.004) risk. PFHxS 1.72; 1.01 2.93; 0.045) PFOA 2.10; 1.21 3.63; 0.011) The RCS showed a (P 0.006). WQS indicated positive relationship 1.34; 1.03 1.75; 0.030). Serum total cholesterol (TC) high-density lipoprotein (HDL) (ORTC, 1.005; 1.001 1.009; 0.026. ORHDL, 1.028; 1.014 1.042; P<0.001), mediated of risk, mediation proportions 5.73% 0.020) 7.27% 0.032), respectively. connected TC HDL this relationship.

Language: Английский

---

PM2.5 constituent exposures and maternal circulatory homocysteine in early pregnancy

Environmental Health, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 7, 2025

Elevated homocysteine (Hcy) is a pathogenic mechanism of adverse pregnancy outcomes and PM2.5–induced cardiovascular diseases. We investigated the associations fine particulate matter (PM2.5) chemical constituent exposures with maternal circulatory Hcy in early pregnancy. Serum 5-methyltetrahydrofolate 324 women (162 normal [NEP] 162 loss [EPL]) were measured by ultra-performance liquid chromatography-tandem triple quadrupole mass spectrometry. Daily to PM2.5 constituents (black carbon [BC], organic matter, nitrate, ammonium, sulfate) accessed using data Tracking Air Pollution China platform. Nonlinear linear average pollutant during post-conception period serum estimated generalized additive models multivariable regression models, respectively. Weekly cumulative distributed lag between within three months before collection analyzed nonlinear combined models. Sensitivity analyses conducted residuals instead concentrations. Three–month five associated elevated all participants, EPL group, NEP 3–12 weeks being susceptible exposure time windows. Pollutants–related generally higher group than group. Higher PM2.5, BC, sulfate increased lower but not subgroup. Sulfate was highest risk residual–related Hcy. BC both three–month periods Maternal exposures, constituent. BC–related may induce EPL. The study protocol registered for clinical trials (ChiCTR1900028619) on December 29, 2019.

Language: Английский

---

Association between cardiometabolic index (CMI) and suicidal ideation: A cross-sectional analysis of NHANES 2005 to 2018 data

Medicine, Journal Year: 2025, Volume and Issue: 104(11), P. e41816 - e41816

Published: March 14, 2025

With suicide ranking as a leading cause of death globally, identifying modifiable risk factors is crucial. Suicidal ideation (SI) significant precursor to suicide, and there growing interest in the role cardiometabolic factors, particularly index (CMI), multiplying triglyceride-to-high-density lipoprotein cholesterol ratio by waist-to-height ratio, mental health outcomes. Previous studies have shown notable relationship among lipid abnormalities, elevated triglyceride levels, depressive symptom severity, including SI. This research investigated correlation between CMI levels adult Americans SI, utilizing data from National Health Nutrition Examination Survey (NHANES) ranging years 2005 2018. After collecting on demographics, physical examinations, laboratory testing, multivariate logistic regression analysis was conducted assess SI while adjusting for relevant factors. The study, which enrolled 15,849 individuals exhibiting symptoms constituting 3.47% total, revealed association A positive found (adjusted OR = 1.07, 95% CI: 1.02-1.13, P .0029). Moreover, nonlinear identified characterized an atypical inverted U-shaped curve with breakpoint at approximately 2.08. Subgroup consistent findings across various demographic clinical subpopulations. this study demonstrate substantial increased incidence within US population. Early interventions targeted such psychological support or lifestyle adjustments, may mitigate

Language: Английский

---