Published: Jan. 1, 2024
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(1), P. 675 - 675
Published: Jan. 4, 2024
Excess body weight constitutes one of the major health challenges for societies and healthcare systems worldwide. Besides type diet, calorie intake lack physical exercise, recent data have highlighted a possible association between endocrine-disrupting chemicals (EDCs), such as bisphenol A, phthalates their analogs, obesity. EDCs represent heterogeneous group that may influence hormonal regulation mass adipose tissue morphology. Based on available from mechanistic, animal epidemiological studies including meta-analyses, evidence points towards contribution to development obesity, associated disorders obesity-related dysfunction by (1) impacting adipogenesis; (2) modulating epigenetic pathways during development, enhancing susceptibility obesity; (3) influencing neuroendocrine signals responsible appetite satiety; (4) promoting proinflammatory milieu in inducing state chronic subclinical inflammation; (5) dysregulating gut microbiome immune homeostasis; (6) thermogenic tissue. Critical periods exposure obesogenic are prenatal, neonatal, pubertal reproductive periods. Interestingly, even at low doses promote transgenerational inheritance adult obesity subsequent generations. The aim this review is summarize role EDCs, specifically BPA phthalate plasticizers, taking into account vitro, epidemiologic studies; discuss mechanisms linking analyze effects critical exposure; present interesting perspectives, preventive measures research area.
Language: Английский
Citations
38
Landscape Ecology, Journal Year: 2024, Volume and Issue: 39(8)
Published: July 17, 2024
Abstract Context Birds, as indicators of biodiversity, are experiencing habitat reduction and loss due to landscape changes. Evidence is mounting that the response bird richness patterns remains controversial on a global scale. In this study, we conducted quantitative synthesis gain comprehensive understanding relationship. Our findings contribute development conservation strategies align with objectives SDG15. Objective Through review, study investigated effects analyzed sources heterogeneity in results. Methods A random-effects model was utilized merge impacts metrics richness, meta-regression analysis performed investigate origins heterogeneity. Results The review encompassed 101 articles from 51 countries worldwide. Field sampling emerged primary method for acquiring data, multiple linear regression generalized models main analytical approaches. meta-analysis results highlighted area crucial factor influencing richness. Regarding composition, proportions forests, shrublands, water bodies positively impacted while agricultural land urban had negative effects. relationship between complexity influenced by factors, including net productivity (NPP) precipitation. Landscape identified contributing increased species Conclusion Compared complexity, composition more suitable reference tools conservation. exhibit variation. Moreover, our underscore role preserving forested areas supporting diversity, emphasizing necessity account regional variations when establishing forest cover thresholds.
Language: Английский
Citations
7
Nutrients, Journal Year: 2024, Volume and Issue: 16(16), P. 2732 - 2732
Published: Aug. 16, 2024
Recent scientific results indicate that diet is the primary source of exposure to endocrine-disrupting chemicals (EDCs) due their use in food processing, pesticides, fertilizers, and migration from packaging food, particularly plastic or canned foods. Although EDCs are not listed on nutrition labels, could inadvertently lead contamination, affecting individuals by inhalation, ingestion, direct contact. The aim our narrative review investigate role phthalates bisphenol A (BPA) foods, assessing risks for precocious puberty (PP) early-onset obesity, which two clinical entities often associated share common pathogenetic mechanisms. diverse outcomes observed across different studies highlight complexity BPA effects human body, both terms early puberty, girls, obesity with its metabolic disruptions. Moreover, independently linked might confound relationship between these pubertal timing. Given potential public health implications, it crucial adopt a precautionary approach, minimizing EDCs, especially vulnerable populations such as children.
Language: Английский
Citations
7
Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15
Published: March 8, 2024
Background Obesity and metabolic syndrome pose significant health challenges in the United States (US), with connections to disruptions sex hormone regulation. The increasing prevalence of obesity might be associated exposure phthalates (PAEs). Further exploration impact PAEs on is crucial, particularly from a perspective. Methods A total 7780 adult participants National Health Nutrition Examination Survey (NHANES) 2013 2016 were included study. Principal component analysis (PCA) coupled multinomial logistic regression was employed elucidate association between urinary metabolite concentrations likelihood obesity. Weighted quartiles sum (WQS) utilized consolidate mixed levels (total testosterone (TT), estradiol hormone-binding globulin (SHBG)). We also delved into machine learning models accurately discern status identify key variables contributing most these models. Results Component 1 (PC1), characterized by mono(2-ethyl-5-carboxypentyl) phthalate (MECPP), mono(2-ethyl-5-hydroxyhexyl) (MEHHP), mono(2-ethyl-5-oxohexyl) (MEOHP) as major contributors, exhibited negative Conversely, PC2, monocarboxyononyl (MCNP), monocarboxyoctyl (MCOP), mono(3-carboxypropyl) (MCPP) showed positive Mixed decreased TT increased SHBG. During interrelations among obesity, hormones, PAEs, based Random Forest (RF) eXtreme Gradient Boosting (XGBoost) algorithms demonstrated best classification efficacy. In both models, hormones highest variable importance, certain metabolites made contributions model’s performance. Conclusions Individuals exhibit lower SHBG, accompanied elevated levels. Exposure disrupts levels, an risk US adults. interrelationships three factors, RF XGBoost algorithm superior performance, displaying higher importance.
Language: Английский
Citations
6
Environmental Pollution, Journal Year: 2024, Volume and Issue: 349, P. 123959 - 123959
Published: April 10, 2024
Language: Английский
Citations
5
Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15
Published: Aug. 15, 2024
Diabetes and its complications significantly affect individuals’ quality of life. The etiology diabetes mellitus associated is complex not yet fully understood. There an increasing emphasis on investigating the effects endocrine disruptors diabetes, as these substances can impact cellular processes, energy production, utilization, ultimately leading to disturbances in homeostasis. Mitochondria play a crucial role generation, any impairment organelles increase susceptibility diabetes. This review examines most recent epidemiological pathogenic evidence concerning link between including complications. analysis suggests that disruptor-induced mitochondrial dysfunction—characterized by disruptions electron transport chain, dysregulation calcium ions (Ca 2+ ), overproduction reactive oxygen species (ROS), initiation signaling pathways related apoptosis—may be key mechanisms connecting development
Language: Английский
Citations
5
Environmental Pollution, Journal Year: 2025, Volume and Issue: unknown, P. 125930 - 125930
Published: March 1, 2025
Language: Английский
Citations
0
Biological Conservation, Journal Year: 2025, Volume and Issue: 307, P. 111190 - 111190
Published: May 1, 2025
Language: Английский
Citations
0
Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 2, 2024
Phthalic acid esters (PAEs) are common organic contaminants in farmland soil throughout agricultural systems, posing significant threats to human health and thus closely associated with food safety concerns. Here, we consolidate the latest findings regarding distribution, ecological effects, bioremediation methods, microbial degradation pathways of PAEs ecosystems. Generally, di(2-ethylhexyl) phthalate (DEHP), di-n-butyl (DnBP), di-isobutyl (DiBP) exhibit highest detection frequencies concentrations soil, air products. The presence these ecosystems can significantly affect plant-associated communities, leading decreased yield quality Bioremediation techniques, such as phytoremediation, frequently explored address issues. Overall, this review provides a comprehensive overview current research on China's systems offers insights into potential problems future directions.
Language: Английский
Citations
3
Environmental Pollution, Journal Year: 2024, Volume and Issue: 350, P. 124044 - 124044
Published: April 25, 2024
Phthalates may be associated with an increased risk of cardiometabolic diseases by interfering glucose and lipid metabolism promoting adipogenesis. This study aimed to perform a systematic review meta-analysis the association between phthalate exposure subclinical carotid atherosclerosis, using surrogate markers such as intima-media thickness (IMT) plaques. The literature search was performed four databases (Web Science, Medline, PubMed, Scopus), this includes all available observational studies until July 6th, 2023. Joanna Briggs Institute critical appraisal tool used assess bias. Meta-analyses were performed, random effects models used. Six high-quality cross-sectional 2570 participants aged 12 70 included. metabolites showed significant associations atherosclerosis. Exposure MBzP, ΣDEHP, MnBP IMT. MEP higher prevalence plaques, MiBP lower prevalence. Mixed results observed for MMP in older adults. meta-analyses high degree heterogeneity, are based on single studies. accurately describes evidence date, suggesting that phthalates IMT Further research is needed elucidate association, still manufacture everyday products, humans continue exposed them, atherosclerosis public health concern.
Language: Английский
Citations
2