Food Safety and Health,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 28, 2024
Abstract
Gastric
ulcer
is
a
common
peptic
that
affects
human
health
and
life
quality
seriously.
As
anti‐gastric
drugs
usually
cause
side‐effects,
polysaccharides
may
be
the
potential
alternatives
because
of
better
effectiveness
less
toxicity.
Although
activities
have
been
widely
reported,
mechanisms
not
yet
well‐disclosed.
In
this
study,
network
pharmacology
analysis
was
performed
to
explore
against
gastric
ulcer,
results
were
validated
by
molecular
docking.
Results
indicated
β‐glucan,
arabinogalactan,
xylan,
arabinan
key
structures,
ABL1,
AKT1,
androgen
receptor,
epidermal
growth
factor
v‐Ha‐ras
Harvey
rat
sarcoma
viral
oncogene
homolog,
HSP90AA1,
mitogen‐activated
protein
kinase
8
(MAPK8),
MAPK14,
NOS2,
PIK3R1,
RAC1,
ras
homolog
gene
family
member
A,
proto‐oncogene
tyrosine‐protein
Src
core
targets
for
in
treating
ulcer.
Polysaccharides
influences
on
1958
GO
items
199
KEGG
pathways,
their
are
related
MAPK,
Ras,
PI3K‐Akt,
vascular
endothelial
factor,
prolactin,
FoxO
Rap1
signaling
etc.
Molecular
docking
validation
showed
credible,
interactions
between
polysaccharide
structures
observed.
This
study
contributes
understanding
provides
references
future
activity
screening
mechanism
research
ABSTRACT
Scope:
Gallic
acid
(GA)
is
recognized
for
its
purported
antiinflammatory
properties.
GA
has
been
demonstrated
to
prevent
and
alleviate
the
symptoms
of
chronic
colitis
through
modulation
gut
microbiota,
improvement
intestinal
barrier,
reduction
inflammation.Methods
results:
In
order
determine
mechanism
by
which
exerts
protective
effect
against
colitis,
mice
were
induced
dextran
sulfate
sodium
(DSS).
The
in
disease
activity
index
25%
decrease
colon
tissue
damage
indicated
that
36
days
intervention
alleviated
DSS‐induced
symptoms.
was
observed
mitigate
weight
loss
2.5%
shortening
17.3%,
diminish
expression
pivotal
proteins
within
TLR4/nuclear
factor
κB
(NF‐κB)
signaling
cascades,
consequently
lowering
generation
inflammatory
cytokines.
Furthermore,
effectively
corrected
microbiota
imbalance,
increased
content
short‐chain
fatty
acids
(SCFAs),
turn
suppressed
inflammation,
enhanced
tight
junction
protein
expression,
thereby
strengthening
barrier.
Conclusion:
capacity
enhance
efficacy
a
multifaceted
mechanism,
influencing
barrier
function,
processes.
findings
highlight
potential
as
preventative
strategy
colitis.
Starch - Stärke,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 24, 2025
ABSTRACT
Soybean
(
Glycine
max
)
and
its
byproducts,
such
as
soybean
hull,
meal,
okara,
are
good
sources
of
non‐starch
polysaccharides
(NSP),
a
kind
potential
functional
food
ingredient.
According
to
in
vitro
vivo
studies,
this
study
reviewed
the
extraction,
purification,
structure,
physiological
functions
NSP.
Currently,
preparation
technology
NSP
was
mature,
their
structure–function
relationship
preliminarily
clear.
Furthermore,
were
indicated
exert
variety
functions,
including
gut
probiotic
effect,
anti‐oxidant
anti‐diabetes,
anti‐obesity,
anti‐cancer,
anti‐inflammation,
anti‐radiation,
so
on.
Nevertheless,
mechanisms
underlying
have
not
been
comprehensively
clarified.
On
other
hand,
standardization
raw
materials
necessary.
The
higher
needed
be
elucidated.
Moreover,
bioactivities
might
revealed
based
on
interaction
between
microbiota.
Therefore,
review
for
prevention
treatment
diseases
may
help
promote
value‐added
utilization
byproducts.
The American Journal of Chinese Medicine,
Journal Year:
2024,
Volume and Issue:
52(05), P. 1427 - 1449
Published: Jan. 1, 2024
Aging
is
an
irresistible
natural
law
of
the
progressive
decline
body
molecules,
organs,
and
overall
function
with
passage
time,
resulting
in
eventual
death.
World
Health
Organization
data
show
that
aging
correlated
a
wide
range
common
chronic
diseases
elderly,
essential
driver
many
diseases.
