Gut Microbiota as a Potential Player in Mn-Induced Neurotoxicity DOI Creative Commons
Alexey A. Tinkov, Airton C. Martins, Daiana Silva Ávila

et al.

Biomolecules, Journal Year: 2021, Volume and Issue: 11(9), P. 1292 - 1292

Published: Aug. 31, 2021

Manganese (Mn) is an essential metal, which at high exposures causes neurotoxic effects and neurodegeneration. The of Mn are mediated by neuroinflammation, oxidative endoplasmic reticulum stress, mitochondrial dysfunction, other mechanisms. Recent findings have demonstrated the potential impact overexposure on gut microbiota dysbiosis, known to contribute neurodegeneration via secretion neuroactive proinflammatory metabolites. Therefore, in this review, we discuss existing data exposure biodiversity, bacterial metabolite production, wall permeability regulating systemic levels. that may affect biodiversity altering abundance Shiegella, Ruminococcus, Dorea, Fusicatenibacter, Roseburia, Parabacteroides, Bacteroidetes, Firmicutes, Ruminococcaceae, Streptococcaceae, phyla. A Mn-induced increase Bacteroidetes a reduced Firmicutes/Bacteroidetes ratio lipopolysaccharide Moreover, addition increased (LPS) levels, capable potentiating LPS neurotoxicity. Due metabolic activity intestinal microflora, perturbations result significant alteration metabolome has least partially mediate biological overexposure. At same time, recent study healthy microbiome transplantation alleviates neurotoxicity, indicative role microflora cascade Mn-mediated High doses cause enterocyte toxicity integrity through disruption tight junctions. resulting further promotes translocation metabolites blood flow, ultimately gaining access brain leading neuroinflammation neurotransmitter imbalance. lead us hypothesize should be considered as target toxicity, although more detailed studies required characterize interplay between gut, well its pathogenesis diseases.

Language: Английский

Mechanisms of manganese-induced neurotoxicity and the pursuit of neurotherapeutic strategies DOI Creative Commons
Edward Pajarillo, Ivan Nyarko‐Danquah, Alexis Digman

et al.

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: Dec. 20, 2022

Chronic exposure to elevated levels of manganese

Language: Английский

Citations

23
Multi-omics analysis reveals Mn exposure affects ferroptosis pathway in zebrafish brain DOI Creative Commons

Shixuan Zhang,

Luli Wu,

Junrou Zhang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 253, P. 114616 - 114616

Published: Feb. 15, 2023

Manganese (Mn) accumulates in the central nervous system and can cause neurotoxicity, but mechanisms of Mn-induced neurotoxicity remain unclear. We performed single-cell RNA sequencing (scRNA-seq) zebrafish brain after Mn exposure identified 10 cell types by marker genes: cholinergic neurons, dopaminergic (DA) glutaminergic GABAergic neuronal precursors, other microglia, oligodendrocyte, radial glia, undefined cells. Each type has its distinct transcriptome profile. Pseudotime analysis revealed that DA neurons had a critical role neurological damage. Combined with metabolomic data, chronic significantly impaired amino acid lipid metabolic processes brain. Furthermore, we found disrupted ferroptosis signaling pathway zebrafish. Overall, our study employed joint multi-omics is novel potential mechanism neurotoxicity.

Language: Английский

Citations

16
Ferroptosis at the crossroads of manganese-induced neurotoxicity: A retrospective study DOI
Yaoyang Liu,

Shanyu Lv,

Guoguo He

et al.

Toxicology, Journal Year: 2024, Volume and Issue: 502, P. 153727 - 153727

Published: Jan. 10, 2024

Language: Английский

Citations

5
SIRT1 regulates mitochondrial fission to alleviate high altitude hypoxia inducedcardiac dysfunction in rats via the PGC-1α-DRP1/FIS1/MFF pathway DOI

Hongbao Xu,

Xiaona Song,

Xiaoru Zhang

et al.

APOPTOSIS, Journal Year: 2024, Volume and Issue: 29(9-10), P. 1663 - 1678

Published: April 27, 2024

Language: Английский

Citations

5
Gut Microbiota as a Potential Player in Mn-Induced Neurotoxicity DOI Creative Commons
Alexey A. Tinkov, Airton C. Martins, Daiana Silva Ávila

et al.

Biomolecules, Journal Year: 2021, Volume and Issue: 11(9), P. 1292 - 1292

Published: Aug. 31, 2021

Manganese (Mn) is an essential metal, which at high exposures causes neurotoxic effects and neurodegeneration. The of Mn are mediated by neuroinflammation, oxidative endoplasmic reticulum stress, mitochondrial dysfunction, other mechanisms. Recent findings have demonstrated the potential impact overexposure on gut microbiota dysbiosis, known to contribute neurodegeneration via secretion neuroactive proinflammatory metabolites. Therefore, in this review, we discuss existing data exposure biodiversity, bacterial metabolite production, wall permeability regulating systemic levels. that may affect biodiversity altering abundance Shiegella, Ruminococcus, Dorea, Fusicatenibacter, Roseburia, Parabacteroides, Bacteroidetes, Firmicutes, Ruminococcaceae, Streptococcaceae, phyla. A Mn-induced increase Bacteroidetes a reduced Firmicutes/Bacteroidetes ratio lipopolysaccharide Moreover, addition increased (LPS) levels, capable potentiating LPS neurotoxicity. Due metabolic activity intestinal microflora, perturbations result significant alteration metabolome has least partially mediate biological overexposure. At same time, recent study healthy microbiome transplantation alleviates neurotoxicity, indicative role microflora cascade Mn-mediated High doses cause enterocyte toxicity integrity through disruption tight junctions. resulting further promotes translocation metabolites blood flow, ultimately gaining access brain leading neuroinflammation neurotransmitter imbalance. lead us hypothesize should be considered as target toxicity, although more detailed studies required characterize interplay between gut, well its pathogenesis diseases.

Language: Английский

Citations

31