medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 6, 2024
Excessive Manganese (Mn) exposure is neurotoxic and can cause Mn-Induced Parkinsonism (MnIP), marked by cognitive motor dysfunction. Although metabolomic lipidomic research in (PD) patients exists, it remains limited. This study hypothesizes distinct profiles based on status, disease diagnosis, their interaction.
Language: Английский
Toxicological Sciences, Journal Year: 2024, Volume and Issue: 199(1), P. 1 - 11
Published: Feb. 20, 2024
Abstract Intestinal failure-associated liver disease (IFALD) is a relatively common complication in individuals receiving parenteral nutrition (PN). IFALD can be manifested as different types of injury, including steatosis, cholestasis, and fibrosis, could result failure some cases. The onset progression are highly dependent on various patient PN-related risk factors. Despite still being under investigation, several mechanisms have been proposed. Liver injury originate due to caloric overload, nutrient deficiency, toxicity, well phytosterol content, omega-6 omega-3 fatty acids ratio contained lipid emulsions. Additional include immature or defective bile acid metabolism, acute heart failure, infections, sepsis exerting negative effects via Toll-like receptor 4 nuclear factor κB inflammatory signaling. Furthermore, lack enteral feeding, gut dysbiosis, altered enterohepatic circulation that affect the farnesoid x receptor-fibroblast growth 19 axis also contribute IFALD. Various best practices adopted minimize developing IFALD, such prevention management central line infections sepsis, preservation intestine’s length, switch oral cyclic PN, avoidance overfeeding soybean oil-based formulations, avoiding hepatotoxic substances. present review thus provides comprehensive overview all relevant aspects inherent Further research focused clinical observations, translational models, advanced toxicological knowledge frameworks needed gain more insight into molecular pathogenesis hepatotoxicity, reduce incidence, encourage safe use PN.
Language: Английский
Citations
8
Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 466, P. 142970 - 142970
Published: April 18, 2023
Language: Английский
Citations
16
EFSA Journal, Journal Year: 2023, Volume and Issue: 21(12)
Published: Dec. 1, 2023
Following a request from the European Commission (EC), EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver scientific opinion tolerable upper intake level (UL) for manganese. Systematic reviews of literature human animal data were conducted assess evidence regarding excess manganese (including authorised salts) priority adverse health effect, i.e. manganese-induced neurotoxicity. Available studies support neurotoxicity as critical however, are not sufficient suitable characterise dose–response relationship identify reference point In absence adequate establish an UL, estimated background dietary intakes (i.e. natural sources only) observed among high consumers (95th percentile) used provide indication highest where there is reasonable confidence effects. A safe 8 mg/day established adults ≥ 18 years pregnant lactating women) ranged between 2 7 other population groups. The application more limited than UL because at which risk effects starts increase defined.
Language: Английский
Citations
15
Epigenomics, Journal Year: 2024, Volume and Issue: 16(1), P. 5 - 21
Published: Jan. 1, 2024
Aim: To explore the specific histone acetylation sites and oxidative stress-related genes that are associated with pathogenesis of manganese toxicity. Methods: We employed liquid chromatography-tandem mass spectrometry bioinformatics analysis to identify acetylated proteins in striatum subchronic manganese-intoxicated rats. Results: identified a total 12 differentially modified sites: H3K9ac, H3K14ac, H3K18ac, H3K56ac H3K79ac were upregulated H3K27ac, H3K36ac, H4K91ac, H4K79ac, H4K31ac, H2BK16ac H2BK20ac downregulated. Additionally, we found CAT, SOD1 SOD2 might be epigenetically regulated involved manganism. Conclusion: This study toxicity, these findings useful search for potential epigenetic targets
Language: Английский
Citations
4
Egyptian Journal of Basic and Applied Sciences, Journal Year: 2025, Volume and Issue: 12(1), P. 169 - 184
Published: Jan. 28, 2025
Language: Английский
Citations
0
Nanotechnology Science and Applications, Journal Year: 2025, Volume and Issue: Volume 18, P. 19 - 34
Published: Feb. 1, 2025
Trace elements such as manganese (Mn) are essential for various biological processes, including enzyme activation, metabolic pathways, and antioxidant defences. Given its involvement in these critical maintaining adequate Mn levels is crucial overall health. The experimental design involved 24 male Wistar rats divided into three groups (n=8 per group): a control group receiving standard supplementation (65 mg/kg), an Mn-deficient group, supplemented with Mn2O₃ nanoparticles mg/kg). 12-week feeding trial assessed selected physiological parameters, tissue composition, caecal health, biochemical markers. Body major organ weights were not significantly affected across (p=0.083 to p=0.579). However, significant differences observed fat percentage (p=0.016) lean (p<0.001). Caecal parameters showed higher ammonia (p=0.030) increased pH (p=0.031) the nano-Mn group. In turn, total SCFA concentrations highest followed by Enzymatic activities of bacteria differed between groups, reduced activity Blood plasma analysis revealed lower insulin (p<0.001) neurotransmitter levels, dopamine serotonin, compared controls. Our findings suggest that both deficiency can lead alterations, affecting metabolism, gut health microbial enzymatic or highlighting role homeostasis potential implications nutritional pharmaceutical interventions.
Language: Английский
Citations
0
Published: Jan. 1, 2025
Language: Английский
Citations
0
Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
0
Heliyon, Journal Year: 2024, Volume and Issue: 10(7), P. e28043 - e28043
Published: March 28, 2024
Rice, a primary food source in many countries of the world accumulate potentially harmful elements which pose significant health hazard to consumers. The current study aimed evaluate toxic and mineral both paddy soils rice grains associated with allied risks Malakand, Pakistan. Rice plants intact root soil were randomly collected from fields analyzed for (PTEs) through inductively coupled plasma optical emission spectrometry (ICP‒OES). Through deterministic probabilistic risk assessment models, daily intake PTEs consumption estimated children adults. results pH (<8.5) electrical conductivity (EC > 400 μs/cm), indicated slightly saline nature. mean phosphorus concentration 291.50 (mg/kg) samples exceeded FAO/WHO permissible limits. normalized variation matrix respect Ni (0.05), Ca EC (0.08), Mg (0.09), influence on mobility. In grains, concentrations (463.81), Al (70.40), As (1.23), Cr (12.53), Cu (36.07), Fe (144.32), Mn (13.89), (1.60) safety transfer factor >1 K, Cu, P Zn bioavailability these grains. Monte Carlo simulations index Cr, Zn, As, certainties 89.93% 90.17%, noncarcinogenic adults consumption. total carcinogenic (TCR) USEPA acceptable limits 1.0E-06 1.0E-04, respectively. sensitivity analysis showed that ingestion rate was key factor. Arsenic (As) primarily influenced cancer children, while chromium (Cr) significantly impacted Deterministic values due inherent uncertainties analysis. poses risks, mainly exposure investigated area.
Language: Английский
Citations
3
Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 101, P. 102498 - 102498
Published: Sept. 6, 2024
Language: Английский
Citations
3