Ferroptosis: A new view on the prevention and treatment of diabetic kidney disease with traditional Chinese medicine DOI Open Access
Yu Chen, Guodong Huang,

Ting Qin

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 170, P. 115952 - 115952

Published: Dec. 5, 2023

Diabetic kidney disease is one of the complications diabetes mellitus, which can eventually progress to end-stage disease. The increasing prevalence diabetic has brought huge economic burden society and seriously jeopardized public health. Ferroptosis an iron-dependent, non-apoptosis-regulated form cell death. regulation ferroptosis involves different molecular mechanisms multiple cellular metabolic pathways. In recent years, been proved be closely related occurrence development disease, interact with pathological changes such as fibrosis, inflammation, oxidative stress, disorders glucose lipid metabolism, destroying structure, function inherent cells kidney, promoting progression Traditional Chinese medicine a long history treating remarkable curative effect. Current scholars have shown that oral administration traditional external treatment regulate GPX4, Nrf2, ACSL4, PTGS2, TFR1 other key signaling molecules, curb ferroptosis, prevent progressive deterioration this paper, mechanism prevention are analyzed summarized, in order provide new ideas plans for

Language: Английский

Co-exposure to environmentally relevant concentrations of cadmium and polystyrene nanoplastics induced oxidative stress, ferroptosis and excessive mitophagy in mice kidney DOI
Wenyue Qiu, Jiali Ye,

Y. Su

et al.

Environmental Pollution, Journal Year: 2023, Volume and Issue: 333, P. 121947 - 121947

Published: June 1, 2023

Language: Английский

Citations

44
Vitexin attenuates chronic kidney disease by inhibiting renal tubular epithelial cell ferroptosis via NRF2 activation DOI Creative Commons
Jiayu Song,

Hongri Wang,

Jingyi Sheng

et al.

Molecular Medicine, Journal Year: 2023, Volume and Issue: 29(1)

Published: Oct. 27, 2023

Chronic kidney disease (CKD) involves a variety of pathological processes, and ferroptosis plays vital role in CKD progression. Targeting is promising strategy for the treatment CKD. However, inhibitors have not been used clinical Vitexin natural flavonoid with many biological activities protective effects against various diseases. whether vitexin can prevent progression known.In vivo, effect on was evaluated by using mouse models unilateral ureteral obstruction (UUO) ischemia-reperfusion (UIR). Western blotting, Sirius red staining transmission electron microscopy were to analyze renal tubular injury, interstitial fibrosis, inflammation kidneys UUO UIR mice. In vitro, CCK8 assays lipid peroxidation performed cell viability human epithelial cells (HK2 cells) induced erastin. The activation fibroblasts (NRK-49 F also analyzed. Additionally, an in-silico protein-drug docking model coimmunoprecipitation determine direct substrate vitexin.In significantly ameliorated our results showed that attenuated UUO- UIR-induced upregulating glutathione peroxidase 4 (GPX4) protein levels inhibiting kidneys. inhibited erastin-induced HK2 cells. Moreover, expression collagen I α-SMA (alpha-smooth muscle actin) NRK-49 supernatant erastin-treated Mechanistically, suggested could activate NRF2/heme oxygenase-1 (HO-1) pathway KEAP1- ubiquitination-mediated degradation NRF2, thereby increasing GPX4, further ferroptosis. knockout NRF2 greatly antiferroptotic vitexin.Taken together, indicate protect activating KEAP1/NRF2/HO-1 drug treat

Language: Английский

Citations

36
Liensinine pretreatment reduces inflammation, oxidative stress, apoptosis, and autophagy to alleviate sepsis acute kidney injury DOI

Wei Zhang,

Huizhen Chen,

Zhaoyun Xu

et al.

International Immunopharmacology, Journal Year: 2023, Volume and Issue: 122, P. 110563 - 110563

Published: June 29, 2023

Language: Английский

Citations

26
The Standardized Extract of Centella asiatica and Its Fractions Exert Antioxidative and Anti-Neuroinflammatory Effects on Microglial Cells and Regulate the Nrf2/HO-1 Signaling Pathway DOI

Aqilah Hambali,

Nor Atiqah Jusril, Nur Fariesha Md Hashim

et al.

Journal of Alzheimer s Disease, Journal Year: 2024, Volume and Issue: 99(s1), P. S119 - S138

Published: Jan. 16, 2024

Neuroinflammation and oxidative stress can aggravate the progression of Alzheimer's disease (AD). Centella asiatica has been traditionally consumed for memory cognition. The triterpenes (asiaticoside, madecassoside, asiatic acid, madecassic acid) have standardized in ethanolic extract (SECA). bioactivity different solvent polarities SECA is still unknown.

Language: Английский

Citations

10
Targeting ferroptosis: a new therapeutic opportunity for kidney diseases DOI Creative Commons
Zhiyong Long,

Yanfang Luo,

Min Yu

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: July 3, 2024

Ferroptosis is a form of non-apoptotic regulated cell death (RCD) that depends on iron and characterized by the accumulation lipid peroxides to lethal levels. involves multiple pathways including redox balance, regulation, mitochondrial function, amino acid, lipid, glycometabolism. Furthermore, various disease-related signaling also play role in regulating process oxidation. In recent years, with emergence concept ferroptosis in-depth study its mechanisms, closely associated biological conditions related kidney diseases, organ development, aging, immunity, cancer. This article reviews development ferroptosis, mechanisms (including GSH-GPX4, FSP1-CoQ1, DHODH-CoQ10, GCH1-BH4, MBOAT1/2 pathways), latest research progress involvement diseases. It summarizes diseases within frameworks metabolism, reactive oxygen biology, biology. The introduces key regulatory factors as well important concepts major open questions natural compounds. hoped future research, further breakthroughs can be made understanding regulation mechanism utilizing promote treatments for such acute injury(AKI), chronic disease (CKD), diabetic nephropathy(DN), renal carcinoma. paves way new approach prevent, treat clinical

Language: Английский

Citations

10
Ferroptosis contribute to neonicotinoid imidacloprid-evoked pyroptosis by activating the HMGB1-RAGE/TLR4-NF-κB signaling pathway DOI Creative Commons
Dongfang Zhang, Chunling Wu,

Deyan Ba

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 253, P. 114655 - 114655

Published: Feb. 20, 2023

Imidacloprid (IMI) is among the common neonicotinoid insecticides used in agriculture worldwide, posing a potential toxic threat to non-target animals and humans. Numerous studies have shown that ferroptosis involved pathophysiological progression of renal diseases. However, it remains unclear whether IMI-induced nephrotoxicity. In present study, we investigated pathogenic role kidney damage vivo. Transmission electron microscopy (TEM) showed mitochondrial crest cells significantly decreased following IMI exposure. Moreover, exposure triggered lipid peroxidation kidney. We confirmed nuclear factor erythroid 2-related 2 (Nrf2)-mediated antioxidant capability was negatively correlated with induced by Importantly, verified NOD-, LRR-, pyrin domain-containing protein 3 (NLRP3)-driven inflammation occurred kidneys exposure, but pretreatment inhibitor ferrostatin (Fer-1) blocked this phenomenon. Additionally, F4/80+ macrophages accumulated proximal tubules kidneys, also increased expression high-mobility group box 1 (HMGB1), receptor for advanced glycation end products (RAGE), (TLR4), kappa-B (NF-κB). contrast, inhibition Fer-1 NLRP3 inflammasome activation, F4/80 positive macrophages, HMGB1-RAGE/TLR4 signaling pathway. To best our knowledge, first study reveal stress can induce Nrf2 inactivation, thereby triggering ferroptosis, causing an initial wave death, activating signaling, which promotes pyroptosis perpetuates dysfunction.

Language: Английский

Citations

22
One‐Pot Synthesis of Luminescent and Photothermal Carbon Boron‐Nitride Quantum Dots Exhibiting Cell Damage Protective Effects DOI

Grazia M. L. Consoli,

Ludovica Maugeri, Nicolò Musso

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(16)

Published: March 21, 2024

Abstract Zero‐dimensional boron nitride quantum dots (BNQDs) are arousing interest for their versatile optical, chemical, and biochemical properties. Introducing carbon contents in BNQDs nanostructures is a great challenge to modulate physicochemical Among the moieties, phenolic groups have attracted attention properties phenol‐containing nanomaterials showing promise biomedical applications. Herein, first example of direct synthesis water dispersible exposing carboxylic presented. The carbon‐BNQDs prepared single‐step by solvent‐assisted reaction urea with boronic reagents characterized optical absorption, luminescence, Raman, Fourier transform infrared NMR spectroscopy, X‐ray photoelectron dynamic light scattering, atomic force microscopy. exhibit nanodimension, stability, high photothermal conversion efficiency, pH‐responsive luminescence Z‐potential. potential provide materials solid embedding agarose substrate successfully investigated. biocompatibility on colorectal adenocarcinoma cells (Caco‐2) protective effects from chemical oxidative stress Caco‐2, osteosarcoma (MG‐63), microglial (HMC‐3) cells. Amplicon mRNA‐seq analyses expression 56 genes involve oxidative‐stress inflammation performed evaluate molecular events responsible cell carbon‐BNQDs.

Language: Английский

Citations

7
Asiatic acid induces ferroptosis of RA-FLS via the Nrf2/HMOX1 pathway to relieve inflammation in rheumatoid arthritis DOI

Miao Sun,

Qian Wang,

Jianhua Huang

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 137, P. 112394 - 112394

Published: June 12, 2024

Language: Английский

Citations

7
Effects of the Vitamin D3 on Alleviating the Oxidative Stress Induced by Diquat in Wenchang Chickens DOI Creative Commons

Keyi Nong,

Youming Liu, Xin Fang

et al.

Animals, Journal Year: 2023, Volume and Issue: 13(4), P. 711 - 711

Published: Feb. 17, 2023

Vitamin D3 (VD3) is an indispensable micronutrient in livestock and poultry feed. Its function antioxidant stress has been reported. We investigate whether the addition of different concentrations VD3 to diet affects production performance, slaughter meat quality, organ index, gut injury on diquat (DQ)-induced model oxidative Wenchang chickens. Four hundred eighty one-day-old chickens were randomly divided into six groups: control (basal diet), 4000 VD + IU per kg feed intake), 1000 VD+DI (DQ, basal 2000 intake). The results showed that promoted DQ-induced weight loss reduced ADFI, rate, splenic pH after 1 h 24 leg muscles. decreased increase content interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) among proinflammatory cytokines (p < 0.05) increased reduction anti-inflammatory interleukin-10 (IL-10) induced by DQ. In addition, liver kidney biomarkers intestinal permeability index serum disordered treatment with DQ 0.05). perfected D-lactic acid (D-LA), diamine oxidase (DAO), total cholesterol (T-CHO), creatinine (CR), blood urea nitrogen (BUN), triglycerides (TG), low-density lipoprotein (LDL-C) content, aspartate transaminase (AST), alanine (ALT), lactate dehydrogenase (LDH) activity 0.05); it decrease albumin (ALB) Meanwhile, regulated morphology barrier. Moreover, a capacity enzyme serum, liver, jejunum 0.05), malonaldehyde (MDA) However, levels could alleviate above phenomenon degrees. Thus, this research suggested can relieve chickens, level acquisition positively correlated remission effect.

Language: Английский

Citations

16
Novel Insight into Ferroptosis in Kidney Diseases DOI
Yang Liu, Yong Liu,

Sijie Zhou

et al.

American Journal of Nephrology, Journal Year: 2023, Volume and Issue: 54(5-6), P. 184 - 199

Published: Jan. 1, 2023

Background: Various kidney diseases such as acute injury, chronic disease, polycystic renal cancer, and stones, are an important part of the global burden, bringing a huge economic burden to people around world. Ferroptosis is type nonapoptotic iron-dependent cell death caused by excess lipid peroxides accompanied abnormal iron metabolism oxidative stress. Over past few decades, several studies have shown that ferroptosis associated with many types diseases. Studying mechanism related agonists inhibitors may provide new ideas directions for treatment various Summary: In this review, we discuss differences between other apoptosis, necroptosis, pyroptosis, cuprotosis, pathophysiological features kidney, ferroptosis-induced injury. We also overview molecular mechanisms involved in events lead ferroptosis. Furthermore, summarize possible clinical applications among Key Message: The current research suggests future therapeutic efforts treat ailments would benefit from focus on

Language: Английский

Citations

16