Medicinal uses, pharmacological activities, phytochemistry, and the molecular mechanisms of Punica granatum L. (pomegranate) plant extracts: A review

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 153, P. 113256 - 113256

Published: July 14, 2022

Language: Английский

---

Production of secondary metabolites using tissue culture-based biotechnological applications

Frontiers in Plant Science, Journal Year: 2023, Volume and Issue: 14

Published: June 29, 2023

Plants are the sources of many bioactive secondary metabolites which present in plant organs including leaves, stems, roots, and flowers. Although they provide advantages to plants cases, not necessary for metabolisms related growth, development, reproduction. They specific species precursor substances, can be modified generations various compounds different species. Secondary used industries, dye, food processing cosmetic agricultural control as well being pharmaceutical raw materials by humans. For this reason, demand is high; therefore, needed obtained large volumes productions achieved using biotechnological methods addition production, done with classical methods. this, biotechnology put action through The most important these include tissue culture gene transfer. genetically agriculturally more productive commercially effective valuable tools industrial medical purposes therapeutic importance. With applications, also first step obtaining transgenic having desirable characteristics, it possible produce large-scale whole or tissues laboratory conditions. Currently, studies going on subject, some them receiving attention found taken place promising applications. In work, particularly benefits metabolites, their culture-based applications discussed literature presence current studies.

Language: Английский

---

New Insights into the Latest Advancement in α-Amylase Inhibitors of Plant Origin with Anti-Diabetic Effects

Plants, Journal Year: 2023, Volume and Issue: 12(16), P. 2944 - 2944

Published: Aug. 14, 2023

The rising predominance of type 2 diabetes, combined with the poor medical effects seen commercially available anti-diabetic medications, has motivated development innovative treatment approaches for regulating postprandial glucose levels. Natural carbohydrate digestion enzyme inhibitors might be a viable option blocking dietary absorption fewer side than manufactured medicines. Alpha-amylase is metalloenzyme that facilitates by breaking down polysaccharides into smaller molecules such as maltose and maltotriose. It also contributes to elevated blood levels hyperglycemia. As result, scientists are being urged target α-amylase create can slow release from chains prolong its absorption, thereby resulting in lower plasma derived plants have gained popularity safe cost-effective alternatives. bioactive components responsible inhibitory actions various plant extracts been identified through phytochemical research, paving way further application. majority findings, however, based on vitro investigations. Only few animal experiments very human investigations confirmed these findings. Despite some promising results, additional investigation needed develop feasible drugs plant-derived pancreatic inhibitors. This review summarizes most recent findings research inhibitors, including compounds. Furthermore, it offers insights structural aspects crucial therapeutic target, α-amylases, addition their interactions

Language: Английский

---

Natural antimicrobials from plants: Recent advances and future prospects

Food Chemistry, Journal Year: 2023, Volume and Issue: 432, P. 137231 - 137231

Published: Aug. 24, 2023

Language: Английский

---

Methods for screening and evaluation of antimicrobial activity: A review of protocols, advantages, and limitations

European Journal of Microbiology and Immunology, Journal Year: 2024, Volume and Issue: 14(2), P. 97 - 115

Published: April 22, 2024

Abstract Infectious diseases pose a formidable global challenge, compounded by the emergence of antimicrobial resistance. Consequently, researchers are actively exploring novel compounds as potential solutions. This endeavor underscores pivotal role methods employed for screening and evaluating activity—a critical step in discovery characterization agents. While traditional techniques such well-diffusion, disk-diffusion, broth-dilution commonly utilized assays, they may encounter limitations concerning reproducibility speed. Additionally, diverse array assays including cross-streaking, poisoned-food, co-culture, time-kill kinetics, resazurin assay, bioautography, etc., routinely evaluations. Advanced flow-cytometry, impedance analysis, bioluminescent technique offer rapid sensitive results, providing deeper insights into impact antimicrobials on cellular integrity. However, their higher cost limited accessibility certain laboratory settings present challenges. article provides comprehensive overview designed to characterize activity, elucidating underlying principles, protocols, advantages, limitations. The primary objective is enhance understanding methodologies agents our relentless battle against infectious diseases. By selecting appropriate testing method, can discern suitable conditions streamline identification effective

Language: Английский

---

Plant Essential Oils as Healthy Functional Ingredients of Nutraceuticals and Diet Supplements: A Review

Molecules, Journal Year: 2023, Volume and Issue: 28(2), P. 901 - 901

Published: Jan. 16, 2023

Essential oils (EOs) are mixtures of volatile molecules endowed with health-promoting biological activities that go beyond their role as aromas and natural preservatives can be exploited to develop functional foods diet supplements. Their composition is briefly addressed along regulatory aspects. The potential health benefit human supplementation EOs outlined through a review the recent literature on available clinical trials preclinical research concerning activity towards: (1) irritable bowel syndrome; (2) inflammatory disease; (3) regulation microbiota; (4) gastroprotection; (5) hepatoprotection; (6) protection urinary tract diuresis; (7) management metabolic disorders including hyperglycemia hyperlipidemia; (8) anti-inflammatory pain control; (9) immunomodulation from influenza; (10) neuroprotection modulation mood cognitive performance. emerging in such selected given focus, particularly green black cumin, bergamot, orange, myrtle, peppermint, sage, eucalyptus, lavender, thyme, lemon balm, ginger, garlic.

Language: Английский

---

Chitosan nanocarriers containing essential oils as a green strategy to improve the functional properties of chitosan: A review

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 236, P. 123954 - 123954

Published: March 9, 2023

Language: Английский

---

Fortification of polysaccharide-based packaging films and coatings with essential oils: A review of their preparation and use in meat preservation

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 242, P. 124767 - 124767

Published: May 8, 2023

Language: Английский

---

Terpenoids in essential oils: Chemistry, classification, and potential impact on human health and industry

Phytomedicine Plus, Journal Year: 2024, Volume and Issue: 4(2), P. 100549 - 100549

Published: March 24, 2024

Terpenoids, present in essential oils (EOs), have gained significant attention due to their diverse pharmacological properties and alignment with the growing global interest natural sustainable products. EOs, derived from various plants, shown promise antimicrobial, anti-inflammatory, antioxidant, other valuable applications. This comprehensive review aims elucidate chemistry roles of terpenoids covering classification, extraction techniques, potential pharmaceutical We delve into functions human immune system, impact on health, contributions environmental sustainability. The synthesizes existing literature, categorizing distinct classes, including monoterpenoids, sesquiterpenoids, diterpenoids, sesterterpenoids, triterpenoids. explore purification methods, such as steam distillation, solvent extraction, chromatography. Additionally, we discuss terpenoids, anticancer activities. Terpenoids EOs exhibit potent antimicrobial antioxidant activities, making them pivotal plant disease resistance. They also offer therapeutic applications phytomedicine, aromatherapy, beyond, capacity enhance system combat viruses, inflammation, cancer. demonstrated multifaceted benefits, contributing well-being highlights medical treatments everyday life, emphasizing need understand pharmacokinetics efficacy for harnessing full beyond.

Language: Английский

---

Anticancer effect of terpenes: focus on malignant melanoma

Pharmacological Reports, Journal Year: 2023, Volume and Issue: 75(5), P. 1115 - 1125

Published: July 29, 2023

Melanoma is a highly aggressive and life-threatening form of skin cancer that accounts for significant proportion cancer-related deaths worldwide. Although conventional therapies, such as surgical excision, chemotherapy, radiation, have been used to treat malignant melanoma, their efficacy often limited due the development resistance adverse side effects. Therefore, there growing interest in developing alternative treatment options melanoma are more effective less toxic. Terpenes, diverse group naturally occurring compounds plant origin, emerged potential anticancer agents ability inhibit tumor growth induce apoptosis cells. In this review, current understanding effects terpenes (including, thymoquinone, β-elemene, carvacrol, limonene, α-pinene, β-caryophyllene, perillyl alcohol, taxol, betulinic acid, α-bisabolol, ursolic linalool, lupeol, artesunate) was summarized, with special focus on therapeutic melanoma.

Language: Английский

---