ROS: Basic Concepts, Sources, Cellular Signaling, and its Implications in Aging Pathways

Oxidative Medicine and Cellular Longevity, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 23

Published: Oct. 19, 2022

Reactive oxygen species (ROS) are bioproducts of cellular metabolism. There is a range molecules with oxidizing properties known as ROS. Despite those being implied negatively in aging and numerous diseases, their key role signaling evident. ROS control several biological processes such inflammation, proliferation, cell death. The redox underlying these events one characteristic the new generation scientists aimed at defining environment. potential, which includes balance sources antioxidant system, implies an important target for understanding cells’ fate derived from signaling. In this review, we summarized chemical, balance, signaling, implications aging.

Language: Английский

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Regulation of Nrf2 by phosphorylation: Consequences for biological function and therapeutic implications

Free Radical Biology and Medicine, Journal Year: 2021, Volume and Issue: 168, P. 129 - 141

Published: March 30, 2021

Language: Английский

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Multi‐omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming

Aging Cell, Journal Year: 2022, Volume and Issue: 21(3)

Published: March 1, 2022

The expression of the pluripotency factors OCT4, SOX2, KLF4, and MYC (OSKM) can convert somatic differentiated cells into pluripotent stem in a process known as reprogramming. Notably, partial reversible reprogramming does not change cell identity but reverse markers aging cells, improve capacity aged mice to repair tissue injuries, extend longevity progeroid mice. However, little is about mechanisms involved. Here, we have studied changes DNA methylome, transcriptome, metabolome naturally subject single period transient OSKM expression. We found that this sufficient methylation occur upon pancreas, liver, spleen, blood. Similarly, observed reversion transcriptional changes, especially regarding biological processes during aging. Finally, some serum metabolites biomarkers altered with were also restored young levels These observations indicate drive epigenetic, transcriptomic, metabolomic toward younger configuration multiple tissues serum.

Language: Английский

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Role of Reactive Oxygen Species in Aging and Age-Related Diseases: A Review

ACS Applied Bio Materials, Journal Year: 2022, Volume and Issue: 5(9), P. 4028 - 4054

Published: Aug. 31, 2022

Research on the role of reactive oxygen species (ROS) in aging process has advanced significantly over last two decades. In light recent findings, ROS takes part cells along with contributing to various physiological signaling pathways. Antioxidants being cells' natural defense mechanism against ROS-mediated alteration, play an imperative maintain intracellular homeostasis. Although complete understanding regulated is yet be fully comprehended, current insights into sources cellular and their correlation age-related diseases are portrayed this review. addition, results effect antioxidants homeostasis as well advances clinical trials also discussed detail. The future perspective ROS-antioxidant dynamics antiaging research marshaled provide directions for fields.

Language: Английский

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Sulforaphane exhibits antiviral activity against pandemic SARS-CoV-2 and seasonal HCoV-OC43 coronaviruses in vitro and in mice

Communications Biology, Journal Year: 2022, Volume and Issue: 5(1)

Published: March 18, 2022

Abstract Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), has incited a global health crisis. Currently, there are limited therapeutic options for prevention and treatment SARS-CoV-2 infections. We evaluated antiviral activity sulforaphane (SFN), principal biologically active phytochemical derived from glucoraphanin, naturally occurring precursor present in high concentrations cruciferous vegetables. SFN inhibited vitro replication six strains SARS-CoV-2, including Delta Omicron, as well that seasonal HCoV-OC43. Further, remdesivir interacted synergistically to inhibit infection vitro. Prophylactic administration K18-hACE2 mice prior intranasal significantly decreased viral load lungs upper respiratory tract reduced lung injury pulmonary pathology compared untreated infected mice. diminished immune cell activation lungs, lower recruitment myeloid cells reduction T cytokine production. Our results suggest should be explored potential agent or

Language: Английский

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Structure and potential anti-fatigue mechanism of polysaccharides from Bupleurum chinense DC

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 306, P. 120608 - 120608

Published: Jan. 20, 2023

Language: Английский

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Metformin decelerates aging clock in male monkeys

Cell, Journal Year: 2024, Volume and Issue: 187(22), P. 6358 - 6378.e29

Published: Sept. 12, 2024

Language: Английский

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Redox toxicology of environmental chemicals causing oxidative stress

Redox Biology, Journal Year: 2020, Volume and Issue: 34, P. 101475 - 101475

Published: April 18, 2020

Living organisms are surrounded with heavy metals such as methylmercury, manganese, cobalt, cadmium, arsenic, well pesticides deltamethrin and paraquat, or atmospheric pollutants quinone. Extensive studies have demonstrated a strong link between environmental human health. Redox toxicity is proposed one of the main mechanisms chemical-induced pathology in humans. Acting both sensor oxidative stress positive regulator antioxidants, nuclear factor erythroid 2-related 2 (NRF2) has attracted recent attention. However, role NRF2 plays pollutant-induced not been systematically addressed. Here, we characterize function response to various pollutants, metals, quinones. related signaling pathways epigenetic regulations also reviewed.

Language: Английский

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Astaxanthin ameliorates oxidative stress and neuronal apoptosis via SIRT1/NRF2/Prx2/ASK1/p38 after traumatic brain injury in mice

British Journal of Pharmacology, Journal Year: 2020, Volume and Issue: 178(5), P. 1114 - 1132

Published: Dec. 17, 2020

Oxidative stress and neuronal apoptosis play key roles in traumatic brain injury. We investigated the protective effects of astaxanthin against injury its underlying mechanisms action.A weight-drop model vivo hydrogen peroxide exposure vitro were established. Brain oedema, behaviour tests, western blot, biochemical analysis, lesion volume, histopathological study cell viability performed.Astaxanthin significantly reduced oxidative insults on Days 1, 3 7 after Neuronal was also ameliorated Day 3. Additionally, improved neurological functions up to weeks Astaxanthin treatment dramatically enhanced expression peroxiredoxin 2 (Prx2), nuclear factor-erythroid 2-related factor (NRF2/Nrf2) sirtuin 1 (SIRT1), while it down-regulated phosphorylation signal-regulating kinase (ASK1) p38. Inhibition Prx2 by siRNA injection reversed beneficial Nrf2 knockout prevented neuroprotective In contrast, overexpression mice attenuated secondary Moreover, inhibiting SIRT1 EX527 inhibited suppressed SIRT1/Nrf2/Prx2/ASK1/p38 pathway both vitro.Astaxanthin protected from injury, primarily reducing death via signalling might be a new candidate ameliorate

Language: Английский

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The potential role of necroptosis in inflammaging and aging

GeroScience, Journal Year: 2019, Volume and Issue: 41(6), P. 795 - 811

Published: Nov. 13, 2019

Language: Английский

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