Journal of Inflammation Research,
Journal Year:
2024,
Volume and Issue:
Volume 17, P. 7819 - 7835
Published: Oct. 1, 2024
Sepsis
is
a
common
critical
illness
characterized
by
high
mortality
rates
and
significant
disease
burden.
In
the
context
of
sepsis-induced
organ
dysfunction,
lungs
are
among
initial
organs
affected,
which
may
progress
to
acute
lung
injury
(ALI)
respiratory
distress
syndrome
(ARDS).
Recent
studies
have
highlighted
crucial
roles
mitophagy
ferroptosis
in
development
progression
ALI/ARDS.
Identifying
key
convergence
points
these
processes
provide
valuable
insights
for
treatment
this
condition.
recent
years,
certain
herbs
their
bioactive
compounds
demonstrated
unique
benefits
managing
ALI/ARDS
modulating
or
ferroptosis.
This
review
summary
mechanisms
ferroptosis,
explores
interactions,
emphasizes
regulatory
Additionally,
it
offers
novel
perspective
on
strategies
summarizing
various
relevant
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Oct. 14, 2024
Iron,
an
essential
mineral
in
the
body,
is
involved
numerous
physiological
processes,
making
maintenance
of
iron
homeostasis
crucial
for
overall
health.
Both
overload
and
deficiency
can
cause
various
disorders
human
diseases.
Ferroptosis,
a
form
cell
death
dependent
on
iron,
characterized
by
extensive
peroxidation
lipids.
Unlike
other
kinds
classical
unprogrammed
death,
ferroptosis
primarily
linked
to
disruptions
metabolism,
lipid
peroxidation,
antioxidant
system
imbalance.
Ferroptosis
regulated
through
transcription,
translation,
post-translational
modifications,
which
affect
cellular
sensitivity
ferroptosis.
Over
past
decade
or
so,
diseases
have
been
as
part
their
etiology,
including
cancers,
metabolic
disorders,
autoimmune
diseases,
central
nervous
cardiovascular
musculoskeletal
Ferroptosis-related
proteins
become
attractive
targets
many
major
that
are
currently
incurable,
some
regulators
shown
therapeutic
effects
clinical
trials
although
further
validation
potential
needed.
Therefore,
in-depth
analysis
its
molecular
mechanisms
may
offer
additional
strategies
prevention
treatment.
In
this
review,
we
discuss
significance
contribution
etiology
development
along
with
evidence
supporting
targeting
approach.
Importantly,
evaluate
recent
promising
interventions,
providing
guidance
future
targeted
treatment
therapies
against
Frontiers in Endocrinology,
Journal Year:
2023,
Volume and Issue:
14
Published: March 14, 2023
Osteoarthritis
(OA)
is
a
typical
joint
disease
associated
with
chronic
inflammation.
The
nuclear
factor-kappaB
(NF-κB)
pathway
plays
an
important
role
in
inflammatory
activity
and
inhibiting
NF-κB-mediated
inflammation
can
be
potential
strategy
for
treating
OA.
Flavonoids
are
class
of
naturally
occurring
polyphenols
anti-inflammatory
properties.
Structurally,
natural
flavonoids
divided
into
several
sub-groups,
including
flavonols,
flavones,
flavanols/catechins,
flavanones,
anthocyanins,
isoflavones.
Increasing
evidence
demonstrates
that
exhibit
protective
against
the
pathological
changes
OA
by
NF-κB
signaling
pathway.
Potentially,
may
suppress
signaling-mediated
responses,
ECM
degradation,
chondrocyte
apoptosis.
different
biological
actions
chondrocytes
might
differentially
substituted
groups
on
structures.
In
this
review,
efficacy
action
mechanism
development
discussed
targeting
could
become
useful
inhibitors
therapeutic
management
Journal of Inflammation Research,
Journal Year:
2023,
Volume and Issue:
Volume 16, P. 4661 - 4677
Published: Oct. 1, 2023
Abstract:
Ferroptosis
is
a
new
cell
fate
decision
discovered
in
recent
years.
Unlike
apoptosis,
autophagy
or
pyroptosis,
ferroptosis
characterized
by
iron-dependent
lipid
peroxidation
and
mitochondrial
morphological
changes.
involved
variety
of
physiological
pathological
processes.
Since
its
discovery,
has
been
increasingly
studied
concerning
bone-related
diseases.
In
this
review,
we
focus
on
the
latest
research
progress
prospects,
summarize
regulatory
mechanisms
ferroptosis,
discuss
role
pathogenesis
diseases,
such
as
osteoporosis
(OP),
osteoarthritis
(OA),
rheumatoid
arthritis
(RA),
osteosarcoma
(OS),
well
therapeutic
potential.
Keywords:
death,
iron
accumulation,
peroxidation,
diseases
Chinese Medicine,
Journal Year:
2024,
Volume and Issue:
19(1)
Published: Jan. 2, 2024
Abstract
Despite
continued
advances
in
prevention
and
treatment
strategies,
cardiovascular
diseases
(CVDs)
remain
the
leading
cause
of
death
worldwide,
more
effective
therapeutic
methods
are
urgently
needed.
Polygonatum
is
a
traditional
Chinese
herbal
medicine
with
variety
pharmacological
applications
biological
activities,
such
as
antioxidant
activity,
anti-inflammation,
antibacterial
effect,
immune-enhancing
glucose
regulation,
lipid-lowering
anti-atherosclerotic
effects,
diabetes
anticancer
effect.
There
has
also
been
evidence
to
support
cardioprotective
effect
recent
years.
However,
up
now,
there
lack
comprehensive
studies
on
active
ingredients
their
pharmacotoxicological
effects
related
diseases.
Therefore,
main
components
(including
Polysaccharides,
Flavonoids,
Saponins)
activities
were
firstly
reviewed
this
paper.
Furthermore,
we
summarized
’s
preventing
treating
CVDs,
its
relevant
toxicological
investigations.
Finally,
emphasize
potential
CVDs.
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
171, P. 116194 - 116194
Published: Jan. 22, 2024
Osteoarthritis
(OA)
is
a
prevalent
degenerative
disease
that
impairs
limb
function,
and
its
pathogenesis
closely
related
to
inflammation.
Sakuranetin
(SK)
cherry
flavonoid
phytoalexin
with
potent
anti-inflammatory,
anti-oxidant,
ant-ifungal
properties.
In
recent
studies,
phytoalexin-related
medicines
have
shown
promise
in
the
treatment
of
OA.
However,
effects
SK
on
chondrocyte
inflammation
chondrogenesis
process
remained
unexplored,
as
functions
OA
treatment.
This
study
sought
confirm
therapeutic
rat
model
reveal
potential
mechanisms
for
protecting
chondrocytes.
The
relevant
were
analyzed
by
network
pharmacology
analysis.
Chondrocytes
subjected
IL-1β
intervention
simulate
an
inflammatory
environment
received
Then,
anabolism,
catabolism,
markers
detected
western
blot,
qPCR,
elisa,
immunofluorescence.
Chondrogenic
ability
was
evaluated
micromass
3D
culture
assays.
rats
treated
destabilization
medial
meniscus
(DMM)
surgery
establish
intra-articular
injections
subsequently.
Histological
staining,
immunohistochemistry,
micro-CT
performed
analyze
structural
morphological
changes
cartilage
subchondral
bone.
chondrocytes,
reduced
chondrogenic
ability,
promoted
exacerbated
triggering
PI3K/AKT/NF-κB
pathway,
whereas
partially
rescued
these
negative
effects.
vivo,
effectively
alleviated
degeneration
bone,
thereby
delaying
progression
summary,
alleviates
promotes
inhibiting
improving
progression.
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
176, P. 116777 - 116777
Published: May 24, 2024
Neuroimmune
and
neurodegenerative
ailments
impose
a
substantial
societal
burden.
disorders
involve
the
intricate
regulatory
interactions
between
immune
system
central
nervous
system.
Prominent
examples
of
neuroimmune
encompass
multiple
sclerosis
neuromyelitis
optica.
Neurodegenerative
diseases
result
from
neuronal
degeneration
or
demyelination
in
brain
spinal
cord,
such
as
Alzheimer's
disease,
Parkinson's
Huntington's
amyotrophic
lateral
sclerosis.
The
precise
underlying
pathogenesis
these
conditions
remains
incompletely
understood.
Ferroptosis,
programmed
form
cell
death
characterised
by
lipid
peroxidation
iron
overload,
plays
pivotal
role
diseases.
In
this
review,
we
provide
detailed
overview
ferroptosis,
its
mechanisms,
pathways,
regulation
during
progression
Furthermore,
summarise
impact
ferroptosis
on
neuroimmune-related
cells
(T
cells,
B
neutrophils,
macrophages)
neural
(glial
neurons).
Finally,
explore
potential
therapeutic
implications
inhibitors
diverse
Journal of Orthopaedic Translation,
Journal Year:
2024,
Volume and Issue:
44, P. 114 - 124
Published: Jan. 1, 2024
Osteoarthritis
(OA)
is
the
most
common
age-related
musculoskeletal
disease.
However,
there
still
a
lack
of
therapy
that
can
modify
OA
progression
due
to
complex
pathogenic
mechanisms.
The
aim
study
was
explore
role
and
mechanism
XJB-5-131
inhibiting
chondrocytes
ferroptosis
alleviate
progression.
We
treated
tert-butyl
hydroperoxide
(TBHP)-induced
mouse
primary
with
in
vitro.
intracellular
ferroptotic
hallmarks,
cartilage
anabolic
catabolic
markers,
regulatory
genes
proteins
were
detected.
Then
we
established
model
via
destabilization
medial
meniscus
(DMM)
surgery.
mice
intra-articular
injection
regularly
(2
μM,
3
times
per
week).
After
4
8
weeks,
performed
micro-CT
histological
examination
evaluate
protection
subjects.
RNA
sequencing
analysis
unveil
key
downstream
gene
exerting
anti-ferroptotic
effect
OA.
significantly
suppressed
TBHP-induced
increases
hallmarks
(ROS,
lipid
peroxidation,
Fe2+
accumulation),
drivers
(Ptgs2,
Pgd,
Tfrc,
Atf3,
Cdo1),
while
restored
expression
suppressors
(Gpx4,
Fth1).
evidently
promoted
decreased
markers.
Moreover,
inhibited
Cox2
Mmp13,
Col2a1,
Gpx4
Fth1
DMM-induced
articular
cartilage.
Further,
identified
Pebp1
as
potential
target
by
analysis.
anti-ferroptosis
chondroprotective
effects
diminished
Locostatin,
specific
antagonist
Pebp1.
protects
from
DMM
surgery-induced
restoring
therapeutic
drug
management
