Ecotoxicology and Environmental Safety,
Journal Year:
2022,
Volume and Issue:
231, P. 113176 - 113176
Published: Jan. 10, 2022
Lead
(Pb),
as
a
toxic
heavy
metal
pollutant,
has
been
paid
much
attention.
Pb
is
often
discharged
into
the
environment
through
soot,
wastewater
and
waste
residue
in
industrial
production,
which
poses
great
threat
to
animal
health.
Selenium
(Se)
trace
element
known
antagonize
toxicity
caused
by
metals.
However,
interaction
between
Se
chicken
kidney
its
specific
biological
mechanism
are
still
unclear.
So,
we
constructed
models
of
exposure
Pb,
co-exposure.
Therefore,
used
western
blot
qRT-PCR
detect
expression
related
genes.
The
results
showed
that
activated
MAPK
signaling
pathway
up-regulating
MARK
genes
induce
pro-apoptotic
necroptosis-related
can
regulate
attenuated
altered
reduce
apoptosis
necroptosis
cells.
Our
study
gives
new
ideas
for
nephrotoxicity
provides
reference
comparative
medicine
clinical
medication.
Frontiers in Physiology,
Journal Year:
2023,
Volume and Issue:
14
Published: June 26, 2023
Microplastics
and
pesticides
are
emerging
contaminants
in
the
marine
biota,
which
cause
many
harmful
effects
on
aquatic
organisms,
especially
fish.
Fish
is
a
staple
affordable
food
source,
rich
animal
protein,
along
with
various
vitamins,
essential
amino
acids,
minerals.
Exposure
of
fish
to
microplastics,
pesticides,
nanoparticles
generates
ROS
induces
oxidative
stress,
inflammation,
immunotoxicity,
genotoxicity,
DNA
damage
alters
gut
microbiota,
thus
reducing
growth
quality
Changes
behavioral
patterns,
swimming,
feeding
habits
were
also
observed
under
exposures
above
contaminants.
These
affect
Nrf-2,
JNK,
ERK,
NF-κB,
MAPK
signaling
pathways.
And
Nrf2-KEAP1
signalling
modulates
redox
status
marinating
enzymes
Effects
found
modulate
antioxidant
enzymes,
including
superoxide
dismutase,
catalase,
glutathione
system.
So,
protect
health
from
contribution
nano-technology
or
nano-formulations
was
researched.
A
decrease
nutritional
population
significantly
impacts
human
diet,
influencing
traditions
economics
worldwide.
On
other
hand,
traces
microplastics
habitat
water
can
enter
humans
by
consuming
contaminated
may
result
serious
hazards.
This
review
summarizes
stress
caused
due
nano-particle
contamination
exposure
their
impact
health.
As
rescue
mechanism,
use
management
disease
discussed.
Ecotoxicology and Environmental Safety,
Journal Year:
2022,
Volume and Issue:
242, P. 113944 - 113944
Published: Aug. 1, 2022
4-tert-butylphenol
(4-tBP)
is
a
toxic
environmental
pollutant
with
moderate
bioaccumulation,
persistence,
and
long-term
toxicity.
Its
toxicity
to
aquatic
organisms
has
become
an
issue
of
concern.
However,
the
molecular
mechanism
4-tBP
remained
unclear.
Liver
target
organ
for
pollutants.
Here,
we
established
4-tBP-exposed
model
in
vivo
primary
hepatocyte
vitro
common
carp
(Cyprinus
carpio
L.).
We
found
increased
hepatic-somatic
index
(HSI)
abnormal
serum
biochemical
indexes
(ALT,
AST,
LDH)
after
exposure,
indicating
liver
damage.
further
revealed
that
damaged
structural
integrity
livers
typical
features
ferroptosis.
Based
on
toxicogenomics
analysis,
ferroptosis
likely
be
involved
4-tBP-induced
Moreover,
our
experiment
provided
evidences
4-tBP-exposure
led
excess
oxidative
stress,
iron
overload,
decreased
MMP,
expression
ferroptosis-related
factors.
Interestingly,
ferrostatin-1
(Fer-1,
inhibitor)
pretreatment
alleviated
above
changes.
In
summary,
demonstrated
triggered
hepatocytes
via
SLC7A11/GSH/GPX4
axis,
ATF4/HSPA5/GPX4
axis.
For
first
time,
discovered
Fer-1
can
ameliorate
4-tBP,
which
needs
more
investigations.
Our
results
scientific
basis
fish
poisoning.
Optical
sorting
combines
optical
tweezers
with
diverse
techniques,
including
spectrum,
artificial
intelligence
(AI)
and
immunoassay,
to
endow
unprecedented
capabilities
in
particle
sorting.
In
comparison
other
methods
such
as
microfluidics,
acoustics
electrophoresis,
offers
appreciable
advantages
nanoscale
precision,
high
resolution,
non-invasiveness,
is
becoming
increasingly
indispensable
fields
of
biophysics,
chemistry,
materials
science.
This
review
aims
offer
a
comprehensive
overview
the
history,
development,
perspectives
various
categorised
passive
active
methods.
To
begin,
we
elucidate
fundamental
physics
attributes
both
conventional
exotic
forces.
We
then
explore
sorting,
which
fuses
diversity
Raman
spectroscopy
machine
learning.
Afterwards,
reveal
essential
roles
played
by
deterministic
light
fields,
configured
lens
systems
or
metasurfaces,
particles
based
on
their
varying
sizes
shapes,
resolutions
speeds.
conclude
our
vision
most
promising
futuristic
directions,
AI-facilitated
ultrafast
bio-morphology-selective
It
can
be
envisioned
that
will
inevitably
become
revolutionary
tool
scientific
research
practical
biomedical
applications.
Redox Biology,
Journal Year:
2022,
Volume and Issue:
50, P. 102255 - 102255
Published: Feb. 4, 2022
The
regeneration
of
adult
skeletal
muscle
after
injury
is
primarily
initiated
by
satellite
cells
(SCs),
but
the
regulatory
mechanisms
committed
to
myogenic
differentiation
remain
poorly
explored.
Small
molecular
selenoprotein
K
(SelK)
plays
crucial
roles
in
modulation
endoplasmic
reticulum
(ER)
stress
and
against
oxidative
stress.
Here,
we
first
showed
that
SelK
expression
activated
during
both
vivo
vitro.
Meanwhile,
loss
delayed
regeneration,
inhibited
development
myoblasts
into
myotubes,
was
accompanied
reduced
factors
(MRFs).
Moreover,
ER
stress,
intracellular
reactive
oxygen
species
(ROS),
autophagy
apoptosis
under
myogenesis
induction
were
more
severe
SelK-deficient
mice
than
corresponding
control
groups.
Supplementation
with
specific
inhibitors
alleviate
excessive
or
partly
rescued
potential
formation
myotubes.
Notably,
demonstrated
Self-mediated
regulation
cellular
redox
status
derived
from
its
subsequent
effects
on
Together,
our
results
suggest
protects
damage
a
regulator
myogenesis.
