Toxics,
Journal Year:
2023,
Volume and Issue:
11(4), P. 362 - 362
Published: April 11, 2023
Arsenic
(As)
and
Cadmium
(Cd)
are
toxic
to
rice
plants.
However,
selenium
(Se)
has
the
potential
regulate
As
Cd
toxicity.
The
present
study
aimed
evaluate
co-exposure
As5+
Se6+
species
in
two
cultivars,
BRS
Pampa
EPAGRI
108.
plants
were
divided
into
six
groups
cultivated
until
complete
maturation
of
grains,
under
greenhouse
conditions.
Regarding
total
inorganic
(i-As)
accumulation
highest
concentrations
found
for
Pampa.
For
Se,
108
presented
concentration
organic
Se
(i-Se
o-Se).
exposure
assessments
showed
that
biofortification
can
mitigate
and,
consequently,
risk
toxicity
grains
human
consumption.
combined
effect
could
represent
an
alternative
biofortify
this
food
a
safe
way
with
higher
percentage
bioavailable
Se.
Although
is
able
plants,
we
different
cultivars
same
growing
conditions
may
responses
exposure.
Cellular and Molecular Life Sciences,
Journal Year:
2024,
Volume and Issue:
81(1)
Published: Jan. 22, 2024
Abstract
Intervertebral
disc
degeneration
(IVDD)
is
one
of
the
most
prevalent
spinal
degenerative
disorders
and
imposes
places
heavy
medical
economic
burdens
on
individuals
society.
Mechanical
overloading
applied
to
intervertebral
(IVD)
has
been
widely
recognized
as
an
important
cause
IVDD.
overloading-induced
chondrocyte
ferroptosis
was
reported,
but
potential
association
between
mechanical
remains
be
illustrated
in
nucleus
pulposus
(NP)
cells.
In
this
study,
we
discovered
that
excessive
loading
induced
endoplasmic
reticulum
(ER)
stress,
which
were
detected
by
mitochondria
associated
markers,
increasing
intracellular
free
Ca
2+
level
through
Piezo1
ion
channel
localized
plasma
membrane
ER
NP
Besides,
proposed
elevation
activation
stress
are
positive
feedback
processes
promote
each
other,
consistent
with
results
coccygeal
discs
aged
Piezo1-CKO
mice
significantly
lower
than
WT
mice.
Then,
confirmed
selenium
supplementation
decreased
mitigating
upregulating
Selenoprotein
K
(SelK)
expression.
caused
impaired
production
function
Glutathione
peroxidase
4
(GPX4)
due
calcium
overload
could
improved
Se-GPX4
axis
Se-SelK
vivo
vitro,
eventually
presenting
stabilization
extracellular
matrix
(ECM).
Our
findings
reveal
role
IVDD,
promotes
significance
attenuate
thus
alleviates
might
provide
insights
into
therapeutic
interventions
for
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(3), P. 370 - 370
Published: March 18, 2024
Lead
(Pb),
a
heavy
metal
environmental
pollutant,
poses
threat
to
the
health
of
humans
and
birds.
Inflammation
is
one
most
common
pathological
phenomena
in
case
illness
poisoning.
However,
underlying
mechanisms
inflammation
remain
unclear.
The
cerebellum
thalamus
are
important
parts
nervous
system.
To
date,
there
have
been
no
reports
Pb
inducing
animal
cerebellums
or
thalami.
Selenium
(Se)
can
relieve
Therefore,
we
aimed
explore
mechanism
by
which
Se
alleviates
toxicity
thalami
chickens
establishing
chicken
or/and
treatment
model.
Our
results
demonstrated
that
exposure
caused
inflammatory
damage
thalami,
evidenced
characteristics
inflammation,
decrease
anti-inflammatory
factors
(interleukin
(IL)-2
interferon-γ
(INF-γ)),
increase
pro-inflammatory
(IL-4,
IL-6,
IL-12β,
IL-17,
nitric
oxide
(NO)).
Moreover,
found
IL-2/IL-17–NO
pathway
took
part
Pb-caused
injury.
above
findings
were
reversed
supplementation
dietary
Se,
meaning
relieved
via
pathway.
In
addition,
an
up-regulated
oxidative
index
malondialdehyde
(MDA)
two
down-regulated
antioxidant
indices
(glutathione
(GSH)
total
capacity
(TAC))
recorded
after
received
stimulation,
indicating
excess
oxidant/antioxidant
imbalance
stress,
stress
mediated
GSH–IL-2
axis.
Interestingly,
inhibited
four
glutathione
peroxidase
(GPx)
family
members
(GPx1,
GPx2,
GPx3,
GPx4),
three
deiodinase
(Dio)
(Dio1,
Dio2,
Dio3),
fifteen
other
selenoproteins
(selenophosphate
synthetase
2
(SPS2),
selenoprotein
(Sel)H,
SelI,
SelK,
SelM,
SelO,
SelP1,
SelPb,
SelS,
SelT,
SelU,
(Sep)n1,
Sepw1,
Sepx1,
Sep15),
suggesting
reduced
resulted
involving
SPS2–GPx1–GSH
supplementation,
as
expected,
changes
mentioned
above,
improved
mitigated
chickens.
For
first
time,
discovered
SPS2–GPx1–GSH–IL-2/IL-17–NO
involved
complex
conclusion,
this
study
Pb-induced
This
offers
novel
insights
into
pollutant-caused
poisoning
provides
theoretical
basis
for
detoxification
effect
against
toxic
pollutants.
Environmental Toxicology,
Journal Year:
2022,
Volume and Issue:
37(10), P. 2483 - 2492
Published: July 6, 2022
Microplastics
(MPs)
generally
refer
to
the
plastic
fragments
or
particles
smaller
than
5
mm
in
diameter,
which
are
closely
concerned
due
their
widespread
presence
environment.
Recent
studies
have
shown
that
MPs
a
serious
threat
on
reproductive
health
of
organisms.
Pigs
often
selected
as
model
animals
because
high
similarity
human
tissues
and
organs.
However,
there
no
reports
effects
mechanisms
exposure
swine
germ
cells.
In
present
study,
we
established
testis
(ST)
cell
models
exposed
250,
500,
1000
μg/ml
polystyrene
microplastics
(PS-MPs,
1-10
μm),
respectively.
The
findings
revealed
PS-MPs
reduced
viability
dose-dependently.
Acridine
orange/ethidium
bromide
staining
flow
cytometry
results
indicated
occurrence
apoptosis
necrosis
ST
cells
under
exposure,
expression
changes
relevant
marker
genes
(B-cell
lymphoma-2,
Bcl-2
Associated
X,
Caspase-3,
Caspase-9,
Receptor-interacting
protein
kinase
1,
3,
Mixed
lineage
domain-like,
Caspase-8)
were
clarified
via
quantitative
real-time
PCR
western
blot.
Further
mechanistic
found
treatment
induced
excessive
intracellular
reactive
oxygen
species
(ROS)
production,
promoted
phosphorylation
mitogen-activated
(MAPK)
pathway-related
(P38,
c-Jun
N-terminal
kinase,
extracellular
regulated
kinases)
activated
downstream
gene
hypoxia-inducible
factor
(HIF1α).
conclusion,
our
study
suggests
causes
necroptosis
ROS/MAPK/HIF1α
signaling
pathway.
