Phenolic metabolites as therapeutic in inflammation and neoplasms: Molecular pathways explaining their efficacy

Pharmacological Research, Journal Year: 2023, Volume and Issue: 193, P. 106812 - 106812

Published: June 2, 2023

Polyphenols, also known as phenolic compounds, are chemical substances containing aromatic rings well at least two hydroxyl groups. Natural compounds exist widely in plants, which protect plants from ultraviolet radiation and other insults. Phenolic have superior pharmacological nutritional properties (antimicrobial, antibacterial, antiviral, anti-sclerosis, antioxidant, anti-inflammatory activities), been paid more attention by the scientific community. Phenols can key cellular components reactive free radical damage, is mainly due to their property activate antioxidant enzymes alleviate oxidative stress inflammation. It inhibit or isolate oxygen species transfer electrons radicals, thereby avoiding cell damage. has a regulatory role glucose metabolism, promising prospect prevention intervention of diabetes. prevents cardiovascular disease regulating blood pressure lipids. Polyphenols proliferation affecting Erk1/2, CDK, PI3K/Akt signaling pathways. function enhancers intrinsic defense systems, including superoxide dismutase (SOD) glutathione peroxidase (GPX). Simultaneously, they modulate multiple proteins transcription factors, making them candidates investigation anti-cancer medications. This review focuses on aspects substances, natural origins, production process, disinfection activity, functions, effects different tumors.

Language: Английский

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The mechanism of ferroptosis and its related diseases

Molecular Biomedicine, Journal Year: 2023, Volume and Issue: 4(1)

Published: Oct. 16, 2023

Abstract Ferroptosis, a regulated form of cellular death characterized by the iron-mediated accumulation lipid peroxides, provides novel avenue for delving into intersection metabolism, oxidative stress, and disease pathology. We have witnessed mounting fascination with ferroptosis, attributed to its pivotal roles across diverse physiological pathological conditions including developmental processes, metabolic dynamics, oncogenic pathways, neurodegenerative cascades, traumatic tissue injuries. By unraveling intricate underpinnings molecular machinery, contributors, signaling conduits, regulatory networks governing researchers aim bridge gap between intricacies this unique mode multifaceted implications health disease. In light rapidly advancing landscape ferroptosis research, we present comprehensive review aiming at extensive in origins progress human diseases. This concludes careful analysis potential treatment approaches carefully designed either inhibit or promote ferroptosis. Additionally, succinctly summarized therapeutic targets compounds that hold promise targeting within various facet underscores burgeoning possibilities manipulating as strategy. summary, enriched insights both investigators practitioners, while fostering an elevated comprehension latent translational utilities. revealing basic processes investigating possibilities, crucial resource scientists medical aiding deep understanding effects situations.

Language: Английский

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International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis

Autophagy, Journal Year: 2024, Volume and Issue: 20(6), P. 1213 - 1246

Published: March 6, 2024

Macroautophagy/autophagy is a complex degradation process with dual role in cell death that influenced by the types are involved and stressors they exposed to. Ferroptosis an iron-dependent oxidative form of characterized unrestricted lipid peroxidation context heterogeneous plastic mechanisms. Recent studies have shed light on involvement specific autophagy (e.g. ferritinophagy, lipophagy, clockophagy) initiating or executing ferroptotic through selective anti-injury proteins organelles. Conversely, other forms reticulophagy lysophagy) enhance cellular defense against damage. Dysregulated autophagy-dependent ferroptosis has implications for diverse range pathological conditions. This review aims to present updated definition ferroptosis, discuss influential substrates receptors, outline experimental methods, propose guidelines interpreting results.

Language: Английский

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Zooming in and out of ferroptosis in human disease

Frontiers of Medicine, Journal Year: 2023, Volume and Issue: 17(2), P. 173 - 206

Published: April 1, 2023

Language: Английский

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Ferroptosis mechanisms and regulations in cardiovascular diseases in the past, present, and future

Cell Biology and Toxicology, Journal Year: 2024, Volume and Issue: 40(1)

Published: March 21, 2024

Abstract Cardiovascular diseases (CVDs) are the main that endanger human health, and their risk factors contribute to high morbidity a rate of hospitalization. Cell death is most important pathophysiology in CVDs. As one cell mechanisms, ferroptosis new form regulated (RCD) broadly participates CVDs (such as myocardial infarction, heart transplantation, atherosclerosis, failure, ischaemia/reperfusion (I/R) injury, atrial fibrillation, cardiomyopathy (radiation-induced cardiomyopathy, diabetes sepsis-induced cardiac doxorubicin-induced iron overload hypertrophic cardiomyopathy), pulmonary arterial hypertension), involving regulation, metabolic mechanism lipid peroxidation. This article reviews recent research on regulation its relationship with occurrence treatment CVDs, aiming provide ideas targets for clinical diagnosis by clarifying latest progress research. Graphical • The identification, development history characterization ferroptosis. role different subcellular organelles organelle-specific regulators includes metabolism, amino acid metabolism. cardiovascular cells diseases. efficacy pathological involved

Language: Английский

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A Systematic Review on Advances in Management of Oxidative Stress-Associated Cardiovascular Diseases

Antioxidants, Journal Year: 2024, Volume and Issue: 13(8), P. 923 - 923

Published: July 29, 2024

Oxidative stress plays a significant role in the pathogenesis of cardiovascular diseases, such as myocardial ischemia/reperfusion injury, atherosclerosis, heart failure, and hypertension. This systematic review aims to integrate most relevant studies on oxidative management diseases. We searched literatures PubMed database using specific keywords. put emphasis those manuscripts that were published more recently higher impact journals. reviewed total 200 articles. examined current managements including supplements like resveratrol, vitamins C E, omega-3 fatty acids, flavonoids, coenzyme-10, which have shown antioxidative properties potential benefits. In addition, we pharmacological treatments newly discovered antioxidants nanoparticles show effects targeting pathways. Lastly, biomarkers, soluble transferrin receptor, transthyretin, cystatin evaluating antioxidant status identifying risk. By addressing mechanisms, this paper emphasizes importance maintaining balance between oxidants progression is registered with International Platform Registered Systematic Review Meta-analysis Protocols (INPLASY), registration # INPLASY202470064.

Language: Английский

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Iron Metabolism in Aging and Age-Related Diseases

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(7), P. 3612 - 3612

Published: March 25, 2022

Iron is a trace metal element necessary to maintain life and also involved in variety of biological processes. Aging refers the natural process which physiological functions various systems, organs, tissues decline, affected by genetic environmental factors. Therefore, it imperative investigate relationship between iron metabolism aging-related diseases, including neurodegenerative diseases. During aging, accumulation nonheme destroys stability intracellular environment. The destruction homeostasis can induce cell damage producing hydroxyl free radicals, leading mitochondrial dysfunction, brain even organismal aging. In this review, we have briefly summarized role metabolic body, then discussed recent developments aging age-related finally, explored some chelators as treatment strategies for those disorders. Understanding roles diseases will fill knowledge gap field. This review could provide new insights into research on

Language: Английский

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Targeting Ferroptosis as a Promising Therapeutic Strategy for Ischemia-Reperfusion Injury

Antioxidants, Journal Year: 2022, Volume and Issue: 11(11), P. 2196 - 2196

Published: Nov. 6, 2022

Ischemia-reperfusion (I/R) injury is a major challenge in perioperative medicine that contributes to pathological damage various conditions, including ischemic stroke, myocardial infarction, acute lung injury, liver transplantation, kidney and hemorrhagic shock. I/R often irreversible, current treatments for are limited. Ferroptosis, type of regulated cell death characterized by the iron-dependent accumulation lipid hydroperoxides, has been implicated multiple diseases, injury. Emerging evidence suggests ferroptosis can serve as therapeutic target alleviate pharmacological strategies targeting have developed models. Here, we systematically summarize recent advances research on provide comprehensive analysis ferroptosis-regulated genes investigated context I/R, well applications regulators, insights into developing this devastating disease.

Language: Английский

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Emerging roles of ferroptosis in cardiovascular diseases

Cell Death Discovery, Journal Year: 2022, Volume and Issue: 8(1)

Published: Sept. 20, 2022

Abstract The mechanism of cardiovascular diseases (CVDs) is complex and threatens human health. Cardiomyocyte death an important participant in the pathophysiological basis CVDs. Ferroptosis a new type iron-dependent programmed cell caused by excessive accumulation lipid peroxides reactive oxygen species (ROS) abnormal iron metabolism. differs from other known pathways, such as apoptosis, necrosis, necroptosis, autophagy pyroptosis. Several compounds have been shown to induce or inhibit ferroptosis regulating related key factors signalling pathways. Recent studies confirmed that associated with development diverse CVDs may be potential therapeutic drug target for In this review, we summarize characteristics mechanisms focus on its role CVDs, goal inspiring novel treatment strategies.

Language: Английский

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Ferroptosis and Its Role in Chronic Diseases

Cells, Journal Year: 2022, Volume and Issue: 11(13), P. 2040 - 2040

Published: June 27, 2022

Ferroptosis, which has been widely associated with many diseases, is an iron-dependent regulated cell death characterized by intracellular lipid peroxide accumulation. It exhibits morphological, biochemical, and genetic characteristics that are unique in comparison to other types of death. The course ferroptosis can be accurately the metabolism iron, lipids, amino acids, various signal pathways. In this review, we summarize basic ferroptosis, its regulation, as well relationship between chronic diseases such cancer, nervous system metabolic inflammatory bowel diseases. Finally, describe regulatory effects food-borne active ingredients on ferroptosis.

Language: Английский

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