Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
178, P. 117183 - 117183
Published: July 30, 2024
Atherosclerosis,
characterized
by
the
accumulation
of
plaque
within
arterial
walls,
is
an
intricate
cardiovascular
disease
that
often
results
in
severe
health
issues.
Recent
studies
have
emphasized
importance
ferroptosis,
a
controlled
type
cell
death
dependent
on
iron,
as
critical
factor
this
state.
Ferroptosis,
distinguished
its
reliance
iron
and
lipid
hydroperoxides,
offers
unique
insight
into
pathology
atherosclerotic
lesions.
This
summary
encapsulates
current
knowledge
role
ferroptosis
plays
onset
progression
atherosclerosis.
It
explores
molecular
processes
through
which
peroxidation
metabolism
contribute
to
development
atheromatous
plaques
evaluates
possibility
utilizing
novel
treatment
approach
for
By
illuminating
relationship
between
ferroptosis-related
atherosclerosis,
review
paves
way
future
clinical
applications
personalized
medicine
approaches
aimed
at
alleviating
effects
Molecular Biomedicine,
Journal Year:
2023,
Volume and Issue:
4(1)
Published: Oct. 16, 2023
Abstract
Ferroptosis,
a
regulated
form
of
cellular
death
characterized
by
the
iron-mediated
accumulation
lipid
peroxides,
provides
novel
avenue
for
delving
into
intersection
metabolism,
oxidative
stress,
and
disease
pathology.
We
have
witnessed
mounting
fascination
with
ferroptosis,
attributed
to
its
pivotal
roles
across
diverse
physiological
pathological
conditions
including
developmental
processes,
metabolic
dynamics,
oncogenic
pathways,
neurodegenerative
cascades,
traumatic
tissue
injuries.
By
unraveling
intricate
underpinnings
molecular
machinery,
contributors,
signaling
conduits,
regulatory
networks
governing
researchers
aim
bridge
gap
between
intricacies
this
unique
mode
multifaceted
implications
health
disease.
In
light
rapidly
advancing
landscape
ferroptosis
research,
we
present
comprehensive
review
aiming
at
extensive
in
origins
progress
human
diseases.
This
concludes
careful
analysis
potential
treatment
approaches
carefully
designed
either
inhibit
or
promote
ferroptosis.
Additionally,
succinctly
summarized
therapeutic
targets
compounds
that
hold
promise
targeting
within
various
facet
underscores
burgeoning
possibilities
manipulating
as
strategy.
summary,
enriched
insights
both
investigators
practitioners,
while
fostering
an
elevated
comprehension
latent
translational
utilities.
revealing
basic
processes
investigating
possibilities,
crucial
resource
scientists
medical
aiding
deep
understanding
effects
situations.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(4), P. 3658 - 3658
Published: Feb. 11, 2023
Senescence
is
a
cellular
aging
process
in
all
multicellular
organisms.
It
characterized
by
decay
functions
and
proliferation,
resulting
increased
damage
death.
This
condition
plays
an
essential
role
the
significantly
contributes
to
development
of
age-related
complications.
On
other
hand,
ferroptosis
systemic
cell
death
pathway
excessive
iron
accumulation
followed
generation
reactive
oxygen
species
(ROS).
Oxidative
stress
common
trigger
this
may
be
induced
various
factors
such
as
toxins,
drugs,
inflammation.
Ferroptosis
linked
numerous
disorders,
including
cardiovascular
disease,
neurodegeneration,
cancer.
believed
contribute
tissue
organ
occurring
with
aging.
has
also
been
pathologies,
diseases,
diabetes,
In
particular,
senescent
cells
have
shown
produce
inflammatory
cytokines
pro-inflammatory
molecules
that
can
these
conditions.
turn,
health
known
play
pathologies
promoting
damaged
or
diseased
contributing
inflammation
often
associated.
Both
senescence
are
complex
pathways
still
not
fully
understood.
Further
research
needed
thoroughly
investigate
processes
identify
potential
interventions
target
order
prevent
treat
systematic
review
aims
assess
mechanisms
underlying
link
connecting
senescence,
ferroptosis,
aging,
whether
they
exploited
block
limit
physiological
elderly
people
for
healthy
longevity.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 10, 2024
Abstract
Doxorubicin
(DOX)
is
an
effective
anticancer
agent,
but
its
clinical
utility
constrained
by
dose‐dependent
cardiotoxicity,
partly
due
to
cardiomyocyte
ferroptosis.
However,
the
progress
of
developing
cardioprotective
medications
counteract
ferroptosis
has
encountered
obstacles.
Protosappanin
A
(PrA),
anti‐inflammatory
compound
derived
from
hematoxylin,
shows
potential
against
DOX‐induced
cardiomyopathy
(DIC).
Here,
it
reported
that
PrA
alleviates
myocardial
damage
and
dysfunction
reducing
maintaining
mitochondrial
homeostasis.
Subsequently,
molecular
target
through
proteome
microarray,
docking,
dynamics
simulation
identified.
Mechanistically,
physically
binds
with
ferroptosis‐related
proteins
acyl‐CoA
synthetase
long‐chain
family
member
4
(ACSL4)
ferritin
heavy
chain
1
(FTH1),
ultimately
inhibiting
ACSL4
phosphorylation
subsequent
phospholipid
peroxidation,
while
also
preventing
FTH1
autophagic
degradation
release
ferrous
ions
(Fe
2+
)
release.
Given
critical
role
in
pathogenesis
ischemia‐reperfusion
(IR)
injury,
this
further
investigation
posits
can
confer
a
protective
effect
IR‐induced
cardiac
Overall,
novel
pharmacological
inhibitor
unveiled
targets
uncover
dual‐regulated
mechanism
for
DIC,
highlighting
additional
therapeutic
options
chemodrug‐induced
cardiotoxicity
ferroptosis‐triggered
disorders.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(16), P. 12928 - 12928
Published: Aug. 18, 2023
Iron
is
essential
for
all
organisms
and
cells.
Diseases
of
iron
imbalance
affect
billions
patients,
including
those
with
overload
other
forms
toxicity.
Excess
load
an
adverse
prognostic
factor
diseases
can
cause
serious
organ
damage
fatalities
following
chronic
red
blood
cell
transfusions
in
patients
many
conditions,
hemoglobinopathies,
myelodyspasia,
hematopoietic
stem
transplantation.
Similar
toxicity
excess
body
but
at
a
slower
rate
disease
progression
found
idiopathic
haemochromatosis
patients.
deposition
different
regions
the
brain
suspected
has
been
identified
by
MRI
T2*
similar
methods
neurodegenerative
diseases,
Alzheimer’s
Parkinson’s
disease.
Based
on
its
role
as
major
biological
catalyst
free
radical
reactions
Fenton
reaction,
also
implicated
associated
pathology
tissue
damage.
Furthermore,
recent
discovery
ferroptosis,
which
death
program
based
generation
membrane
lipid
oxidation,
sparked
thousands
investigations
association
cardiac,
kidney,
liver,
cancer
infections.
The
implications
labile,
non-protein
bound
form
complexes
dietary
molecules
such
vitamin
C
drugs
doxorubicin
xenobiotic
relation
to
carcinogenesis
are
discussed.
In
each
case
toxicity,
mechanistic
insights,
diagnostic
criteria,
molecular
interactions
design
new
effective
therapeutic
interventions
future
targeted
strategies.
particular,
this
approach
successful
treatment
most
loading
conditions
especially
transition
thalassemia
from
fatal
due
protocols
resulting
complete
elimination
Circulation Research,
Journal Year:
2023,
Volume and Issue:
132(8), P. 1013 - 1033
Published: April 13, 2023
Diseases
of
the
heart
and
kidney,
including
failure
chronic
kidney
disease,
can
dramatically
impair
life
expectancy
quality
patients.
The
form
a
functional
axis;
therefore,
impairment
1
organ
will
inevitably
affect
function
other.
Fibrosis
represents
common
final
pathway
diseases
both
organs,
regardless
disease
entity.
Thus,
inhibition
fibrosis
promising
therapeutic
approach
to
treat
organs
resolve
impairment.
However,
despite
growing
knowledge
in
this
field,
exact
pathomechanisms
that
drive
remain
elusive.
RNA-sequencing
approaches,
particularly
single-cell
RNA-sequencing,
have
revolutionized
investigation
at
molecular
level
facilitated
discovery
disease-associated
cell
types
mechanisms.
In
review,
we
give
brief
overview
over
evolution
techniques,
summarize
most
recent
insights
into
pathogenesis
fibrosis,
discuss
how
transcriptomic
data
be
used,
identify
new
drug
targets
develop
novel
strategies.
Journal of Inflammation Research,
Journal Year:
2023,
Volume and Issue:
Volume 16, P. 4661 - 4677
Published: Oct. 1, 2023
Abstract:
Ferroptosis
is
a
new
cell
fate
decision
discovered
in
recent
years.
Unlike
apoptosis,
autophagy
or
pyroptosis,
ferroptosis
characterized
by
iron-dependent
lipid
peroxidation
and
mitochondrial
morphological
changes.
involved
variety
of
physiological
pathological
processes.
Since
its
discovery,
has
been
increasingly
studied
concerning
bone-related
diseases.
In
this
review,
we
focus
on
the
latest
research
progress
prospects,
summarize
regulatory
mechanisms
ferroptosis,
discuss
role
pathogenesis
diseases,
such
as
osteoporosis
(OP),
osteoarthritis
(OA),
rheumatoid
arthritis
(RA),
osteosarcoma
(OS),
well
therapeutic
potential.
Keywords:
death,
iron
accumulation,
peroxidation,
diseases
