Improving Neuropsychological Rehabilitation for COVID-19 Patients

Zeitschrift für Neuropsychologie, Journal Year: 2023, Volume and Issue: 34(2), P. 57 - 70

Published: May 24, 2023

Abstract: Cognitive sequelae after recovery from an initial COVID-19 disease are present in a subset of affected individuals, coalescing around several important issues such as effects age, severity, comorbidities, and other factors. Some neuropsychological symptoms appear more common among certain patient populations. Comorbidities may complicate assessment well. Hence, we need guideline-based evaluation to guide rehabilitation. Drawing the recent revision German National Guideline for Long- Post-COVID Syndrome current advances international guidance on assessment, this article provides practical scientifically informed recommendations individuals recovering coronavirus-related diseases.

Language: Английский

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Post-acute sequelae of SARS-CoV-2 infection: relationship of central nervous system manifestations with physical disability and systemic inflammation

Psychological Medicine, Journal Year: 2022, Volume and Issue: 52(12), P. 2387 - 2398

Published: May 6, 2022

Abstract Background Despite the multitude of clinical manifestations post-acute sequelae SARS-CoV-2 infection (PASC), studies applying statistical methods to directly investigate patterns symptom co-occurrence and their biological correlates are scarce. Methods We assessed 30 symptoms pertaining different organ systems in 749 adults (age = 55 ± 14 years; 47% female) during in-person visits conducted at 6–11 months after hospitalization due coronavirus disease 2019 (COVID-19), including six psychiatric cognitive manifestations. Symptom was initially investigated using exploratory factor analysis (EFA), latent variable modeling then Item Response Theory (IRT). associations severity with objective indices persistent physical disability, pulmonary kidney dysfunction, C-reactive protein D-dimer blood levels, measured same follow-up assessment. Results The EFA extracted one factor, explaining 64.8% variance; loadings were positive for all symptoms, above 0.35 16 them. trait generated IRT placed fatigue, psychiatric, as most discriminative (coefficients > 1.5, p < 0.001). Latent associated decreased body weight poorer performance 0.240; ⩽ 0.003), elevated levels (coefficient 0.378; 95% CI 0.215–0.541; 0.001) 0.412; 0.123–0.702; 0.005). similar excluding subjects pro-inflammatory comorbidities. Conclusions Different that persist several moderate or severe COVID-19 may unite within PASC. This is dominated by fatigue signs disability systemic inflammation.

Language: Английский

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Dissipating the fog: Cognitive trajectories and risk factors 1 year after COVID‐19 hospitalization

Alzheimer s & Dementia, Journal Year: 2023, Volume and Issue: 19(9), P. 3771 - 3782

Published: March 2, 2023

Abstract Introduction Cognitive impairment is common after severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. However, associations between post‐hospital discharge risk factors and cognitive trajectories have not been explored. Methods A total of 1105 adults (mean age ± SD 64.9 9.9 years, 44% women, 63% White) with disease 2019 (COVID‐19) were evaluated for function 1 year hospital discharge. Scores from tests harmonized, clusters defined using sequential analysis. Results Three groups observed during the follow‐up: no impairment, initial short‐term long‐term impairment. Predictors decline COVID‐19 older ( β = −0.013, 95% CI −0.023;−0.003), female sex −0.230, −0.413;−0.047), previous dementia diagnosis or substantial memory complaints −0.606, −0.877;−0.335), frailty before hospitalization −0.191, −0.264;−0.119), higher platelet count −0.101, −0.185;−0.018), delirium −0.483, −0.724;−0.244). Post‐discharge predictors included readmissions frailty. Discussion was patterns depended on sociodemographic, in‐hospital, post‐hospitalization predictors. Highlights associated age, less education, hospitalization, a number hospitalizations post discharge, hospitalization. Frequent evaluations 12‐month post‐COVID‐19 showed three possible trajectories: This study highlights importance frequent testing to determine given high frequency incident

Language: Английский

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Beyond the acute phase: a comprehensive literature review of long-term sequelae resulting from infectious diseases

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 31, 2024

Infectious diseases have consistently served as pivotal influences on numerous civilizations, inducing morbidity, mortality, and consequently redirecting the course of history. Their impact extends far beyond acute phase, characterized by majority symptom presentations, to a multitude adverse events sequelae that follow viral, parasitic, fungal, or bacterial infections. In this context, myriad related various infectious been identified, spanning short long-term durations. Although these are known affect thousands individuals individually, comprehensive evaluation all potential effects has yet be undertaken. We present literature review delineating primary attributable major diseases, categorized systems, symptoms, duration. This compilation serves crucial resource, illuminating ramifications for healthcare professionals worldwide. Moreover, highlights substantial burden impose global health economies, facet often overshadowed predominant focus phase. Patients frequently discharged following resolution with minimal follow-up comprehend address sequelae. emphasizes pressing need sustained vigilance, thorough patient monitoring, strategic management, rigorous research understand mitigate lasting economic impacts more fully.

Language: Английский

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Characterization of cognitive symptoms in post COVID-19 patients

European Archives of Psychiatry and Clinical Neuroscience, Journal Year: 2024, Volume and Issue: unknown

Published: May 13, 2024

Abstract Cognitive symptoms (CS) belong to the most common manifestations of Post COVID-19 (PC) condition. We sought objectify CS in PC patients using routine diagnostic assessments: neurocognitive testing (NCT) and brain imaging (BI). Further, we investigated possible associations with patient reported outcomes (PROs), risk factors for developing CS. Clinical data PROs 315 were assessed at a mean 6 months after SARS-CoV-2 infection. 231 (73.3%) any sort Among them, 78 underwent NCT 55 received BI. In NCT, cognitive domains affected working memory, attention, concentration. Nonetheless, pathological thresholds exceeded only few cases. Neurocognitive performance did not differ significantly between complaining severe (n = 26) versus non-severe 52) BI findings abnormal 8 (14.5%) cases but likely related PC. Patients reporting high severity scored worse PHQ-9, FSS, WHOQOL-BREF, more report impaired sleep, had higher prevalence psychiatric diagnoses. Overall, could confirm mild impairment some all CS, while studies affect results, associated depression (PHQ-9), fatigue (FSS), reduced quality life (WHOQOL-BREF) illnesses. These support importance BI, neuro-psychological assessment work-up Trial registration number date registration: DRKS00030974, 22 Dec 2022, retrospectively registered.

Language: Английский

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What We Know About Neurocognitive Outcomes in Long-/Post-COVID-19 Adults

Zeitschrift für Neuropsychologie, Journal Year: 2024, Volume and Issue: 35(2), P. 63 - 76

Published: May 1, 2024

Abstract: This review assesses neurocognitive studies on long-/post-COVID-19 adult patients, highlighting the research gaps. We categorize populations by infection severity, demographics, inclusion of controls, and psychological/biological factors. Methodologically, we analyzed 73 (95,600 subjects) from December 2019 to October 2022 using PRISMA-ScR guidelines PICO framework. Our findings revealed that most lacked control groups (88 %) reported unclear overall cognitive outcomes (73 %). While frequently assessed executive functions (86 attention (85 %), there were few longitudinal studies. Varied reporting sample sizes further complicated analysis. The identified gaps encompass convenience sampling, limited studies, inadequate use test batteries, leading a discrepancy between expected outcomes. absence standardized comparisons inconsistent statistical methods exacerbated these

Language: Английский

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Executive Function Deficit in Patients with Long COVID Syndrome: A Systematic Review

Heliyon, Journal Year: 2025, Volume and Issue: 11(3), P. e41987 - e41987

Published: Jan. 20, 2025

Post-COVID-19 condition (Long COVID) refers to a in which patients endure persistent symptoms for more than 12 weeks, typically occurring at least 3 months after the onset of Coronavirus disease 2019 (COVID-19) infection. It occurs when constellation persists following initial illness, and this may obstruct daily routine impose difficulty life. Therefore, study aimed systematically review published articles assessing neurocognitive profile long COVID patients, with specific emphasis on executive function (EF), determine correlation between EF deficits brain alterations through utilisation neuroimaging modalities. A thorough search was conducted using PubMed/MEDLINE Web Science online databases PICOS PRISMA 2020 guidelines. All included studies were deemed be high quality according Newcastle-Ottawa Scale (NOS). total 31 out 3268 present study. The main outcome is proportion individuals cognitive deficits, particularly domain, as detected by neuropsychological assessments. also revealed that are correlated disruptions frontal cerebellar regions, affecting processes such nonverbal reasoning, aspects language, recall. This consistent disturbance emphasised COVID. highlights importance evaluating patients. insight has potential improve future treatments interventions.

Language: Английский

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Cognitive reserve moderates the effect of COVID-19 on cognition: A systematic review and meta-analysis of individual participant data

Neuroscience & Biobehavioral Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 106067 - 106067

Published: Feb. 1, 2025

Language: Английский

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Cognitive performance of post-covid patients in mild, moderate, and severe clinical situations

BMC Psychology, Journal Year: 2024, Volume and Issue: 12(1)

Published: April 26, 2024

Abstract Background Studying individuals with varying symptoms, from mild to severe, can provide valuable insights into the spectrum of cognitive outcomes after COVID-19. We investigated performance adults who recovered novel coronavirus disease (COVID-19) without prior complaints, considering (not hospitalized), moderate (ward), and severe (intensive care unit) symptoms. Methods This cross-sectional study included 302 patients COVID-19 (mild, n = 102; moderate, 98). assessed intellectual quotient (IQ), attention, memory, processing speed, visual-constructive ability, as well symptoms depression, anxiety, stress, at least eighteen months infection. The mean length hospitalization was M days =8.2 ( SD 3.9) =14.4 8.2) in groups, respectively. Results Cognitive difficulties were present all three groups: 12, 11.7%), 40, 39.2%), 48, 48.9%). Using Multinomial Logistic Regression odds ratio, our results indicated that a one-point increase sustained visual working memory might decrease being categorized group by 20%, 24%, 77%, respectively, compared group. Conclusions Our findings empirical evidence regarding long-term effects COVID-19, particularly experiencing manifestations disease. also highlighted need for comprehensive, multidimensional approach rehabilitation programs address enduring impacts

Language: Английский

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Acute and long‑term psychiatric symptoms associated with COVID‑19 (Review)

Biomedical Reports, Journal Year: 2022, Volume and Issue: 18(1)

Published: Nov. 17, 2022

Coronavirus disease 2019 (COVID‑19) started spreading at the end of and despite immediate actions various governments with strict control, more individuals became infected daily. Due to uncertainty insecurity that still exists around this pandemic, there is an acute need for information knowledge what severe respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infection entails. Respiratory other physical symptoms received most medical attention, however, patients were also risk developing psychiatric mental health disorders, such as depression, anxiety, sleep disturbances. Available research reports a so‑called 'post‑COVID‑19 syndrome', which refers new and/or persistent signs over 12 weeks, following SARS. The aim present review was provide general overview developed during SARS‑CoV‑2 their long‑term outcome, highlighting that, through follow‑up surviving it revealed some COVID‑19 persisted long time after discharge associated negative effects on global functioning lower quality life.

Language: Английский

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